Patents Assigned to University of Miami
  • Patent number: 11344604
    Abstract: Disclosed herein is a method of treating or preventing renal disease in a subject suffering from Alport Syndrome, as well a method of treating or preventing chronic kidney disease. The method comprises administering to a subject in need thereof an effective amount of human apolipoprotein M.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: May 31, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Alessia Fornoni, Sandra Merscher
  • Patent number: 11332712
    Abstract: A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base; phosphoethanolamine; selenium; transferrin; triiodothyronine; all-trans-retinoic acid (ATRA) and vitamin C; zinc, magnesium, and copper; an agent that increases intracellular cAMP; epidermal growth factor (EGF); hydrocortisone; insulin; and charcoal stripped fetal bovine serum, wherein said cell culture medium is substantially free, if not entirely free, of vitamin D, androgenic hormones, androgenic ligands, estrogenic hormones, estrogenic ligands, and/or androgenic receptors.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: May 17, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventor: Tan Ince
  • Publication number: 20220125294
    Abstract: A method is disclosed for improving accuracy of visual field testing in head-mounted displays. The method includes retrieving a visual field testing pattern for a head-mounted display, the visual field testing pattern including icons displayed at respective locations in a visual field of the head-mounted display. The visual field testing pattern is generated on the head-mounted display. Data is retrieved from a tilt sensor, located at the head-mounted display, for detecting degrees of head tilt of a user wearing the head-mounted display and the degree of head tilt is determined. A comparison is made between the degree of head tilt of the user to a first threshold degree. In response to the degree of head tilt of the user meeting or exceeding the first threshold degree, a recommendation to the user is generated for display on the head-mounted display.
    Type: Application
    Filed: April 30, 2021
    Publication date: April 28, 2022
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Mohamed ABOU SHOUSHA, Rashed Kashem
  • Publication number: 20220125295
    Abstract: In some embodiments, initial feedback indicating threshold characteristics (under which a user sees initial stimuli presented on a user interface) may be provided to a prediction model, and a set of predicted characteristics (for a set of locations of the user interface) and a set of confidence scores associated with the set of locations may be obtained via the prediction model. Based on the set of confidence scores, one or more locations may be selected to be tested during a visual test presentation. As an example, the locations may be selected over one or more other locations of the set of locations based on the set of confidence scores. Based on predicted characteristics associated with the selected locations, stimuli may be presented at the selected locations during the visual test presentation. Visual defect information for the user may be generated based on feedback from the visual test presentation.
    Type: Application
    Filed: June 9, 2021
    Publication date: April 28, 2022
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Mohamed ABOU SHOUSHA, Amr Saad Mohamed ELSAWY
  • Publication number: 20220125296
    Abstract: In some embodiments, initial feedback indicating threshold characteristics (under which a user sees initial stimuli presented on a user interface) may be provided to a prediction model, and a set of predicted characteristics (for a set of locations of the user interface) and a set of confidence scores associated with the set of locations may be obtained via the prediction model. Based on the set of confidence scores, one or more locations may be selected to be tested during a visual test presentation. As an example, the locations may be selected over one or more other locations of the set of locations based on the set of confidence scores. Based on predicted characteristics associated with the selected locations, stimuli may be presented at the selected locations during the visual test presentation. Visual defect information for the user may be generated based on feedback from the visual test presentation.
    Type: Application
    Filed: July 30, 2021
    Publication date: April 28, 2022
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Mohamed ABOU SHOUSHA, Amr Saad Mohamed ELSAWY
  • Patent number: 11311537
    Abstract: The present disclosure relates, in general, a method of diagnosing and treatment of lymphoproliferative disorders.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: April 26, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Izidore Lossos, Ramiro E. Verdun
  • Patent number: 11283187
    Abstract: Double reflector electromagnetic systems implementable in miniaturized satellites and other applications for compact, light weight, and broadband antennas. The disclosed methods and devices include primary and secondary reflectors, where the secondary reflector is held in the aperture plane of the primary reflector to minimize required space. A specific Cassegrain configuration is also described.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: March 22, 2022
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF MIAMI
    Inventors: Paul F. Goldsmith, Lorene A. Samoska, Maria Alonso Del Pino, Joshua O. Gundersen, Pekka Kangaslahti
  • Patent number: 11253602
    Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: February 22, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
  • Patent number: 11249082
    Abstract: Provided herein are Zika virus (ZIKV) binding constructs, e.g., antibodies and antigen-binding fragments thereof and antibody mimetics, as well as related conjugates, polypeptides, nucleic acids, expression vectors, host cells, kits, and assay systems. Methods detecting ZIKV infection and/or ZIKV exposure and/or ZIKV immunity are provided.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: February 15, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Sylvia Daunert, Sapna K. Deo, Emre Dikici, Marcello Mascini, Devon Pawley
  • Publication number: 20220023421
    Abstract: Conjugates of synthetic nanocarriers, complexed with syngeneic (self) proteins adducted with haptens or other poorly immunogenic antigens (antigens of low immunogenicity), elicit selective humoral responses or antibodies against the hapten or antigen and not to self-protein. Compositions include these conjugates, which can be used as vaccines. Methods of making and using them are described herein. In a typical embodiment, a conjugate including a hapten or antigen of low immunogenicity associated with a particular disease (e.g., infection, cancer) can be used as a vaccine by eliciting antibodies that specifically neutralize the hapten or antigen. These hapten (and other poorly immunogenic antigen)-carrying nanocarriers selectively target antigen presenting cells resulting in a strong anti-hapten humoral response, and thus find use in vaccines for cancer (e.g., cancers of lung, cervix, breast, brain, liver pancreas, ovaries, skin, etc.
    Type: Application
    Filed: August 17, 2021
    Publication date: January 27, 2022
    Applicant: University of Miami
    Inventors: Victor L. Perez Quinones, Pirouz Daftarian
  • Publication number: 20220008247
    Abstract: A device to change the temperature of a localized volume of material. A workable device includes at least one heat transfer mechanism having an external surface for direct contact with an exposed surface of the material. A working fluid is directed by input and output conduits to contact an internal surface of the heat transfer mechanism. The heat transfer mechanism exchanges heat between the working fluid and the material. Temperature of the working fluid may be regulated by a thermal system disposed at a remote location. An optional temperature sensing element may monitor a local temperature of the heat transfer mechanism or otherwise infer a temperature of a portion of the material. Sometimes, a device includes a cooperating anchoring arrangement to facilitate holding the heat transfer mechanism in a desired spot. Certain devices may be plastically deformed to a desired device shape.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 13, 2022
    Applicants: Lucent Medical Systems, Inc., University of Miami
    Inventors: Curtis S. King, Suhrud Rajguru, Abhishek Prasad
  • Publication number: 20220008560
    Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.
    Type: Application
    Filed: March 13, 2020
    Publication date: January 13, 2022
    Applicants: University of Miami, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael KAPILOFF, Jinliang LI
  • Publication number: 20210364497
    Abstract: The present disclosure relates, in general, to methods for screening for modulators of IFN? activity using a GLuc/SEAP dual reporter system.
    Type: Application
    Filed: April 2, 2019
    Publication date: November 25, 2021
    Applicant: UNIVERSITY OF MIAMI
    Inventor: GLEN N BARBER
  • Patent number: 11174307
    Abstract: The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for treating viral-associated lung inflammation, for example lung inflammation associated with viral infections such as SARS-CoV-2.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: November 16, 2021
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Robert W. Keane, W. Dalton Dietrich, Juan Pablo De Rivero Vaccari, Helen M. Bramlett
  • Patent number: 11154052
    Abstract: A device and method for preserving corneal graft tissue. In one embodiment, a device for preserving corneal graft tissue comprises: a first chamber; a second chamber; and a corneal graft tissue suspension assembly that is configured to retain and suspend the corneal graft tissue between the first chamber and the second chamber, the first chamber being fluidly isolated from the second chamber when the corneal graft tissue is graft tissue is retained and suspended within the corneal graft tissue suspension assembly. In one embodiment, a method includes filling a first chamber of a device with a first preservation medium and filling a second chamber of the device with a second preservation medium different than or the same as the first, a corneal graft tissue being located between the first and second chambers.
    Type: Grant
    Filed: September 14, 2019
    Date of Patent: October 26, 2021
    Assignees: University of Miami, TissueCor, LLC
    Inventors: Alfonso L. Sabater, Alejandro M. Sabater, William B. Buras
  • Patent number: 11102462
    Abstract: In certain embodiments, vision defect information may be generated via a dynamic eye-characteristic-based fixation point. In some embodiments, a first stimulus may be displayed at a first location on a user interface based on a fixation point for a visual test presentation. The fixation point for the visual test presentation may be adjusted during the visual test presentation based on eye characteristic information related to a user. As an example, the eye characteristic information may indicate a characteristic of an eye of the user that occurred during the visual test presentation. A second stimulus may be displayed during the visual test presentation at a second interface location on the user interface based on the adjusted fixation point for the visual test presentation. Vision defect information associated with the user may be generated based on feedback information indicating feedback related to the first stimulus and feedback related to the second stimulus.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: August 24, 2021
    Assignee: UNIVERSITY OF MIAMI
    Inventor: Mohamed Abou Shousha
  • Patent number: 11076786
    Abstract: The subject invention provides sensor systems that can detect biomarkers related to wound healing (e.g., uric acid, adenosine, arginine and/or xanthine). In one embodiment, the subject invention pertains to materials and methods for monitoring biomarkers non-invasively in a wound and a biofluid (e.g., sweat) in the proximity of the wound, optionally, including other physiological fluids. Skin based, non-invasive enzymatic electrochemical biosensor on a wearable platform (e.g., sweat patch) that can evaluate the healing of wounds through assessment of its biomarker levels are provided. This non-invasive detection from physiologically biofluids can reduce or eliminate occlusion effects.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: August 3, 2021
    Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, UNIVERSITY OF MIAMI
    Inventors: Sohini Roy Choudhury, Yogeswaran Umasankar, Shekhar Bhansali, Robert S. Kirsner, Hadar A. Lev-Tov
  • Patent number: 11064905
    Abstract: An ingestible capsule device collects fluid aspirates from locations within the body, locations such as the small intestine, and retains the fluid aspirates free from contamination as the capsule device is expelled from the body. The device allows for microbial and metabolomics analysis for a variety of gastrointestinal, allergic, endocrinologic, and oncologic diseases. In some examples, the capsule device is a multi-stroke device that includes a capsule shell and two reservoirs located within the shell. Check valves work in conjunction with a vacuum pressure pumping mechanism to control fluid movement from one reservoir to another, where one of the reservoirs may be expandable and permeable to some fluids. In other examples, the capsule device employs a peristaltic pump fluid control with the capsule device, and a single semi-permeable bladder stores collected fluid aspirate.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 20, 2021
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Baharak Moshiree, Alex Espinosa
  • Patent number: 11039745
    Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. A modified version of the live video stream data may be generated and displayed to the user based on the live video stream and the set of modification parameters.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: June 22, 2021
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan
  • Patent number: RE48599
    Abstract: Compositions comprising TL1A-Ig fusion proteins and methods of their use, e.g., for the treatment of diseases and disorders associated with antigen-specific immune responses, are described. Also described are combination therapies that include the administration of a TNFRSF25 agonist and an interleukin (e.g., IL-2) and/or an mTOR inhibitor (e.g., rapamycin).
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: June 22, 2021
    Assignee: University of Miami
    Inventors: Eckhard R. Podack, Taylor H. Schreiber, Samia Q. Khan