Abstract: This document provides methods and materials for preventing cytokine release syndrome (CRS). For example, methods and materials for using one or more catecholamine inhibitors to prevent a mammal from developing CRS are provided.
Type:
Grant
Filed:
December 11, 2018
Date of Patent:
April 18, 2023
Assignee:
The Johns Hopkins University
Inventors:
Bert Vogelstein, Kenneth W. Kinzler, Nickolas Papadopoulos, Shibin Zhou, Verena Staedtke, Renyuan Bai, Gregory J. Riggins
Abstract: A method for diagnosing and predicting operation conditions of large-scale equipment based on feature fusion and conversion, including: collecting a vibration signal of each operating condition of the equipment, and establishing an original vibration acceleration data set of the vibration signal; performing noise reduction on the original vibration acceleration data set, and calculating a time domain parameter; performing EMD on a de-noised vibration acceleration and calculating a frequency domain parameter; constructing a training sample data set through the time domain parameter and the frequency domain parameter; establishing a GBDT model, and inputting the training sample data set into the GBDT model; extracting a leaf node number set from a trained GBDT model; performing one-hot encoding on the leaf node number set to obtain a sparse matrix; and inputting the sparse matrix into a factorization machine to obtain a prediction result.
Type:
Grant
Filed:
July 15, 2022
Date of Patent:
April 18, 2023
Assignee:
Sichuan University
Inventors:
Jianbo Wu, Ziheng Huang, Zhaoyuan Xu, Qiao Qiu, Jun Zheng, Jinhang Li, Zhiyuan Shi
Abstract: A method and reactor are disclosed for separating and removing heavy metals from wastewater using a sulfhydryl-modified nano-magnetized activated carbon. The method includes the steps of preparing a sulfhydryl-modified nano-magnetized activated carbon first; introducing heavy-metal-containing wastewater into a reactor which is equipped with a stirrer and keeping stirring, and then adding the sulfhydryl-modified nano-magnetized activated carbon, continuously stirring for a reaction; after reacting for a period, precipitating under a magnetic field generated by a magnet separator, discharging the resulting supernate, and then discharging the precipitated sludge.
Abstract: A method, a system, and a computer program for executing high resolution spectrum monitoring. A sensor receives an input signal having a varying frequency content over time. One or more samples of the received input signal are sampled. The samples of the received input signal include one or more swept signal samples generated by sweeping, using a center frequency of the sensor, the received input signal across an entire frequency spectrum associated with the received input signal. Sampling of the samples of the received signal is performed while performing the sweeping. The signal samples are processed.
Type:
Grant
Filed:
April 15, 2020
Date of Patent:
April 18, 2023
Assignee:
The Regents of the University of California
Abstract: A computer-based system and method for generating a current pain assessment of a neonate using facial expressions along with crying sounds, body movement, and vital signs changes and for using the current pain objective assessment to predict future pain objective assessment and assign a future pain probability score by incorporation spatiotemporal data into the multimodal assessment.
Type:
Grant
Filed:
November 9, 2020
Date of Patent:
April 18, 2023
Assignee:
University of South Florida
Inventors:
Peter Randolph Mouton, Sammie Lee Elkins, Md Sirajus Salekin, Dmitry Goldgof, Yu Sun, Thao Ho, Ghadh Alzamzmi
Abstract: A system and method utilizing a novel waveform structure based on unique word (UW)—orthogonal frequency division multiplexing (OFDM) is proposed for the applications of joint radar-sensing and communication (JRC). A predetermined chirp sequence is used as the UW in the waveform. The predetermined chirp sequence is used to perform radar functionality, which also increases power efficiency of linear power amplifier that is critical for radar applications.
Abstract: Embodiments of the present disclosure provide for compositions including polymer particles, methods of making compositions, methods of using the composition, stimuli-responsive methods of delivering agents, and the like.
Type:
Grant
Filed:
December 29, 2016
Date of Patent:
April 18, 2023
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Brent S. Sumerlin, Shaun Paul Jensen, Megan R. Hill, Mingsheng Chen, Gloria A Moore, Zhenli L He, Sangwoo Park
Abstract: The present invention is directed to compounds, compositions and methods for preventing, treating or curing Hepatitis B (HBV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment, prevention or eradication of HBV infection.
Type:
Grant
Filed:
August 20, 2020
Date of Patent:
April 18, 2023
Assignee:
Emory University
Inventors:
Raymond F. Schinazi, Sebastien Boucle, Franck Amblard, Ozkan Sari, Leda Bassit
Abstract: Compositions and methods are provided for loading cargoes onto red blood cells. Provided herein are novel antibodies, fragments, fusion proteins and other conjugates which specifically bind red blood cells via RHCE or Band 3.
Type:
Grant
Filed:
December 5, 2018
Date of Patent:
April 18, 2023
Assignee:
The Trustees of the University of
Pennsylvania
Inventors:
Carlos H. Villa, Vladimir R. Muzykantov, Donald L. Siegel, Colin Greineder
Abstract: A method of treating neurodegenerative diseases using hUCB plasma is presented herein. hUCB plasma attenuated the hyperactive response (Group III) and potentiated the normal response in Group I ALS patients, but did not alter that of the non-responders to PHA (Group II). The elevated activity of caspase 3/7 observed in the MNCs from ALS patients was significantly reduced by hUCB plasma treatment. The ability of hUCB plasma to modulate the mitogen cell response and reduce caspase activity suggest that the use of hUCB plasma alone, or with stem cells, may prove useful as a therapeutic in ALS patients. hUCB plasma was shown to increase therapeutic efficacy of MNCs as well as decrease apoptosis of MNCs. The cytokine profile of hUCB plasma supports its usefulness as a sole therapeutic as well as an additive to MNCs.
Type:
Grant
Filed:
October 17, 2019
Date of Patent:
April 18, 2023
Assignees:
University of South Florida, Saneron CCEL Therapeutics, Inc.
Inventors:
Svitlana Garbuzova-Davis, Jared Carl Ehrhart, Paul R. Sanberg
Abstract: Methods and systems for provable, auditable and secure software updates for resource-constrained IoT devices are provided via a security framework and a protocol for owner-controlled software updates for IoT devices through blockchain.
Type:
Grant
Filed:
September 20, 2022
Date of Patent:
April 18, 2023
Assignee:
Santa Clara University
Inventors:
Gabriel Jerome Solomon, Peng Zhang, Yuhong Liu, Rachael Brooks
Abstract: A vacuum cathode arc-induced pulsed thruster includes a housing where a triggering room and an electric discharging room are defined and are in communication with each other, a first anode unit and a first cathode unit concentrically disposed in the triggering room, a second anode unit disposed in the electric discharging room, an insulating fuel layer concentrically located between the first anode unit and the first cathode unit, a main insulating layer concentrically surrounded by the first cathode unit, and a second cathode unit inserted from the triggering room into the electric discharging room. Thus, the vacuum cathode arc-induced pulse thruster is lightweight and has low manufacturing costs, low system complexity, and less energy consumption. Carbon deposition caused during an electric discharging process is prevented from affecting an inducing effect to thereby prolong the service life of the thruster and increase the control precision and inducing precision effectively.
Type:
Grant
Filed:
July 13, 2021
Date of Patent:
April 18, 2023
Assignees:
National Cheng Kung University, Taiwan Space Agency
Abstract: In alternative embodiments, provided are compositions and methods for making a chimeric polypeptide comprising an S-layer polypeptide and a heterologous polypeptide or peptide. In alternative embodiments, the compositions and methods comprise recombinantly engineering a methylotrophic or methanotrophic bacteria to recombinantly express a chimeric polypeptide comprising an S-layer polypeptide and a heterologous polypeptide or peptide. Also provided are compositions and methods for displaying or immobilizing proteins on a methanotrophic S-layer. In alternative embodiments, provided are compositions and methods comprising recombinant methylotrophic or methanotrophic bacteria comprising assembled or self-assembled recombinant or isolated chimeric S-layer polypeptides. In alternative embodiments, provided are compositions and methods using recombinant methylotrophic or methanotrophic bacteria, optionally a Methylomicrobium alcaliphilum, optionally a M. alcaliphilum sp.
Type:
Grant
Filed:
August 29, 2018
Date of Patent:
April 18, 2023
Assignee:
San Diego State University (SDSU) Foundation
Abstract: A sensor includes at least one optical waveguide and an optical reflector optically coupled to the at least one optical waveguide. The optical reflector includes a first substrate portion configured to reflect a first portion of a light beam back to the at least one optical waveguide and a diaphragm configured to reflect a second portion of the light beam back to the at least one optical waveguide. The diaphragm is responsive to a perturbation by moving relative to the first substrate portion. The light beam is centered on a region between the first substrate portion and the diaphragm.
Type:
Grant
Filed:
November 29, 2021
Date of Patent:
April 18, 2023
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Michel J.F. Digonnet, Behrad Habib Afshar
Abstract: A system and method for controlling a controllable appliance resident in an environment which includes a device adapted to receive speech input. The system and method establishes a noise threshold for the environment in which the device is operating, receives at the device a speech input, determines a noise level for the environment at the time the speech input is received by the device, compares the determined noise level to the established noise threshold, and causes one or more commands to be automatically issued to the controllable device to thereby cause the controllable device to transition from a first volume level to a second volume level that is less than the first volume level when the determined noise level for the environment is greater than the established noise threshold for the environment.
Abstract: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples.
Type:
Grant
Filed:
April 22, 2021
Date of Patent:
April 18, 2023
Assignee:
Colorado State University Research Foundation
Abstract: Disclosed is a superconducting magnet with improved thermal and electrical stabilities and a method for manufacturing the same. The superconducting magnet includes a bobbin disposed at a center of the superconducting magnet, a superconducting winding wound around an outer face of the bobbin, and an epoxy impregnated at an exterior of the superconducting winding, wherein the epoxy contains carbon nanotubes.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
April 18, 2023
Assignee:
Korea University Research and Business Foundation
Abstract: An air purifying system may include a main air purifier placed in an indoor space, a handheld air purifier mounted on the main air purifier, and an air quality sensor IOT device that communicates with the main air purifier. The air quality sensor IOT device may be fixed in an outdoor space adjacent to the indoor space, or may be carried by a user to measure air quality data while the user travels. The main air purifier may automatically operate based on air quality data received from the air quality sensor IOT device.
Type:
Grant
Filed:
March 17, 2020
Date of Patent:
April 18, 2023
Assignees:
LG ELECTRONICS INC., Chungang University Industry Academic Cooperation Foundation
Inventors:
David Kangseong Lee, Haeyoong Chung, Jongkeon Jeon, Jiyoung Kang, Daeyoung Kwak, Sohee Park
Abstract: The present disclosure is directed to compositions and structures of supported metal catalysts for use in applications such as direct methanol fuel cells. Generally, implementations include supported metal catalysts that include Pt active sites that have been modified by addition or co-localization of a second metal such as Cu, Co, Ni, and/or other base metals to lower the inhibiting effect of strongly-adsorbed CO, an intermediate of methanol oxidation. An example aspect of the present disclosure includes catalyst compositions where the exterior metal sites in the supported catalyst include at least two metals: Pt and a competitive binder (e.g., a second metal).
Type:
Grant
Filed:
January 22, 2020
Date of Patent:
April 18, 2023
Assignee:
University of South Carolina
Inventors:
John R. Monnier, Gregory L. Tate, Wen Xiong, Benjamin H. Meekins
Abstract: A method of coating a structure is disclosed. Method steps include providing a structure having a first portion of a first material having a first surface and providing a second portion of a second material having a second surface, wherein a mask is provided over the first surface. Another step includes exposing the mask and the second surface to a solution comprising a polymer and a solvent, wherein the solution dewets from the mask and the polymer collects onto the second surface to form a polymer coating over the second surface without forming a polymer coating on the first surface.
Type:
Grant
Filed:
November 27, 2019
Date of Patent:
April 18, 2023
Assignee:
The Regents of the University of California