Abstract: A suction and irrigation device for medical use comprises a valve body with an irrigation passage and a suction passage. At least one irrigation pipe and at least one suction pipe are connectable to the irrigation passage and the suction passage by connections at a proximal side of the valve body. A suction/irrigation tube is connectable to the irrigation passage and the suction passage at a distal side of the valve body by at least one further connection. A valve assembly is provided within the valve body, which in a first position opens the suction passage and closes the irrigation passage and in a second position closes the suction passage and opens the irrigation passage. The device comprises at least one push element which interacts with at least one movable element of the valve assembly, whereas the movable element is movable by mechanical force acted upon the push element such, that the push element activates the valve assembly from one position to the other position.

Abstract: Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

Abstract: A hopper having a passage through which a medicine can be passed downward is provided. A part of a lower portion of the hopper is a deformable portion having flexibility, and the deformable portion is deformable so as to open and close the passage. According to this configuration, the deformable portion that is a part of the hopper is deformed to open and close the passage. Thus, there is no portion such as an opening and closing plate on which the medicine remains, thereby preventing a gap in which the medicine remains from being formed in the hopper, and preventing the medicine from easily remaining in the hopper.

Abstract: An imaging method for radiologically guiding an instrument during medical interventions on an object comprising: providing a first image of said object followed by providing updated images on-the-fly during the intervention to an operator by measuring an undersampled set of projections of said object and reconstructing said updated image based on changes between said first image or an update of said first image and said undersampled set of projections. The invention further relates to particular uses of the method and a system for radiologically guiding medical interventions on an object, comprising means to provide a first image of the object; an imaging apparatus measuring undersampled sets of projections; processing means in communication with the imaging apparatus for providing updated images on-the-fly during the intervention by reconstructing said updated image based on changes between said first image or an update of said first image and said undersampled set of projections.

Abstract: The present invention relates to a method for detecting at least one direct factor Xa inhibitor in a sample other than citrate plasma, comprising the step of mixing a sample containing a factor Xa inhibitor with a composition containing factor Xa under conditions which allow the factor Xa to release a detectable substance from a chromogenic substrate.

Abstract: The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like-molecule, for the prevention or treatment of Alzheimer's disease. Similarly, siRNA, antisense or transcription factor modulators of gene expression of p19, p35, p40, IL-12R-?1, IL-12R-?2, and/or IL-23R for the prevention or treatment of Alzheimer's disease are provided.

Abstract: The present invention describes a method for building models in layers, wherein a first material and subsequent thereto selectively a second material are applied in layers in a build space, and these two application steps are repeated until a desired model is obtained. The two materials form a solid object in a suitable mixing ratio, the first material including a particulate material and the second material being applied with the aid of a print head. The first material, the second material and/or the particulate material include one or more diamines and/or one or more dicarbonyl compounds as the binder.

Abstract: A radiation source that provides high order harmonic radiation (HHG radiation) in an UV or XUV wavelength range comprising a resonant cavity that guides laser light pulses that includes at least two cavity mirrors, a first non-linear medium that provides the HHG radiation by harmonic generation based on an interaction of the laser light pulses with the first non-linear medium, wherein the first non-linear medium is arranged in the resonant cavity in an environment of reduced pressure, and a second non-linear medium arranged in the resonant cavity and adapted for at least one of amplifying the laser light pulses and phase locking longitudinal modes of the laser light pulses in the resonant cavity.

Abstract: Compounds according to the general formula (I) wherein X1, X2, X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different, and wherein up to 3 of the group X1, X2, X3 and X4 may be N; A is a 5- or 6-membered aromatic or heteroaromtic cycle containing 1 to 3 heteroatoms selected from the group consisting of N, O and S wherein A may be substituted by 1 to 5 substituents R which may be same or different; their solvates, hydrates, and pharmaceutically acceptable salts for the treatment of a disorder or disease associated with an aberrant activation of Wnt signalling in a mammal selected from a cell proliferative disorder, rheumatoid arthritis, increased bone density, aging or age-related disorders and/or diseases or Dupuytren disease (superficial fibromatosis).

Abstract: A method is provided for detecting an increased susceptibility to ulcerative colitis by determining the presence of a polymorphism at position 256 of the nucleotide sequence of rs3024505 in which C is substituted by T or the presence of a polymorphism at position 501 of the nucleotide sequence of rs12612347 in which G is substituted by A.

Abstract: Subject of the present invention are compounds with high affinity for the A? protein, ?-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in vivo diagnosis of neurodegenerative disorders like e.g. Alzheimer's disease and Parkinson's disease. The compounds are characterized by suitable physicochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) as well as a high affinity and selectivity for the target proteins.

Abstract: The present invention relates to shortened peptides comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptides for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical compositions comprising said peptides and a method for treating or preventing disorders associated with muscular malfunction using said peptides or said pharmaceutical compositions.

Abstract: There is provided a visual localization method comprising: (a) transmitting data representative of one or more detected visual features from a mobile device to a server; (b) estimating the location of the mobile device at the server based on the visual features 5 received from the mobile device; (c) transmitting reference data associated with the estimated location from the server to the mobile device; and (d) the mobile device determining its location based on the reference data received from the server.

Abstract: A double-resonance structure for DNP-NMR experiments and/or ENDOR experiments and methods using such a double-resonance structure. The double-resonance structure comprises a microwave resonator for generating electromagnetic fields suitable for EPR and an HF resonator for generating electromagnetic fields suitable for NMR. The HF resonator is formed by a strip resonator, a section of the strip resonator at the same time forming a portion of the microwave resonator.

Abstract: The present invention relates to the use of popcorn as material that provides structure and that stabilizes dimensions, for lignocellulose-containing molded articles, such as wood/composite materials, and also to the use of popcorn as binder for formaldehyde in wood/composite materials.

Abstract: Substantially pure biological culture of a strain of the species Pseudomonas graminis, deposited with number CBS124167 at the depositary institution “Centraalbureau voor Schimmelcultures” (CBS) in Utrecht, Netherlands. Use of the CBS124167 culture as an antagonist for the biocontrol of foodborne pathogenic bacteria in fruit intended for human consumption. Method for treating the fruit which comprises the step of applying a preparation that comprises a culture of a strain of the species Pseudomonas graminis, deposited with number CBS124167 at the depositary institution “Centraalbureau voor Schimmelcultures” (CBS) in Utrecht, Netherlands, to the fruit. The application thereof makes it possible to reduce the growth of pathogens during the shelf life of the product, especially when the cold chain is broken.

Abstract: An integrated catheter navigation system (100) and method (200) that combines anatomical imaging (302, 304) with catheter tip-to force information (306, 308) during an ablation procedure.

Abstract: The present invention is directed to an isolated miR-206 target site, comprising or consisting of a nucleic acid sequence with a sequence identity of at least 80% compared to wild type miR-206 target site with SEQ ID No. 1, characterized in that the nucleic acid sequence comprises at least one nucleotide substitution at a position from nucleotide 2 to 8 and/or at least one nucleotide substitution at a position from nucleotide 12 to 16 of SEQ D No. 1, wherein the nucleotide positions of SEQ ID No. 1 are numbered from the 3?- to the 5?-end; as well as to an expression cassette, vector and pharmaceutical composition comprising at least one isolated miR-206 target site of the invention.

Abstract: A method and a system are for compensating optical aberrations in a telescope. The method is applicable to a telescope wherein the element for receiving a primary beam is an image acquisition device (3), and involves using an algorithm without an image processing sensor for: a) detecting optical aberrations affecting the primary focus, by analyzing the images acquired by the image acquisition device (3), and b) calculating and generating first positional correction values, by processing the detected optical aberration values. The method also includes a step c) consisting in moving, in a controlled manner, the image acquisition device (3), applying suitable control signals generated from the first positional correction values. The system is suitable for implementing the proposed method.

Abstract: The invention relates to an apparatus (1) for non-incremental position and form measurement of moving solid bodies (7), containing a laser Doppler distance sensor (10) in wavelength multiplexing technique with at least two different wavelengths (?1, ?2) and with a modular fibre optic measurement head in its sensor design, which contains two additional modules, which are connected to the measuring head by means of fibre optics a light source unit (2) and a detection unit (4). Two laser light bundles (37) of different wavelengths (?1, ?2) in the light source unit (2) are coupled into a glass fibre (24). The bichromatic scattered light in the detection unit (4) is split into the different wavelengths (?1, ?2) corresponding to the two measurement channels (41, 42) and subsequently are detected separately by means of two photo detectors (43, 44).