Patents Assigned to University of Miami
  • Patent number: 11963786
    Abstract: Systems, methods, and computer readable media for determining cognitive impairment (CI) in patients are provided herein. Various regional structural-functional parameters of the retina can serve as biomarkers for the detection of CI. The method can include forming a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, providing a baseline cognitive impairment (CI) reference. The method can include determining a measure of functionality of neurons in the retina based on an electroretinogram (ERG) of a patient. The method can include determining a structural measure of the first retina based on a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and a lacunarity parameter of the skeletonized retinal image. The method can include determining a level of cognitive impairment based on the structural and functional measures.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: April 23, 2024
    Assignee: University of Miami
    Inventor: Delia DeBuc
  • Publication number: 20240124570
    Abstract: The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for detecting and treating early-stage Alzheimer's disease as well as other inflammatory neurologic conditions.
    Type: Application
    Filed: September 8, 2023
    Publication date: April 18, 2024
    Applicant: University of Miami
    Inventors: Juan Pablo De Rivero Vaccari, Robert W. Keane, W. Dalton Deitrich, Helen M. Bramlett
  • Patent number: 11957569
    Abstract: A device and method for aspirating graft tissue and delivering the graft tissue to a target delivery site (for example, when performing Descemet's membrane endothelial keratoplasty). In one embodiment, an injector comprises a cylinder and a plunger at least partially located within the cylinder, the plunger being rotatably advanceable and retractable within the cylinder. In one aspect of the embodiment, rotating the plunger in a first direction within the cylinder controllably aspirates a graft tissue into the injector and rotating the plunger in a second direction opposite the first direction controllably ejects the graft tissue from the injector.
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: April 16, 2024
    Assignees: TissueCor, LLC, University of Miami
    Inventors: Alfonso L. Sabater, Abhishek Shah, William B. Buras, Alejandro M. Sabater
  • Patent number: 11938198
    Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: March 26, 2024
    Assignees: University of Miami, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael S. Kapiloff, Jinliang Li
  • Publication number: 20240084276
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
    Type: Application
    Filed: November 21, 2023
    Publication date: March 14, 2024
    Applicants: Precision Biosciences, Inc., University of Miami
    Inventors: James Jefferson Smith, Ginger Tomberlin, John Morris, Wendy Shoop, Carlos T. Moraes
  • Patent number: 11866747
    Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: January 9, 2024
    Assignees: University of Miami, Precision BioSciences, Inc.
    Inventors: James Jefferson Smith, Ginger Tomberlin, John Morris, Wendy Shoop, Carlos T. Moraes
  • Publication number: 20230337905
    Abstract: In certain embodiments, double-vision-related vision defects determinations or modifications may be facilitated. In some embodiments, a stimulus may be to be presented at a first time at a position on a first display for a deviating eye of a user (e.g., without a stimulus being presented on a second display of for a reference eye of the user) to cause the deviating eye to fixate on the position on the first display. A deviation measurement for the deviating eye may be determined based on an amount of movement of the deviating eye occurring upon the presentation on the first display for the deviating eye at the first time. In some embodiments, a modification profile associated with the user may be determined based on the deviation measurement, where the modification profile includes one or more modification parameters to be applied to modify an image for the user.
    Type: Application
    Filed: May 18, 2023
    Publication date: October 26, 2023
    Applicant: University of Miami
    Inventor: Mohamed ABOU SHOUSHA
  • Publication number: 20230296626
    Abstract: Compositions and methods for detecting components of the inflammasome in a sample from a subject as markers for inflammasome-related diseases or disorders such as multiple sclerosis, stroke, mild cognitive impairment, Alzheimer's disease, age-related macular degeneration, NASH, inflammaging or traumatic brain injury. Methods of using such inflammasome markers to determine prognosis, direct treatment and monitor response to treatment for the subject with an inflammasome-related disease or disorder such as multiple sclerosis, stroke, mild cognitive impairment, Alzheimer's disease, age-related macular degeneration, NASH, inflammaging or traumatic brain injury are also described.
    Type: Application
    Filed: April 27, 2021
    Publication date: September 21, 2023
    Applicant: University of Miami
    Inventors: Robert W. Keane, Dalton W. Deitrich, Juan Pablo de Rivero Vaccari, Helen M. Bramlett
  • Patent number: 11701000
    Abstract: In certain embodiments, double-vision-related vision defects determinations or modifications may be facilitated. In some embodiments, a stimulus may be to be presented at a first time at a position on a first display for a deviating eye of a user (e.g., without a stimulus being presented on a second display of for a reference eye of the user) to cause the deviating eye to fixate on the position on the first display. A deviation measurement for the deviating eye may be determined based on an amount of movement of the deviating eye occurring upon the presentation on the first display for the deviating eye at the first time. In some embodiments, a modification profile associated with the user may be determined based on the deviation measurement, where the modification profile includes one or more modification parameters to be applied to modify an image for the user.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: July 18, 2023
    Assignee: University of Miami
    Inventor: Mohamed Abou Shousha
  • Publication number: 20230218199
    Abstract: Systems and methods for assessing, monitoring, or theranosing a condition or disorder based on a comparison of limb stability for one or more limbs of a subject from a baseline. The method includes placing two or more inertial measurement sensors on the limbs of the subject, acquiring baseline limb excursion data from the inertial measurement sensors while a patient is performing at least one of a static balance activity and a dynamic balance activity by tracking the relative displacement of the respective two or more inertial measurement sensors; acquiring post-injury limb excursion data after an injury from the inertial measurement sensors while a patient is performing at least one of a static balance activity and a dynamic balance activity; and determining the activity clearance index as a function of a comparison of the baseline limb excursion data compared to the post-injury limb excursion data.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 13, 2023
    Applicant: University of Miami
    Inventors: Kyoung Jae Kim, Robert Gailey, Ignacio Gaunaud, Christopher Bennett
  • Patent number: 11666649
    Abstract: The present invention provides an expression vector, host cells, methods and kits for the treatment or prevention of a flavivirus infection in a subject.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: June 6, 2023
    Assignee: University of Miami
    Inventors: Natasa Strbo, Laura Romero
  • Patent number: 11659987
    Abstract: In some embodiments, initial feedback indicating threshold characteristics (under which a user sees initial stimuli presented on a user interface) may be provided to a prediction model, and a set of predicted characteristics (for a set of locations of the user interface) and a set of confidence scores associated with the set of locations may be obtained via the prediction model. Based on the set of confidence scores, one or more locations may be selected to be tested during a visual test presentation. As an example, the locations may be selected over one or more other locations of the set of locations based on the set of confidence scores. Based on predicted characteristics associated with the selected locations, stimuli may be presented at the selected locations during the visual test presentation. Visual defect information for the user may be generated based on feedback from the visual test presentation.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: May 30, 2023
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
  • Patent number: 11659988
    Abstract: In some embodiments, initial feedback indicating threshold characteristics (under which a user sees initial stimuli presented on a user interface) may be provided to a prediction model, and a set of predicted characteristics (for a set of locations of the user interface) and a set of confidence scores associated with the set of locations may be obtained via the prediction model. Based on the set of confidence scores, one or more locations may be selected to be tested during a visual test presentation. As an example, the locations may be selected over one or more other locations of the set of locations based on the set of confidence scores. Based on predicted characteristics associated with the selected locations, stimuli may be presented at the selected locations during the visual test presentation. Visual defect information for the user may be generated based on feedback from the visual test presentation.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: May 30, 2023
    Assignee: University of Miami
    Inventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
  • Publication number: 20230149292
    Abstract: Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.
    Type: Application
    Filed: April 4, 2022
    Publication date: May 18, 2023
    Applicant: University of Miami
    Inventors: Sung Lan Hsia, Niven Rajin Narain, Jie Li, Kathryn J. Russell, Karrune V. Woan, Indushekhar Persaud
  • Publication number: 20230079120
    Abstract: Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising Interleukin-2 (IL-2) or a functional variant or fragment thereof; and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL-2R?) or a functional variant or fragment thereof, and wherein the fusion protein has IL-2 activity. Various methods are provided for modulating the immune response in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the IL-2/IL-2R? fusion protein disclosed herein.
    Type: Application
    Filed: August 25, 2022
    Publication date: March 16, 2023
    Applicant: University of Miami
    Inventor: Thomas MALEK
  • Patent number: 11591655
    Abstract: Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: February 28, 2023
    Assignee: University of Miami
    Inventors: Joshua Hare, Bettina Heidecker
  • Patent number: 11536542
    Abstract: Systems and devices for temporarily disabling an assailant or other target using disabling flashes of light from a light-emitting device. A tactical lighting system also includes protective eyewear that is paired with the light-emitting device and configured to shutter in synchronization with the pattern of disabling light flashes to protect the wearer's eyes while disabling an assailant or other target.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: December 27, 2022
    Assignee: University of Miami
    Inventor: Brian Arwari
  • Publication number: 20220287590
    Abstract: Quantification of symmetry and repeatability in limb motion for treating abnormal motion patterns. In the context of gait analysis, gait data may be acquired as signals from inertial sensors (e.g., gryoscopes). Each signal represents an angular velocity of a lower limb segment of a subject during ambulation. Each signal may be segmented into stride signals, and a gait metric may be calculated based on the stride signals. The gait metric may comprise a symmetry metric that represents a similarity of the stride signals across two signals acquired for at least one pair of contralateral limb segments. Additionally or alternatively, the gait metric may comprise a repeatability metric that represents a similarity of the stride signals within a signal. In other embodiments, other types of sensors may be used and/or motion data may be acquired and metrics calculated for other types of motions and/or for upper limb segments.
    Type: Application
    Filed: September 4, 2020
    Publication date: September 15, 2022
    Applicant: University of Miami
    Inventors: Robert Gailey, Kyoung Jae Kim
  • Patent number: 11428690
    Abstract: A plasmonic photoconductor sensing platform is provided. The plasmonic photoconductor sensing platform includes an insulating substrate; a semiconducting film placed on top of the insulating substrate; two metal contacts placed at least in part on the semiconducting film to enforce an electric field; a plurality of plasmonic nanostructures deposited on the semiconducting film and physically separated from metal contacts; an insulating layer, the insulating electrically isolating the plasmonic nanostructures from semiconductor; at least one energy source; and at least one microfluidic channel disposed on the insulating layer.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 30, 2022
    Assignee: University of Miami
    Inventors: Xu Han, Hossein Shokri Kojori, Roger M. LeBlanc, Sung Jin Kim
  • Publication number: 20220257160
    Abstract: Device for arterial puncture assistance. In an embodiment, the device comprises an upper component, lower component, and coupling mechanism that couples the lower component to the upper component. The upper component may comprise a platform configured to support a syringe. The lower component may comprise one or more finger holes, wherein each of the one or more finger holes is configured to receive a human finger therethrough, so as to enable contemporaneous stabilization of the lower component on the human finger and palpation of an arterial pulse by the human finger during an arterial puncture.
    Type: Application
    Filed: July 15, 2020
    Publication date: August 18, 2022
    Applicant: University of Miami
    Inventors: RICARDO PALACIOS, ELIZABETH DECKLER