Abstract: The invention relates to a miniature linear vibrotactile actuator comprising: a first element 14, 104 of generally cylindrical shape, comprising permanent magnets 15, 105 aligned so that two adjacent sides of two adjacent magnets 15, 105 have identical polarities; a second element 11, 101 defining a cylindrical cavity 12, 102 into which the first element 14, 104 is inserted with play so as to be able to slide therein in a sliding direction X2, the second element 11, 101 comprising coils 13, 103 of conductive wire having strands that extend perpendicularly to the sliding direction X2, in order to form magnetic force generators, and that are placed so as to be able to influence the first element 14, 104 electromagnetically; and means 25, 41, 125 for returning and guiding the first element 14, 104 toward an equilibrium position in the second element 11, 101, in which position a median plane P2 between two adjacent magnets substantially coincides with a median plane P1 of a facing force generator 111.

Abstract: A multipurpose computing device includes a solver receiving a working matrix and an initial matrix corresponding to a system of equations and residual data; and an adapter receiving the initial matrix as well as a filtering matrix and calculates a working matrix corresponding to an equation system solved by the solver. The working matrix checks a stability condition with the initial matrix, comprising a comparison of two matrix products including the filtering matrix or the transpose thereof, and the initial matrix and the working matrix, respectively. The adapter renumbers the initial matrix and the filtering matrix in order to produce a modified matrix and a modified filtering matrix using an ordering rule that is a function of a dependency condition, and recursively calculates the working matrix representation with these matrices. The solver works recursively on the working matrix to provide a solution without inverting the initial matrix.

Abstract: A method of 3D reconstruction of a scene, including the implementation of at least two sensors each having a series of elementary receivers arranged so as to view the scene according to distinct respective solid angles and which are each sensitive to a physical characteristic of a signal received by the receiver originating from the scene. The sensors are adapted for emitting an asynchronous stream of events indicative of a modification of the signal received by one of the elementary receivers at a given instant, as well as the implementation of a 3D reconstruction algorithm having a step of pairing elementary receivers of each of the sensors utilizing signals generated by the sensors, the pairing including pairing between them events generated by each of the sensors and temporarily close together.

Abstract: The present invention describes the use of nucleoside analogues for the treatment of viral infections, in particular of an HIV infection, and also compositions comprising at least one of these analogues, and a method for evaluating the sensitivity to said treatment.

Abstract: The present invention relates to a method for producing polyphenol compounds, i.e. phloroglucinol or one of its derivatives, with a polyketide synthase of type III (PKSIII) from a brown marine alga. The invention also relates to recombinant nucleic acids coding for a polyketide synthase of type III (PKSIII) from the brown alga Ectocarpus siliculosus (E. siliculosus), to recombinant vectors comprising these nucleic acids, as well as to host cells comprising these vectors. Finally, the invention relates to a method for preparing of various compounds by means of polyphenol compounds produced according to the aforementioned method.

Abstract: A method is provided for storing hydrogen in a macroporous monolithic material by the heterogeneous nucleation of a metal hydride. A composite material is provided for storing hydrogen directly obtained by the method. A method is also provided for employing the material for the production of dihydrogen, as well as a method for producing dihydrogen using such a composite material.

Abstract: A carbon or ceramic monolithic materials with an M2 (macroporous/microporous) hierarchised porous structure is provided as well as method for preparing said materials using a macro/meso/microporous silica cavity. Such materials may be used, in particular for the production of hydrogen purifiers, supercapacitors or electrodes, or else for carrying out catalysed chemical reactions in a heterogeneous phase.

Abstract: The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance according to a 3D geometry associating aligned domains and cholesteric domains, and also isotropic domains where they are not organized; and a mineral phase (II) comprising apatite crystals having a hexagonal crystalline structure, space group 6/m, comprising at least calcium ions and phosphate ions; the axis c of said apatite crystals of the mineral phase is coaligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content in the material is at least 75 mg/cm3.

Abstract: The present invention relates in particular to proteins, coding nucleic acid sequences for same, vectors comprising said coding sequences, a method for producing said proteins, and an oligosaccharide hydrolysis method using same. In particular, the invention relates to the protein of sequence SEQ ID no. 1. The present invention can be applied to the recycling of bio-natural resources formed by organisms and microorganisms including ulvans, in particular green algae.

Abstract: The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfhydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine, and the use thereof for MHC class I and MHC class II presentation of antigens.

Abstract: The present disclosure relates to iminosugar derivatives and processes for the preparation thereof. The disclosed compounds have glycosidase inhibiting properties, and are useful in the treatment of various diseases, such as type 2 diabetes, neurodegenerative diseases or lysosomal storage disorders. The present disclosure also relates to pharmaceutical compositions containing the disclosed compounds and to their use as biochemical tools.

Abstract: A method for employing certain cobalt complexes as electron donors and in combination with an electron acceptor is provided for preparing an active layer in a photovoltaic conversion cell, as well as to the photovoltaic conversion cell in which the electron donor of the active layer includes such cobalt complexes.

Abstract: The invention relates to a device for guiding a medical instrument (2) inserted into a natural duel (101) or an artificial duct of a patient in order to bring at least a distal end (1) of the instrument in proximity to an internal organ (100), the device comprising an articulated arm (3) with a plurality of degrees of freedom, for moving a proximal end (4) of the instrument, and controlled blocking means (7) for blocking the degrees of freedom of the articulated arm. According to the invention, the blocking means are designed in such a way that, for at Mast one of the degrees of freedom, a blockage imposed on said degree of freedom can be enforced when an outer stress exerted on the instrument (2) exceeds a predetermined threshold.

Abstract: The invention relates to a surgical instrument (100; 200) comprising: an elongated arm (111; 207) according to a longitudinal axis and having a distal end (105; 204) mounted with a pivot joint on the elongated arm according to an axis substantially orthogonal to the longitudinal axis; a drive shaft (103; 3), substantially coaxial with the elongated arm, comprising means forming a universal joint (104; 206) facing the pivot joint; and, distal tool (9) securely fastened on the drive shaft and rotatively mounted on and in the extension of the distal end of the elongated arm, such that the distal tool has two rotational degrees of freedom, distinct and independent of each other, one being around an axis substantially perpendicular to the longitudinal axis of the elongated arm and the other being around an axis substantially collinear to an own axis of the distal tool, characterized in that the means forming a universal joint comprise a flexible drive sleeve (104; 206).

Abstract: The invention relates to the use of at least one globin and/or at least one globin protomer and/or at least one naturally extracellular native hemoglobin for the preservation of organs, tissues, organ and tissue cells and cell cultures.

Abstract: The present invention relates to compositions and methods for producing an immune response or reaction, as well as to vaccines, kits, processes, cells and uses thereof. This invention more particularly relates to compositions and methods of using a synthetic viral particle to produce, modify or regulate an immune response in a subject. In a more preferred embodiment, the invention is based, generally, on compositions using synthetic viral particles as an adjuvant and/or vehicle to raise an immune response against selected antigen(s) or epitopes, in particular a cellular and/or a humoral immune response.

Abstract: A system (1) for treating at least one sensory capacity of a person with the help of a stimulation device comprising: an electronic converter (7) of a sensory signal into an electronic signal for controlling at least one transducer for emitting signals that are images of the sensory signal; the stimulation device is a device (3) for direct ultrasound stimulation of the sensory cortex of the patient's brain (B), comprising: at least one support (2) that is implantable in the patient's skull (C) and that includes at least one internal wall (22); and at least one ultrasound transducer (4) carried by the support (2) and including means for emitting focused ultrasound waves (U) through the internal wall (22) of the support towards a determined zone of the sensory cortex of the patient's brain (B) in order to generate modulation of the brain activity in the cortex, the ultrasound transducer (4) being driven by the electronic converter to emit focused ultrasound signals (U) that are images of the sensory signal.

Abstract: The invention relates to a system comprising an oculometer for measuring movements of at least one eye of an operator, wherein it comprises furthermore a display for displaying, for the eye, a frame of at least one point performing a blinking, so that the operator can perform at least one smooth tracking movement of the eye while looking at the display while operating. The invention also relates to a method implemented on such a system, and a corresponding computer program product.

Abstract: A method for merging information of high semantic level representing complex situations including several objects originating from several sensors ci, said information possibly being heterogeneous, said method including acquiring the various items of information arising from said sensors in raw form and transforming them so as to cast them into the form of conceptual graphs, a conceptual graph representing several concepts and the relations which exist between them, and being composed of entity nodes and relation nodes, with E the set of concept nodes defined on a support S, G1 and G2 two conceptual graphs defined on S, wherein the method determines a merging strategy denoted strategymerge as follows: strategymerge=fmerge?fcomp:E×E?E?{E×E} and said merging strategy is applied to the various items of information taking the form of graphs.

Abstract: The invention relates to a method for determining a predictive function for discriminating patients according to their disease activity status, comprising steps of: a—measuring values of biological markers for each patient of a first group of patients having a first known disease activity status, and for each patient of a second group of patients having a second known disease activity status, the measured values forming a dataset b—analyzing the dataset for identifying biological markers which are differentially expressed between the first group of patients and the second group of patients, c—among the biological markers identified at step b, determining correlated markers as markers which are correlated with other markers above a predetermined significance level, d—removing from the dataset, values measured for a biological marker identified as correlated marker, e—analyzing the dataset obtained at step d for determining a predictive function that predicts a disease activity status of a patient as a combinat