Abstract: The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses means and methods for single molecule protein sequencing and/or amino acid identification using cleavage inducing agent. Said cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the kinetics of said reaction.

Abstract: A photonic integrated circuit-based dual frequency comb source, an integrated system for dual comb spectroscopy and corresponding method are disclosed. The dual comb source includes, on a same substrate of the photonic integrated circuit, a first and second semiconductor integrated mode-locked laser, a master laser, and connection arrangement between the master laser and each of the first and second mode-locked laser. The master laser is configured for generating a lasing line for simultaneous optical injection-locking of the first and second mode-locked laser, the first and second mode-locked laser are configured for generating a first and second frequency comb respectively, and the connection arrangement is suitable for coherently transferring lasing light from the master laser to each mode-locked laser. The mode-locked lasers include a gain section and a saturable absorber section to provide mode-locking, and an extended optical cavity formed in the substrate.

Abstract: The invention relates to a composition comprising an epoxy-derived covalent adaptable network, preferably an epoxy vitrimer comprising at least one unit of formula (I) The invention further relates to a method for preparing a composition comprising an epoxy-derived covalent adaptable network by contacting at least one amine comprising primary, at least one vinylogous precursor comprising vinylogous precursor groups and at least one epoxide comprising epoxide groups whereby the number of amine groups, the number of vinylogous precursor groups and the number of epoxide groups is controlled.

Abstract: The present invention is in the field of cardiac arrhythmia. In particular, the present invention relates to systems and methods for identifying ablation lines, which can then be used to correct cardiac arrhythmia.

Abstract: The present invention relates to a cementitious composition comprising one or more cementitious material(s); and a silver-containing, crosslinked polymer, wherein the crosslinked polymer is a covalently crosslinked polymer, and preferably wherein said silver-containing, crosslinked polymer comprises -A? Ag? groups; wherein A? is an anion, preferably a carboxylate anion or a sulphonate anion. The present invention further relates to a silver-containing covalently crosslinked polymer, as comprised in said cementitious composition, and various uses of such compositions and polymers for preparing concrete materials with improved properties or for coating concrete structures.

Abstract: A stimulation circuitry for a multichannel potentiostat has individually controllable stimulation channels, and includes at least one circuit group. The circuit group includes: (i) a controllable current source; (ii) a transient suppression module having an input resistively coupled to an output of the current source, the transient suppression module being a module for controllably suppressing a transient current with respect to an output of said transient suppression module; (iii) a demultiplexer having an input resistively coupled to the output of the transient suppression module; and (iv) a controller for selecting an output of the demultiplexer and for operating the transient suppression module with respect to said output selection.

Abstract: A sampling circuit for sampling an analog input signal including: a capacitive means, a reset switch, and a sampling switch; the reset switch and the sampling switch being connected to a signal generator circuit configured to provide periodic reset and sampling control signals to the respective switches for controlling their operation. The respective periodic reset and sampling control signals have equal duty factors and signal periods, and a phase delay with respect to one another being less than the signals' duty factor, thereby forming an overlap period during which the reset switch and the sampling switch remain closed.

Abstract: The present invention relates to a method and composition for optimized intracellular delivery of nucleic acids, in particular mRNA. In addition to mRNA, the composition, in particular a nanoparticle, may include a glycolipid antigen. Combinations with checkpoint inhibitors are also provided. The method and composition of the invention targets antigen presenting cells and is especially useful for immunotherapy and vaccination purposes.

Abstract: A method to modify the surface of III-V quantum dots. III-V quantum dots provided with X type ligands and L type ligands at their outer surface are dispersed in a solvent include an additional compound. The additional compound has an organic acid of formula RYH or an organic salt of formula RYH+Z? and has at least one acidic proton H+ having a pKa in water equal to or lower than 16. During dispersion the acidic proton H+ protonates at least part of the L type ligands and at least part of the X type ligands are replaced. Surface modified quantum dots, dispersions having such surface modified quantum dots and to the use of such dispersions are disclosed.

Abstract: A method for light field rendering includes: obtaining an n-dimensional mixture model, with n a natural number equal to or larger than 4, of a light field. The model is made of kernels wherein each kernel represents light information and is expressed by parameter values; mathematically reducing the n-dimensional mixture model into a 2-dimensional mixture model of an image given a certain point of view, wherein the 2-dimensional model is also made of kernels; rendering a view in a pixel domain from the 2-dimensional model made of kernels.

Abstract: According to an aspect there is provided an optical monitoring device comprising: a first input for receiving a portion of a first optical signal coupled from a first waveguide into the first input; a second input for receiving at least a portion of a second optical signal coupled into the second input; a mixing unit for controlling combining of the portion of the first optical signal with the at least a portion of the second optical signal into a combined signal at an output from the mixing unit; and at least one photodetector for detecting the combined signal. The optical monitoring device is configured to apply a modulation signal to modulate at least one of a phase of the portion of the first and/or second optical signal, a coupling of the portion of the first and/or second optical signal into the respective input, or an amplitude of the portion of the first and/or second optical signal being transferred into the combined signal.

Abstract: The present invention is in the field of agricultural pathogen control. More specifically the invention relates to methods and compounds for controlling herbivorous arthropods, in particular insects and mites. The invention also provides for compositions comprising the same, methods of making the same, and methods of controlling plant disease.

Abstract: The present invention relates, in part, to agents that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the FAP binding agents and their use in the treatment of various diseases.

Abstract: Catheter for delivery of therapeutic liquid formulation Provided is a catheter (100) having a proximal end (10) and a distal end (12) for distribution of a liquid outflow, the catheter (100) comprising. First (120) and second (140) lumens are comprised in a tube (160) wherein a lumen (162) of the tube is partitioned into the first (120) and second (140) lumens by a partitioning wall (150) attached to the tube lumen wall (164), the outlets (122a to c) of the plurality on the distal (12) side of the distribution inlet (110) are longitudinally positioned and sized in mirrored symmetry with the plurality of outlets (122d to f) on the proximal (10) side of the distribution inlet (110). The plurality of outlets (122a to f) is configured to counteract a reduction in outflow as the distance from the distribution inlet (110) increases in the longitudinal direction (L).

Abstract: The present invention relates to an accelerated method to generate high yields of type-1 polarizing mRNA loaded dendritic cells for use in immunotherapy, and in particular for use in cancer vaccination.

Abstract: A method is for correcting a concentration of a bone turnover marker to obtain an adjusted value which gives an indication of an individual's bone health status or amount of changes occurred over time or by treatment while eliminating the influence of possible pre-analytical variability. The method includes: obtaining the concentration of the bone turnover marker of a sample; correcting the obtained concentration using a mathematical model which comprises at least three factors, different from the bone health status, such that for the adjusted value variabilities in the concentration of the bone turnover marker, that are caused by the at least three factors, are substantially filtered out by the mathematical model.

Abstract: A system for sensing diaper content includes a diaper, an outer coupling layer and a sensing circuitry. The diaper has a circuitry layer having inner input capacitor plates, tracks arranged to provide a resistive coupling between the inner capacitor plates dependent on the content, and inner output capacitor plates in galvanic contact with the respective inner input capacitor plates. The outer coupling layer contains outer input- and output capacitor plates arranged to form respective input- and output capacitors with the inner input- and output capacitor plates in the diaper when the outer coupling layer is provided onto the outside of the diaper. The sensing circuitry is arranged to apply an input signal onto the outer input capacitor plates, and to measure an output signal from the outer output capacitor plates resulting from the input signal and the resistive coupling thereby sensing the content.

Abstract: Provided herein are lipidated imidazoquinoline compounds and compositions comprising such compounds. The lipidated imidazoquinoline compounds may be used as an adjuvant to enhance to immune response elicited by an antigen of interest. Accordingly, also provided herein are methods for enhancing the immune response of an antigen of interest in a subject, comprising administering to the subject an antigen of interest with a lipidated imidazoquinoline compound described herein in an immunogenic composition, or administering to the subject a composition comprising a lipidated imidazoquinoline compound described herein in combination with (e.g., prior to, concurrently, or subsequently) the administration of an immunogenic composition comprising an antigen of interest to the subject.

Abstract: The present invention is in the field of hearing tests. In particular, the present invention relates to systems and methods for determining the integrity of Auditory Nerve Fibers (ANFs) and/or afferent Auditory Nerve Synapses (ANSs) and/or inner-hair cells (IHC) in a subject.

Abstract: A method of provisioning a service in a communication network is described, in which the service comprises at least one virtual network function and at least one virtual network path, which at least one virtual network function and at least one virtual network path are to be implemented in the communication network. The method including obtaining affinity constraints and/or anti-affinity constraints relating to mapping the at least one virtual network path onto the communication network, optionally obtaining affinity constraints and/or anti-affinity constraints relating to mapping the at least one virtual network function onto the communication network, and mapping the at least one virtual network function and at least one virtual network path onto the communication network subject to said constraints.