Abstract: The invention relates to a sensor molecule for detecting a target molecule comprising: (a) a rod-like molecule L and a rod-like molecule R connected to each other by a joint molecule C to form a hinge; (b) a target binding molecule A bonded to the end of rod-like molecule L opposite to the joint molecule C; (c) a binding molecule A? bonded to the end of rod-like molecule R opposite the joint molecule C; wherein the target binding molecule A is arranged to bind to an epitope or nucleic acid sequence of the target molecule to be detected, and binding molecule A? is arranged to bind to the same epitope or same nucleic acid sequence, or portion thereof of the target molecule as target binding molecule A; and wherein the hinge is biased into an open position, such that target binding molecule A and binding molecule A? are biased apart by the hinge. The invention also relates to analyte dependent activation of pharmaceuticals and chemo-toxins.

Abstract: A novel and useful discrete time IIR bandpass filter is disclosed that takes advantage of clock phase reuse thereby leading to significant improvements in filtering, especially stop band rejection in comparison to prior art filters. The bandpass filter of the present invention achieves improved filtering performance without adding any additional clock phases to the circuit. In particular, reuse of the already existing clock phases increases the order and performance of the filter. The invention exploits reuse of the clock phases to provide higher order filtering along with a discrete time IIR filter design which is capable of operating at high frequency. Consequently, much better filtering is achieved and the quality factor of the filter is improved leading to sharper transition bands especially for close-in band blockers in modern 4G/5G receivers.

Abstract: The invention relates to novel chemical entities that act as thromboxane (TX) A2 receptor, or T prostanoid receptor (TP), antagonists and to their use in the treatment of human diseases in which thromboxane (TX) A and of all other agents that act as incidental ligands of TP, including the endoperoxide prostaglandin (PG)G2/PGH2, 20-hydroxyeicosatetraenoic acid (20-HETE) and the free-radical derived isoprostanes (e.g., 8-iso-prostaglandin (PG)F2?), play a role. Compounds of the invention preferably include a benzenesulfonyl urea in which the benzene is substituted by a substituted biphenylyloxy group (e.g., at the 2 position) and by a nitrile group (e.g., at the 5 position), which compounds show promising results as TP-isoform selective TP antagonists.

Abstract: A primary video and a second instance of a reference video can be simultaneously transmitted to a system through at least a first node of a communication network, the second instance of the reference video configured to be compared to a first instance of the reference video stored by the system to generate at least one quality of experience (QoE) value that infers a perceptual quality of the primary video as received by the system. The QoE value can be received from the system. A determination can be made as to whether the QoE value is less than a threshold value. Responsive to determining that the QoE value is less than the threshold value, the perceptual quality of the primary video can be improved by re-routing transmission of the primary video to the system.

Abstract: A novel and useful high-order discrete-time charge rotating (CR) infinite impulse response (IIR) low pass filter is presented. The filter utilizes history capacitor arrays incorporating banks of capacitors. A linear interpolation technique is used in the IIR filter with second order antialiasing filtering, whose transfer function is sinc(x)2 per stage. It also uses a gm cell, rather than operational amplifiers, and is thus compatible with digital nanoscale technology. A 7th-order charge-sampling discrete time filter is disclosed. The order of the filter is easily extendable to higher orders. The charge rotating filter is process scalable with Moore's law and amenable to digital nanoscale CMOS technology. Bandwidth of the filter is precise and robust to PVT variation. The filter exhibits very low power consumption per filter pole, low input-referred noise, wide tuning range, excellent linearity and low area per minimum bandwidth and filter pole.

Abstract: A novel and useful variable step serial DAC having a desired trajectory between input samples with a defined slope at intermediate points to form the output dynamic curve. The serial DAC is implemented to achieve higher order interpolation between the input sample points in the analog domain using switched capacitor CMOS circuits and without the use of a sample and hold circuit at the output. Conceptually, only two capacitors are needed for defining the output voltage for the conventional serial DAC. Dynamically programmable capacitor arrays define, via digital codes, the desired interpolation trajectory or output curve for the DAC between input sample points by defining the ratio of input charge Q(i) to the total capacitance C(i) at the ith time interval [Q(i)/C(i)]. The voltage at the output of the DAC is defined by incremental charge transfer at a defined rate between the input sample points. This technique uses minimum energy and area to define the dynamic curve for the DAC.

Abstract: The Applicant has identified a novel DON-responsive orphan gene (ENST1—SEQ ID NO: 1), and its promoter, which features DON-responsive elements, which can be used to drive the expression of FHB resistance genes. The Applicant has isolated two variants of the gene from wheat that share approximately 94% homology with ENST1. The Applicant has shown that this gene has homologs of >62% nucleotide sequence identity exist in Aegilops tauschii, Brachypodium distachyon, Festuca pratensis, Hordeum vulgare and Triticum aestivum.

Abstract: A method of generating hydrogen from photoelectrochemical water splitting using a technique that combines an external electric field with light-driven water splitting. In particular, an electric field is applied at a semiconductor-water interface in a manner that boosts the efficiency and performance of photoelectrochemical water splitting, e.g. by selecting properties of the external electric field to increase susceptibility of water molecules to break up. The radiation that drives water-splitting may be solar radiation, which effectively represents a zero-cost energy input. The advantage of the invention arises because the increase in hydrogen generated that follows from application of the external electric field can have a calorific value greater than the energy required to generate the external electric field. The external electric field thus has a quasi-catalytic effect to promote more efficient conversion of the radiation into hydrogen.

Abstract: Processes for stereoselective preparation of a chiral alcohol or a chiral amine are described.

Abstract: A method of monitoring sleep comprises simultaneously recording a person's electrocardiogram (ECG) and photoplethysmogram (PPG), deriving a plurality of parameters from the recorded data, and providing an output indicative of a sleep characteristic based upon an analysis of the parameters. The ECG and PPG may be recorded using an apparatus which is a combination of a Holter monitor and a pulse oximeter, which is wearable in ambulatory manner.

Abstract: A novel and useful variable step serial DAC having a desired trajectory between input samples with a defined slope at intermediate points to form the output dynamic curve. The serial DAC is implemented to achieve higher order interpolation between the input sample points in the analog domain using switched capacitor CMOS circuits and without the use of a sample and hold circuit at the output. Conceptually, only two capacitors are needed for defining the output voltage for the conventional serial DAC. Dynamically programmable capacitor arrays define, via digital codes, the desired interpolation trajectory or output curve for the DAC between input sample points by defining the ratio of input charge Q(i) to the total capacitance C(i) at the ith time interval [Q(i)/C(i)]. The voltage at the output of the DAC is defined by incremental charge transfer at a defined rate between the input sample points. This technique uses minimum energy and area to define the dynamic curve for the DAC.

Abstract: A curable coating composition comprising: (a) a silicate, such as sodium silicate, potassium silicate or lithium silicate; (b) a phosphate, such calcium phosphate, magnesium phosphate or sodium phosphate; and (c) a metal oxide, such as magnesium oxide, aluminum (III) oxide, scandium (III) oxide, yttrium (III) oxide, or zirconium oxide. Such curable coating compositions may be used as non-thermochromic (tailored based on expected operating environment) thermal control coating compositions for application to spacecraft and components thereof. As an alternative metal oxide component, for use in lower temperature applications, or in applications for which thermochromism at elevated temperatures is not a concern, the metal oxide may comprise zinc oxide. Also provided is a curable coating composition comprising: (a) a silicate (e.g. as above); (b) a phosphate (e.g. as above); and (c) a metal sulphate, such as a barium sulphate.

Abstract: A system and method for cognitive risk mitigation are presented. Embodiments comprise journey prediction, parsing of data sources, risk assessment and mitigation, and natural-language user interaction by a cognitive processor. Data is gathered from a plurality of data sources and analyzed in the context of one or more of the user's intention(s). A dialogue with the user, in natural language, aims to provide and select one or more suggestions relating to the one or more user intention(s) such that the risk(s) relating to the one or more user's intention(s) is reduced. During the dialogue, cognitive reasoning may be performed, wherein the cognitive reasoning includes the ability to justify each suggestion and the ability to infer information from the interaction such as, for example, data obtained in a dialogue may inform subsequent inferences. The embodiments may use speech synthesis and speech recognition in an interactive spoken dialogue.

Abstract: A peptide having 12 to 60 amino acids and including (a) a sequence of SEQUENCE ID NO: 11, or (b) a fragment of SEQUENCE ID NO: 11 that includes the sequence of SEQUENCE ID NO: 1 or 5, is described for use in improving glycemic management in a mammal. A composition, for example a food product, that includes substantially all of the peptides of SEQUENCE ID NO:'s 1 to 11, that is capable of reducing post-prandial blood glucose levels, and increasing insulin secretion in humans, is also described.

Abstract: A first mobile device determines a second mobile device losing connectivity to a second network or a communication link between the second mobile device and the second network degrading below a threshold value, the second mobile device assigned a role of sharing broker that brokers sharing of network resources of at least a first network among a plurality of other mobile devices via the second network, the first mobile device and the plurality of other mobile devices participating in a sharing group. Responsive to the determination, the role of sharing broker is activated on the first mobile device.

Abstract: There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.

Abstract: A method for predicting risk of recurrence of cancer in an individual with cancer, the method comprising a step of assaying a cancer sample from the individual for positive expression of at least two genes or proteins encoded by those genes selected from the group consisting of FOXM1, UHRF1, PTTG1, E2F1, MYBL2, HMGB2, ATAD2, E2F8, ZNF367 and TCF19, wherein positive expression of the at least two genes correlates with increased risk of recurrence of cancer compared with an individual who does not exhibit positive expression of the at least two genes or proteins encoded by those genes.

Abstract: Compounds and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age-related macular degeneration, diabetic retinopathy or cancer.

Abstract: A first mobile device receives, from each of a plurality of other mobile devices, information related to the availability of at least one network resource provided by at least a first network offered for sharing by the respective other mobile device. The first mobile device also receives a request from a second mobile device to access the network resource provided by the first network shared by at least one of the plurality of other mobile devices. The first mobile device selects at least one of the other mobile devices to share the network resource provided by the first network with the second mobile device. The first mobile device communicates to the second mobile device peer-to-peer network connection information of the selected at least one of the other mobile devices.

Abstract: The invention relates to novel chemical entities that act as thromboxane (TX) A2 receptor, or T prostanoid receptor (TP), antagonists and to their use in the treatment of human diseases in which thromboxane (TX) A and of all other agents that act as incidental ligands of TP, including the endoperoxide prostaglandin (PG)G2/PGH2, 20-hydroxyeicosatetraenoic acid (20-HETE) and the free-radical derived isoprostanes (e.g., 8-iso-prostaglandin (PG)F2?), play a role. Compounds of the invention preferably include a benzenesulfonyl urea in which the benzene is substituted by a substituted biphenylyloxy group (e.g., at the 2 position) and by a nitrile group (e.g., at the 5 position), which compounds show promising results as TP-isoform selective TP antagonists.