Abstract: Nanostructured shapes comprising at least a first part and a second part. The first part has a longitudinal axis L and comprises a first absorbing material and an emitting material. The second part is connected to the first part and comprises a second absorbing material. The second part mainly absorbs light with direction of polarization other than the long axis L of the first part, and the nanostructured shape emits light mainly polarized along the long axis L of the first part. The disclosure further relates to an assembly of nanostructured shapes, to a method of synthesizing nanostructured shapes and to a polarizing light emitting plate comprising such nanostructured shapes.

Abstract: A method and hearing device (100) for emulating cochlear processing of auditory stimuli are disclosed, in which a multilayer convolutional encoder-decoder neural network (10) sequentially compresses and then decompresses a time-domain input comprising a plurality of samples. At least one nonlinear unit for applying a nonlinear transformation is mimicking a level-dependent cochlear filter tuning associated with cochlear mechanics and outer hair cells. Other described modules cover inner-hair-cell and auditory-nerve fiber processing. A plurality of shortcut connections (15) is directly forwarding inputs between convolutional layers of the encoder (11) and the decoder (12). An output layer (14) is generating, for each input to the neural network, N output sequences of cochlear response parameters corresponding to N emulated cochlear filters associated with N different center frequencies to span a cochlear tonotopic place-frequency map.

Abstract: The present invention in general relates to a pharmaceutical dosage form comprising one or more granules, and a method for manufacturing thereof. The granules of the dosage form are prepared via the extrusion/spheronization technique using partially hydrolysed polyvinyl alcohol. These granules have the advantage that a high drug load can be contained therein.

Abstract: This disclosure relates to a ball comprising a core and a porous structure encompassing the core. The porous structure comprises a plurality of perforations in its outer surface, which are connected with a plurality of hollow confined spaces within the porous structure allowing a liquid to be at least partly absorbed by the hollow confined spaces upon contact of the ball with the liquid. A shell with shell perforations encompasses the porous structure. The ball comprises control means for controlling the absorption of liquid by the ball and the release of absorbed liquid from the ball.

Abstract: The invention concerns a dye for use in a method of photoporation of the inner limiting membrane (ILM) of an eye in a subject. Preferably, the method comprises: administering the dye to the vitreous chamber of the eye of the subject; and irradiating at least part of the ILM of the eye of the subject, thereby photoporating at least part of the ILM in the subject. The invention further relates to a dye and optionally a therapeutic agent for use in a method of treating a retinal disease or a choroidal disease of an eye in a subject.

Abstract: An integrated photoacoustic transducer, sensing system and method for assisting in sensing a concentration of a species in a fluid such that the integrated photoacoustic transducer includes a waveguide structure. The waveguide structure has an optical resonance spectrally overlapping a spectral absorption line or band of the species. The photoacoustic transducer includes at least one acoustic cavity formed in a portion of the waveguide structure and configured for receiving the fluid for sensing comprising the species. The at least one acoustic cavity has an acoustic resonance spectrally overlapping with a harmonic of a modulation frequency. At least one acoustic transducer comprising a deformable mechanical portion is included in the photoacoustic transducer.

Abstract: The invention provides in an electron microscopy grid, comprising: - a perforated substrate; - a support film on the perforated substrate; - a mixture of different linker molecules according to Structure (I), wherein AG is an anchoring group, for anchoring the linker molecule to the solid support; BU is a binding unit, for binding to the analyte; L1 is a first linear linker section; L2 is a second linear linker section; ? is the angle between the linear linker section L1 and the linear linker section L2; AS is an angled linker section, connecting the linear linker section L1 and the linear linker section L2. The invention further provides in method of structural determination of analytes, using such EM-grids.

Abstract: A clutch comprising a hub and a cam connected to the hub, said cam comprising a ring-shaped part having grooves formed on a bottom surface of the ring-shaped part; a spring plate having recesses formed on a top surface of the spring plate; an output flange and a part of a roller bearing connected to each other, said output flange comprising a ring-shaped part configured to accommodate the spring plate, a plurality of transmission elements arranged in an angular direction between the spring plate and the cam; a plurality of springs arranged in the angular direction between the spring plate and the output flange; and a sliding bearing provided at an interface between the hub and the output flange, wherein the clutch is configured to be changed between first and second states. A high-speed industrial robot capable of moving on a plurality of axes, and use thereof.

Abstract: A method for deriving a calibration curve for determining a concentration of an analyte in an electrochemical reactor comprises determining a current level between a functionalized electrode and a reference electrode in the electrochemical reactor in absence of an analyte, the current level forming a zero-concentration current; injecting a fluid comprising an analyte in a first given concentration in the electrochemical reactor, determining after the predetermined amount of time a first calibration current level corresponding to the first given concentration and calculating a first current ratio of the first current level to the zero-concentration current; repeating the previous step for at least a second given concentration of the analyte, yielding at least a second current ratio of a second current level to the zero-concentration current; obtaining a calibration curve indicative of current ratio as a function of concentration from the first current ratio and at least the second current ratio.

Abstract: Hydrogels are provided that include an antimicrobial agent and a cross-linkable urethane-based polymer (CUP). Such hydrogels may be used for the controlled-release of antimicrobial agents as well as in the manufacturing of wound dressings. Wound dressings are provided that comprise a hydrogel as defined herein.

Abstract: The invention concerns a dye for use in a method of treating a vitreous opacity-related disease in a subject. The method preferably comprises administering the dye to the vitreous body of an affected eye of the subject; and irradiating at least part of the vitreous opacity, thereby inducing destruction of the vitreous opacity in the subject. The invention further relates to the use of a dye for photodestruction of a vitreous opacity in an eye of a subject, and to a method of photodestruction of a vitreous opacity in an eye of a subject, the method comprising: administering a dye to the vitreous body of the eye of the subject; and irradiating at least part of the vitreous opacity, thereby inducing destruction of the vitreous opacity of the subject.

Abstract: It is a first object of the present invention to provide a method for preparing a Tile vector, being a vector, which comprises a selectable marker and a coding polynucleotide, wherein said coding polynucleotide is immediately preceded and followed by a type IIs recognition sequence, wherein said preceding and following recognition sequences are recognized by a same type IIs restriction enzyme, but have an opposite orientation. More particularly, the position and orientation of said preceding and following type IIs recognition sequences provides for the cleavage of said Tile vector by a corresponding type IIs restriction enzyme resulting in the release of said coding polynucleotide sequence having at its respective ends overhang sequences with a known orientation and length, while lacking said preceding and following type IIs recognition sequences.

Abstract: A data processing device for motion segmentation in images obtained by cameras that move in a background environment includes an input for receiving a temporal sequence of images from the cameras and a processor. The processor is adapted for, for at least two images, of the temporal sequence of images, that are obtained by at least two cameras at different points in time, determining epipoles, defining corresponding image regions of limited image disparity due to parallax around the epipoles in the at least two images, and applying a motion segmentation algorithm to the corresponding image regions. Warping is applied to the corresponding image regions to compensate for camera rotation and misalignment beyond a threshold value.

Abstract: A method for generating vapour bubbles in an object comprises introducing a composition into the object, the composition comprising carbon-based nano- or microparticles that can couple with a photon wave of electromagnetic radiation. The method also comprises irradiating said object using electromagnetic radiation. The irradiation thereby is adapted for using a set of carbon-based nano- or microparticles for subsequently forming first vapour bubbles and at least second vapour bubbles using the same carbon-based nano- or microparticles.

Abstract: The present invention relates to antagonists, particularly antibodies and antigen binding fragments thereof, that bind to the protein galectin-10, particularly human galectin-10. The galectin-10 antagonists disrupt the crystallization of galectin-10 and are therefore useful in methods of preventing and treating diseases and conditions wherein the pathology is linked to the formation/presence of Charcot-Leyden crystals (CLCs).

Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.

Abstract: The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses means and methods for single molecule protein sequencing and/or amino acid identification using cleavage inducing agent. Said cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the kinetics of said reaction.

Abstract: A mobile music listening device synchronizing in a personalized way music and movement, and dedicated to improving the kinematics of the runner. Thanks to inertial units connected to a smartphone, the runner's steps are detected in real time by the mobile application. A dedicated algorithm adapts the pulsation of the musical excerpts in such a way as to bring the runner to a suitable cadence, capable of preventing injuries. A method for the synchronization of the rhythmic stimulation with the biological variability using a Kuramoto model characterized in that phase oscillator with a coupling term from the movement dynamics with parameters of, coupling strength, maximum and minimum frequencies for a fraction of the unmodified song frequency, maximum difference between the tempo and target frequency, Target the target frequency.

Abstract: A photonics reservoir computing system is described. The system is configured for propagating at least one optical signal so as to create resulting radiation signals in the output channels. The photonics reservoir computing system further comprises weighting elements for weighting signals from the output channels, and at least one optical detector for optically detecting signals from the output channels. The system is adapted for estimating signals from the output channels through an output of the optical detector.

Abstract: The present invention relates, in part, to chimeric proteins that find use in various immunotherapies. Particularly, the present invention provides targeted therapeutic agents that modulate the immune system for the treatment of diseases such as cancer.