Abstract: Provided is an active user detection and channel estimation method of a base station in a wireless communication system based on grant-free uplink transmission. The method, according to one embodiment, comprises the steps of: receiving superimposed signals () from k active terminals; by using a first artificial neural network and using the received signals () as input, calculating, for all terminals in a cell of a base station, an estimated probability ({circumflex over (?)}) of each of the terminals being an active terminal; and estimating channels of the active terminals by using a second artificial neural network and using the received signals () and an active user detection result value as input.

Abstract: The present disclosure relates to compounds of formula (I) and their anti-tumor uses, and their intermediates of formula (III), intermediates of formula (IV), and uses of the intermediates. The compound of formula (I) has a degrading effect on a specific target protein, which is mainly composed of three parts. The first part is a small molecule compound (SMBP, Small Molecules Binding Protein) that can bind to a protein, the second part LIN is a linker, and the three-part ULM is a ubiquitin ligand (ULM, Ubiquitin Ligase Binding Moiety), wherein SMBP is covalently bound to LIN, and LIN is covalently bound to ULM. A series of compounds designed and synthesized in the present disclosure have a wide range of pharmacological activities, including the functions of degrading specific proteins and/or inhibiting activities of specific proteins, and thus can be used in related tumor treatments.

Abstract: The present disclosure relates to the technical field of biomedicine, and provides an anti-physaliatoxin single-domain antibody, and a preparation method and use thereof. The single-domain antibody is a VHH antibody with an amino acid sequence shown in SEQ ID NO. 1. Affinity analysis shows that the single-domain antibody of the present disclosure has prominent affinity. It is proved by small animal experiments that, after mice in an antibody protection group pre-injected with the single-domain antibody of the present disclosure are injected with physaliatoxin, no mice shows toxic symptoms, and during continuous observation for one month, no toxic lethality occurs, indicating that the single-domain antibody of the present disclosure shows excellent anti-physaliatoxin effects, excellent preventive or therapeutic effects on jellyfish stings, and promising clinical application prospects.

Abstract: The present application discloses an anthropogenic heat flux estimation method and system based on flux observation data. The method includes: performing grid division on the selected region, and acquiring building vector data, land utilization data and instrument observation data in the selected region; calculating and correcting sensible heat fluxes and latent heat fluxes of different underlying surface types in a vorticity correlator flux source region; calculating temporal-spatial distribution of the sensible heat flux and the latent heat flux of each grid in a large-aperture scintillometer flux source region, and calculating temporal-spatial distribution of an anthropogenic heat flux of each grid in the flux source region in combination with a surface energy balance equation; and constructing an anthropogenic heat flux estimation model based on a convolutional neural network, and accurately estimating temporal-spatial distribution of the anthropogenic heat flux of each grid in the selected region.

Abstract: The present invention pertains to the field of oilfield stimulation technologies for oil and gas field development, in particular to an instant soluble temperature and salt resistant polyacrylamide and the preparation method and application thereof, and the polyacrylamide is modified by adding rigid temperature and salt resistant monomer containing benzene ring and cationic fluorinated hydrophobic monomer on the basis of acrylamide monomer and sodium acrylate monomer, and then polymerized to obtain instant soluble temperature and salt resistant polyacrylamide. The temperature and salt resistant monomer containing benzene ring can improve the thermal stability and temperature and salt resistance of polyacrylamide, while the long-chain cationic fluorinated hydrophobic monomer can enhance the hydrophobicity of polymer. The comprehensive properties of polymer is improved by appropriate intermolecular association.

Abstract: In some aspects and embodiments, the present application provides a wide range of porous 1-D polymeric graphitic carbon-nitride materials that are atomically doped with binary metals in different morphologies. In some embodiments, the graphitic carbon-nitride materials can be prepared with high mass production from inexpensive and natural abundant precursors. In some embodiments, the materials were used successfully for the oxidation of CO to CO2 under ambient reaction temperature in addition to the reduction of CO2 into hydrocarbons. In some embodiments, the materials can be used for practical and large-scale gas conversion for household or industrial applications.

Abstract: A polypyrrole-graphene/polyurethane antifouling coating as well as a preparation method and an application thereof are provided. The polypyrrole-graphene/polyurethane antifouling coating includes component A and component B, wherein the component A mainly includes the following raw materials in parts by weight: 500 parts of group-hydrolyzable polyurethane prepolymer, 25-50 parts of bentonite, 25-50 parts of titanium dioxide, 60-120 parts of zinc oxide, 15-30 parts of talcum powder, and 15-30 parts of polypyrrole-graphene nanofiller; and the component B mainly includes the following raw materials in parts by weight: 5-7 parts of leveling agent, 5-7 parts of defoamer, 6-15 parts of chain extender, 10-25 parts of silane coupling agent, and 1-2 parts of catalyst. The two-component polyurethane coating of the present invention has relatively good adhesion, collision resistance and cracking resistance, and the antifouling property and the antifouling durability can be improved.

Abstract: An apparatus includes a battery pack with N battery bricks, each with a DC output voltage. The output of each brick is connected in series providing a bus voltage. Each brick includes battery power modules (“BPMs”) connected in parallel and each connected to a battery cell. Each BPM charges/discharges the connected battery cell. Each brick has a battery brick controller that provides a control signal to each brick's BPMs. A control signal of a BPM is derived from a BPM error signal that includes a battery cell current of the battery cell of BPM subtracted from a summation of an average current signal, a local droop current and a balancing current. The balancing current is based on a current SOC of the battery cell connected to the BPM and a desired SOC for the battery cell connected to the BPM. A BMS derives the balancing current for the BPMs.

Abstract: A CD20-OR-CD19 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD20-OR-CD19 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD20-OR-CD19 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

Abstract: Among the various aspects of the present disclosure is the provision of methods of treating a microglial dysfunction-associated diseases, disorder, and conditions. The present disclosure provides for a method for treating microglial dysfunction in a subject having a microglial dysfunction-associated neurodegenerative disease comprising administering to a subject a therapeutically effective amount of a microglial rescuing agent. The present disclosure also provides for a method of reversing neuronal damage in a subject having a microglial dysfunction-associated neurodegenerative disease, wherein the microglial dysfunction-associated neurodegenerative disease is characterized by a single nucleotide polymorphisms (SNPs) or mutation in Trem2 or ApoE affecting microglial functions.

Abstract: Filtration membrane with improved mechanical stability and increased resistance to pressure is provided. The filtration membrane is useful for in vivo implantable filtration devices, such as, an artificial kidney. In vivo implantable filtration devices are also provided.

Abstract: A catheter-based imaging apparatus comprises a catheter having a proximal end and a distal end. An optical emitter is configured to emit optical excitation signals from a distal portion of the catheter. One or more ultrasound transducers are configured for: (a) transmission of acoustic excitation signals from the distal portion of the catheter; and (b) detection of ultrasound response signals from an object of interest at or near to the distal portion of the catheter at frequencies which include a lower receive frequency at least as low as 10 MHz and a higher receive frequency at least as high as 35 MHz. The one or more ultrasound transducers are thereby configured to detect response signals comprising photoacoustic response signals from the object of interest at the lower receive frequency and high resolution imaging signals from the object of interest at the higher receive frequency.

Abstract: A method and a system for filtering ill corpus are provided. The method includes following steps: acquiring a text corpus to be recognized, and preprocessing the text corpus to be recognized to obtain a basic text corpus; extracting entities in the basic text corpus, and performing matching search on the entities of the basic text corpus according to an ill-text knowledge graph to obtain a first recognition result; detecting and recognizing the basic text corpus according to a corpus recognition model to obtain a second recognition result; and filtering the text corpus to be recognized according to the first or/and the second recognition result, and updating the ill-text knowledge graph according to the second recognition result. With semantic network essence and strong correlation ability of knowledge graph technology, candidate ill entities can be obtained, thus facilitating filtering of obscure ill information in forms of pinyin, homophonic words and split words.

Abstract: The present disclosure provides a two-stage cavitation generator for organic wastewater treatment, including a shrouded impeller, a stator, and a rotor. The shrouded impeller includes a front cover plate, blades, and a rear cover plate. Several blades are evenly distributed between the front cover plate and the rear cover plate. A working surface of the blade is an arc surface, and a back of the blade protrudes locally, so that a flow channel between the back of the blade and a working surface of its adjacent blade is narrowed locally, forming a throat structure. An outlet of the shrouded impeller is provided with the stator and the rotor, and the stator is located at an outer edge of the front cover plate and fixed on an inner wall of a volute. The rotor is mounted on the rear cover plate.

Abstract: Described herein is a reconfigurable asymmetrical load-modulated balanced amplifier. The reconfigurable asymmetrical load-modulated balanced amplifier can include a radio frequency (RF) input port, an RF output port, a peaking amplifier circuit operably coupled between the RF input and RF output ports, where the peaking amplifier circuit is a balanced amplifier that comprises a pair of asymmetrical power amplifiers, and a carrier amplifier circuit operably coupled to the RF input port.

Abstract: Described herein is a general scalable synthesis method for a high density of single metal atoms in a supported catalyst, supported isolated atoms featuring unique reactivity and the support materials determine the stability, electronic properties, and local environment which can be adjusted for targeted heterogeneous catalysis applications.

Abstract: A stool includes a base with a post extending therefrom. A seat is connected to a distal end of the post. In some configurations, the seat may be configured to act as a deployable back rest. A deployable anti-fatigue mat is connected to the base. In some configurations, the deployable anti-fatigue mat is attached to the base via a hinged connection. In some configurations, the deployable anti-fatigue mat is attached to the base with a sliding connection that allows the deployable anti-fatigue mat to slide out from the base.

Abstract: The present disclosure is concerned with benzimidazole compounds and methods of using these compounds for the treatment of hepatitis (e.g., hepatitis C), RNA virus infections (e.g., Zika virus, dengue virus, Powassan virus, Chikungunya virus, Enterovirus, respiratory syntactical virus (RSV), Rift Valley fever, Influenza virus, Tacaribe virus, Mayaro virus, West Nile virus, yellow fever virus, and coronavirus), and disorders of uncontrolled cellular proliferation (e.g., cancer). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such as maternal plasma, containing a background of maternal nucleic acid sequences. The percentage of fetal DNA can be calculated from the same or different data used to determine the cutoff value, and can use a locus where the mother is homozygous and the fetus is heterozygous. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing (SPRT).

Abstract: A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 ?m or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.