Patents Assigned to University of Miami
  • Patent number: 11992345
    Abstract: A system measures performance activity of a user using a motion capture device, such as one or more knee sleeves each a plurality of inertial-measurement unit. Captured motion characteristic data is classified against previously captured data and then mapped to particular audio effects, which are then altered in different ways depending on the classification and provided the user. The audio feedback works to improve the user's performance of the activity by changing between negative and positive feedback depending on the user's performance. The system regularly measures the motion capture data, altering audio effects provided to the user, until the user reaches an improvement goal.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: May 28, 2024
    Assignee: University of Miami
    Inventors: Christopher Bennett, Robert Gailey, Vibhor Agrawal, Colby Leider
  • Patent number: 11994511
    Abstract: Described herein are materials and methods for the treatment of prostate cancer.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: May 28, 2024
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Kerry L. Burnstein, Fiorella Magani
  • Publication number: 20240165268
    Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.
    Type: Application
    Filed: January 23, 2024
    Publication date: May 23, 2024
    Applicants: University of Miami, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael S. KAPILOFF, Jinliang LI
  • Publication number: 20240158801
    Abstract: Activation of STimulator of INterferon Genes (STING) triggers cytokine production and facilitates tumor antigen cross-presentation. In an embodiment of the present invention, STING-dependent innate immune signaling pathway activators (STAVs) can be delivered to antigen presenting cells. In various embodiments of the present invention, the STAVs can be delivered in lipid nanoparticle formulations. In various embodiments of the present invention, the range of cancers amenable to STAV therapy can be extended using a non-cell-based nanoparticle strategy that effectively delivers Nano-STAVs into the Tumor Micro Environment (TME) to potently generate anti-tumor cytotoxic T cell activity. The STAV formulations can be introduced into solid tumors present in the mammal. Alternatively, the Nano-STAVs can be introduced through direct inoculation. The lipid nanoparticles stick to the tumor cells and are co-phagocytosed to activate STING in APC's.
    Type: Application
    Filed: December 21, 2023
    Publication date: May 16, 2024
    Applicant: UNIVERSITY OF MIAMI
    Inventor: Glen N Barber
  • Patent number: 11981660
    Abstract: Provided herein are compounds useful in treating a central nervous system disorder associated with neuronal and/or axonal damage, methods for their preparation, and related pharmaceutical compositions. For example provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: May 14, 2024
    Assignees: UNIVERSITY OF MIAMI, Torrey Pines Institute for Molecular Studies
    Inventors: Vance Lemmon, Hassan Al-Ali, John Bixby, Marc Giulianotti
  • Patent number: 11963786
    Abstract: Systems, methods, and computer readable media for determining cognitive impairment (CI) in patients are provided herein. Various regional structural-functional parameters of the retina can serve as biomarkers for the detection of CI. The method can include forming a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, providing a baseline cognitive impairment (CI) reference. The method can include determining a measure of functionality of neurons in the retina based on an electroretinogram (ERG) of a patient. The method can include determining a structural measure of the first retina based on a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and a lacunarity parameter of the skeletonized retinal image. The method can include determining a level of cognitive impairment based on the structural and functional measures.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: April 23, 2024
    Assignee: University of Miami
    Inventor: Delia DeBuc
  • Publication number: 20240124570
    Abstract: The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for detecting and treating early-stage Alzheimer's disease as well as other inflammatory neurologic conditions.
    Type: Application
    Filed: September 8, 2023
    Publication date: April 18, 2024
    Applicant: University of Miami
    Inventors: Juan Pablo De Rivero Vaccari, Robert W. Keane, W. Dalton Deitrich, Helen M. Bramlett
  • Patent number: 11957569
    Abstract: A device and method for aspirating graft tissue and delivering the graft tissue to a target delivery site (for example, when performing Descemet's membrane endothelial keratoplasty). In one embodiment, an injector comprises a cylinder and a plunger at least partially located within the cylinder, the plunger being rotatably advanceable and retractable within the cylinder. In one aspect of the embodiment, rotating the plunger in a first direction within the cylinder controllably aspirates a graft tissue into the injector and rotating the plunger in a second direction opposite the first direction controllably ejects the graft tissue from the injector.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: April 16, 2024
    Assignees: TissueCor, LLC, University of Miami
    Inventors: Alfonso L. Sabater, Abhishek Shah, William B. Buras, Alejandro M. Sabater
  • Publication number: 20240108593
    Abstract: The disclosure provides a method of treating a polyamine imbalance-related disorder. The method comprises administering phenylbutyrate to a subject in need thereof, thereby treating the polyamine imbalance-related disorder.
    Type: Application
    Filed: December 6, 2021
    Publication date: April 4, 2024
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Rong Grace Zhai, Xianzun Tao, Chong Li, Yi Zhu, Zoraida Diaz-Perez
  • Patent number: 11938198
    Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: March 26, 2024
    Assignees: University of Miami, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael S. Kapiloff, Jinliang Li
  • Patent number: 11932898
    Abstract: Computer-implemented processes for precision therapeutic biomarker screening for cancer include using a model-based overlapping clustering framework to assess large numbers of possible drugs and drug combinations against patient data, including cell line responsiveness. A multivariate regression model has been developed, along with a latent overlapping cluster indicator variable. The techniques employ a new finite mixture of multivariate regression (FMMR) model and expectation-maximization (EM) algorithm for modeling. The techniques can analyze large amounts of drug data and identify complex overlapping drug clusters, as well as cluster-wise drivers that facilitate identification of new drugs for treating pathologies, such as cancer, in patients.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: March 19, 2024
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Jonnagadda Sunil Rao, Hongmei Liu
  • Publication number: 20240084276
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicants: Precision Biosciences, Inc., University of Miami
    Inventors: James Jefferson Smith, Ginger Tomberlin, John Morris, Wendy Shoop, Carlos T. Moraes
  • Patent number: 11926613
    Abstract: Provided herein are compounds of the general Formula (I) which act as kinase inhibitors, e.g. ROCK, S6K, and/or PKC inhibitors, and are useful in neurite growth and axonal growth.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: March 12, 2024
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Hassan Al-Ali, Vance Lemmon, John Bixby
  • Patent number: 11918659
    Abstract: Described herein are materials and methods for inducing therapeutic hypothermia in a subject in need thereof.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: March 5, 2024
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Sylvia Daunert, Suzana Hamdan, Dalton Dietrich, Sapna Deo, Helen Bramlett
  • Patent number: 11911450
    Abstract: The invention provides a method of treating or preventing pain in a subject in need thereof. The method comprising administering to the subject an expression vector comprising a nucleic acid sequence encoding carbonic anhydrase (10) or carbonic anhydrase (11) such that the nucleic acid is expressed to produce carbonic anhydrase (10) or carbonic anhydrase (11). Alternatively, the method comprising administering to the subject an expression vector comprising a nucleic acid sequence encoding a carbonic anhydrase (8) fragment such that the nucleic acid is expressed to produce the carbonic anhydrase (8) fragment.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: February 27, 2024
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Roy Levitt, Gerald Z. Zhuang
  • Patent number: 11913962
    Abstract: Described herein are materials and methods for stratifying risk for reactivation of a latent viral infection, such as CMV infection. The methods are particularly useful for immune compromised subjects. Also described herein are interventions, including therapeutic, prophylactic, and monitoring interventions, for subjects determined to be at elevated risk.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: February 27, 2024
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Krishna Komanduri, Eric Wieder, Jose Camargo, Erik Kimble
  • Patent number: 11866747
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: January 9, 2024
    Assignees: University of Miami, Precision BioSciences, Inc.
    Inventors: James Jefferson Smith, Ginger Tomberlin, John Morris, Wendy Shoop, Carlos T. Moraes
  • Patent number: 11850035
    Abstract: Systems and methods for diagnosing a condition in an individual by analyzing the individual's breath are provided. Sensors may be configured to capture data associated with the breath of an individual. The data captured by the sensors may include a change in resistance measurements recorded by solid-state sensors when the sensors are exposed to the individual's breath at several different temperatures. This captured data may be analyzed to identify one or more volatile organic compound (VOC) biomarkers in the individual's breath. Based on the identified VOC biomarkers, a condition associated with the individual may be determined. For example, a medical condition, or a condition of drowsiness or fatigue associated with the individual may be determined based on the VOC biomarkers in the individual's breath. In some examples, the sensors may be positioned inside a vehicle for determination of condition associated with a driver of the vehicle.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: December 26, 2023
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Sylvia Daunert, Jeramy Lee Rueff Baum, Carl Ivan Schulman, Sapna K. Deo, Emre Dikici, Chitvan Killawala, Kelly Withum, Kevin Miller
  • Patent number: 11840565
    Abstract: The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for treating viral-associated lung inflammation, for example lung inflammation associated with viral infections such as SARS-CoV-2.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: December 12, 2023
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Robert W. Keane, W. Dalton Dietrich, Juan Pablo De Rivero Vaccari, Helen M. Bramlett
  • Patent number: 11830582
    Abstract: Provided herein are methods implemented by a processor in a computer for designing a clamp peptide comprising the structure A1-B-A2 wherein A1 is a first peptide arm that binds to a first binding site of a target protein, A2 is a second peptide arm that binds to a second binding site of the target protein, and B is a bridge peptide which links A1 to A2. Also provided herein are computer-readable storage media having stored thereon machine-readable instructions executable by a processor and systems. Related methods of manufacturing a clamp peptide and the clamp peptides manufactures by the methods are provided.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: November 28, 2023
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Sylvia Daunert, Sapna K. Deo, Emre Dikici, Marcello Mascini