Patents Assigned to Universiteit Gent
  • Laser ablation probe
    Patent number: 11293872
    Abstract: A laser ablation probe comprises a tubular element adapted for conducting a carrier fluid in a substantially laminar flow. The tubular element comprises a fluid inlet and a fluid outlet arranged at opposite end portions of the tubular element for enabling the carrier fluid to flow through the tubular element. The tubular element further comprises a central portion having an aperture defined therein for admitting an aerosol generated by laser ablation from a material sample into the carrier fluid flow when this sample is positioned outside the tubular element at a distance in the range of 0 ?m to 100 ?m from the aperture.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: April 5, 2022
    Assignee: UNIVERSITEIT GENT
    Inventors: Frank Vanhaecke, Stijn Van Malderen
  • Methods for obtaining colored or chromic substrates
    Patent number: 11293138
    Abstract: The present invention provides a post-fabrication modification approach for the fabrication of colored and chromic materials and sensors using plasma surface modification to covalently bind the coloring agent to the substrate, thus avoiding leaching of the dye. Advantageously, in said methods, said coloring agent is a dye or pigment linked to a radical sensitive functional group, such as an alkenyl or alkynyl functional group, and is applied to the substrate prior to the gas plasma treatment. The methods envisaged herein are generic in nature, which allow the covalent immobilization of various dyes on different materials. The covalently coated materials after plasma surface modification, particularly the covalently coated chromic materials and sensors, can be used in many different applications, such as protective textile and wound dressing applications.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 5, 2022
    Assignee: UNIVERSITEIT GENT
    Inventors: Richard Hoogenboom, Gertjan Vancoillie
  • Cells producing glycoproteins having altered N- and O-glycosylation patterns and methods and use thereof
    Patent number: 11293012
    Abstract: The present application relates to the field of glyco-engineering and, more specifically, to eukaryotic cells wherein both an endoglucosaminidase is present and made deficient in UDP-galactose 4-epimerase (GalE). Typically, a glycoprotein is also present in the cells. These cells can be used to deglycosylate or partly deglycosylate the (exogenous) glycoprotein, in particular, without the need for adding an extra enzyme. Methods are also provided for the application of these cells in protein production.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: April 5, 2022
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Nico Callewaert, Leander Meuris, Francis Santens
  • CD20 binding single domain antibodies
    Patent number: 11248057
    Abstract: The present application relates, in part, to agents that bind CD20 and their use as therapeutic agents. The present application further relates to pharmaceutical compositions comprising the CD20 binding agents and their use in the treatment of various diseases.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: February 15, 2022
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Jan Tavernier, Anje Cauwels, José Van Der Heyden
  • Dispersive optical phased array for two-dimensional scanning
    Patent number: 11249371
    Abstract: A dispersive optical phased array for two-dimensional scanning is disclosed herein. The array comprises antenna blocks positioned adjacent one another. The antenna blocks comprise a plurality of antennas positioned adjacent one another and a plurality of delay lines to couple a coherent source signal to each of the antennas within the block, each delay line having an optical path length. Each of the antenna blocks acts as a dispersive phased array. The antenna blocks are arranged such that the blocks form a larger phased array where the antennas between the blocks are in phase for a discrete set of wavelengths. All antennas over the dispersive phased array can experience the same phase difference such that the beams of the individual antenna blocks align with one of the diffraction orders of the array of blocks.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: February 15, 2022
    Assignees: IMEC vzw, Universiteit Gent
    Inventor: Wim Bogaerts
  • Polarization independent processing in integrated photonics
    Patent number: 11243352
    Abstract: A photonic integrated circuit comprises an input interface adapted for receiving an optical input signal and splitting it into two distinct polarization modes and furthermore adapted for rotating the polarization of one of the modes for providing the splitted signals in a common polarization mode. The PIC also comprises a combiner adapted for combining the first mode signal and the second mode signal into a combined signal and a decohering means adapted for transforming at least one of the first mode signal and the second mode signal such that the first mode signal and the second mode signal are received by the combiner in a mutually incoherent state. A processing component for receiving and processing said combined signal is also comprised.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: February 8, 2022
    Assignees: UNIVERSITEIT GENT, IMEC VZW
    Inventors: Dries Van Thourhout, Andrea Trita
  • Prebiotic oral care compositions containing amino acids
    Patent number: 11241474
    Abstract: The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: February 8, 2022
    Assignees: Colgate-Palmolive Company, Katholieke Universiteit Leuven, Universiteit Gent
    Inventors: Hansruedi Stettler, Wim Teughels, Marc Quirynen, Nico Boon
  • Cytoplasmic protein complex comprising a kinase substrate sensor, cells comprising the complex, and associated detection methods
    Patent number: 11242511
    Abstract: The disclosure relates to a cytoplasmic protein complex comprising: (a) a first recombinant fusion protein comprising a kinase, fused to a first interaction polypeptide; and (b) a second recombinant fusion protein comprising a domain comprising a reporter phosphorylation site, whereby the domain is fused to a second interaction polypeptide. The disclosure relates further to a method to detect compound-compound-interaction using the cytoplasmic protein complex, and to cells comprising such cytoplasmic protein complex.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: February 8, 2022
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Jan Tavernier, Samuel Lievens
  • Communication hardware virtualization
    Patent number: 11245512
    Abstract: A communication system comprising: input buffers adapted for buffering incoming data streams of samples from one or more channels; a receiver adapted for sequentially processing data from the input buffers; a processing rate of the receiver is higher than or equal to an incoming data rate of the incoming data; context memory adapted for saving an internal status of the receiver after processing the data corresponding with an input buffer before switching to a next input buffer and for restoring the internal status, wherein the receiver is adapted for processing the incoming data in a frame detection phase, and in a frame demodulation phase in which frames and/or subframes are demodulated into bits and wherein the internal status of the receiver related to an input buffer is only saved and restored in the frame detection phase or before and after demodulating subframes.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: February 8, 2022
    Assignees: UNIVERSITEIT GENT, IMEC VZW
    Inventors: Xianjun Jiao, Wei Liu, Felipe Augusto Pereira De Figueiredo, Ingrid Moerman
  • IMPROVED PRODUCTION OF SYMMETRICAL BOLAFORM SOPHOROSIDES
    Publication number: 20220033869
    Abstract: The present invention relates to the field of microbial production of novel biosurfactants. More specifically, the present invention discloses the usage of a fungal strain such as the yeast Starmerellabombicola having a dysfunctional CYP52M1 cytochrome P450 monooxygenase and a dysfunctional FAO1 fatty alcohol oxidase for producing high amounts of so-called “symmetrical bolaform sophorosides” where both sophorose moieties are attached through a terminal glycosidic linkage to the hydrophobic linker. In addition, the present invention further discloses that the latter yeast can also be used to produce alkyl sophorosides and symmetrical bolaform glucosides.
    Type: Application
    Filed: November 21, 2019
    Publication date: February 3, 2022
    Applicants: UNIVERSITEIT GENT, BIO BASE EUROPE PILOT PLANT
    Inventors: Sophie Roelants, Lisa Van Renterghem, Wim Soetaert, Jelle Remmery
  • CD8 binding agents
    Patent number: 11236166
    Abstract: The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: February 1, 2022
    Assignees: Orionis Biosciences BV, VIB VZW, UNIVERSITEIT GENT
    Inventors: Nikolai Kley, Jan Tavernier, Anje Cauwels, Sarah Gerlo
  • Method for detecting protein-protein interactions in a cell utilizing particle-forming polypeptide-bait fusion proteins and virus-like particles
    Patent number: 11237174
    Abstract: The disclosure relates to a virus-like particle in which a protein complex is entrapped, ensuring the formation of the protein complex under physiological conditions, while protecting the protein complex during purification and identification. The disclosure further relates to the use of such virus-like particle for the isolation and identification of protein complexes.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: February 1, 2022
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Jan Tavernier, Sven Eyckerman
  • Targeted mutant interferon-beta and uses thereof
    Patent number: 11236141
    Abstract: The present invention relates, in part, to chimeric proteins comprising mutant interferon-? and their use as therapeutic agents.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: February 1, 2022
    Assignees: Orionis Biosciences BV, VIB VZW, Universiteit Gent
    Inventors: Nikolai Kley, Jan Tavernier, Frank Peelman
  • ACCELERATED HUMAN HEMATOPOEITIC STEM CELL DIFFERENTIATION TOWARDS MATURE NATURAL KILLER CELLS WITH ENHANCED ANTIBODY-DEPENDENT CYTOTOXIC ACTIVITY
    Publication number: 20220025327
    Abstract: The present invention in general relates to a method of differentiating human hematopoietic stem cells (HSC) into mature natural killer (NK) cells; wherein said method is in particular characterized in that mature NK cells are obtainable very early during the differentiation method, and that these NK cells display increased CD16 expression and antibody-dependent cellular cytotoxicity (ADCC) (FIG. 11). The method of the invention specifically encompasses transfecting and/or transducing HSCs with at least one transcription factor selected from T-Box expressed in T cells (T-BET) and Eomesodermin (EOMES); or a combination thereof.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 27, 2022
    Applicant: Universiteit Gent
    Inventors: Laura Kiekens, Georges Leclercq
  • Virus-like particle (VLP) based small molecule-protein interaction trap
    Patent number: 11231416
    Abstract: This disclosure relates to a virus-like particle in which a small molecule-protein complex is entrapped, ensuring the formation of the small molecule-protein complex under physiological conditions, while protecting the small molecule-protein complex during purification and identification. The disclosure further relates to the use of such virus-like particle for the isolation and identification of small molecule-protein complexes.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: January 25, 2022
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Jan Tavernier, Sven Eyckerman
  • METHOD FOR INTEGRATING AN ELECTRONIC CIRCUIT IN OR ON A STENT
    Publication number: 20220015930
    Abstract: The present invention relates to a method for integrating an electronic circuit in or on a medical stent. The method comprises obtaining (101) a deformable medical stent (21) in a substantially planar shape, in which the deformable medical stent is adapted for being deployed in a substantially cylindrical shape in the body. The method also comprises attaching (104) a deformable electronic circuit (22) onto the deformable medical stent in the planar shape thereby forming a deformable hybrid structure. The method also comprises shaping (107) said hybrid structure into the cylindrical shape.
    Type: Application
    Filed: November 28, 2019
    Publication date: January 20, 2022
    Applicants: Universiteit Gent, IMEC VZW
    Inventors: Rik Verplancke, Jan Vanfleteren
  • Particles comprising surfactant protein B and one or more lipids
    Patent number: 11213573
    Abstract: The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.
    Type: Grant
    Filed: November 23, 2017
    Date of Patent: January 4, 2022
    Assignees: UNIVERSITEIT GENT, UNIVERSIDAD COMPLUTENSE DE MADRID
    Inventors: Koen Raemdonck, Stefaan De Smedt, Jésus Pérez-Gil
  • Netwell assay plate system
    Patent number: 11213815
    Abstract: The invention relates to a device and a method for growing and screening of plant samples, comprising a specialized multiwell plate system well-suited for housing granular media, for use in in vivo screening methods of uninterrupted plant tissue growth.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: January 4, 2022
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Dirk Gustaaf Inzé, Stijn Dhondt
  • Means and methods for regulating secondary metabolite production in plants
    Patent number: 11208667
    Abstract: This disclosure relates to the field of secondary metabolite production in plants. More specifically, the disclosure relates to chimeric genes encoding a bHLH protein of subfamily Iva comprising a bHLH domain and their use in the regulation of biosynthesis and/or production of secondary metabolites in plants and plant-derived cell cultures.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: December 28, 2021
    Assignees: VIB VZW, Universiteit Gent, Universiteit Leiden
    Inventors: Alain Goossens, Jan Mertens, Alex Van Moerkercke, Jacob Pollier, Johan Memelink
  • ACRYLATE END-CAPPED URETHANE- OR UREA-BASED POLYMERS
    Publication number: 20210388151
    Abstract: The present invention in general relates to acrylate end-capped urethane-based polymers, which are in particular characterized by the presence of at least 3 acrylate end-groups, thereby making them particularly suitable for further processing using multiple kinds of technologies such as 2-photon polymerization, stereolithography (SLA printing), electrospinning, film casting, porogen leaching, extrusion based 3D-printing, spray drying, cryogenic treatment, coatings, cross-linkable micelles, spincoating, and electrospraying.
    Type: Application
    Filed: November 5, 2019
    Publication date: December 16, 2021
    Applicants: Universiteit Gent, Allnex Belgium SA
    Inventors: Aysu Arslan, Hugues van den Bergen, Patrice Roose, Dirk Bontinck, Sandra van Vlierberghe, Peter Dubruel