Abstract: Compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, where: R1 is selected from the group consisting of: phenyl, and phenyl mono-, di-, or tri-substituted by a radical independently selected from the group consisting of F, Cl, Br, I, (C1-C6)-alkyl, COO-(C1-C6)-alkyl, and (C1-C6)-alkoxy; and R2 is a radical selected from the same group as R1, further including a phenyl substituted in 4-position by a radical independently selected from the group consisting of —O(CH2)CONH(CH2)3CH3 and OCH2COOC(CH3)3, a biphenyl-4-yl, thiazol-2-yl, and a thiazol-2-yl mono- or di-substituted by a radical selected from F and phenyl; inhibit cell proliferation of tumor cells independently of p53 protein and may also induce apoptosis in several tumor cells independently of p53 protein, being useful for the treatment of several types of cancer.

Abstract: The present invention relates to a micro-valve which is formed from two firmly connected substrates and preferably has an actuator element, for example that is diaphragm-driven, for the controlled opening and closing of a first and/or second passage. The invention further relates to a method for producing such a micro-valve and to a micro-pump which uses at least one such micro-valve. Said micro-pump is intended to be used in particular in conjunction with the development of an artificial sphincter. The micro-valve has a first substrate and a second substrate which are non-detachably joined to each other in order to form a controllable fluid flow section, and at least one first passage and at least one second passage. According to the invention, the micro-valve has at least one elastically deformable seal structure which, for example, can be formed by a photostructurable silicone, to seal off the first and/or second passage.

Abstract: The present invention relates to a human in vitro model system of the blood cerebrospinal fluid barrier (BCSFB), to a method for producing said model system, as well as to uses thereof.

Abstract: The invention relates to a circuit for a system for contactless, inductive power transmission, in particular for use in supplying power to mobile devices, and to an associated charging circuit. The circuit comprises a primary-side circuit, which is disposed on a primary side and can be connected to a primary-side supply voltage, and a secondary-side circuit, which is disposed on a secondary side and can be connected to a load to be supplied with power. Furthermore a transformer stage having galvanic isolation is provided for the contactless transfer of power from the primary side over an air gap to the secondary side, wherein at least two magnetically coupled coils are provided for inductive power transmission and can be spatially separated from one another by distancing the secondary side from the primary side. The transformer stage has a resonant converter and the secondary-side circuit further comprises a restabilisation stage.

Abstract: The invention relates to the discovery that HNA-3a and HNA-3b are antigens within a polypeptide sequence that is highly similar to the CTL2 amino acid sequence.

Abstract: Systems, methods, and apparatus are provided for distributed augmentation. In one implementation, a system is provided. The system includes one or more presentation applications, each presentation application operable to provide a presentation output and a plurality of augmentation and presentation control (iAPC) modules operable to provide user augmentations of the presentation output. The system also includes one or more distributed augmentation and presentation management (DAPm) modules operable to separately manage augmentations from the presentation output and to provide an augmented presentation output and one or more display devices for presenting the augmented presentation output.

Abstract: The invention at hand concerns a novel class of gas sensors, in particular for hydrogen or hydrogen-containing fluids (gases or liquids), such as hydrocarbons, hydrogen sulphides or more complex gas mixtures or gas compositions which contain hydrogen or hydrogen compounds.

Abstract: The transporter that translocates ergothioneine has been identified. Described are methods for identifying and obtaining compounds capable of modulating ergothioneine transport as well as the use of such compounds for the treatment of diseases ergothioneine may be involved in such as autoimmune diseases, in particular rheumatoid arthritis, as well as other diseases arising from cell damage caused by radiation, radicals and relative oxidant species. Furthermore, diagnostic means and methods for determining the presence or susceptibility to such a disease are provided.

Abstract: A device for repeated piercing of an organic tissue and method thereof are disclosed. The device may comprise an arrangement of application tools each of which is connected to an operating mechanism and has a distal tool end which is formed for at least one application tool with a penetration device, whereby by way of the operating mechanism the tools can be displaced relative to each other between an initial position and a penetration position. During the relative movement, the effect direction of an application force provided by at least one application tool is counter to the effect direction of the application force provided by the other application tool. A mechanical actuation device, which is connected to the operating mechanism, is suitable for repeatedly effecting the relative displacement of the at least one application tool between the initial position and the penetration with an operating frequency.

Abstract: A hyperpolarized liquid contrast agent is for use in a MRT device. The liquid contrast agent passes through a conduit of a MW resonator in the magnetic field of the MRT device. A microwave with a frequency of at least 40 GHz couples into the MW resonator for polarizing the liquid contrast agent upon passage through the conduit in the MW resonator using DNP. The contrast agent is polarized in a continuous passage in the MW resonator and administered immediately. A MW mode is formed in the MW resonator which has an antinode in the magnetic field strength and a node in the electric field strength. The power of the introduced microwave and coupling of the microwave into the resonator are adjusted such that in the area of the line, an amplitude of the MW magnetic field strength B1?1.5·10?2 Ts 1/T1,e results, wherein T1,e is the relaxation time of the DNP-active electrons.

Abstract: The present invention relates to an electronic circuit with which input voltages at an input of the circuit are converted into higher output voltages at an output of the circuit, whereby the voltage conversion already starts at low voltages at the input. According to the present invention, the DC converter circuit for the generation of an output voltage from an input voltage (Vin) comprises a transformer (Tr) with a first primary winding (1) that can be connected to the input voltage (Vin) via a first transistor (T1) that is connected in series, and a second primary winding (2) that can be connected to the input voltage (Vin) via a second transistor (T2) that is connected in series.

Abstract: The present invention relates to a process for obtaining nanocrystalline corundum, characterised in that it comprises a first step of thermal treatment of the raw material used in the process at standard pressure, to a temperature greater than that of the last endothermic accident of the differential thermal analysis record of the raw material, performed to 925° C.; and a second step of fast cooling from the maximum temperature reached in the preceding step to room temperature. Moreover, the present invention relates to the nanocrystalline corundum obtainable from the process described, as well as to multiple uses of said corundum. Furthermore, this material may be disaggregated, for example by means of high-energy grinding, to produce a fine aggregate that may be used as an abrasive or as a functional load in plastic polymers or other types of materials.

Abstract: In summary, the present invention relates to a method for analyzing and/or testing at least one user interface, comprising the steps of: transmitting an address of at least one user interface, in particular a web-based user interface, and/or a source code together with the associated graphical elements of at least one user interface, in particular a web-based user interface, to an evaluation apparatus (10); transmitting the address of the at least one user interface and/or the source code together with the associated graphical elements of the at least one user interface to at least two differently configured presentation apparatuses (12, 14); generating at least one pixel image of the user interface on each presentation apparatus (12, 14); transmitting each generated pixel image to the evaluation apparatus (10); automatically determining and/or representing at least one difference between the generated pixel images of the at least one user interface.

Abstract: The invention relates to a system and method for measuring light diffusion in the eyeball or eye region, by recording and processing retinal images. The inventive system includes a double-pass ophthalmoscopic system having means for correcting low-order aberrations. Said system can be used to record images of the plane of the retina on a CCD camera, the outer part of said images containing information relating to ocular scattering. The aforementioned images can be used to obtain the objective scattering index (OSI), providing the ratio between the energy on the outer part of the image and the energy in the central part, or, alternatively, the modulation transfer function (MTF) area can be used for this purpose once the low frequencies have been filtered. According to the inventive method, the low-order aberrations are corrected before a retinal image or a temporal sequence of retinal images is captured and recorded.

Abstract: The present invention relates to imidazolium salts, particularly imidazolium salts of the general formula I as well as the respective carbene metal complexes and their utilisation as bioanalytical tags for biomolecules.

Abstract: A device for combined optical and nuclear image comprises a nuclear image acquisition module and a reference image acquisition module. The reference image acquisition module has: an optical image sensor and an optical imaging system for deflecting the optical radiation from a reference field of view to the image sensor, wherein the optical imaging system comprises a mirror for the optical radiation, which mirror is arranged between the reference field of view and the optical image sensor. On the image sensor, a respective image area is assigned to at least one of nuclear partial fields of view. The optical imaging system is arranged such that the optical radiation coming from the at least one nuclear partial field of view is deflected substantially exactly to the respectively assigned of the image areas.

Abstract: The invention relates to a method for heating and cooling a working fluid (2) using at least one thermochemical heat accumulator medium (3), wherein the working fluid (2) is guided through at least one thermochemical heat accumulator (6) comprising the heat accumulator medium (3), wherein the working fluid (2) is guided without contact to the heat accumulator medium (3), wherein upon charging of the heat accumulator medium (3) a heat flow (Q) is transferred from the working fluid (2) to the heat accumulator medium (3) and at least one substance (15) is released from the heat accumulator medium (3) and discharged from the heat accumulator (6), and wherein upon discharging of the heat accumulator medium (3) the substance (15) is fed with release of heat to the heat accumulator medium (3) or at least to a reaction product of the heat accumulator medium (3) that was produced during charging of the heat accumulator medium (3), and a heat flow (Q) is transferred to the working fluid (2).

Abstract: A process for the electrochemical deposition of nanoscale catalyst particles using a sacrificial hydrogen anode as counter electrode for the working electrode is disclosed, whereby a concurrent development of hydrogen at the working electrode is mostly or completely avoided.

Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.

Abstract: The invention relates to a device for an atomic force microscope (AFM) for the study and/or modification of surface properties. The device comprises a cantilever (flexible bar) having an integrated, piezoresistive sensor, an integrated bimorphic actuator, and a measuring tip. The measuring tip carries at least two metal electrodes, which can be activated via electrical terminals. The measuring tip and/or the cantilever have at least one nanoscopic hole through which synchrotron radiation or laser light is directed onto the material surface to be studied. Furthermore, the invention relates to a method for the study and modification of surface properties and surface-proximal properties, which can be executed using such a device. To this end, atomic force microscopy (AFM), surface enhanced Raman scattering (SERS), photo emission spectroscopy (XPS, XAS), and material modification by local exposure are executed in sequence or simultaneously using the same device.