Abstract: Disclosed herein are optogenetic circuits for the bacterium Escherichia coli that induce gene expression in darkness and repress it under blue light. Applying them to metabolic engineering improves chemical production compared to chemically induced controls in light-controlled fermentations. More particularly, these circuits can be used to control protein production with light. The system and method use light as a suitable alternative to chemical induction for microbial production of chemicals and proteins.

Abstract: A computer-implemented model is trained or otherwise configured for real-time production control. The model incorporates a plurality of classes of residence time control and optimizes produce performance by managing an associated machine's behavior according to real-time system states. The model can formulate a Markov decision process and feature-extraction method and feature-based approximation architecture to reduce state space of the model. Simulation is employed in training to estimate parameters of feature-based approximate architecture to obtain a lookahead function of the Markov decision process.

Abstract: A signal channel according to embodiments of the present disclosure includes a plurality of signal lines disposed on a plurality of layers spaced apart from each other in a first direction and connecting first points and second points to each other. A plurality of sections are defined between the first points and the second points. A first signal line disposed on a first layer of the plurality of layers in a first section of the plurality of sections is electrically connected to a second signal line disposed on a second layer of the plurality of layers in a second section of the plurality of sections.

Abstract: A shape memory polymer scaffold for treatment of a fistula. The scaffold is formed from a shape memory polymer foam that can be triggered to expand from a compressed shape to an expanded shape in response to hydration and/or heating. The shape memory polymer foam includes an antibacterial component and a biodegradable component so that the scaffold addresses infective agents in the fistula and will degrade over time as the fistula heals. The foam may comprise poly(vinyl alcohol), starch, and a phenolic acid.

Abstract: Disclosed are methods and a pharmaceutical composition for the prevention and treatment of fibrosis by the inhibition of fibronectin matrix assembly, as well as insights into the molecular mechanism by which cell-mediated assembly of fibronectin (FN) matrix contributes to extracellular matrix (ECM) accumulation. Peptides S2, S3, S20, and variants thereof may be utilized, either alone or fused to one or more proteins. In one aspect, a construct comprising a first protein fused to a first end of a peptide and a second protein fused to a second end of the peptide may be used, where the peptide has at least 80% sequence identity to S2, S3, or S20. The peptide may then be allowed to interact with fibronectin.

Abstract: The present invention relates to a composition for promoting the migration of adult stem cells, including miR-29a or miR-30c as an active ingredient, miR-29a or miR-30c, and a method for promoting the migration of adult stem cells, and it has been confirmed that the overexpression of miR-29a or miR-30c restores polarity, forms normal focal adhesions, and restores actomyosin-dependent contractile and traction forces, thereby promoting the migration of stem cells.

Abstract: A computer-readable storage medium according to an embodiment may store one or more programs, wherein the one or more programs include instructions, when executed by a processor of an electronic device, to cause the electronic device to: provide first training data to a first neural network for learning actions of an object; perform data sampling on hit reaction data so as to identify second training data; provide the second training data to a second neural network for learning a hit reaction of the object; and when the object is hit, acquire a result of the hit reaction of the object on the basis of the output of the first neural network and the second neural network. Various other embodiments are possible.

Abstract: Embodiments are provided for determining simulated optical microscopy images of formalin-fixed paraffin embedded (FFPE) stained tissue samples from stimulated Raman scattering microscopy (SRSM) images of frozen tissue samples. These embodiments include applying the SRSM images to a first generative model to generate simulated optical microscopy images of thawed, stained tissue samples corresponding to the SRS imaged tissue samples. The simulated optical microscopy images are then applied to a second generative model to generate simulated FFPE microscopy images of the frozen tissue samples.

Abstract: In a dicing film, an adhesive strength of an adhesive layer constituting the dicing film may sufficiently decrease after heat treatment, and a semiconductor die may be easily separated from the dicing film. Accordingly, the effect of improving pickup performance of the semiconductor die may be obtained.

Abstract: A combined pessary and menstrual cup useful for a human needing a pessary during menstruation is described.

Abstract: A robot joint device may include a first frame unit having a first hollow portion, a second frame unit having a second hollow portion, the second frame unit spaced apart from the first frame unit, a rotational axis unit on and between the first and second hollow portions and configured to rotate around first, second and third axes which are perpendicular to one another, a first link unit extending to bypass the rotational axis unit, connected to each of the first and second frame units with the rotational axis unit interposed therebetween, and configured to rotate around the first and second axes, and a second link unit extending to bypass the rotational axis unit while intersecting with the first link unit, connected to each of the first and second frame units with the rotational axis unit interposed therebetween, and configured to rotate around the first and second axes.

Abstract: Embodiments pertain to methods of evaluating fiber quality by (1) receiving at least one in-line hologram image of the fiber; (2) reconstructing the in-line hologram image of the fiber into at least one three-dimensional image of the fiber that includes fiber-related data; and (3) correlating the fiber-related data to fiber quality. Such methods may also include: (4) adjusting fiber-related conditions; and (5) repeating steps 1-3 after the adjustment. Further embodiments pertain to systems for evaluating fiber quality in accordance with the aforementioned methods. Such systems may include a receiving area with a region for housing a fiber, a light source associated with the receiving area, a chamber associated with the light source and receiving area, a camera within the chamber, a processor in electrical communication with the camera, a storage device, an algorithm associated with the storage device and a graphical user interface (GUI) associated with the processor.

Abstract: The invention relates to a computer-implemented method for improving data security in a computing device (10), the computing device (10) including a computer system (12) with a processor (16) for executing computer instructions (18) and a physical memory (20) accessible to the processor (16), the computer system (12) being configured as an implementation of a computer architecture suitable for switching between a trusted execution environment (22) for executing a trusted computing process (24) and a rich execution environment (26) for executing a client computing process (28) corresponding to the trusted computing process (24), wherein an access of the rich execution environment (26) on the trusted execution environment (22) is restricted and/or secured, wherein the rich execution environment (26) and the trusted execution environment (24) respectively are switchable between a user mode (30) in which execution of one or more selected computer instructions (18) for accessing the physical memory (20) is restric

Abstract: Disclosed is an optical atomizer. The optical atomizer according to the present disclosure includes a laser transmitter unit configured to transmit a laser beam oscillated by a laser oscillator to one side, and a sprayer unit connected to the laser transmitter unit, and configured to heat a liquid for spraying received in the sprayer unit by the laser beam transmitted from the laser transmitter unit and spray the evaporated liquid for spraying to outside.

Abstract: The present invention provides, in some embodiments, methods, compositions, systems, and kits comprising nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; 3-25 satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and at least one additional property. In other embodiments, provided herein are nano-satellite complexes comprising: a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; a plurality of satellite particles attached to, or absorbed to, said biocompatible coating; a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and a plurality of LIGHT (TNFSF14) peptides conjugated to, or absorbed to, said satellite particles.

Abstract: Fastening an object onto a lathe, such that the location of the centre of rotation of the object may be adjusted relative to the centre of the lathe axis, wherein the centre of rotation of the object relative to the centre of the lathe may be displaced steplessly and biaxially, according to a predetermined calculation, without removing the object from the chuck.

Abstract: Methods and systems to remotely operate robotic devices are provided. A number of embodiments allow users to remotely operate robotic devices using generalized consumer devices (e.g., cell phones). Additional embodiments provide for a platform to allow communication between consumer devices and the robotic devices. Further embodiments allow for training robotic devices to operate autonomously by training the robotic device with machine learning algorithms using data collected from scalable methods of controlling robotic devices.

Abstract: The present invention relates to compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules may act as therapeutics.

Abstract: The present disclosure provides methods for diagnosing and determining the disease progression of neurodegenerative disorders in patients using neurophysiological biomarkers.

Abstract: Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The animals and offspring have chromosomal modifications of a CD163 gene. The invention further relates to methods of breeding to create pathogen-resistant animals and populations of animals made using such methods.