Patents Assigned to Universität
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Patent number: 11628065Abstract: The present invention relates to the diagnosis and treatment of joint-related diseases, in particular osteoarthritis. Based on the analysis of the microarchitecture, such as microchannels, of the subchondral bone, the present invention provides methods for evaluating the health state of a joint as well as determining whether a joint is prone to develop or has already developed a disease correlated to joint and cartilage destruction. The invention further provides for membranes and other implants mimicking healthy subchondral bone structure suitable for promoting regeneration of joint structure and function.Type: GrantFiled: March 24, 2020Date of Patent: April 18, 2023Assignee: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, UniversitätsmedizinInventors: Arndt F. Schilling, Shahed Taheri
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Publication number: 20230110824Abstract: A fluorescent probe includes one or more metal binding functional group, such as phosphonic acid group and an arsonic acid group, in which the functional group is covalently linked to a fluorescent core via a sp2-carbon atom of the fluorescent core. In embodiments, the fluorescent core is an organic fluorescent compound/moiety, that can be a tetrapyrrole derivative, such as porphyrin or phthalocyanine, acridine, BODIPY, cyanine or cyanine derivatives, carbazole, coumarine or coumarine derivatives, xanthene or xanthene derivatives such as fluorescein or rhodamine. The fluorescent probe can bind to calcium and/or a calcification, such as hydroxyapatite (HAP). In a further aspect, a fluorescent probe is used in a method of detecting calcium, such as a calcification or HAP, in a bodily tissue. The use of the fluorescent probe is also provided for detecting calcium, a calcification and/or HAP, such as calcium depositions in a bodily tissue.Type: ApplicationFiled: February 26, 2021Publication date: April 13, 2023Applicant: TECHNISCHE UNIVERSITÄT BERLINInventors: Gündog Yücesan, Hajo Haase
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Publication number: 20230109693Abstract: The invention relates to an assembly for damping vibrations of a structure (I), having a wall element (5a, 5b, 5c, 5d) to be fitted in a upright position, a casing element (Sa, Sb, Sc, 8d) and a damping device (22a, 22b, 22c, 22d), which is connected to the casing element (Sa, Sb, Sc, 8d) and to the wall element (5a, 5b, 5c, 5d) such that a relative movement between the wall element (5a, 5b, 5c, 5d) and the casing element (Sa, Sb, Sc, 8d) is transmitted to the damping device (22a, 22b, 22c, 22d). The damping device (22a, 22b, 22c, 22d) is designed to damp a vibrating movement of the wall element (5a, 5b, 5c, 5d) in a damping direction and is arranged such that the damping device is oriented substantially parallel to a surface of the wall element (5a, 5b, 5c, 5d). The invention further relates to a method for damping vibrations of a structure.Type: ApplicationFiled: March 16, 2021Publication date: April 13, 2023Applicants: BRANDENBURGISCHE TECHNISCHE UNIVERSITÄT COTTBUS-SENFTENBERG, TECHNISCHE UNIVERSITÄT BERLINInventors: Achim BLEICHER, Thomas SCHAUER, Yangwen ZHANG, Wulf WULFF, Laurenz WERNICKE
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Publication number: 20230116496Abstract: A modular artificial neural sensing system includes a hierarchical network of neural sensing units including a neuromimetic sensor array of artificial sensory synapses and sensory neurons for receiving physicochemical sensed signals and for outputting sensor output signals. An artificial neural network processor is adapted for processing the sensor output signals and includes processor neurons interconnected by processor synapses forming first connections and second connections. The processor outputs processor output signals. A first sensor interface feeds processed or unprocessed sensed signals into the processor. A second sensor interface receives output predicted signals from other neural sensing units and feeds processed or unprocessed output predicted signals into the processor. A signal decoder decodes the processor output signals and outputs decoder output signals.Type: ApplicationFiled: January 21, 2021Publication date: April 13, 2023Applicants: UNIVERSITÄT ZÜRICH, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICASInventors: Josep Maria MARGARIT TAULÉ, Shih-Chii LIU, Cecilia JIMÉNEZ JORQUERA
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Patent number: 11622958Abstract: A first aspect of the invention relates to novel compounds and more precisely to novel bifunctional prodrugs and drugs. An additional aspect of the invention relates to antibody compound conjugates, wherein the compound is a claimed compound, and to pharmaceutical compositions containing the compound or antibody compound conjugate. The invention lastly relates to the use of this compound or antibody compound conjugates according to the invention in order to treat tumour diseases, particularly in mammals.Type: GrantFiled: October 28, 2016Date of Patent: April 11, 2023Assignee: GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTSInventors: Lutz F. Tietze, Kamala Penchalaiah
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Patent number: 11623360Abstract: A rotary cutting disc (10) comprising two coaxial mutually opposed disc-shaped elements (12a, 12b) each having a circumferential edge, wherein circumferential edges (14a, 14b) of the disc-shaped elements (12a, 12b) are joined together forming a cutting edge (16) of the cutting disc (10); wherein each of the disc-shaped elements (12a, 12b) comprises one or more at least partly curved elongated deformation lines (30), wherein the one or more deformation lines (30) have a radial distance from the centre (26) of the cutting disc (10) that increases along at least a part of the length of the deformation line (30). The rotary cutting disc (10) has an increased critical speed that allows improving the efficiency of a cutting operation with a cutting disc while maintaining acceptable levels of quality, cutting precision and safety.Type: GrantFiled: June 22, 2018Date of Patent: April 11, 2023Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventor: Marcus Mäder
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Publication number: 20230107228Abstract: A computer-implemented method is used to adapt a first artificial neural network for data classification tasks. The first artificial neural network is characterized by a first number of first weight parameters, and includes a set of first network layers. The method includes freezing at least some of the first weight parameters of the first neural network to obtain frozen first weight parameters and duplicating the frozen first weight parameters to obtain duplicated first weight parameters. A second artificial neural network is applied to the duplicated first weight parameters to obtain modulated first weight parameters. The second artificial neural network is characterized by a second number of second weight parameters, the second number being smaller than the first number. The frozen first weight parameters are replaced in the first neural network with the modulated first weight parameters to obtain a modulated first artificial neural network adapted for a data classification task.Type: ApplicationFiled: October 5, 2022Publication date: April 6, 2023Applicant: UNIVERSITÄT ZÜRICHInventors: Yuhuang HU, Shih-Chii LIU
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Publication number: 20230106313Abstract: The invention provides a bacterial composition comprising, or consisting of, one or more of the genera of bacteria selected from Anaerostipes, and/or Roseburia, for treatment, or for prevention of recurrence, of cancer. In another aspect, the invention relates to a combination medicament for use in the treatment or the prevention of recurrence of cancer comprising a bacterial composition as specified herein and an antineoplastic treatment, particularly a combination medicament comprising a bacterial composition and a cancer chemotherapy drug, or a bacterial composition as provided herein and a cancer immunotherapy drug.Type: ApplicationFiled: February 11, 2021Publication date: April 6, 2023Applicant: UNIVERSITÄT ZÜRICHInventors: Michael SCHARL, Ana MONTALBAN-ARQUES, Lubor BORSIG
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Patent number: 11618913Abstract: The present invention relates to a method for preparing oligosaccharides which can be used among others as food additives to reduce calorie content, to sweeten food products, to increase the fiber content of food products, to improve the texture of food products and to stimulate the gut microbiome bacteria. Furthermore they can be applied in the fields of animal feed, or other applications. More particularly, this invention is directed to a high temperature hydrolysis of xyloglucan polysaccharide to defined xyloglucan oligosaccharides. The invention further relates to oligosaccharide hydrolysates produced with the method of the invention and to the use of said oligosaccharide hydrolysates in human and/or animal nutrition, as prebiotic or other uses. Further provided are novel endoglucanases for use in the method of the invention as well as in other applications.Type: GrantFiled: November 16, 2018Date of Patent: April 4, 2023Assignee: TECHNISCHE UNIVERSITÄT MÜNCHENInventors: Sigrid Graubner, Vladimir Zverlov, Wolfgang Schwarz, Petra Eichinger, Björn Andreessen, Jonathan Herlet, Matthias Mechelke, Philipp Schulte, Wolfgang Liebl
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Patent number: 11617495Abstract: A medical endodevice for an intervention inside a human or animal body includes an elongated liaising structure having a distal end arrangeable inside a body of the human or animal being and a proximal end arrangeable outside the body while the distal end is inside the body. The endodevice has an intervention tool arranged to manipulate a target tissue inside the human or animal body. The intervention tool is arranged at the distal end of the liaising structure. The endodevice further includes a positioning unit having a moving formation arranged to dislocate the intervention tool relative to the target tissue, and an anchoring formation arranged to fix the moving formation to a fixing tissue inside the human or animal body such that the target tissue is positioned in a workspace of the intervention tool.Type: GrantFiled: June 25, 2018Date of Patent: April 4, 2023Assignee: UNIVERSITÄT BASELInventors: Manuela Eugster, Patrick Weber, Georg Rauter
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Patent number: 11618773Abstract: The present invention relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence separated by a spacer sequence, to said polynucleotide for use in treating and/or preventing disease, and to viral particles, compositions, and uses related thereto. The present invention further relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence for use in treating and/or preventing an NFAT-mediated disease.Type: GrantFiled: January 14, 2019Date of Patent: April 4, 2023Assignee: Universität HeidelbergInventors: Markus Hecker, Andreas Wagner, Andreas Jungmann, Oliver Müller, Anca Remes, Hugo Katus
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Patent number: 11618227Abstract: The present invention relates to a method for manufacturing an electronic or electrical system, the method comprising the layer-free production of at least one physical structure (101, 102) which is designed to guide electromagnetic waves, using at least one additively operating apparatus, wherein the layer-free production of the spatial, layer-free structure comprises the simultaneous or sequential application and/or removal of one or more materials in the spatial arrangement, as a result of which the electronic or electrical system is partially or completely formed. The invention further relates to a system which is manufactured in accordance with the method.Type: GrantFiled: January 16, 2018Date of Patent: April 4, 2023Assignee: FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERGInventors: Gerald Gold, Klaus Helmreich, Johannes Hörber, Konstantin Lomakin, Mark Sippel
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Publication number: 20230099822Abstract: The invention relates to a method for modulating an interaction between an MR1 polypeptide and an MR1-specific T cell receptor molecule, whereby a MR1 polypeptide is contacted with a MR1 ligand compound that is a nucleobase adduct product reflecting a state of metabolic distress of a cell. The invention further relates to the use of compounds identified as MR1 ligands in vaccination or modulation of an MR1-restricted immune response.Type: ApplicationFiled: January 18, 2021Publication date: March 30, 2023Applicant: UNIVERSITÄT BASELInventors: Gennaro DE LIBERO, Lucia MORI, Alessandro VACCHINI, Andrew CHANCELLOR, Julian SPAGNUOLO, Qinmei YANG
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Publication number: 20230100972Abstract: In a method for coating a base body, a first target and a second target are arranged in a vacuum chamber. A base body to be coated is arranged in the vacuum chamber is heated to a coating temperature of less than 600° C. During sputtering with sputter gas ions, first target particles are liberated from the first target and second target particles are liberated from the second target and are deposited as coating particles on the base body. A first sputter rate is specified for the first target and a second sputter rate is specified for the second target such that, during the sputtering process, the coating is generated as an A15 phase with an intended stoichiometric ratio of the first target particles to the second target particles. A functional element has a base body and a coating of Nb3Sn applied directly on the surface of the base body.Type: ApplicationFiled: March 12, 2021Publication date: March 30, 2023Applicant: Technische Universität DarmstadtInventors: Nils SCHÄFER, Lambert ALFF, Márton MAJOR, Stefan PETZOLD
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Patent number: 11612646Abstract: The present invention provides a novel PSMA binding antibody termed 10B3 and pharmaceutical and diagnostic uses of the antibody 10B3. The PSMA antibody 10B3 does not cross-compete with the state of the art PMSA binding antibody J591 and has a reduced induction of antigen shift compared to J591 and a unique reactivity with squamous cell carcinoma (SCC) cells of different origin.Type: GrantFiled: January 16, 2017Date of Patent: March 28, 2023Assignees: Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts, Eberhard Karls Universität TübingenInventors: Helmut Salih, Fabian Vogt, Gundram Jung, Latifa Zekri-Metref
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Patent number: 11614143Abstract: A toothed belt includes at least one tension member and a plastics material matrix which at least partially encases the tension member. The at least one tension member extends in the plastics material matrix in a running direction and teeth of the toothed belt are formed transversely to the running direction in the plastics material matrix. The tension member is formed from an electrically conductive material and the plastics material matrix is formed from an electrically insulating material. The toothed belt has at least one electronic component which is embedded in the plastics material matrix and has at least one sensor which detects data on a condition parameter of the toothed belt. The at least one electronic component is coupled to the tension member via at least two voltage taps to tap a voltage induced in the tension member to supply the at least one electronic component with power.Type: GrantFiled: December 9, 2020Date of Patent: March 28, 2023Assignees: TECHNISCHE UNIVERSITÄT DARMSTADT, BRECO ANTRIEBSTECHNIK BREHER GMBH & CO. KGInventors: Thomas Steinert, Dominik Großkurth
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Publication number: 20230087264Abstract: The invention relates to a method for obtaining a visual field map of an observer, particularly a perimetry method, wherein a plurality of test locations in front of the observer is provided, at each test location of a subset of said plurality a respective perceived sensitivity threshold 5 is measured, wherein at least one light signal is provided at the respective test location, and wherein it is monitored whether said observer observes said at least one light signal, and wherein for each test location a respective estimate of the perceived sensitivity threshold is derived from the previously measured perceived sensitivity thresholds of said subset, and wherein said light signal is provided at a light intensity value derived from the estimate of the 10 perceived sensitivity threshold of said respective test location.Type: ApplicationFiled: October 14, 2022Publication date: March 23, 2023Applicant: UNIVERSITÄT BERNInventors: Serife Seda KUCUR, Raphael SZNITMAN
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Publication number: 20230092437Abstract: Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol resulting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from. the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.Type: ApplicationFiled: May 5, 2022Publication date: March 23, 2023Applicants: California Institute of Technology, The Regents of the University of California, Technische Universität BerlinInventors: Philipp Walk, Babak Hassibi, Peter Jung, Hamid Jafarkhani
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Publication number: 20230087805Abstract: The present invention relates to inhibitors of the interaction between H. pylori HopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.Type: ApplicationFiled: September 21, 2022Publication date: March 23, 2023Applicants: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Anahita JAVAHERI, Tobias KRUSE, Markus GERHARD, Bernhard B. SINGER, Daniel HORNBURG, Han REMAUT, Matthias MANN, Felix MEISSNER, Steffen BACKERT
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Patent number: 11609231Abstract: Methods, kits, and active ingredients for diagnosing or treating arthritis or a degenerative disease of the skeletal system, or for selection of subjects for therapy. The methods for diagnosing arthritis involve the detection of an autoantibody, which is associated with arthritis, or excluding the presence of an autoantibody against collagen II. The methods for diagnosing a degenerative disease of the skeletal system, involve the detection of an autoantibody against thrombospondin-4 or COMP. The kits contain a detection agent for an autoantibody and can be used for diagnosing arthritis or a degenerative disease of the skeletal system. The active ingredient can be used for treating or preventing autoimmune-associated arthritis.Type: GrantFiled: December 12, 2018Date of Patent: March 21, 2023Assignee: UNIVERSITÄT ZU KÖLNInventors: Andreas R. Klatt, Johannes Ruthard, Benedikt Ostendorf, Matthias Schneider, Georg Pongratz, Gabriele Hermes