Abstract: The present invention relates to a method and composition for optimized intracellular delivery of nucleic acids, in particular mRNA. In addition to mRNA, the composition, in particular a nanoparticle, may include a glycolipid antigen. Combinations with checkpoint inhibitors are also provided. The method and composition of the invention targets antigen presenting cells and is especially useful for immunotherapy and vaccination purposes.

Abstract: A method to modify the surface of III-V quantum dots. III-V quantum dots provided with X type ligands and L type ligands at their outer surface are dispersed in a solvent include an additional compound. The additional compound has an organic acid of formula RYH or an organic salt of formula RYH+Z? and has at least one acidic proton H+ having a pKa in water equal to or lower than 16. During dispersion the acidic proton H+ protonates at least part of the L type ligands and at least part of the X type ligands are replaced. Surface modified quantum dots, dispersions having such surface modified quantum dots and to the use of such dispersions are disclosed.

Abstract: A method for light field rendering includes: obtaining an n-dimensional mixture model, with n a natural number equal to or larger than 4, of a light field. The model is made of kernels wherein each kernel represents light information and is expressed by parameter values; mathematically reducing the n-dimensional mixture model into a 2-dimensional mixture model of an image given a certain point of view, wherein the 2-dimensional model is also made of kernels; rendering a view in a pixel domain from the 2-dimensional model made of kernels.

Abstract: According to an aspect there is provided an optical monitoring device comprising: a first input for receiving a portion of a first optical signal coupled from a first waveguide into the first input; a second input for receiving at least a portion of a second optical signal coupled into the second input; a mixing unit for controlling combining of the portion of the first optical signal with the at least a portion of the second optical signal into a combined signal at an output from the mixing unit; and at least one photodetector for detecting the combined signal. The optical monitoring device is configured to apply a modulation signal to modulate at least one of a phase of the portion of the first and/or second optical signal, a coupling of the portion of the first and/or second optical signal into the respective input, or an amplitude of the portion of the first and/or second optical signal being transferred into the combined signal.

Abstract: The present invention is in the field of agricultural pathogen control. More specifically the invention relates to methods and compounds for controlling herbivorous arthropods, in particular insects and mites. The invention also provides for compositions comprising the same, methods of making the same, and methods of controlling plant disease.

Abstract: The present invention relates, in part, to agents that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the FAP binding agents and their use in the treatment of various diseases.

Abstract: Catheter for delivery of therapeutic liquid formulation Provided is a catheter (100) having a proximal end (10) and a distal end (12) for distribution of a liquid outflow, the catheter (100) comprising. First (120) and second (140) lumens are comprised in a tube (160) wherein a lumen (162) of the tube is partitioned into the first (120) and second (140) lumens by a partitioning wall (150) attached to the tube lumen wall (164), the outlets (122a to c) of the plurality on the distal (12) side of the distribution inlet (110) are longitudinally positioned and sized in mirrored symmetry with the plurality of outlets (122d to f) on the proximal (10) side of the distribution inlet (110). The plurality of outlets (122a to f) is configured to counteract a reduction in outflow as the distance from the distribution inlet (110) increases in the longitudinal direction (L).

Abstract: The present invention relates to an accelerated method to generate high yields of type-1 polarizing mRNA loaded dendritic cells for use in immunotherapy, and in particular for use in cancer vaccination.

Abstract: A method is for correcting a concentration of a bone turnover marker to obtain an adjusted value which gives an indication of an individual's bone health status or amount of changes occurred over time or by treatment while eliminating the influence of possible pre-analytical variability. The method includes: obtaining the concentration of the bone turnover marker of a sample; correcting the obtained concentration using a mathematical model which comprises at least three factors, different from the bone health status, such that for the adjusted value variabilities in the concentration of the bone turnover marker, that are caused by the at least three factors, are substantially filtered out by the mathematical model.

Abstract: A system for sensing diaper content includes a diaper, an outer coupling layer and a sensing circuitry. The diaper has a circuitry layer having inner input capacitor plates, tracks arranged to provide a resistive coupling between the inner capacitor plates dependent on the content, and inner output capacitor plates in galvanic contact with the respective inner input capacitor plates. The outer coupling layer contains outer input- and output capacitor plates arranged to form respective input- and output capacitors with the inner input- and output capacitor plates in the diaper when the outer coupling layer is provided onto the outside of the diaper. The sensing circuitry is arranged to apply an input signal onto the outer input capacitor plates, and to measure an output signal from the outer output capacitor plates resulting from the input signal and the resistive coupling thereby sensing the content.

Abstract: Provided herein are lipidated imidazoquinoline compounds and compositions comprising such compounds. The lipidated imidazoquinoline compounds may be used as an adjuvant to enhance to immune response elicited by an antigen of interest. Accordingly, also provided herein are methods for enhancing the immune response of an antigen of interest in a subject, comprising administering to the subject an antigen of interest with a lipidated imidazoquinoline compound described herein in an immunogenic composition, or administering to the subject a composition comprising a lipidated imidazoquinoline compound described herein in combination with (e.g., prior to, concurrently, or subsequently) the administration of an immunogenic composition comprising an antigen of interest to the subject.

Abstract: The present invention is in the field of hearing tests. In particular, the present invention relates to systems and methods for determining the integrity of Auditory Nerve Fibers (ANFs) and/or afferent Auditory Nerve Synapses (ANSs) and/or inner-hair cells (IHC) in a subject.

Abstract: A computer-implemented method providing a neural network for identifying radio technologies employed in an environment. The neural network includes an autoencoder having an encoder, and a classifier. The method has the steps of sensing a radio spectrum of the environment thereby obtaining a set of data samples, labelling a subset of the data samples by a respective radio technology thereby obtaining labelled data samples, training the autoencoder in an unsupervised way by unlabelled data samples, training the classifier in a supervised way by the labelled data samples, and providing the neural network by coupling the output of an encoder network of the autoencoder to an input of the classifier.

Abstract: The present invention relates, in part, to chimeric protein or chimeric protein complex comprising a CD13 targeting moiety and a signaling agent (e.g., without limitation TNF or IFN-?) and methods of treatment using such compositions.

Abstract: The present application relates, in part, to agents that bind CD20 and their use as therapeutic agents. The present application further relates to pharmaceutical compositions comprising the CD20 binding agents and their use in the treatment of various diseases.

Abstract: The present invention is directed to a sampling device for the collection and isolation of a biological specimen from a sample or from a location. The sampling device comprises a swab tip and a support body wherein the support body has a hollow conformation with a first end and a second end and wherein said first end is in fluid connection with the internal surface of the swab tip. Typical for the present sampling device is that the swab tip comprises a filter material with a pore size that decreases from the external surface of the swab tip to the internal surface of the swab tip. The invention further also discloses the use of said sampling device and a method for the collection and isolation of a biological specimen.

Abstract: A switchable optical element, a smart window having the same, and a method for switching between optical states of the element such that the optical element includes a pair of substrates disposed facing each other, and at least one cell arranged between the pair of substrates and filled with scattering particles. An electrode configuration is provided on the pair of substrates such that a first group of cell electrodes is interleaved with electrodes of a second group of cell electrodes on a face of a first substrate, and a third group of cell electrodes is interleaved with electrodes of a fourth group of cell electrodes on a face of a second substrate. Switching of the cell includes laterally transporting over at least a distance corresponding to two adjacent cell electrodes of one same cell electrode group and confining the scattering particles to a confinement region within the cell.

Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by chimeric proteins which comprise modified signaling agents two or more targeting moieties. Methods of treatment and pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.

Abstract: The present disclosure relates to a cluster-based consensus approach for generating recombinant neuraminidase (NA) polypeptides. The disclosure further relates to influenza vaccine compositions comprising the recombinant NA polypeptides.

Abstract: A method of provisioning a service in a communication network is described, in which the service comprises at least one virtual network function and at least one virtual network path, which at least one virtual network function and at least one virtual network path are to be implemented in the communication network. The method including obtaining affinity constraints and/or anti-affinity constraints relating to mapping the at least one virtual network path onto the communication network, optionally obtaining affinity constraints and/or anti-affinity constraints relating to mapping the at least one virtual network function onto the communication network, and mapping the at least one virtual network function and at least one virtual network path onto the communication network subject to said constraints.