Abstract: The present application relates to the field of glyco-engineering, more specifically to glyco-engineering of Fc-containing molecules, such as antibodies. It is shown herein that Fc-containing molecules with a specific glycosylation pattern have a considerably longer circulating half-life in vivo, without having an altered binding affinity for their respective antigen. This has therapeutic implications in reducing the frequency with which these molecules need to be administered, without affecting therapeutic efficacy. Also, cells are provided that can produce the Fc molecules with the desired glycosylation pattern.

Abstract: A method and hearing device (100) for emulating cochlear processing of auditory stimuli are disclosed, in which a multilayer convolutional encoder-decoder neural network (10) sequentially compresses and then decompresses a time-domain input comprising a plurality of samples. At least one nonlinear unit for applying a nonlinear transformation is mimicking a level-dependent cochlear filter tuning associated with cochlear mechanics and outer hair cells. Other described modules cover inner-hair-cell and auditory-nerve fiber processing. A plurality of shortcut connections (15) is directly forwarding inputs between convolutional layers of the encoder (11) and the decoder (12). An output layer (14) is generating, for each input to the neural network, N output sequences of cochlear response parameters corresponding to N emulated cochlear filters associated with N different center frequencies to span a cochlear tonotopic place-frequency map.

Abstract: The present invention is directed to a sampling device for the collection and isolation of a biological specimen from a sample or from a location. The sampling device comprises a swab tip and a support body wherein the support body has a hollow conformation with a first end and a second end and wherein said first end is in fluid connection with the internal surface of the swab tip. Typical for the present sampling device is that the swab tip comprises a filter material with a pore size that decreases from the external surface of the swab tip to the internal surface of the swab tip. The invention further also discloses the use of said sampling device and a method for the collection and isolation of a biological specimen.

Abstract: The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is specifically delivered to target cells. Preferably, said modified cytokine is a single chain variant of the TNF superfamily, even more preferably, one or more of the chains can-y one or more mutations, resulting in a low affinity to the receptor, wherein said mutant cytokine is specifically delivered to target cells. The targeting is realized by fusion of the modified cytokine of the TNF superfamily to a targeting moiety, preferably an antibody or antibody-like molecule. The invention relates further to the use of such targeted modified cytokine of the TNF superfamily to treat diseases.

Abstract: The present invention relates to a method for covalently binding a cell surface protein and a ligand, the ligand being capable of specifically binding to the cell surface protein, the method consisting essentially of contacting the living cells expressing the cell surface protein with the ligand comprising at least one furan moiety, thereby covalently binding the cell surface protein and the ligand.

Abstract: A yokeless stator for an axial flux machine, comprising a housing, the housing comprising a circumferential portion and a plurality of elongated portions extending radially inwards therefrom, and a plurality of discrete stator teeth arranged within the circumferential portion, each discrete stator tooth comprising a ferromagnetic material and an electrical winding; the housing further comprising an electrically isolating filling material filling empty space inside the housing. The circumferential portion of the housing is made of a first non-ferromagnetic material and the elongated portions are made of a second non-ferromagnetic material. The housing comprises a laminated structure, which comprises at least part of the plurality of inwardly directed elongated portions.

Abstract: The present invention relates, in part, to chimeric proteins comprising at least one targeting moiety that recognizes and binds SIRP1? and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.

Abstract: An interleaver for combining at least two incoming signals into an analog output signal includes at least a first signal path and a second signal path. Each signal path has: an input terminal, a first gain stage for multiplying a signal coming from the input terminal with a first gain (a) to obtain a first signal, a mixer and a second gain stage for multiplying a signal coming from the input terminal with a second gain (b) before or after mixing it with a clock signal to obtain a second signal, an adder for adding the first and second signal to obtain an output signal of the signal path wherein the first and second gain are different from zero. The interleaver comprises an adder for adding the output signals from the signal paths.

Abstract: An integrated wavelength-selective filter device comprises a first optical element, for directing received radiation into a direction defined by a first angle, and a second optical element being a diffractive element configured for diffracting the directed radiation under a second angle. The second angle is such that for a single reference wavelength the diffracted radiation is directed into a propagation medium for advancing therein towards a predetermined position on the first optical element or on a further optical element for filtering radiation having a wavelength substantially matching the reference wavelength from radiation having a substantially different wavelength. The propagation medium is formed from a material that is different from any material of the substrate of the first and the second optical element.

Abstract: A treatment of cancer, particularly the treatment of neuroblastoma. Indeed, the discloses that a particular long non-coding RNA (lncRNA) is specifically up-regulated in neuroblastoma cells as compared to other cancer cells and that high expression of the lncRNA correlates with a lower survival probability. Inhibition of this lncRNA in neuroblastoma cells leads to a reduction in cell growth and induction of apoptosis and is a novel therapeutic strategy in the treatment of neuroblastoma.

Abstract: The present invention relates to a fusion protein comprising at least two cytokines, of which at least one is a modified cytokine with a strongly reduced binding affinity to its receptor, or to one of its receptors. Preferably, both cytokines are connected by a linker, preferably a GGS linker. The invention relates further to said fusion protein for use in treatment of diseases.

Abstract: In a first aspect, the present disclosure relates to a method for designing a pattern of a stress relief layer for a flat device to be transformed into a shape-retaining non-flat device by deformation of the flat device. The flat device (and thus also the non-flat device) may comprise at least two components and at least one electrical interconnection between two components. In a second aspect, the present disclosure is related to a method of manufacturing a shape-retaining non-flat device by deformation of a flat device, wherein the flat device is attached to a patterned stress relief layer designed in accordance with the first aspect of the present disclosure. In preferred embodiments, the stress relief layer is a thermoplastic layer or a layer comprising a thermoplastic material and deformation of the flat device comprises deformation by a thermoforming process, after attachment of the flat device to the stress relief layer.

Abstract: A transcoder for transcoding a basic representation of a videostream into one or more arbitrary representations comprises: a receiver adapted for receiving the basic representation and at least one frame information set comprising one or more frame information packets; a decoder adapted for decoding the basic representation; a re-encoder adapted for selecting at least one frame information set and for selecting one or more frame information packets from this at least one frame information set for forming a arbitrary representation, the re-encoder is adapted for extracting coding information from the frame information packets, and for re-encoding the decoded basic representation using the coding information thereby obtaining the one or more arbitrary representations.

Abstract: The present invention in general relates to the field of bioconjugation. More in particular, the invention relates to novel bioconjugation reactants based on an ?,? unsaturated ?-hydroxylactam structure, amongst others allowing a higher degree of functionalization compared to classical bioconjugation reactants such as maleimide. The present invention also provides methods of preparing the novel bioconjugation reactants, as well as uses thereof in human and/or veterinary medicine; and conjugation processes.

Abstract: An enhancement device (10, 116) for enhancing service requests (120) and a method of allocating network resources to a network service in a communication network is provided. The communication network comprises network resources capable of providing a network service specified in a service request issued by a client. The service request (120) comprises a direct part (121) and an indirect part (122), while the indirect part comprises at least one allocation condition.

Abstract: A communication system includes a base station, at least one remote radio head, and at least one channel. The base station has at least two digital modulators adapted for modulating a first and a second incoming radio signal to obtain a first and a second quantized signal, a multiplexer for interleaving the quantized signals, and a transmitter adapted for transmitting the resulting quantized signal over the channel to the remote radio head. The remote radio head includes a receiver adapted for capturing the quantized signal, a clock extraction module adapted for converting the signal from the receiver into a clock signal, a demultiplexer for splitting the quantized signal using the clock signal to obtain at least two quantized signals, and a filter adapted for removing quantization noise from the quantized signal from the receiver or the demultiplexer.

Abstract: The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatment of stroke, myocardial infarction, diabetes, sepsis, the prevention of transplant rejection, neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, dementia with Lewy bodies and Friedreich's ataxia. The present invention further relates to pharmaceutical compositions of these compounds and discloses methods for making the compounds and the corresponding intermediate.

Abstract: A multi-user access node for receiving concurrent signals which are carrying redundant chip sequences at a baseband rate, the access node including: a plurality of antennas organized in an antenna configuration; a main transceiver comprising an analog receiver and an ADC for converting an incoming signal into a digital signal which comprises the incoming chip sequences; a switch for switching the transceiver between the plurality of antennas; a controller configured for: initializing the multi-user access node by switching the transceiver between the plurality of antennas to capture a spatial character of the different users based on unique initialization chip sequences from the different users, separating collided chip sequences transmitted by different users by switching the transceiver between the plurality of antennas according to a scrambling sequence and by using the spatial character in combination with the applied scrambling sequence.

Abstract: The invention entails the combination of basic catalysts, specifically guanidine-based catalysts, such as TBD, in conjunction with functionalized amines having a hydrogen bond donating or accepting functionality, to facilitate the accelerated transamidation of polymer compounds with non-activated ester side chains.

Abstract: A transimpedance amplifier is provided for converting a current between its two input terminals to a voltage over its two output terminals comprising a high-speed level shifter configured for creating a difference in input DC voltage and for being transparent for alternating voltages, an input biasing network configured for reverse biasing a photodiode connected to at least one of the input terminals and transparent for a feedback signal from the feedback network which is differentially and DC-coupled with the output terminals of the voltage amplifier and outputs of the feedback network are differentially and DC-coupled with the input biasing network of which outputs are coupled with inputs of the level shifter which is differentially and DC-coupled with input terminals of the voltage amplifier.