Patents Assigned to University College Dublin
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Publication number: 20220296683Abstract: The invention provides a method of preparing a silica-protein sub-micron particle, the method comprising contacting, in an aqueous medium having a pH in the range of about 7.5 to 10 and having an ionic strength in the range of about 1.2 to 60 mM, (i) protein sub-micron particle cores comprising 0.2 to 3 ?moles, per mg of the protein sub-micron particle cores, of a basic compound of formula (I) or an ester and/or amide thereof wherein n is an integer selected from 1 to 10, and p is an integer selected from 1 to 3, with (ii) orthosilicic acid or an ester thereof, in an amount equivalent to 5 to 60% (w/w) orthosilicic acid per mg of the protein sub-micron particle cores, to form the silica-protein sub-micron particle. The invention also provides a method of making a GLP-1 receptor agonist sub-micron particle core, by a. contacting a peptide in an aqueous medium at a pH of about 5.0-8.0 and comprising about 0.3-1.Type: ApplicationFiled: September 21, 2020Publication date: September 22, 2022Applicant: University College DublinInventors: David James Brayden, Delyan HRISTOV, Eugene MAHON, Sourav BHATTACHARJEE, Jason BEIRNE, Fiona MCCARTNEY
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Patent number: 11428687Abstract: The invention relates to a sensor molecule for detecting a target molecule comprising: (a) a rod-like molecule L and a rod-like molecule R connected to each other by a joint molecule C to form a hinge; (b) a target binding molecule A bonded to the end of rod-like molecule L opposite to the joint molecule C; (c) a binding molecule A? bonded to the end of rod-like molecule R opposite the joint molecule C; wherein the target binding molecule A is arranged to bind to an epitope or nucleic acid sequence of the target molecule to be detected, and binding molecule A? is arranged to bind to the same epitope or same nucleic acid sequence, or portion thereof of the target molecule as target binding molecule A; and wherein the hinge is biased into an open position, such that target binding molecule A and binding molecule A? are biased apart by the hinge. The invention also relates to analyte dependent activation of pharmaceuticals and chemo-toxins.Type: GrantFiled: September 8, 2017Date of Patent: August 30, 2022Assignee: University College Dublin, National University of Ireland, DublinInventor: Donal Mackernan
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Patent number: 11415512Abstract: An imaging apparatus (1) for imaging a sample (7) comprising an array of electronically addressable pixels (6) wherein each pixel is arranged to support a surface plasmon resonance thereinto generate an evanescent electromagnetic field (8) which extends transversely from the pixel so as to be salient from plane of the array for illuminating the sample (7). An optical detector (12) is arranged for detecting optical radiation (9, 10, 11) scattered from the evanescent electromagnetic field (8) by the sample (7). A processing unit (4) arranged to associate the detected optical radiation (9, 10, 11) with the address of the pixel or pixels within the array at which the surface plasmon resonance was generated.Type: GrantFiled: December 20, 2018Date of Patent: August 16, 2022Assignee: UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLINInventor: Dominic Zerulla
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Patent number: 11273454Abstract: There is provided system and a separation substrate device for use with an NLM separator in separating and/or detecting at least one target analyte in a sample, the substrate comprising a micromagnet array of a plurality of micromagnets, the micromagnet array comprising a first capture region, a second focusing region, and, a third detection region, the focusing region comprising a converging and/or diverging micromagnet array region. Also provided is a method for separating and detecting at least one target analyte in a sample.Type: GrantFiled: July 4, 2016Date of Patent: March 15, 2022Assignee: University College Dublin, National University of Ireland, DublinInventors: Devrim Kilinc, Peng Li, Gil Lee, Dhruv Ghandi, Stefano Rampini
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Patent number: 11274283Abstract: A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.Type: GrantFiled: September 23, 2020Date of Patent: March 15, 2022Assignee: University College Dublin, National University of Ireland, DublinInventors: Kevin O'Connor, Susan Molloy, Reeta Davis, Wesley Shaw
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Patent number: 11190167Abstract: A novel and useful discrete time IIR bandpass filter is disclosed that takes advantage of clock phase reuse thereby leading to significant improvements in filtering, especially stop band rejection in comparison to prior art filters. The bandpass filter of the present invention achieves improved filtering performance without adding any additional clock phases to the circuit. In particular, reuse of the already existing clock phases increases the order and performance of the filter. The invention exploits reuse of the clock phases to provide higher order filtering along with a discrete time IIR filter design which is capable of operating at high frequency. Consequently, much better filtering is achieved and the quality factor of the filter is improved leading to sharper transition bands especially for close-in band blockers in modern 4G/5G receivers.Type: GrantFiled: January 18, 2019Date of Patent: November 30, 2021Assignee: UNIVERSITY COLLEGE DUBLINInventors: Amirhossein Ansari Bozorg, Robert Bogdan Staszewski
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Patent number: 11161824Abstract: The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; wherein R2 is an optionally substituted alkoxy or aryloxy group, or with R1 forms a bond; wherein R3 is an optionally substituted alkyl group; and wherein R4 is CH2, CMe2 or O. Such compounds may be used in the treatment or prophylaxis of a disease or condition in which inhibition of acute inflammation and/or promotion of its resolution and/or suppression of fibrosis.Type: GrantFiled: August 18, 2017Date of Patent: November 2, 2021Assignee: University College Dublin, National University of Ireland, DublinInventors: Patrick Guiry, Catherine Godson, Monica De Gaetano, Eibhlin Butler, Claire Wilson, Catherine Tighe, Denise Moran, Andrea Zanetti, Kevin Gahan
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Patent number: 11140686Abstract: A role of sharing broker can be activated on a first mobile device, the role of sharing broker brokering sharing of network resources of at least a first network among a plurality of other mobile devices. Data usage by the first mobile device on at least the first network can be monitored. Responsive to the data usage by the first mobile device on at least the first network exceeding a threshold value, an amount of data usage on at least the first network being shared by the first mobile device among the plurality of other mobile devices can be adjusted.Type: GrantFiled: September 23, 2019Date of Patent: October 5, 2021Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, UNIVERSITY COLLEGE DUBLINInventors: Jonathan Dunne, Paul B. French, James P. Galvin, Jr., Yi Han, Patrick J. O'Sullivan
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Patent number: 11051517Abstract: A composition comprising a silica-based nanobead having its surface functionalized by a moiety selected from moieties that are reactive to and combine with a fouling layer on a material surface.Type: GrantFiled: September 16, 2016Date of Patent: July 6, 2021Assignee: University College Dublin, National University of Ireland, DublinInventors: Michele Zanoni, Jessica Amadio, Eoin Casey, Olivier Habimana
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Patent number: 11040327Abstract: A barrel reactor (100) comprises a rotatable barrel (102); a first roller (110) located outside of the barrel (102) and arranged to facilitate rotation of the barrel, wherein the roller (110) comprises at least part of a first electrode; and a second electrode (120). A plasma is formed between the electrodes (110, 120). The second electrode (120) may also comprise a roller and the barrel (102) may be mounted on the rollers (110, 120). The spacing between, or positions of, the electrodes (110, 120) may be adjusted so as to accommodate different barrels (102) and/or to change the plasma distribution within the barrel (102).Type: GrantFiled: April 20, 2017Date of Patent: June 22, 2021Assignee: University College Dublin, National University of IrelandInventors: Peter Dobbyn, Denis Dowling
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Patent number: 11039179Abstract: A primary video and a second instance of a reference video can be simultaneously transmitted to a system through at least a first node of a communication network, the second instance of the reference video configured to be compared to a first instance of the reference video stored by the system to generate at least one quality of experience (QoE) value that infers a perceptual quality of the primary video as received by the system. The QoE value can be received from the system. A determination can be made as to whether the QoE value is less than a threshold value. Responsive to determining that the QoE value is less than the threshold value, the perceptual quality of the primary video can be improved by allocating greater bandwidth for transmission of the primary video.Type: GrantFiled: June 30, 2019Date of Patent: June 15, 2021Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, UNIVERSITY COLLEGE DUBLINInventors: Jonathan Dunne, Paul B. French, James P. Galvin, Jr., Patrick McDonagh, Patrick J. O'Sullivan
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Patent number: 11021506Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a thiosaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.Type: GrantFiled: November 22, 2019Date of Patent: June 1, 2021Assignees: The Regents of the University of California, University College DublinInventors: Stefan Oscarson, John Vincent Fahy, Shaopeng Yuan, Stephen Carrington
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Patent number: 10992302Abstract: A waveform synthesizer comprises a controllable oscillator for generating an oscillator waveform having an oscillator cycle; a reference input for accepting a reference signal having a reference cycle; and a waveform detector coupled to said oscillator and said reference input. The waveform detector is arranged to sample said waveform in response to said reference input and to determine waveform information about said oscillator. The waveform information is operative to adjust said controllable oscillator.Type: GrantFiled: January 30, 2017Date of Patent: April 27, 2021Assignee: UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELANDInventors: Teerachot Siriburanon, Vivek Govindaraj, Robert Bogdan Staszewski
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Publication number: 20210095349Abstract: A method of determining the risk of metastatic prostate cancer in an individual diagnosed with prostate cancer, the method comprising a step of assaying a biological sample obtained from the individual for the presence of at last one methylated regulatory DNA sequence selected from group comprising: SEQ ID NO: 1 to SEQ ID NO: 16, or variants thereof, and correlating the presence or absence of the methylated regulatory DNA sequence with aggressive (metastatic) prostate cancer.Type: ApplicationFiled: October 5, 2020Publication date: April 1, 2021Applicant: UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLINInventor: Antoinette PERRY
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Patent number: 10869834Abstract: A delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, for use in a method for the treatment or prevention of inflammatory bowel disease in a mammal, is described. The method comprises a step of orally administering to the mammal the delivery system, wherein the delivery system is formulated for oral delivery and release of the hydrogen peroxide or hydrogen peroxide generator system in-situ at a target location in the mammalian gastrointestinal tract. Also described is an oral dosage delivery system comprising hydrogen peroxide or a hydrogen peroxide generator system, in which the delivery system is configured for oral administration to a mammal and release of the hydrogen peroxide or hydrogen peroxide generator system at a target location within the mammalian gastrointestinal tract thereby effecting a localised increase in hydrogen peroxide levels at the target location in the mammalian gut or airways.Type: GrantFiled: April 6, 2017Date of Patent: December 22, 2020Assignee: University College Dublin, National University of Ireland, DublinInventor: Ulla Knaus
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Patent number: 10862423Abstract: A novel and useful mm-wave frequency generation system is disclosed that takes advantage of injection locking techniques to generate an output oscillator signal with improved phase noise (PN) performance and power efficiency. Low frequency and high frequency DCOs as well as a pulse generator make up the oscillator system. A fundamental low frequency (e.g., 30 GHz) signal and its sufficiently strong higher (e.g., fifth) harmonic (e.g., 150 GHz) are generated simultaneously in a single oscillator system. The second high frequency DCO having normally poor phase noise is injected locked to the first low frequency DCO having good phase noise. Due to injection locking, the high frequency output signal generated by the second DCO exhibits good phase noise since the phase noise of the second DCO tracks that of the first DCO.Type: GrantFiled: January 24, 2019Date of Patent: December 8, 2020Assignee: UNIVERSITY COLLEGE DUBLINInventors: Amirhossein Ansari Bozorg, Robert Bogdan Staszewski
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Publication number: 20200376969Abstract: Provided are an apparatus and system for directing power flow between multiple devices, the apparatus comprising: one or more inlet ports for connection to one or more devices; a plurality of outlet ports configured for supplying electrical power; and a computing device configured to route power from the one or more inlet ports to the outlet ports. The system comprises a plurality of the apparatus connected to each other.Type: ApplicationFiled: November 29, 2018Publication date: December 3, 2020Applicant: University College Dublin, National University of Ireland, DublinInventors: Robert SHORTEN, Julia O'CONNELL, Barry CARDIFF, Giovanni RUSSO, Pietro FERRARO, Paul Dermot CUFFE
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Patent number: 10837965Abstract: A method is provided for characterising and/or prognosing prostate cancer in a subject comprising measuring the level of at least one protein from a panel or at least one peptide thereof in a sample from the subject. The method may be used to determine the grade and stage of the prostate cancer. Also disclosed is a method for selecting a treatment for prostate cancer, together with corresponding methods of treatment. Systems and computing devices for performing the methods are also provided.Type: GrantFiled: December 19, 2014Date of Patent: November 17, 2020Assignee: UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELANDInventors: Stephen Pennington, Brendan Murphy, William Watson
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Patent number: 10840890Abstract: A novel and useful high-order discrete-time charge rotating (CR) infinite impulse response (IIR) low pass filter is presented. The filter utilizes history capacitor arrays incorporating banks of capacitors. A linear interpolation technique is used in the IIR filter with second order antialiasing filtering, whose transfer function is sinc(x)2 per stage. It also uses a gm cell, rather than operational amplifiers, and is thus compatible with digital nanoscale technology. A 7th-order charge-sampling discrete time filter is disclosed. The order of the filter is easily extendable to higher orders. The charge rotating filter is process scalable with Moore's law and amenable to digital nanoscale CMOS technology. Bandwidth of the filter is precise and robust to PVT variation. The filter exhibits very low power consumption per filter pole, low input-referred noise, wide tuning range, excellent linearity and low area per minimum bandwidth and filter pole.Type: GrantFiled: January 3, 2019Date of Patent: November 17, 2020Assignee: UNIVERSITY COLLEGE DUBLINInventors: Amirhossein Ansari Bozorg, Robert Bogdan Staszewski
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Patent number: 10822594Abstract: A method for the enzymatic conversion of a phenol substrate into a corresponding catechol product comprises the step of incubating the phenol substrate with a Ralstonia solanacearum tyrosinase enzyme, or a functional derivative thereof, in a reaction mixture, for a period of time sufficient to allow the enzyme convert at least some of the phenol substrate into the catechol product.Type: GrantFiled: December 9, 2015Date of Patent: November 3, 2020Assignee: University College Dublin, National University of Ireland, DublinInventors: Kevin O'Connor, Susan Molloy, Reeta Davis, Wesley Shaw