Abstract: Provided is a process for the environmental-friendly treatment of sulfate-containing wastewater. The acidic, sulfate-containing wastewater is treated in a sulfate reducing bioreactor with influent and effluent looped through to the cathode compartment of an electrochemical cell. The electrochemical cell stabilizes the pH in the bioreactor by the in-situ production of base in the cathode compartment. Additionally, hydrogen is produced which is used in the bioreactor as electron donor for the sulfate reduction. The middle compartment of the electrochemical cell contains a sulfide rich aqueous solution in which the extracted cations are displaced by protons from the anode compartment. This results in the acidification of the sulfide rich solution, which is beneficial for the extraction of sulfides as H2S. This H2S can be used for the precipitation of metals in the beginning of the process, forming another loop.

Abstract: A photonic integrated circuit is provided for performing optical transient computing on an RF-modulated optical carrier signal. The photonic circuit includes at least two optical signal processing units, each including a filter device and a delay element for providing a delayed feedback signal to the filter device. The group delay induced by the delay element is in the range from 1 ps to 100 ps and the 3 dB bandwidth of the filter band is less than the inverse of the group delay. The delay element is adapted to spectrally align at least a portion of the filter band with a resonance in the feedback signal and center frequencies of filter bands are offset between 1 GHz and 100 GHz to allow filtering of different portions of the modulated carrier signal spectrum. The signal processing device has a trainable readout circuit.

Abstract: The present application relates to glycosylated immunoglobulin domains. The invention provides nucleotide sequences encoding polypeptides comprising immunoglobulin variable domains with engineered glycosylation acceptor sites. Accordingly, the invention provides immunoglobulin variable domain proteins modified with selected glycans and specific glycan-conjugates thereof. Also provided herein are methods for the production of glycosylated immunoglobulin variable domains and glycan-conjugates thereof.

Abstract: The present invention relates, in part, to vaccine compositions, adjuvants, chimeric proteins, or chimeric protein complexes and their use as vaccines or therapeutic agents. The present invention further relates to methods of vaccination or treatment of various diseases.

Abstract: The present invention relates, in part, to chimeric proteins that find use in various immunotherapies. Particularly, the present invention provides targeted therapeutic agents that modulate the immune system for the treatment of diseases such as cancer.

Abstract: The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule. In a preferred embodiment, the cytokine antagonist is a modified cytokine which binds to the receptor, but doesn't induce the receptor signalling. The invention relates further to a fusion protein according to the invention for use in treatment of cancer and immune- or inflammation-related disorders.

Abstract: The present invention relates to single-domain antibodies that specifically bind aminopeptidase N (APN), and more in particular to polypeptides, and nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the single-domain antibodies of the present invention are capable of targeting a moiety to a mucosal surface.

Abstract: According to an aspect of the present inventive concept there is provided a textile device comprising: a first fabric comprising at least one electrically conductive wire; an electronic component, wherein the electronic component is fixated to the first fabric and wherein the at least one electrically conductive wire is electrically connected to the electronic component; wherein the textile device has a transition region at an area of the first fabric arranged laterally from the electronic component; wherein the textile device further comprises a strengthening element at the transition region, wherein the strengthening element comprises: a second fabric arranged around the first fabric; and a thermoplastic material arranged in relation to at least a first portion of the second fabric, wherein the thermoplastic material is arranged around the first fabric and fills a spacing between the first fabric and the second fabric at least in the first portion of the second fabric.

Abstract: A method is provided for deriving a surface profile of a free-form master lens for patterning one or two photo-alignment layers of a planar optical component. The method includes obtaining a desired optical function of the planar optical component; and obtaining an actual optical function of the planar optical component, the actual optical function being described as recorded using a free-form test lens with a surface profile configured to provide the desired optical function. The method includes estimating a deviation between the desired optical function and the actual optical function; and correcting the surface profile of the free-form test lens using the estimated deviation, thereby deriving a surface profile for the free-form master lens.

Abstract: Described herein is a composition of two or more bacterial strains, wherein the composition comprises a bacterial strain of at least two of the following genera: Phascolarctobacterium, Veillonella, Eubacterium, Agathobacter, Lactiplantibacillus, and Anaerostipes. Aspects and embodiments described herein may be used in the treatment of joint inflammation, symptoms thereof, and underlying diseases and conditions.

Abstract: A system for open-path sensing of a property of a fluid in an environment comprises: a sensing light source; a pumping light source for outputting a pumping beam into the environment for inducing a change of light propagation characteristics of the fluid; wherein the system outputs a probing beam and a reference beam into the environment, such that the probing beam has a larger intersection with the pumping beam than the reference beam; wherein a first interferometer detects a phase shift and/or an intensity change of a received probing beam; and wherein a second interferometer detects a phase shift and/or an intensity change of a received reference beam.

Abstract: The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses means and methods for single molecule protein sequencing and/or amino acid identification using cleavage inducing agent. Said cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the kinetics of said reaction.

Abstract: A photonic integrated circuit-based dual frequency comb source, an integrated system for dual comb spectroscopy and corresponding method are disclosed. The dual comb source includes, on a same substrate of the photonic integrated circuit, a first and second semiconductor integrated mode-locked laser, a master laser, and connection arrangement between the master laser and each of the first and second mode-locked laser. The master laser is configured for generating a lasing line for simultaneous optical injection-locking of the first and second mode-locked laser, the first and second mode-locked laser are configured for generating a first and second frequency comb respectively, and the connection arrangement is suitable for coherently transferring lasing light from the master laser to each mode-locked laser. The mode-locked lasers include a gain section and a saturable absorber section to provide mode-locking, and an extended optical cavity formed in the substrate.

Abstract: The invention relates to a composition comprising an epoxy-derived covalent adaptable network, preferably an epoxy vitrimer comprising at least one unit of formula (I) The invention further relates to a method for preparing a composition comprising an epoxy-derived covalent adaptable network by contacting at least one amine comprising primary, at least one vinylogous precursor comprising vinylogous precursor groups and at least one epoxide comprising epoxide groups whereby the number of amine groups, the number of vinylogous precursor groups and the number of epoxide groups is controlled.

Abstract: The present invention is in the field of cardiac arrhythmia. In particular, the present invention relates to systems and methods for identifying ablation lines, which can then be used to correct cardiac arrhythmia.

Abstract: The present invention relates to a cementitious composition comprising one or more cementitious material(s); and a silver-containing, crosslinked polymer, wherein the crosslinked polymer is a covalently crosslinked polymer, and preferably wherein said silver-containing, crosslinked polymer comprises -A? Ag? groups; wherein A? is an anion, preferably a carboxylate anion or a sulphonate anion. The present invention further relates to a silver-containing covalently crosslinked polymer, as comprised in said cementitious composition, and various uses of such compositions and polymers for preparing concrete materials with improved properties or for coating concrete structures.

Abstract: A stimulation circuitry for a multichannel potentiostat has individually controllable stimulation channels, and includes at least one circuit group. The circuit group includes: (i) a controllable current source; (ii) a transient suppression module having an input resistively coupled to an output of the current source, the transient suppression module being a module for controllably suppressing a transient current with respect to an output of said transient suppression module; (iii) a demultiplexer having an input resistively coupled to the output of the transient suppression module; and (iv) a controller for selecting an output of the demultiplexer and for operating the transient suppression module with respect to said output selection.

Abstract: A sampling circuit for sampling an analog input signal including: a capacitive means, a reset switch, and a sampling switch; the reset switch and the sampling switch being connected to a signal generator circuit configured to provide periodic reset and sampling control signals to the respective switches for controlling their operation. The respective periodic reset and sampling control signals have equal duty factors and signal periods, and a phase delay with respect to one another being less than the signals' duty factor, thereby forming an overlap period during which the reset switch and the sampling switch remain closed.

Abstract: The present invention relates to a method and composition for optimized intracellular delivery of nucleic acids, in particular mRNA. In addition to mRNA, the composition, in particular a nanoparticle, may include a glycolipid antigen. Combinations with checkpoint inhibitors are also provided. The method and composition of the invention targets antigen presenting cells and is especially useful for immunotherapy and vaccination purposes.

Abstract: A method to modify the surface of III-V quantum dots. III-V quantum dots provided with X type ligands and L type ligands at their outer surface are dispersed in a solvent include an additional compound. The additional compound has an organic acid of formula RYH or an organic salt of formula RYH+Z? and has at least one acidic proton H+ having a pKa in water equal to or lower than 16. During dispersion the acidic proton H+ protonates at least part of the L type ligands and at least part of the X type ligands are replaced. Surface modified quantum dots, dispersions having such surface modified quantum dots and to the use of such dispersions are disclosed.