Abstract: A method of determining the risk of metastatic prostate cancer in an individual diagnosed with prostate cancer, the method comprising a step of assaying a biological sample obtained from the individual for the presence of at last one methylated regulatory DNA sequence selected from group comprising: SEQUENCE ID No's 1 to 16, or variants thereof, and correlating the presence or absence of the methylated regulatory DNA sequence with aggressive (metastatic) prostate cancer.

Abstract: Use of an isolated Ensifer adhaerens strain OV14 deposited under NCIMB Accession Number 4177, or an isolated variant thereof characterized by a 16S rRNA gene having at least 98.6% sequence homology with SEQUENCE ID NO: 1, as a gene delivery system in the genetic transformation of a plant cell or plant material is described.

Abstract: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.

Abstract: A computer-implemented method, computer program product, and computing system is provided for decoding media streams. In an implementation, a method may include selecting a time window for monitoring discontinuities in a plurality of packets in a media transmission stream having a first time and a second time. The first time may indicate a beginning of the time window and the second time may indicate an end of the time window. The method may also include determining the number of discontinuities in the plurality of packets at the first time at a network node. The method may also include determining the number of discontinuities in the plurality of packets at the second time at the network node. The method may also include determining the number of discontinuities in the plurality of packets within the time window. The method may also include comparing the number of discontinuities within the time widow to a plurality of predefined discontinuities threshold values.

Abstract: The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TP?) or TPbeta (TP?) receptor subtype.

Abstract: The invention generally relates to methods and compounds for treating proliferative disorders, viral infections, or both. In some embodiments, the invention provides an anticancer or antiviral compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating a proliferative disorder or a viral infection including administering an anticancer or antiviral compound that binds to a thromboxane receptor, has preferential binding for either TPalpha (TP?) or TPbeta (TP?) receptor subtype.

Abstract: A method and apparatus for stimulating the lower back and abdominal muscles in a patient comprising applying a first electrode A1/A2 substantially centrally to the lower lumbar region of the patient's body, and applying second and third electrodes B, C respectively to opposite side flanks of the patient's body. The electrodes are energized to apply a first group of muscular stimulation current pulses which flow between the second and third electrodes and a second group of muscular stimulation current pulses which flow between the first electrode and the second and third electrodes alternately.

Abstract: A method of labelling a target molecule forming part of a corona of molecules on a nanosized object is described. The method comprising the steps of incubating the nanosized object with a plurality of probes, in which the plurality of probes comprise small nanoparticles labelled with a recognition motif specific for the target molecule, separating the nanosized object and unbound probe. The invention also provides a method of determining the location or spatial distribution of a molecule forming part of a corona of molecules on the surface of a nanoparticle.

Abstract: A first instance of a reference video is stored. A primary video and a second instance of the reference video are simultaneously received. At least one quality of experience value that infers a perceptual quality of the primary video as received by a system is generated by comparing the first instance of the reference video to the second instance of the reference video on a pixel-by-pixel, frame-by-frame, basis and determining whether each pixel and each frame contained in the first instance of the reference video are contained in the second instance of the reference video.

Abstract: A first instance of a reference video is stored. A primary video and a second instance of the reference video are simultaneously received. At least one quality of experience value that infers a perceptual quality of the primary video as received by a system is generated by comparing the first instance of the reference video to the second instance of the reference video on a pixel-by-pixel, frame-by-frame, basis and determining whether each pixel and each frame contained in the first instance of the reference video are contained in the second instance of the reference video.

Abstract: The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TP?) or TPbeta (TP?) receptor subtype.

Abstract: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.

Abstract: A method is provided for characterising and/or prognosing prostate cancer in a subject comprising measuring the level of at least one protein from a panel or at least one peptide thereof in a sample from the subject. The method may be used to determine the grade and stage of the prostate cancer. Also disclosed is a method for selecting a treatment for prostate cancer, together with corresponding methods of treatment. Systems and computing devices for performing the methods are also provided.

Abstract: The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TP?) or TPbeta (TP?) receptor subtype.

Abstract: Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age-related macular degeneration, diabetic retinopathy or cancer.

Abstract: A first mobile device receives, from each of a plurality of other mobile devices, information related to the availability of at least one network resource provided by at least a first network offered for sharing by the respective other mobile device. The first mobile device also receives a request from a second mobile device to access the network resource provided by the first network shared by at least one of the plurality of other mobile devices. The first mobile device selects at least one of the other mobile devices to share the network resource provided by the first network with the second mobile device. The first mobile device communicates to the second mobile device peer-to-peer network connection information of the selected at least one of the other mobile devices.

Abstract: A flow enhanced method and system for flow non-linear magnetophoresis (F-NLM) is described. By tuning an external field frequency and the flow rate the migration velocities of different bead types may be caused to differ by several orders of magnitude over an extended range of frequencies to allow for separation of particles. Use of such efficiency in separation in bio-separation and similar assays is described.

Abstract: (E)-2-(2-Quinolin-2-yl-propenyl)-phenol, 2-Quinolin-2-yl-ylethynyl-phenol and salts thereof are useful as medicaments, especially for treatment of an angiogenesis-related disease or disorder.

Abstract: The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TP?) or TPbeta (TP?) receptor subtype.

Abstract: Use of an isolated Ensifer adhaerens strain OV14 deposited under NCIMB Accession Number 4177, or an isolated variant thereof characterized by a 16S rRNA gene having at least 98.6% sequence homology with SEQUENCE ID NO: 1, as a gene delivery system in the genetic transformation of a plant cell or plant material is described.