Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: Aspects of the disclosure provide a method for denoising an image. The method can include receiving an acquired image from an image acquisition system, and processing the acquired image with a nonlinear diffusion coefficient based filter having a diffusion coefficient that is calculated using gradient vector orientation information in the acquired image.

Abstract: A healthcare provider user interface for treatment option and authorization is disclosed herein. In embodiments, a healthcare provider interface includes a display coupled to one or more processors. The display includes a graphical user interface comprising one or more input interface display pages and one or more output interface display pages. The one or more input interface display pages may include one or more fields configured to receive information including patient demographic and physiological information, insurance information, past treatments, and one or more medical diagnoses. The one or more output interface display pages may include a treatment list generated based on the received information and a prior authorization output.

Abstract: A class of design topologies in the field of nonlinear networks (NLN) or nonlinear transmission lines (NLTL) that re-utilize direct current (DC) and low-frequency (LF) signal content reflected from a load or an output filter to yield increased pulse to radio frequency conversion efficiency and increased overall system efficiency. A nonlinear transmission line topology comprises a plurality of series inductive elements and a plurality of nonlinear capacitive elements. The inductive elements and the capacitive elements are arranged in a periodic structure forming a nonlinear network. An output coupling circuit connected across an output of the nonlinear network is configured to transmit high-frequency content to a load and to reflect back direct current and low-frequency content into the nonlinear network.

Abstract: A method for visualizing and analyzing contributions of various input features for traffic safety status prediction is provided. The method includes initializing a deep belief network (DBN) with input features; performing unsupervised learning/training by observing changes of weights of the input features during the unsupervised learning/training; when the unsupervised learning/training process is complete, performing supervised learning/training process by generating a reconstructed input layer based on results of each hidden layer; and continually running the supervised learning/training and generating a weight diagram based on both visualization and numerical analysis that calculates contributions of the input features. The input features may include one or more of annual average daily commercial traffic (AADCT), median width, left shoulder width, right shoulder width, curve deflection, and exposure for traffic safety status prediction.

Abstract: Techniques are described for efficiently reducing the amount of total computation in convolutional neural networks (CNNs) without affecting the output result or classification accuracy. Computation redundancy in CNNs is reduced by exploiting the computing nature of the convolution and subsequent pooling (e.g., sub-sampling) operations. In some implementations, the input features may be divided into a group of precision values and the operation(s) may be cascaded. A maximum may be identified (e.g., by 90% probability) using a small number of bits in the input features, and the full-precision convolution may then be performed on the maximum input. Accordingly, the total number of bits used to perform the convolution is reduced without affecting the output features or the final classification accuracy.

Abstract: The present invention includes compositions and methods of modulating the length of one or more cotton fibers in a plant by contacting the plant or tissue derived therefrom with at least one of: a nucleotide; a modulator of ectoapyrase gene transcription; or an anti-ectoapyrase antibody or fragments thereof, at a concentration that modulates growth of one or more cotton fibers.

Abstract: Micro-Organosphers, including Patient-Derived Micro-Organospheres (PMOS s), apparatuses and methods of making them, and apparatuses and methods of using them. Also described herein are methods and systems for screening a patient using these Patient-Derived Micro-Organospheres, including personalized therapies.

Abstract: A nested anti-resonant nodeless hollow core fiber (NANF) enables transmission of multi-kilowatt, continuous wave (CW) light beams operating in wavelengths between 1050 nm and 1100 nm provided by single mode lasers. Such a NANF has little loss over kilometer ranges, and can be employed in long distance subsurface applications, such as in the petroleum industry.

Abstract: A recombinant vector having an expression cassette is provided which comprises a modified human low density lipoprotein receptor (hLDLR) gene is provided, wherein said hLDLR gene encodes a modified hLDLR comprising (a) one or more of the following amino acid substitutions: L318H, N295D, H306D, V307D, N309A, D310N, L318H, and/or L318D; or (b) an amino acid substitution of any of (a) in combination with one or more of the following amino acid substitutions: K796, K809R and/or C818A. Also provided are pharmaceutical compositions containing this vector and uses therefor in lowering cholesterol and/or treating familial hypercholesterolemia.

Abstract: Electrolytes and electrochemical cells include a novel ionic liquid having a quaternary cation and a boron cluster anion. In some versions, the boron cluster anion will be a functionalized or unfunctionalized icosahedral boranyl or carboranyl anion. Electrochemical cells have an electrolyte including the ionic liquid. In some versions, the ionic liquid is used as a solvent to dissolve an ionic shuttle salt for transport of active material, with an optional co-solvent. Methods to synthesize the ionic liquid include contacting a boron cluster salt with a quaternary salt to form the ionic liquid by a metathesis reaction.

Abstract: A compound of Formula I, and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Abstract: In vivo and ex vivo positionable filtration devices are provided that are functionalized to bind one or more therapeutic agents in blood flowing in a blood vessel.

Abstract: A soft conductive composition can include: a crosslinked silicone composition; and single-walled or multi-walled carbon nanotubes in the silicone composition. A neural probe or other implant can include the soft conducive composition on a least a portion of the implant body. A method of making an implant can include: selecting PDMS precursors; cross-linking the PDMS precursor to obtain an elastic modulus of about 3-9 kPa or +/?1%, 5%, 10%, 20%, or 50%; selecting the carbon nanotubes; introducing the carbon nanotubes into the crosslinked PDMS to form a soft conductive composite composition; and coating the soft conductive composite composition onto at least a portion of an implant. A method of measuring properties at a neural interface can include: providing a neural probe having a soft conductive composition; implanting the neural probe having the soft conductive composition at a neural interface; and measuring a property with the neural probe.

Abstract: A novel composition is disclosed comprising the complex avobenzone-calix[8]-PO3H2. In another embodiment, the present invention is a sunscreen composition comprising the complex avobenzone-calix[8]-PO3H2 and a cosmetically acceptable carrier.

Abstract: Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1 vaccines comprising a carrier, a population episensus antigen, and a tailored antigen. Also provided are methods of designing and producing an HIV-1 vaccine for a subject comprising designing vaccine antigens to optimally cover the diversity within a geographic area using an antigen amino acid sequence generated using the EpiGraph approach, and producing said designed vaccine antigen. Also provided are methods of inducing an effector memory T cell response comprising designing the one or more EpiGraph amino acid sequences, producing a vaccine comprising the one or more EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. Further provided are methods of treating HIV-1 in a subject comprising administering an effective amount of the described HIV-1 vaccines to the subject in need thereof.

Abstract: A pumpless microfluidic system is disclosed that can be used to mimic the interaction of organ systems with the immune system. Also disclosed is a method for mimicking an immune system, comprising culturing a plurality of organ cells and at least one population of immune cells in the disclosed pumpless microfluidic system under physiological conditions. The method can further comprise activating an immune reaction in the pumpless microfluidic system, continuing the culture for a defined period, collecting a sample of culture medium from the system, and assaying the sample for one or more indicators of an immune response.

Abstract: Methods for calculating a MetaKG signal are provided. The method including illuminating a region of interest in a sample with a near-infrared (NIR) light source and/or a visible light source. The region of interest includes a sample portion and background portion, each having a different set of optical characteristics. Images of the region of interest are acquired and processed to obtain metadata associated with the acquired images. MetaKG signals are calculated for the region of interest and for the background. The MetaKG signal for the background is used to adjust the MetaKG signal for the region of interest to provide a final adjusted MetaKG signal for the region of interest.

Abstract: A system for generating X-ray beams from a liquid target includes a vacuum chamber, a diamond window assembly, an electron source, a target material flow system, and an X-ray detector/imager. An electron beam from the electron source travels through the diamond window assembly and into a dynamic target material of the flow system. Preferably, the dynamic target material is lead bismuth eutectic in a liquid state. Upon colliding with the dynamic target material, X-rays are generated. The generated X-rays exit through an X-ray exit window to be captured by the X-ray detector/imager. Since the dynamic target material is constantly in fluid motion within a pipeline of the flow system, the electron beam always has a new target area which is at a controlled operational temperature and thus, prevents overheating issues. By providing a small focus area for the electron beams, the overall imaging resolution of the X-rays is also improved.

Abstract: This application relates to a synchronization circuit for synchronizing signals used in a threshold implementation operation process performing in an S-box of an encryption circuit. In one aspect, the synchronization circuit includes an enable signal generator configured to generate an enable signal. The synchronization circuit may also include a synchronization unit included in an encryption circuit and located inside an S-box that performs a threshold implementation operation that calculates by dividing bits of an input signal into bits equal to or greater than the number of bits of the input signal. The synchronization unit may be configured to synchronize signals used in a threshold implementation operation process based on the generated enable signal.