Patents Assigned to Universität
  • Patent number: 11649252
    Abstract: The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle sizc distribution and a large surface. The product is homogenous and very pure.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: May 16, 2023
    Assignee: TECHNISCHE UNIVERSITAT CLAUSTHAL
    Inventors: Dieter E. Kaufmann, Jan C. Namyslo, Roman Florescu, Birgit Wawrzinek
  • Patent number: 11649502
    Abstract: The present invention relates to methods for detecting activation of a brown/beige fat cell or brown/beige adipose tissue (BAT) in a biological sample taken from a mammal to be diagnosed, comprising measuring the amount of miR-92 in said sample. The invention furthermore relates to diagnostic and clinical applications of the methods of the invention.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: May 16, 2023
    Assignees: Rheinische Friedrich-Wilhelms-Universität Bonn, Maastricht University
    Inventors: Alexander Pfeifer, Joschka Buyel, Yong Chen, Wouter Van Marken Lichtenbelt
  • Patent number: 11651049
    Abstract: A computer-implemented method to capture and detect clusters in, or determined by, a set V of discrete digital data comprising; computing, from the set V, an abstract separation system ASS that consists of a finite set S, whose elements are called separations; of a predetermined transitive, antisymmetric and reflexive order relation ? on S; and of an order-reversing involution *: S?S, that is, a mapping s?s* with the property that, (s*)*=s and that r?s implies s*<r* for all r, s?S; predetermining a set of consistency requirements (CRs), that is, a set F of subsets of S; computing, from the ASS (S,?, *), one or more abstract tangles, that is, any set T?S that contains exactly one of each pair {s, s*} for s?S, and does not contain any of the forbidden configurations F?F as a subset; or determining that there is no abstract tangle; and determining that any abstract tangle T represents a cluster in, or determined by, the data set V.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: May 16, 2023
    Assignees: Universitat Hamburg, Victoria Link Limited
    Inventors: Reinhard Diestel, Geoffrey Whittle
  • Patent number: 11647960
    Abstract: A flexible neural electrode array is provided, comprising a layer of metal which is arranged on a first layer of polymeric material and which forms a number of contact pads. The first layer of polymeric material is flexible along a predefined direction, each contact pad of the number of contact pads having a sequence of cuts through the metal, each cut extending in a straight line across the predefined direction. Each cut has an inner end and an outer end, the inner end being within the contact pad, the outer end being at an edge of the contact pad, and each second cut of the sequence of cuts having its outer end at the same edge of the contact pad. A method is further provided for fabricating a flexible neural electrode array.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: May 16, 2023
    Assignees: CorTec GmbH, Albert-Ludwigs-Universitat Freiburg
    Inventors: Martin Schuettler, Juan Sebastian Ordonez, Tom Colin Bierbrauer
  • Publication number: 20230145938
    Abstract: The invention relates to an X-ray source (10) comprising at least one waveguide (30) for X-ray radiation, wherein the at least one waveguide (30) has a core (32) and a casing (40) surrounding the core (32), and wherein at least one part of the waveguide (30) is designed to emit X-ray radiation (50), if the part of the waveguide (30) is bombarded with electrons (52). The invention also relates to a system for generating X-ray radiation comprising an X-ray source of this type, and a method for generating X-ray radiation by means of an X-ray source of this type or a system of this type.
    Type: Application
    Filed: April 7, 2021
    Publication date: May 11, 2023
    Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts
    Inventors: Malte VASSHOLZ, Tim SALDITT
  • Publication number: 20230140949
    Abstract: A method for the preparation of isocyanates in which: (i) a first organosilicon compound having at least one silicon atom Si1 and a unit of formula G-I bound thereto is converted to a third organosilicon compound having a unit of formula G-II by silylation of the NH group of the unit of formula G-I with a second organosilicon compound having one silicon atom Si2; and (ii) the third organosilicon compound is reacted to an isocyanate by thermolysis, whereby the unit of formula G-II is converted to an isocyanate group.
    Type: Application
    Filed: March 30, 2021
    Publication date: May 11, 2023
    Applicant: TECHNISCHE UNIVERSITÄT BERGAKADEMIE FREIBERG
    Inventors: Edwin KROKE, Franziska GRÜNDLER, Marcus HERBIG, Marlene-Kirstin BAUMHARDT
  • Publication number: 20230146949
    Abstract: A delivery system (10, 110) is provided for delivering and deploying an implantable balloon-based occlusion device (20) including an inflatable balloon (22). The delivery system (10, 110) includes a delivery handle (11), which includes a fluid-retaining chamber (41, 141); a plunger, which is slidingly disposed in the fluid-retaining chamber (41, 141); and a proximal rotatable user-control knob (31). A fluid-conveyance lumen catheter (18) defines a catheter fluid-conveyance lumen (19) in fluid communication with the fluid-retaining chamber (41, 141) and the inflatable balloon (22). A catheter lumen shaft (26) is in reversible connection with the balloon-based occlusion device (20), longitudinally slidable with respect to the delivery handle (11).
    Type: Application
    Filed: March 25, 2021
    Publication date: May 11, 2023
    Applicant: UNIVERSITAT ZURICH
    Inventors: Andrea GUIDOTTI, Boaz HARARI, Luca VICENTINI, Pietro GOZZOLI
  • Publication number: 20230145905
    Abstract: An articulating robotic arm for minimally invasive surgery, comprising a proximal arm segment extending along a longitudinal axis of the robotic arm and a distal arm segment connected to the proximal arm segment, pivotable about a pivot axis orthogonal to the longitudinal axis. The distal arm segment comprises a pinion segment formed with pinion teeth arranged about the pivot axis in the form of a pinion. A rack element is arranged on the proximal arm segment such that the rack element is movable in the longitudinal direction of the rack element parallel to the longitudinal axis by means of a translation, and rack teeth formed on the rack element are engaged with the pinion teeth so that a movement of the rack element in the longitudinal direction via the rack teeth and the pinion teeth is converted into a rotational movement of the distal arm segment about the pivot axis, and so that the distal arm segment pivots relative to the proximal arm segment about the pivot axis.
    Type: Application
    Filed: November 4, 2022
    Publication date: May 11, 2023
    Applicant: TECHNISCHE UNIVERSITÄT BERLIN
    Inventors: Sven FRITSCH, Dirk OBERSCHMIDT
  • Patent number: 11646099
    Abstract: In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements. In embodiments, the invention distinguishes between PMBCL and DLBCL based on gene expression signatures, and can further distinguish between DLBCL subtypes. In embodiments of the invention, the distinctions are used in methods of treatment.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 9, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, British Columbia Cancer Agency, Mayo Foundation for Medical Education and Research, Julius-Maximilians-University of Würzburg, Boatd of Regents of the University of Nebraska, Oslo University Hospital HF, Hospital Clinic de Barcelona, Universitat de Barceloa, Institut D'Investigacions Biomédiques Pi I Sunyer (IDIBAPS), Robert Bosch Gesellschaft feuer medizinische Forshung mbH, Oregon Health & Science University, City of Hope, The Cleveland Clinic Foundation
    Inventors: Louis M. Staudt, Christian Steidl, Anja Mottok, George W. Wright, David William Scott, Lisa M. Rimsza, Andreas Rosenwald, Randy Gascoyne, Timothy Greiner, Dennis Weisenburger, Erlend B. Smeland, Jan Delabie, Elias Campo Guerri, German Ott, Rita Braziel, Elaine S. Jaffe, Kai Fu, Wing C. Chan, Joo Song, James R. Cook
  • Patent number: 11643643
    Abstract: The present invention pertains to a novel architecture of non-ribosomal peptide synthases (NRPS). The invention provides artificial NRPS wherein the naturally occurring terminal condensation or thioesterase-domain is replaced by internal condensation or dual condensation/epimerization domains. Moreover, the present invention enables the portability of terminal condensation domains to unrelated NRPS in respect of peptide release of linear peptides. The replacement results in a product independent release of the synthesized product and therefore enables the rational design of NRPS. The invention provides the new NRPS, nucleic acids encoding them, methods for artificial NRPS generation, and methods for producing non-ribosomal peptides.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: May 9, 2023
    Assignee: Johann Wolfgang Goethe-Universität Frankfurt am Main
    Inventors: Helge B. Bode, Kenan Bozhüyük, Florian Fleischhacker
  • Patent number: 11644387
    Abstract: The invention relates to a method for dynamic load simulation, wherein loads are specified by target signals and applied to a test object by a parallel kinematic excitation unit via an end effector, including the following operations: measuring loads at a contact point (200), comparing the measured loads with the target signals (300), and determining target pressures (400) for individual actuators of the parallel kinematic excitation unit for applying the target signals by use of a control algorithm (Fq,ref). This provides a method for dynamic load simulation that reduces the time and cost expenditure compared to previously known methods and at the same time enables hardware-in-the-loop simulations to be used.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: May 9, 2023
    Assignee: Universität Paderborn
    Inventors: Ansgar Trächtler, Karl-Peter Jäker, Simon Olma, Andreas Kohlstedt, Phillip Traphöner
  • Publication number: 20230139165
    Abstract: The present invention relates to an immersion microscope objective (10) for inspecting a sample (S) in an immersion medium (M), comprising: at least one concave minor (3), at least one optical element (1) comprising an aspherical surface (2) facing the at least one concave minor (3), and an internal space (4) arranged between the at least one concave minor (3) and said aspherical surface (2), said internal space (4) being configured to be filled with an immersion medium (M) such that the immersion medium (M) contacts the at least one concave minor (3) and the aspherical surface (2). According to the present invention, the aspherical interface (2) is shaped such that the working distance (7) of the immersion microscope objective (10) varies by less than 1% when the refractive index n of said immersion medium (M) is increased or decreased by at least 0.025.
    Type: Application
    Filed: April 12, 2021
    Publication date: May 4, 2023
    Applicant: UNIVERSITÄT ZÜRICH
    Inventors: Fabian Friedrich VOIGT, Fritjof HELMCHEN
  • Patent number: 11639373
    Abstract: The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit CXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: May 2, 2023
    Assignee: TECHNISCHE UNIVERSITÄT MÜNCHEN
    Inventors: Theresa Osl, Hans-Jürgen Wester, Margret Schottelius
  • Publication number: 20230129245
    Abstract: The invention relates to a method for welding a first workpiece (11) to a second workpiece (12) by means of a laser. It is an object of the invention to provide a reliable, repeatable and reproducible approach for laser welding of two workpieces one of which consists of a semiconductor material.
    Type: Application
    Filed: June 15, 2021
    Publication date: April 27, 2023
    Applicants: Friedrich-Schiller-Universität Jena, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Maxime CHAMBONNEAU, Stefan NOLTE, Qingfeng LI
  • Publication number: 20230128889
    Abstract: The present invention concerns screening methods to identify compounds that regulate activity of RSH enzymes such as Rel, and specifically Rel synthetase and/or Rel hydrolase activity. Also intended are compounds that interact and regulate Rel synthetase and/or hydrolase activity. These compounds are valuable to target persister cells not affected by traditional antibiotics.
    Type: Application
    Filed: March 30, 2020
    Publication date: April 27, 2023
    Applicants: Université Libre de Bruxelles, Universitat Autónoma de Barcelona
    Inventors: Abel GARCIA PINO, Cédric Pierre GOVAERTS, Hanna AINELO, Hedvig TAMMAN, Vasili HAURYLIUK, Leonardo PARDO CARASCO, Minos Timotheos MATSOUKAS
  • Publication number: 20230128742
    Abstract: Systems and methods for transmitting data using various Modulation on Zeros schemes are described. In many embodiments, a communication system is utilized that includes a transmitter having a modulator that modulates a plurality of information bits to encode the bits in the zeros of the z-transform of a discrete-time baseband signal. In addition, the communication system includes a receiver having a decoder configured to decode a plurality of bits of information from the samples of a received signal by: determining a plurality of zeros of a z-transform of a received discrete-time baseband signal based upon samples from a received continuous-time signal, identifying zeros that encode the plurality of information bits, and outputting a plurality of decoded information bits based upon the identified zeros.
    Type: Application
    Filed: June 2, 2022
    Publication date: April 27, 2023
    Applicants: California Institute of Technology, Technische Universität Berlin
    Inventors: Philipp Walk, Babak Hassibi, Peter Jung
  • Patent number: 11634482
    Abstract: The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric anti-bodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine anti-bodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: April 25, 2023
    Assignee: Julius-Maxmilians-Universitat Wurzburg
    Inventors: Jörg Wischhusen, Markus Junker, Tina Schäfer, Dirk Pühringer
  • Publication number: 20230119290
    Abstract: The present invention relates to a column comprising a vascular endothelial growth factor (VEGF) dimer molecule, a method for preparing such a column, a VEGF dimer molecule, an expression vector and a recombinant host cell encoding for a VEGF dimer, as well as uses and methods related thereto.
    Type: Application
    Filed: March 18, 2021
    Publication date: April 20, 2023
    Applicant: Universität Zu Köln
    Inventors: Henning HAGMANN, Thomas BENZING, Bernhard SCHERMER, Manuel KOCH, Mahsa MATIN
  • Publication number: 20230121197
    Abstract: The present invention relates to an antibody specifically binding the carboxymethylated catalytic subunit of protein phosphatase 2A (PP2Ac). Also provided are diagnostic uses of said antibody and screening methods employing the inventive antibody.
    Type: Application
    Filed: January 25, 2021
    Publication date: April 20, 2023
    Applicants: Medizinische Universität Wien, Regents of The University of Michigan
    Inventors: Egon OGRIS, Goutham NARLA
  • Patent number: 11629361
    Abstract: The present invention relates to adeno-associated viral vector useful for transducing adipose tissue. The invention also relates to polynucleotides, plasmids, vectors and methods for the production of such adeno-associated viral vector. The invention also relates to gene therapy methods useful for the treatment of a disease that requires the regulation of the expression levels of a gene.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: April 18, 2023
    Assignee: Universitat Autònoma de Barcelona
    Inventors: Verónica Jiménez Cenzano, Fátima Bosch Tubert