Abstract: Bioactive peptides and methods for their use for preventing, treating, and/or reducing the incidence and/or symptoms of an autoimmune disease or disorder that may result from chronic inflammation, damage to ?-cells of the pancreas, and other conditions that are implicated by the CD40-CD154 dyad. In particular, small peptides that are capable of interacting with CD40, thereby interfering with the ability of CD40 to interact with CD154, which impacts inflammation, autoimmunity, and disease progression. The use of such peptides in reducing diabetes mellitus, and in particular, the autoimmune inflammatory response that may be a driving factor thereof. Methods and materials for preventing and modulating diabetes mellitus and autoimmune diseases especially in dogs, cats, and horses.

Abstract: Provided are compositions and methods that include a CasY transactivating noncoding RNA (trancRNA) (referred to herein as a “CasY trancRNA”), nucleic acids encoding the CasY trancRNA, and/or a modified host cell comprising the CasY trancRNA (and/or a nucleic acid encoding the same). Subject compositions and methods can also include one or more of: (a) a “CasY” protein (also referred to as a CasY polypeptide, a Cas12d protein, and a Cas12d polypeptide), a nucleic acid encoding the CasY protein, and/or a modified host cell comprising the CasY protein (and/or a nucleic acid encoding the same); and (b) a CasY guide RNA (also referred to herein as a “Cas12d guide RNA”) that binds to and provides sequence specificity to the CasY protein, a nucleic acid encoding the CasY guide RNA, and/or a modified host cell comprising the CasY guide RNA (and/or a nucleic acid encoding the same).

Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The parent's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.

Abstract: Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.

Abstract: A method for identifying, locating, and mapping targets of interest using unmanned aerial vehicle (UAV) camera footage in GPS-denied environments. In one embodiment, the method comprises obtaining UAV visual data, passing the UAV visual data through a convolutional neural network (CNN) in order to detect targets of interest based on visual features disposed in the UAV visual data, wherein the detection by the CNN defines reference points and pixel coordinates for the UAV visual data, applying a geometric transformation to known and defined pixel coordinates to obtain real-world orthogonal positions; and projecting the detected targets of interest onto an orthogonal map based on the obtained real-world orthogonal positions, all without GPS data.

Abstract: Compositions and methods for preventing, treating, or delaying the onset of rheumatoid arthritis involving 14-3-3?, are described. Provided is a method for preventing, treating, or delaying the onset of rheumatoid arthritis, the method comprising administering an effective amount of 14-3-3?, or a variant thereof, to a subject at risk for developing rheumatoid arthritis, and preventing, treating, or delaying the onset of rheumatoid arthritis in the subject.

Abstract: Systems, methods and devices for a computer vision-based pixel-level rail components detection system using an improved one-stage instance segmentation model and prior knowledge, aiming to inspect railway components in a rapid, accurate, and convenient fashion.

Abstract: Disclosed are a colorimetric sensor kit for screening a therapeutic agent for a neurodegenerative disease, capable of easily detecting the degradation of amyloids by a drug, and a method for screening a therapeutic agent for a neurodegenerative disease.

Abstract: The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one or more pyrazolyl-containing compounds, or a derivative thereof.

Abstract: Provided are methods for enhancing immunosuppression in the lung of a subject, In some embodiments, the methods include administering to the subject a composition comprising at least one eosinophil recruiting agent, wherein the administering is in an amount and via a route of administration sufficient to induce recruitment of eosinophils to the lung of the subject to thereby enhance immunosuppression in the lung of the subject. Also provided are methods for enhancing tolerance to lung transplants, enhancing recruitment of eosinophils to the lungs, modulating T cell-mediated immune responses in the lungs, and reducing TCR signal transduction in the lungs.

Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.

Abstract: An algebraic proof-of-work algorithm is provided that can be used as part of the consensus algorithm used by cryptocurrencies such as Bitcoin. Instead of solving blocks using a hash puzzle, the present algorithm uses an algebraic puzzle such as a lattice-based puzzle based on the shortest vector problem and/or the knapsack problem. A cryptocurrency using the proposed proof-of-work algorithm has only a small quantum advantage when compared with existing proof-of-work algorithms.

Abstract: A vapor source system based on vapor-liquid ejector supercharging combined with flash vaporization technology belongs to the technical fields of waste heat utilization and steam generation. The system comprises a vapor-liquid ejector, a flash vaporization tank and a intermediate heat exchanger, wherein the vapor-liquid ejector uses high-pressure steam to raise temperature and pressure of low-pressure water absorbed from the flash vaporization tank; the pressure-increased water is flashed into low-pressure saturated steam after entering the flash vaporization tank; the saturated water which is not flashed is collected at the bottom of the flash vaporization tank.

Abstract: The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4 A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers.

Abstract: Devices, systems, and techniques are provided for improved OVJP deposition using a shutter disposed within the OVJP print head, between the print head inlet and the nozzle outlets. An OVJP print head as disclosed includes an inlet for organic material entrained in a carrier gas, a micronozzle array outlet, and a shutter disposed in the gas flow path between the inlet and the micronozzle array outlet. The shutter allows for rapid cutoff of carrier gas flow through the print head with extremely low latency.

Abstract: Provided herein are systems for controlling a network of distributed non-terrestrial nodes including a control framework operative to train and control a plurality of the non-terrestrial nodes, the control framework including a control interface in communication with a network operator to receive one or more specified control objectives, and a learning engine operative to train a virtual non-terrestrial network, wherein the control framework is further operative to transfer knowledge gained through the training of the virtual non-terrestrial network to the network of distributed non-terrestrial nodes as data-driven logic unit configurations tailored for the specified control objectives.

Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for preventing or slowing the spread of a viral infection, wherein optionally the viral infection is a coronavirus infection, optionally a COVID-19 infection or variant thereof, or a human immunodeficiency virus (HIV) infection, preventing or decreasing coronavirus or HIV-co-morbidities in an individual, or inhibiting, or slowing the rate of, coronavirus (optionally COVID-19) or HIV replication in vitro and in vivo.

Abstract: A method for preparing a monodomain liquid crystal elastomer smart fiber incudes: during cross-linking process of the liquid crystal elastomer, drawing of liquid crystal elastomer fibers with uniform diameter from a polymer solution when the viscosity of the cross-linked polymer solution increases to a point where filaments can be drawn; heating by an infrared lamp to form filamentous liquid crystal elastomer fiber; natural air drying to remove excess solvent in the fiber; and stretching and collection of the fiber, followed by placement of the fiber, whereby the monodomain liquid crystal elastomer smart fiber is obtained.

Abstract: The present disclosure provides a conductive paste for preparing flexible porous piezoresistive sensor, a method for making the same, and application thereof. The conductive paste includes a conductive carbon material, a sacrificial template and a high molecular polymer matrix. The high molecular polymer matrix includes a high molecular polymer and an organic solvent, and the mass ratio of the high molecular polymer to the organic solvent is 1:2 to 1:3; and based on the total mass of the conductive carbon material, the sacrificial template and the high molecular polymer, the mass percentage of the conductive carbon material is 2%-5%, the mass percentage of the sacrificial template is 75%-85%, and the mass percentage of the high molecular polymer is 10%-23%. This disclosure uses a sacrificial template with adjustable particle size to prepare conductive paste, greatly increasing number of nanopores or micropores after conductive paste is formed into a film.