Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.

Abstract: The invention disclosed herein provides methods and materials useful in gene therapy regimens designed to inhibit myelination abnormalities that occur in the urea cycle disorder arginase deficiency. The underlying cause of the progressive neurological dysfunction that occurs in this disorder has been previously unknown and conventional therapies, at best, only slow the onset of neurological dysfunction. This neurological dysfunction results at least in part from the dysmyelination that occurs in the central nervous system due to the lack of adequate hepatic expression of arginase 1. We have discovered an origin of this neurological dysfunction and, using this information, designed materials and associated methods of gene therapy. The methods and materials disclosed herein can inhibit and essentially prevent neurological dysfunction in a murine model of arginase deficiency.

Abstract: Provided herein are compositions related to vaccines, e.g., influenza vaccines, including, peptide based vaccines, nucleic acid based vaccines, recombinant virus based vaccines, antibody based vaccines, and virus based vaccines. Also provided herein are methods related to vaccines, e.g., influenza vaccines, including methods of identifying epitopes for the vaccines, producing, formulating, and administering the vaccines.

Abstract: Systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: A preparation method and application of a titanium nitride fiber-enhanced quasi-solid-state electrolyte, which relates to a synthetic method and application of a solid-state electrolyte. The object of the present disclosure is to solve the problem that the existing polymer electrolyte has low ionic conductivity, poor lithium ion transference number, and insufficient inhibition of lithium dendrite growth. The method includes the following steps: 1. preparation of TiN nanofiber, and 2. preparation of electrolyte. The TiN nanofiber-enhanced electrolyte is used as a solid-state electrolyte of lithium ion batteries. The electrolyte material provided by the present disclosure has excellent rate performance, high cycle stability, and long-term cycle life. In the present disclosure, a TiN nanofiber-enhanced quasi-solid-state electrolyte can be obtained.

Abstract: Devices and methods for detecting an analyte in a gas involve the use of plasmonic excitation of a nanostructured sensing element that is tuned to absorb at a narrow bandwidth specific for light absorbed by the analyte. The sensing element can be used as a capacitive or inductive element in a circuit.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: The present invention relates to methods and apparatuses for estimating the status of a bladder, especially with respect to the likelihood of an imminent voiding of the bladder. The apparatuses carry out computer-implemented methods of estimating a bladder status employing a bladder monitor which collects bladder data (e.g. using ultrasound) and transmits the bladder data to a data processor for algorithmic conversion to a bladder status. Such algorithms may be trained and tuned to a particular person's bladder. Having established a bladder status based on otherwise esoteric bladder data, the data processor may then trigger an alert signal where the bladder status meets particular criteria indicating an imminent voiding event. Such a trigger signal may be used to alert a nocturnal enuresis patient to an impending void so that they can be awoken before any bedwetting occurs.

Abstract: Two or more micropipettes are used to increase a microinjection throughput in an automated system for microinjecting adherent cells on a Petri dish. In the system, a motorized stage carrying the Petri dish sequentially visits the cells according to an optimized injection sequence. The sequence is selected by minimizing a total distance traveled by the motorized stage such that each cell is visited once by one of the micropipettes. Using multiple micropipettes advantageously reduces the minimized total distance over using a single micropipette to thereby increase the throughput. The optimized injection sequence is obtained by solving an equality-generalized traveling salesman problem. Each micropipette is mounted on a motorized micromanipulator. The motorized stage and motorized micromanipulators operate coordinately that each micromanipulator goes down or up during movement of the motorized stage to compensate for unevenness between a focus plane and a moving trajectory of the motorized stage.

Abstract: An electrode is provided. The electrode includes a contact pad composed of boron-doped polycrystalline diamond (BDD); a fiber core composed of BDD extending longitudinally from the contact pad from a first end that is in direct contact with the contact pad to an opposing second end; and a polycrystalline diamond (PCD) cladding that coats and hermetically seals the contact pad and the fiber core. A first portion of the contact pad and a second portion at or near the second end of the fiber core are not coated and hermetically scaled by the PCD cladding. A method of fabricating the electrode is also provided.

Abstract: The present invention includes systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: Small molecule radiohalogenated PSMA inhibitors and metal complexes thereof and their use in radioimaging and radiotherapy for treating PSMA-related diseases, including prostate cancer, are disclosed. The combination of small molecule radiohalogenated PSMA inhibitors with a competitive PSMA ligand for reducing off-target accumulation of the radiohalogenated PSMA inhibitor also is disclosed.

Abstract: Described herein are methods and systems for identifying and/or treating subjects having cancer who are more likely to respond to treatment with an inhibitor of the transcription factor HIF-2?.

Abstract: Disclosed is an underwater robot for a mine flooding rescue, including a starting unit configured to control the implementation of a whole rescue action; a drive unit connected with the starting unit and configured to provide a robot with power to move; and an execution unit connected with the drive unit and configured to salvage underwater life sources.

Abstract: A time-synchronized micro-scale continuous point-on-wave (CPoW) measurement device, referred to as micro-CPoW, is provided. The distribution system is an integral part of the electric power system, but not much is known about how it behaves in real-time. To address this knowledge gap, a low-cost, time-synchronized, CPoW measurement system is designed, built, and characterized herein. The purpose of the micro-CPoW measurement device is to monitor the instantaneous electric current flowing through a distribution line in real time. Detection of harmonics, identification of incipient fault conditions, and general power quality monitoring are typical uses for the measured information. Because the micro-CPoW measurement device is self-powered by the line current and communicates wirelessly, it can be installed without ground-mounted instrument transformers, low-voltage power sources, or communications cabling.

Abstract: The invention relates to liposomes, methods of producing liposomes, and methods of loading cell-derived liposomes with cargo molecules. The invention extends to such liposomes per se, and to the use of these liposomes as cellular delivery systems for the delivery of biologically and therapeutically active payload molecules, such as small molecules, RNAi molecules (e.g. siRNA), bioactive proteins, genome editing tools (e.g. Cas9) and drugs into cells for treating a range of disorders. The liposomes may also be used in a range of diagnostic and theranostic applications. The invention extends to pharmaceutical compositions comprising such liposomes, including populations of extracellular vesicles (EV), exosomes and to fusion proteins.

Abstract: A compound and the method for treating bacterial infections thereof are provided, wherein the compound is derived from AS101 and having a general formula (I) or a general formula (II), and wherein the method includes administering an effective amount of compound having the general formula (I) or a compound having the general formula (I) and its pharmaceutically acceptable salt thereof.

Abstract: The new blueberry plant variety ‘IBUGA002’ is provided. ‘IBUGA002’ is a commercial variety that does not require chilling hours. The variety is produced from open pollination of the ‘TH-909’ variety (not patented). ‘IBUGA002’ displays a semi-erect to prostrate plant with strong vigor, provides early berry ripening, displays clustered inflorescence, and exhibits large fruit that are firm.

Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.

Abstract: Disclosed are a molecular imaging method using Raman spectra and system based on machine learning cascade. The system includes a coordinate localization module, a hierarchical clustering analysis module, a Raman predictive imaging module, and a similarity analysis module. An untreated frozen tissue slice is attached to a stainless steel slide, and an adjacent slice is attached to a glass slide. The coordinate localization module can match a Raman white light image of a detection sample attached to the stainless steel slide with an immunohistochemistry (IHC) image of the adjacent slice, such that Raman spectra of a target region are accurately collected. The hierarchical clustering analysis module purifies different types of Raman spectra. A machine learning classifier is configured to build a Raman predictive imaging model. The similarity analysis module can evaluate similarity between a predicted Raman predictive image and the IHC image of the adjacent slice.