Patents Assigned to University of Miami
  • Publication number: 20200197434
    Abstract: The present invention relates, in part, to methods of generating immune responses in subjects that have a likelihood of developing cancer.
    Type: Application
    Filed: June 8, 2018
    Publication date: June 25, 2020
    Applicant: University of Miami
    Inventors: Eli GILBOA, Greta GARRIDO, Brett SCHRAND, Agata LEVAY
  • Patent number: 10689716
    Abstract: The disclosure relates to test kits and methods for detecting the presence of Coronavirus polynucleotides in a biological sample.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: June 23, 2020
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Sylvia Daunert, Sapna K. Deo, Jean-Marc Zingg
  • Patent number: 10674127
    Abstract: In certain embodiments, a user's field of view may be increased and/or modified. In some embodiments, views of a scene may be obtained via a wearable device. A first region of the scene may be determined, where the first region is common to the views and represented in the views at proximate a center of each of the views. For each view of the views, a second region of the scene may be determined, where the second region is represented in the view and related to peripheral vision of the user. A modified view may be generated based on (i) a portion of at least one of the views that corresponds to the common first region and (ii) portions of the views that correspond to the second regions such that the modified view comprises a representation of the common first region and representations of the second regions.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: June 2, 2020
    Assignee: University of Miami
    Inventor: Mohamed Abou Shousha
  • Patent number: 10666918
    Abstract: In certain embodiments, vision-related alerting may be facilitated based on a physical contact prediction. In some embodiments, a prediction indicating defective visual field portions of a user's visual field may be generated based on feedback related to a set of stimuli displayed to the user. The defective visual field portions may be visual field portions of the visual field that fail to satisfy one or more vision criteria. Based on the prediction of the defective visual field portions, a modified video stream derived from a live video stream to be presented via a wearable device. Activation of an alert may be caused via the wearable device based on (i) a prediction of physical contact (of an object with the user) and (ii) the object not being sufficiently in any image portion of the modified video stream that corresponds to at least one visual field portion satisfying the vision criteria.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: May 26, 2020
    Assignee: University of Miami
    Inventor: Mohamed Abou Shousha
  • Patent number: 10624950
    Abstract: This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25 agonists disclosed herein have an anti-inflammatory and healing effect. They can be used, e.g., to treat disease caused by asthma and chronic inflammation, such as inflammatory bowel diseases including ulcerative colitis and Crohn's Disease. TNFR25 antagonists disclosed herein can inhibit CD8 T cell-mediated cellular immune responses and can, for example, mitigate organ or tissue rejection following a tissue transplantation. TNFR25 agonists disclosed herein represent biological response modifiers that alter the interaction between the body's cellular immune defenses and cancer cells to boost, direct, or restore the body's ability to fight the cancer when given with tumor vaccines.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: April 21, 2020
    Assignee: University of Miami
    Inventors: Eckhard R. Podack, Vadim Deyev, Robert Levy
  • Publication number: 20200087621
    Abstract: Sodium cellulose sulfate (NaCS) is employed as a novel GAG mimetic. Schwann cells (SCs) could be used in combination with a scaffold because the SCs can secrete neurotrophic factors stimulating neuron survival and extension of axons. Furthermore, the conduit may be used alone or combination with Schwann cells for spinal cord repair. In addition, the conduit also can be used for peripheral nerve repair. Also described herein are compositions and methods useful for promoting the growth and/or differentiation and/or repair of a cell and/or tissue in the peripheral nervous system, central nervous system, and specifically the spinal cord. In certain aspects, the present disclosure includes a scaffold supporting and promoting growth, differentiation, and/or regeneration and repair. The scaffold in one embodiment closely mimics the natural extracellular matrix (ECM) of the spinal cord.
    Type: Application
    Filed: September 17, 2019
    Publication date: March 19, 2020
    Applicants: New Jersey Institute of Technology, University of Miami
    Inventors: Treena Lynne Arinzeh, Roseline Menezes, George Collins, Sharareh Hashemi, Martin Oudega
  • Patent number: 10561741
    Abstract: Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: February 18, 2020
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Paolo Serafini, Jennifer Vella, Vincenzo Bronte, Pirouz Daftarian, Angel Kaifer, Serena Zilio
  • Patent number: 10562848
    Abstract: Disclosed herein are inhibitors of TNF superfamily costimulatory interactions, and methods for their use in modulating TNF superfamily costimulatory interactions and treating immune system related disorders. In particular, disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof: wherein the substituents are described herein.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: February 18, 2020
    Assignee: UNIVERSITY OF MIAMI
    Inventor: Peter Buchwald
  • Patent number: 10555987
    Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat disorders, such as ischemia and reperfusion injury. In one embodiment, a method of treating a reperfusion injury in a subject in need may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In additional embodiment, a method of promoting vasculogenesis in a mammal may involve administering a therapeutically effective amount of at least one GHRH agonist peptide to the subject. In a further embodiment, a method of promoting differentiation of mesenchymal stem cells into endothelial cells may involve contacting mesenchymal stem cells with at least one GHRH agonist peptide.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: February 11, 2020
    Assignees: UNIVERSITY OF MIAMI, U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Andrew Schally, Joshua M. Hare, Norman Block, Samirah Gomes, Rosemeire M. Kanashiro-Takeuchi
  • Patent number: 10531795
    Abstract: In certain embodiments, vision defect information may be generated via a dynamic eye-characteristic-based fixation point. In some embodiments, a first stimulus may be displayed at a first location on a user interface based on a fixation point for a visual test presentation. The fixation point for the visual test presentation may be adjusted during the visual test presentation based on eye characteristic information related to a user. As an example, the eye characteristic information may indicate a characteristic of an eye of the user that occurred during the visual test presentation. A second stimulus may be displayed during the visual test presentation at a second interface location on the user interface based on the adjusted fixation point for the visual test presentation. Vision defect information associated with the user may be generated based on feedback information indicating feedback related to the first stimulus and feedback related to the second stimulus.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: January 14, 2020
    Assignee: University of Miami
    Inventor: Mohamed Abou Shousha
  • Publication number: 20190391398
    Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of wearable device may be adjusted, where the transparent display portions enable the user to see through the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. A modified video stream derived from the live video stream may be displayed on one or more other display portions of the wearable device.
    Type: Application
    Filed: September 4, 2019
    Publication date: December 26, 2019
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Mohamed ABOU SHOUSHA, Ahmed SAYED
  • Patent number: 10501413
    Abstract: Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: December 10, 2019
    Assignees: UNIVERSITY OF MIAMI, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Anthony J. Capobianco, Alex Mackerell, Jr., Mark Spyvee
  • Patent number: 10500231
    Abstract: The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and/or mobility, or alter normal cell growth and/or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: December 10, 2019
    Assignee: University of Miami
    Inventors: Evangelos V. Badiavas, Arsalan Q. Shabbir, Stephen C. Davis
  • Patent number: 10493163
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 3, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
  • Patent number: 10485421
    Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. A modified version of the live video stream data may be generated and displayed to the user based on the live video stream and the set of modification parameters.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 26, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan
  • Patent number: 10481402
    Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of wearable device may be adjusted, where the transparent display portions enable the user to see through the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. A modified video stream derived from the live video stream may be displayed on one or more other display portions of the wearable device.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 19, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Ahmed Sayed
  • Patent number: 10468142
    Abstract: A method of predicting a disease or condition of a cornea or an anterior segment of an eye includes inputting input data into an AI model, processing the input data, and generating a set of scores and outputting a prediction. The input data may be representative of a cornea or anterior segment of an eye. Processing the input data may include processing the data through the plurality of convolutional layers, the fully connected layer, and the output layer. Each score of the set of scores may be generated by a corresponding node in the output layer. The output prediction may be related to the cornea or anterior segment of the eye represented by the input data processed through the AI model. The prediction may be determined by at least one score of the set of scores.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: November 5, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
  • Patent number: 10465166
    Abstract: A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base; phosphoethanolamine; selenium; transferrin; triiodothyronine; all-trans-retinoic acid (ATRA) and vitamin C; zinc, magnesium, and copper; an agent that increases intracellular cAMP; epidermal growth factor (EGF); hydrocortisone; insulin; and charcoal stripped fetal bovine serum, wherein said cell culture medium is substantially free, if not entirely free, of vitamin D, androgenic hormones, androgenic ligands, estrogenic hormones, estrogenic ligands, and/or androgenic receptors.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: November 5, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventor: Tan Ince
  • Patent number: 10444514
    Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of a screen of wearable device may be adjusted, where the transparent display portions enable the user to see through the screen of the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. An enhanced video stream derived from the live video stream may be displayed on one or more other display portions of the screen of the wearable device.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: October 15, 2019
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Ahmed Sayed
  • Patent number: 10444403
    Abstract: A water body drifter device for tracking movement of a fluid is disclosed. The drifter may include a floater assembly having a toroid shaped buoy fixedly connected to a floater head disposed interiorly to the toroid shaped buoy, the floater head having a recess and a cap sealably attached to the recess for housing a network-enabled controller. The drifter may also include one or more sensors mounted to the floater assembly to capture physical, chemical or biological data from the water body and/or from the environment around the water body, a drogue formed of a plurality of blades each spaced from one another, and a flexible connector attached to the floater assembly at one end and the drogue at another end. The floater assembly, the drogue, and the flexible connector may each be formed of one or more biodegradable materials.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 15, 2019
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Tamay Ozgokmen, Charles Cousin, Guillaume Novelli, Cedric Guigand