Patents Assigned to University of Miami
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Patent number: 10742944Abstract: In certain embodiments, double-vision-related vision defects determinations or modifications may be facilitated. In some embodiments, a stimulus may be to be presented at a first time at a position on a first display for a deviating eye of a user (e.g., without a stimulus being presented on a second display of for a reference eye of the user) to cause the deviating eye to fixate on the position on the first display. A deviation measurement for the deviating eye may be determined based on an amount of movement of the deviating eye occurring upon the presentation on the first display for the deviating eye at the first time. In some embodiments, a modification profile associated with the user may be determined based on the deviation measurement, where the modification profile includes one or more modification parameters to be applied to modify an image for the user.Type: GrantFiled: October 16, 2019Date of Patent: August 11, 2020Assignee: University of MiamiInventor: Mohamed Abou Shousha
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Publication number: 20200197434Abstract: The present invention relates, in part, to methods of generating immune responses in subjects that have a likelihood of developing cancer.Type: ApplicationFiled: June 8, 2018Publication date: June 25, 2020Applicant: University of MiamiInventors: Eli GILBOA, Greta GARRIDO, Brett SCHRAND, Agata LEVAY
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Patent number: 10674127Abstract: In certain embodiments, a user's field of view may be increased and/or modified. In some embodiments, views of a scene may be obtained via a wearable device. A first region of the scene may be determined, where the first region is common to the views and represented in the views at proximate a center of each of the views. For each view of the views, a second region of the scene may be determined, where the second region is represented in the view and related to peripheral vision of the user. A modified view may be generated based on (i) a portion of at least one of the views that corresponds to the common first region and (ii) portions of the views that correspond to the second regions such that the modified view comprises a representation of the common first region and representations of the second regions.Type: GrantFiled: July 9, 2019Date of Patent: June 2, 2020Assignee: University of MiamiInventor: Mohamed Abou Shousha
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Patent number: 10667732Abstract: Devices and methods of making and using the device for the non-invasive detection of volatile anesthetics are provided. The devices are capable of measuring the concentration of volatile anesthetics transdermally and in a non-invasive manner. The devices and methods can be applied in detection of volatile anesthetics in samples collected from human skin perspiration.Type: GrantFiled: May 12, 2017Date of Patent: June 2, 2020Assignees: The Florida International University Board of Trustees, University of MiamiInventors: Yogeswaran Umasankar, Shekhar Bhansali, Ernesto A. Pretto, Jr.
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Patent number: 10666918Abstract: In certain embodiments, vision-related alerting may be facilitated based on a physical contact prediction. In some embodiments, a prediction indicating defective visual field portions of a user's visual field may be generated based on feedback related to a set of stimuli displayed to the user. The defective visual field portions may be visual field portions of the visual field that fail to satisfy one or more vision criteria. Based on the prediction of the defective visual field portions, a modified video stream derived from a live video stream to be presented via a wearable device. Activation of an alert may be caused via the wearable device based on (i) a prediction of physical contact (of an object with the user) and (ii) the object not being sufficiently in any image portion of the modified video stream that corresponds to at least one visual field portion satisfying the vision criteria.Type: GrantFiled: August 12, 2019Date of Patent: May 26, 2020Assignee: University of MiamiInventor: Mohamed Abou Shousha
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Patent number: 10624950Abstract: This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. TNFR25 agonists disclosed herein have an anti-inflammatory and healing effect. They can be used, e.g., to treat disease caused by asthma and chronic inflammation, such as inflammatory bowel diseases including ulcerative colitis and Crohn's Disease. TNFR25 antagonists disclosed herein can inhibit CD8 T cell-mediated cellular immune responses and can, for example, mitigate organ or tissue rejection following a tissue transplantation. TNFR25 agonists disclosed herein represent biological response modifiers that alter the interaction between the body's cellular immune defenses and cancer cells to boost, direct, or restore the body's ability to fight the cancer when given with tumor vaccines.Type: GrantFiled: September 14, 2017Date of Patent: April 21, 2020Assignee: University of MiamiInventors: Eckhard R. Podack, Vadim Deyev, Robert Levy
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Publication number: 20200087621Abstract: Sodium cellulose sulfate (NaCS) is employed as a novel GAG mimetic. Schwann cells (SCs) could be used in combination with a scaffold because the SCs can secrete neurotrophic factors stimulating neuron survival and extension of axons. Furthermore, the conduit may be used alone or combination with Schwann cells for spinal cord repair. In addition, the conduit also can be used for peripheral nerve repair. Also described herein are compositions and methods useful for promoting the growth and/or differentiation and/or repair of a cell and/or tissue in the peripheral nervous system, central nervous system, and specifically the spinal cord. In certain aspects, the present disclosure includes a scaffold supporting and promoting growth, differentiation, and/or regeneration and repair. The scaffold in one embodiment closely mimics the natural extracellular matrix (ECM) of the spinal cord.Type: ApplicationFiled: September 17, 2019Publication date: March 19, 2020Applicants: New Jersey Institute of Technology, University of MiamiInventors: Treena Lynne Arinzeh, Roseline Menezes, George Collins, Sharareh Hashemi, Martin Oudega
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Patent number: 10531795Abstract: In certain embodiments, vision defect information may be generated via a dynamic eye-characteristic-based fixation point. In some embodiments, a first stimulus may be displayed at a first location on a user interface based on a fixation point for a visual test presentation. The fixation point for the visual test presentation may be adjusted during the visual test presentation based on eye characteristic information related to a user. As an example, the eye characteristic information may indicate a characteristic of an eye of the user that occurred during the visual test presentation. A second stimulus may be displayed during the visual test presentation at a second interface location on the user interface based on the adjusted fixation point for the visual test presentation. Vision defect information associated with the user may be generated based on feedback information indicating feedback related to the first stimulus and feedback related to the second stimulus.Type: GrantFiled: June 18, 2019Date of Patent: January 14, 2020Assignee: University of MiamiInventor: Mohamed Abou Shousha
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Patent number: 10500231Abstract: The present invention relates to the fields of medicine, cell biology, molecular biology and genetics. In particular, the present invention provides methods to isolate and purify microvesicles from cell culture supernatants and biological fluids. The present invention also provides pharmaceutical compositions of microvesicles to promote or enhance wound healing, stimulate tissue regeneration, remodel scarred tissue, modulate immune reactions, alter neoplastic cell growth and/or mobility, or alter normal cell growth and/or mobility. The present invention also provides compositions of microvesicles to be used as diagnostic reagents, and methods to prepare the compositions of microvesicles.Type: GrantFiled: March 12, 2014Date of Patent: December 10, 2019Assignee: University of MiamiInventors: Evangelos V. Badiavas, Arsalan Q. Shabbir, Stephen C. Davis
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Patent number: 10485421Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. A modified version of the live video stream data may be generated and displayed to the user based on the live video stream and the set of modification parameters.Type: GrantFiled: May 31, 2019Date of Patent: November 26, 2019Assignee: University of MiamiInventors: Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan
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Patent number: 10481402Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of wearable device may be adjusted, where the transparent display portions enable the user to see through the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. A modified video stream derived from the live video stream may be displayed on one or more other display portions of the wearable device.Type: GrantFiled: May 31, 2019Date of Patent: November 19, 2019Assignee: University of MiamiInventors: Mohamed Abou Shousha, Ahmed Sayed
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Patent number: 10468142Abstract: A method of predicting a disease or condition of a cornea or an anterior segment of an eye includes inputting input data into an AI model, processing the input data, and generating a set of scores and outputting a prediction. The input data may be representative of a cornea or anterior segment of an eye. Processing the input data may include processing the data through the plurality of convolutional layers, the fully connected layer, and the output layer. Each score of the set of scores may be generated by a corresponding node in the output layer. The output prediction may be related to the cornea or anterior segment of the eye represented by the input data processed through the AI model. The prediction may be determined by at least one score of the set of scores.Type: GrantFiled: July 27, 2018Date of Patent: November 5, 2019Assignee: University of MiamiInventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
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Patent number: 10444514Abstract: In certain embodiments, enhancement of a field of view of a user may be facilitated via one or more dynamic display portions. In some embodiments, one or more changes related to one or more eyes of a user may be monitored. Based on the monitoring, one or more positions of one or more transparent display portions of a screen of wearable device may be adjusted, where the transparent display portions enable the user to see through the screen of the wearable device. A live video stream representing an environment of the user may be obtained via the wearable device. An enhanced video stream derived from the live video stream may be displayed on one or more other display portions of the screen of the wearable device.Type: GrantFiled: March 28, 2019Date of Patent: October 15, 2019Assignee: University of MiamiInventors: Mohamed Abou Shousha, Ahmed Sayed
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Patent number: 10443056Abstract: Disclosed herein are methods for treating/and or preventing diabetes using a specific inhibitor of SMAD7 expression or function. Also disclosed are methods of promoting organ and/or cell, e.g., pancreatic islet cell, survival after transplantation using a specific inhibitor of SMAD7 expression or function.Type: GrantFiled: August 10, 2018Date of Patent: October 15, 2019Assignees: Nogra Pharma Limited, University of MiamiInventors: Giovanni Monteleone, Peter Buchwald, Luca Inverardi, Antonello Pileggi, Camillo Ricordi, Alice Tomei
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Patent number: 10409071Abstract: In certain embodiments, live image data modifications may be facilitated for dynamic vision defects. In some embodiments, one or more eyes of a user may be monitored while a set of stimuli are displayed to the user. Feedback related to the set of stimuli may be obtained, where the feedback indicates (i) whether or how the user sees one or more stimuli of the set and (ii) one or more characteristics related to the eyes that occurred when such stimuli are displayed. A set of modification profiles associated with the user may be generated based on the feedback, where each modification profile of the set (i) is associated with eye-related characteristics and (ii) includes modification parameters to be applied to an image to modify the image for the user when eye-related characteristics of the user matches the associated eye-related characteristics.Type: GrantFiled: March 28, 2019Date of Patent: September 10, 2019Assignee: University of MiamiInventors: Mohamed Abou Shousha, Ahmed Sayed, Ozgur Gundogan
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Patent number: 10389989Abstract: In certain embodiments, enhancement of a vision of a user may be facilitated. In some embodiments, a visual test presentation including a set of stimuli may be provided to a user. Feedback related to the set of stimuli may be obtained during the visual test presentation. The feedback may be provided to a prediction model, and the prediction model may be configured based on the feedback. Subsequent to the configuring of the prediction model, live video stream data, eye characteristic information, or other information may be provided to the prediction model to obtain a set of modification parameters. An enhanced image may be generated and displayed to the user based on the live video stream and the set of modification parameters.Type: GrantFiled: March 28, 2019Date of Patent: August 20, 2019Assignee: University of MiamiInventors: Mohamed Abou Shousha, Amr Elsawy, Ahmed Sayed, Ozgur Gundogan
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Publication number: 20190247302Abstract: The disclosure provides an ophthalmic formulation comprising a bromodomain inhibitor, a polar aprotic solvent (e.g., dimethyl sulfoxide (DMSO)), polysorbate, salt, and Captisol, as well as a method of treating or preventing ophthalmic inflammation in a subject in need thereof comprising locally administering the formulation to the eye of the subject.Type: ApplicationFiled: October 20, 2017Publication date: August 15, 2019Applicant: University of MiamiInventors: Robert B. Levy, Victor L. Perez, Claes Wahlestedt, Casey O. Lightbourn, Sabrina Copsel, Henry Barreras, Stephanie Duffort
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Patent number: 10368735Abstract: Techniques for improved diagnosis, treatment, and monitoring of corneal pathologies use enhanced mapping of the cornea or corneal regions, to develop three-dimensional mapping of corneal thickness, while retaining particular corneal micro-layer thickness data. Anterior and posterior surface identifications, along with surface apex determinations, are used for registration of segmentation of these micro-layers. 3D heat maps and bull's-eye maps are generated from resulting thickness date. The maps provided enhanced evaluation and diagnosis of a corneal pathologies, such as keratoconus, pellucid marginal degeneration, post-refractive surgery ectasia, keratoglobus, corneal transplant rejection and corneal transplant failed grafts, Fuchs dystrophy, corneal limbal stem cell deficiency, dry eye syndrome, and post-corneal collagen crosslinking evaluation.Type: GrantFiled: January 11, 2018Date of Patent: August 6, 2019Assignee: University of MiamiInventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
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Publication number: 20190209006Abstract: In some embodiments, images of a cornea may be obtained, and the images of the cornea may be segmented to detect a tear film layer of the cornea and an epithelium layer of the cornea. Thickness of the tear film layer and thickness of the epithelium layer may be determined based on the segmentation of the images of the cornea. A thickness map may be generated based on the thickness of the tear film layer and the thickness of the epithelium layer. As an example, the thickness map may comprise visual differences in thickness across the tear film layer and the epithelium layer. In some embodiments, the foregoing may be performed with respect to one or more other microlayers of the cornea in addition to or alternatively to the tear film layer or the epithelium layer.Type: ApplicationFiled: February 6, 2019Publication date: July 11, 2019Applicant: University of MiamiInventors: Mohamed Abou Shousha, Amr Saad Mohamed Elsawy, Marco Ruggeri
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Patent number: 10333069Abstract: The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the first carbon nanotubes from the second carbon nanotubes, thereby generating a purified layer of carbon nanotubes. Devices benefiting from enhanced electrical properties enabled by the purified layer of carbon nanotubes are also described.Type: GrantFiled: November 17, 2016Date of Patent: June 25, 2019Assignees: The Board of Trustees of The University of Illinois, Northwestern University, University of MiamiInventors: John A. Rogers, William L. Wilson, Sung Hun Jin, Simon N. Dunham, Xu Xie, Ahmad Islam, Frank Du, Yonggang Huang, Jizhou Song