Patents Assigned to Universität
  • Photon pair source and method for its production
    Patent number: 8559479
    Abstract: The invention relates to a method for the production of a photon pair source, which generates entangled photon pairs, having at least one quantum dot, wherein in the method the operational behaviour of the photon pair source is determined by adjusting the fine structure splitting of the excitonic energy level of the at least one quantum dot. It is provided according to the invention for the fine structure splitting of the excitonic energy level to be adjusted by depositing the at least one quantum dot on a {111} crystal surface of a semiconductor substrate.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: October 15, 2013
    Assignee: Technische Universitat Berlin
    Inventors: Momme Winkelnkemper, Andrei Schliwa, Dieter Bimberg
  • Tripodal Bisphosphonate Derivatives
    Publication number: 20130267731
    Abstract: The present invention describes tripodal bisphosphonate derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. A fourth remaining position of the flexible framework is suitable to be optionally functionalised by so-called click reactions, for example with biomolecules, polyethylene glycol or active agents.
    Type: Application
    Filed: September 7, 2011
    Publication date: October 10, 2013
    Applicant: JUSTUS-LIEBIG-UNIVERSITAT GIESSEN
    Inventors: Wolfgang Maison, Elisa Franzmann, Faiza Khalil
  • MEANS AND METHODS FOR DIAGNOSING CANCER USING AN ANTIBODY WHICH SPECIFICALLY BINDS TO BRAF V600E
    Publication number: 20130266962
    Abstract: The present invention relates to the field of diagnostic tests and diagnostic tools. Specifically, contemplated is to a method for diagnosing cancer in a sample of a subject suspected to suffer from cancer comprising contacting the sample with an antibody which specifically binds to the epitope characterized by SEQ ID NO 1 on a BRAF polypeptide under conditions which allow for binding of said antibody to the epitope and determining binding of the antibody to the epitope, whereby cancer is diagnosed. Further contemplated are antibodies which specifically bind to the epitope characterized by SEQ ID NO 1 on a BRAF polypeptide and a device or kit comprising such antibodies.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 10, 2013
    Applicants: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG, DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventor: Ulrike Zentgraf
  • SYSTEM AND METHOD FOR THE SIMULTANEOUS, NON-INVASIVE ESTIMATION OF BLOOD GLUCOSE, GLUCOCORTICOID LEVEL AND BLOOD PRESSURE
    Publication number: 20130267796
    Abstract: System and method for the simultaneous and non-invasive estimation of blood glucose, glucocorticoid and pressure levels. It comprises an activity module detector for a digitalized signal acquired by a sensor, representing the distal heartbeat of a person, selecting a segment of consecutive signal samples of fixed duration Swindow(t) and using the same to generate sub-windows Sframe(t, n) of shorter duration; a signal processing module which receives the two signals Swindow(t) and Sframe(t, n) and which delivers a vector XF at its output with the parameters of a physiological model and module based on automatic learning, which receives the XF vector and information on a person's characteristics and provides an estimation of blood glucose levels (BGL), systolic pressure levels (SPL), diastolic pressure levels (DPL) and glucocorticoid levels (GCL) at its output.
    Type: Application
    Filed: November 30, 2011
    Publication date: October 10, 2013
    Applicant: UNIVERSITAT POLITECNICA DE CATALUNYA
    Inventor: Enric Enric Monte Moreno
  • DERIVATIVES OF STEROID BENZYLAMINES, HAVING AN ANTIPARASITIC ANTIBACTERIAL, ANTIMYCOTIC AND/OR ANTIVIRAL ACTION
    Publication number: 20130266645
    Abstract: The present invention relates to compounds derived from steroids of the general formula (I) wherein L represents a linker and R# represents a steroid residue, the use of compounds of the general formula (I) in medicine and for the prophylaxis and/or the treatment of infectious diseases. Furthermore described are pharmaceutical compositions containing at least one compound of the general formula (I). A further aspect of the invention relates to the synthesis of said compounds of the general formula (I).
    Type: Application
    Filed: October 6, 2011
    Publication date: October 10, 2013
    Applicant: Justus-Liebig-Universitat Giessen
    Inventors: Katja Becker, Reimar Krieg, Bruno Schönecker
  • METHOD AND AGENTS FOR PRODUCING N-ACETYLNEURAMINIC ACID (NEUNAC)
    Publication number: 20130266987
    Abstract: The invention relates to an isolated nucleic acid molecule comprising at least one promoter that is active in fungal cells of the trichoderma species, wherein a nucleic acid sequence encoding an N-acetylglucosamine-2-epimerase and/or an N-acetylneuraminic acid synthase is operatively bound to each promoter. The at least one promoter that is active in fungal cells is a constitutive promoter.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 10, 2013
    Applicant: TECHNISCHE UNIVERSITÄT WIEN
    Inventors: Astrid Mach-Aigner, Robert Mach, Matthias G. Steiger
  • GENERATION OF NANODISPERSE INCLUSIONS IN A HIGH-VISCOSITY MATRIX
    Publication number: 20130260133
    Abstract: The invention relates to a process for generating a porous material having homogeneous, gas-containing inclusions in the micrometer and sub-micrometer range, and also to the material produced by such process.
    Type: Application
    Filed: December 1, 2011
    Publication date: October 3, 2013
    Applicant: UNIVERSITAT ZU KOLN
    Inventors: Reinhard Strey, Alexander Müller
  • USE OF PROKARYOTIC SPHINGOSINE-1-PHOSPHATE LYASES AND OF SPHINGOSINE-1-PHOSPHATE LYASES LACKING A TRANSMEMBRANE DOMAIN FOR TREATING HYPERPROLIFERATIVE AND OTHER DISEASES
    Publication number: 20130259851
    Abstract: The present invention relates to the use of prokaryotic sphingosine-1-phosphate lyases (S1PL) and S1PLs that lack a transmembrane domain or of a nucleic acid encoding such an S1PL in the prevention or treatment of a disease condition associated with elevated levels of sphingosine-1-phosphate (S1P), and for which S1P elevation is directly or indirectly causative. In addition, the invention relates to a new product in the form of S1PL lacking the N-terminal loop domain.
    Type: Application
    Filed: November 30, 2011
    Publication date: October 3, 2013
    Applicants: UNIVERSITAT ZURICH, UNIVERSITAT BERN
    Inventors: Uwe Zangemeister-Wittke, Andrea Huwiler, Markus G. Grutter, Florence Bourquin
  • Distributive resistive mixer
    Patent number: 8547158
    Abstract: The invention relates to devices comprising field effect transistors to detect the power of an electromagnetic high frequency signal VRF. According to the prior art, the high frequency signal is coupled into the gate G and via a capacitor CGD into the drain D of the field effect transistor FET, the gate G being biased with a direct voltage Vg which corresponds to the threshold value of the FET transistor. The resulting current at the source S contains a direct current portion Ids which is proportional to the square of the amplitude of the high frequency signal. The operating frequency of said power detectors is limited to a few gigahertz (GHz) by the discrete arrangement and especially by the predetermined gate length of the field effect transistor. The aim of the invention is to improve a resistive mixer in such a manner that it can be operated at high gigahertz and terahertz frequencies.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: October 1, 2013
    Assignee: Johann Wolfgang Goeth-Universität Frankfurt a.M.
    Inventors: Ullrich Pfeiffer, Erik Oejefors, Hartmut G. Roskos, Alvydas Lisauskas
  • Chimeric human beta defensins
    Patent number: 8546525
    Abstract: The invention relates to a nucleic acid molecule selected from the group comprising a) a nucleic acid molecule having one of the nucleotide sequences presented in SEQ ID:NO 4 to SEQ ID:NO 8, b) a nucleic acid molecule that codes for a peptide having one of the amino acid sequences presented in SEQ ID:NO 12 to SEQ ID:NO 16, c) a nucleic acid molecule, the complementary strand of which hybridizes to a nucleic acid molecule according to a) or b) and which codes for a peptide having antimicrobial activity, and d) a nucleic acid molecule, the nucleotide sequence of which deviates from the nucleotide sequence of a nucleic acid molecule according to c) because of the degenerated genetic code.
    Type: Grant
    Filed: November 20, 2010
    Date of Patent: October 1, 2013
    Assignee: Christian-Albrechts-Universität zu Kiel
    Inventor: Joachim Grötzinger
  • RECOMBINANT EQUINE HERPESVIRUS-1 VACCINE CONTAINING MUTATED GLYCOPROTEIN C AND USES THEREOF
    Publication number: 20130251747
    Abstract: The present invention provides compositions or vaccines that contain a recombinant EHV-1 that elicit an immune response in animals against equine herpesvirus, including compositions comprising said recombinant EHV-1, methods of vaccination against equine herpesvirus, and kits for use with such methods and compositions.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 26, 2013
    Applicants: FREIE UNIVERSITÄT BERLIN, MERIAL LIMITED
    Inventors: Jean Christophe Audonnet, Jules Maarten Minke, Nikolaus Osterrieder, Guanggang Ma
  • LIPOSOMES CONTAINING PERMEATION ENHANCERS FOR ORAL DRUG DELIVERY
    Publication number: 20130251783
    Abstract: The present invention relates to liposomal compositions and their application for delivery of pharmaceuticals for the treatment of disease.
    Type: Application
    Filed: September 14, 2012
    Publication date: September 26, 2013
    Applicants: Universitat Heidelberg, MULLER-BORE & PARTNER
    Inventors: Johannes Parmentier, Gert Fricker, Felix Gropp, Klaus Hartmann
  • NITRIC OXIDE DONORS IN THERAPY OF NITRIC OXIDE DEFICIENCY-INDUCED DISTURBANCES OF CEREBRAL MICROCIRCULATION
    Publication number: 20130252959
    Abstract: The present invention relates to nitric oxide releasing compounds and their use in the prevention, amelioration and/or therapy of nitric oxide (NO) deficiency induced disturbances of the cerebral microcirculation. The NO deficiency induced disturbances of the cerebral microcirculation may be due to an intracranial hemorrhage or stroke and can cause cerebrovascular spasms (or cerebral vasospasms) (CVS) and/or malperfusion of brain parenchyma caused by blood vessel and blood flow dysregulation which, in turn, can cause secondary neurological deficiencies (DIND) and/or brain infarction. Particularly, the present invention relates to the prevention, amelioration and/or therapy of delayed cerebral vasospasm-associated disorders after survived subarachnoidal hemorrhage by applying a NO-donor, most preferably Molsidomine.
    Type: Application
    Filed: November 25, 2011
    Publication date: September 26, 2013
    Applicant: West-Falische Wilhelms-Universitat Munster
    Inventors: Angelika Ehlert, Christoph Schmidt
  • BONE MARROW APLASIA WITH HAEMORRHAGIC DISEASE IN CALVES CAUSED BY NOVEL PATHOGEN
    Publication number: 20130251719
    Abstract: The present invention refers to a novel circovirus as causative agent of bone marrow aplasia with haemorrhagic disease in cattle. The present invention provides novel nucleic acid and protein sequences for diagnostic and therapeutic uses.
    Type: Application
    Filed: October 22, 2010
    Publication date: September 26, 2013
    Applicants: Tiergesundheitsdienst Bayern E.V., Universitat Leipzig
    Inventors: Hermann Muller, Mohammad Yahya Halami, Jens Bottcher, Eva Kappe, Benjamin Schade
  • Synthesis of Trivalent Flexible Frameworks with Ligands Comprising Catechol Units for Functionalizing Surfaces
    Publication number: 20130245270
    Abstract: The present invention describes tripodal catechol derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. The remaining fourth bridgehead position is easily suitable to be further functionalised via so-called click reactions, e.g. with biomolecules, dyes, radiomarkers, polyethylene glycol or active agents.
    Type: Application
    Filed: September 7, 2011
    Publication date: September 19, 2013
    Applicant: JUSTUS-LIEBIG-UNIVERSITAT GIESSEN
    Inventors: Wolfgang Maison, Faiza Khalil, Elisa Franzmann
  • METHOD AND SYSTEM FOR IMPROVING CHARACTERISTIC PEAK SIGNALS IN ANALYTICAL ELECTRON MICROSCOPY
    Publication number: 20130240728
    Abstract: A method and system are disclosed for improving characteristic peak signals in electron energy loss spectroscopy (EELS) and energy dispersive x-ray spectroscopy (EDS) measurements of crystalline materials. A beam scanning protocol is applied which varies the inclination, azimuthal angle, or a combination thereof of the incident beam while spectroscopic data is acquired. The method and system may be applied to compositional mapping.
    Type: Application
    Filed: November 19, 2012
    Publication date: September 19, 2013
    Applicants: Universitat de Barcelona, AppFive LLC, Nanomegas SPRL
    Inventors: Sonia Estrade Albiol, Joaquin Portillo Serra, Francisca Peiro Martinez, José Manuel Rebled Corsellas, Lluis Yedra Cardona, Stavros Nicolopoulos, Steven Kim, Jon Karl Weiss
  • USE OF CONKUNITZIN-S1 FOR THE MODULATION OF GLUCOSE-INDUCED INSULIN SECRETION
    Publication number: 20130244933
    Abstract: The present invention relates to a (poly)peptide or a peptidomimetic thereof having the biological activity of Conkunitzin-S1, wherein said (poly)peptide is selected from (a) a polypeptide comprising or having the amino acid sequence of SEQ ID NO: 1; (b) a polypeptide having at least 85% sequence identity to SEQ ID NO:1; or (c) a fragment of a) or b); wherein said (poly)peptide or peptidomimetic specifically modulates the activity of a channel having the activity of a Kv1.7 containing channel, for the treatment or prevention of metabolic diseases or conditions, or secondary diseases or conditions related to said metabolic diseases or conditions.
    Type: Application
    Filed: April 8, 2013
    Publication date: September 19, 2013
    Applicants: Universitat zu Lubeck, Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Heinrich Terlau, Rocio Finol-Urdaneta, Stefan Becker, Walter Raasch
  • CONTINUOUS SYSTEM AND PROCEDURE OF STERILIZATION AND PHYSICAL STABILIZATION OF PUMPABLE FLUIDS BY MEANS OF AN ULTRA-HIGH PRESSURE HOMOGENIZATION
    Publication number: 20130243644
    Abstract: Continuous system and procedure of sterilization and physical stabilization of pumpable fluids, food, or other type of fluids, through ultra-high pressure homogenization (UHPH) includes a first heat exchanger 1 which preheats the fluid at temperature Tp between 40 and 90° C.; an ultra-homogenizer 3 through which fluid at temperature Tp is introduced at a pressure Pu between 200 and 600 MPa increasing its temperature up to a final value Tu. A second heat exchanger 4 has its cooling temperature adjusted at value Te. An aseptic tank 5 receives the cooled down fluid at value Te, from which it is pumped by sterile air pressure into an aseptic packaging machine, for the packaging of the final product.
    Type: Application
    Filed: July 18, 2011
    Publication date: September 19, 2013
    Applicant: UNIVERSITAT AUTONOMA DE BARCELONA
    Inventors: Buenaventura Guamis Lopez, Antonio Jose Trujillo Mesa, Victoria Ferragut Perez, Joan Miquel Quevedo Terre, Tomas Lopez Pedemonte, Martin Nicolas Buffa Dunat
  • Antibody (11C7) anti Nogo-A and its pharmaceutical use
    Patent number: 8535666
    Abstract: This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or human NogoA_623-640 with a dissociation constant, 1000 nM; polynucleotides encoding such a binding molecule; an expression vector comprising such polynucleotides; the use of such a binding molecule in the treatment of nerve repair, a pharmaceutical composition comprising such a binding molecule; and to a method of treatment of diseases associated with nerve repair.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: September 17, 2013
    Assignees: Novartis AG, Universitat Zurich
    Inventors: Carmen Barske, Anis Khusro Mir, Thomas Oertle, Lisa Schnell, Martin E. Schwab, Alessandra Vitaliti, Mauro Zurini
  • BUILDING BLOCKS AND METHODS FOR THE SYNTHESIS OF 5-HYDROXYMETHYLCYTOSINE-CONTAINING NUCLEIC ACIDS
    Publication number: 20130237697
    Abstract: The present invention relates to building blocks and methods for the efficient synthesis of 5-hydroxymethylcytosine-containing nucleic acids such as DNA or RNA.
    Type: Application
    Filed: November 11, 2011
    Publication date: September 12, 2013
    Applicant: LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
    Inventors: Thomas Carell, Martin Munzel