Abstract: A sensor apparatus for detecting a heavy metal in a sample.

Abstract: The present invention is directed to provide novel RNA molecules, chimeric NA molecules, double-stranded RNA molecules, and double-stranded chimeric NA molecules. Specifically, an embodiment of the present invention is an RNA molecule for RNA interference to target a mutant allele with a point mutation, in which (1) the molecule has a nucleotide sequence complementary to a nucleotide sequence of a coding region of the mutant allele; and (2) when counted from the base at the 5?-end in a nucleotide sequence complementary to a nucleotide sequence of the mutant allele, (2-1) a base at position 5 or 6 is mismatched to a base in the mutant allele; (2-2) a position 10 or 11 corresponds to the position of the point mutation; and (2-3) a group at the 2?-position of a pentose at positions 6-8 or positions 7 and 8 is modified with, e.g., OCH3. In this RNA molecule, one or more ribonucleotides may be replaced by, e.g., a deoxyribonucleotide. The molecule may form a double-stranded RNA with a complementary strand.

Abstract: Provided herein are novel materials and methods for site-specific incorporation of phosphotyrosines into proteins. The novel methods of the invention encompass the use of a novel aminoacyl tRNA synthetase capable of charging compatible tRNAs with a phosphotyrosine precursor. The phosphotyrosine precursor is then incorporated, site-specifically, into a protein at sites where phosphotyrosine residues are desired. The phosphotyrosine precursors are subsequently treated to convert them into phosphotyrosine residues, yielding proteins with phosphotyrosines at selected sites. The scope of the invention encompasses novel aminoacyl tRNA synthetases, novel phosphotyrosine precursors, and methods of using these materials to create site-specific phosphorylated tyrosine residues in a protein.

Abstract: Provided herein are compositions and methods for assembling multiple DNA molecules into a linear concatemer, with applications to nanopore sequencing of DNA sequence variations.

Abstract: Systems and methods of assessing significance of metabolites in diseases are provided. A multi-omics downstream analysis pipeline can represent lung microbiome ecology as a heterogeneous network of microbes and metabolites. Such an analysis can demonstrate the significance of a particular metabolite in the microbiome of a patient (e.g., a human patient).

Abstract: The present disclosure provides a cellular foam composition, a method for producing and using the same. One particular aspect of the disclosure provides a cellular foam composition comprising a plurality of foam layers, where each foam layer is made from a hollow microstructure material. In particular, the density of the hollow microstructure material in each foam layer is different from the density of the hollow microstructure material that forms the adjacent foam layer. In some embodiments, cellular foam compositions of the disclosure further include an interfacial layer comprising interfacial voids in between adjacent layers.

Abstract: Provided herein, in some embodiments, are nucleic acid constructs encoding RNA molecules comprising one or more introns that can be regulated (e.g., autoregulated), and that are useful for delivery in a recombinant viral vector. Aspects of the application provide compositions and methods for delivering regulated (e.g., auto-regulated) gem expression constructs to a subject.

Abstract: Disclosed herein, inter alfa, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

Abstract: A two-factor authentication system includes a mobile device having a vibration element configured to generate a vibration sequence based on a unique vibration code received by the mobile device. A two-factor authentication server is communicatively coupled to the mobile device and is configured to send the unique vibration code to the mobile device in response to the two-factor authentication server receiving a two-factor authentication request. A vibration receiver is configured to support the mobile device and communicatively coupled to the two-factor authentication server. The vibration receiver includes a vibration sensor configured to detect the vibration sequence generated by the mobile device based on the unique vibration code and generate a vibration authentication signal based on the detected vibration sequence.

Abstract: A metal compound including a first ligand LA having the Formula: Formula I, is disclosed. The metal compounds are useful in the emissive layer in organic light emitting devices.

Abstract: Disclosed herein is a method of treating a cancer in a subject having or suspected of having the cancer that has a mutated PREX2 expressed thereon. According to the embodiment of the present disclosure, the mutation is G258V, S1113R, E1346D or K400fs. The method includes the step of administering an effective amount of a composition to the subject, wherein the composition includes a therapeutic molecule for producing a polypeptide that exhibits a binding affinity to the mutated PREX2 protein expressed in the cancer in the subject.

Abstract: A material for endobronchial occlusion capable of repairing or replacing tissue is disclosed. The material contains a protein (A), wherein the protein (A) contains at least one of a polypeptide chain (Y) or a polypeptide chain (Y?), a total number of the polypeptide chain (Y) and the polypeptide chain (Y?) in the protein (A) is 1 to 100, the polypeptide chain (Y) is a polypeptide chain consisting of 2 to 200 tandem repeats of at least one amino acid sequence (X) among an amino acid sequence VPGVG, an amino acid sequence GVGVP 4, GPP, GAP, and an amino acid sequence GAHGPAGPK, the polypeptide chain (Y?) is a polypeptide chain in which each of a total of 5% or less of amino acids in the polypeptide chain (Y) is replaced by at least one of a lysine residue or an arginine residue, with a total number of the lysine and arginine residues being 1 to 100.

Abstract: Systems and methods for controlling performance of a digital character depicted at a display device are disclosed. According to at least one embodiment, a method for controlling performance of a digital character depicted at a display device includes: determining a presence of a person located in a physical environment; and in response to determining the presence of the person, facilitating control of the performance of the digital character depicted at the display device by a human operator, by an artificial intelligence (AI) game-engine, or by a combination thereof.

Abstract: Disclosed herein are ladder polymers comprising fused aromatic and non-aromatic rings. Also disclosed are the manufacture and use of these ladder polymers, e.g., in separation membranes, such as membrane for gas separation.

Abstract: Provided herein are methods and compositions for enhancing an immune response and/or for the treatment of an immune-related condition in an individual, e.g., cancer, comprising killing, disabling, or depleting non-stimulatory myeloid cells using an antigen binding protein such as an antibody or antigen binding fragment thereof.

Abstract: The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”).

Abstract: The present invention provides an actuator-equipped knee ankle foot orthosis in which a control device calculates a thigh phase angle based on an angle-related signal detected by a thigh orientation detecting means at one sampling point, applies the thigh phase angle at that sampling point to an assisting force control data, which is stored in the control device in advance and indicates the relationship between the thigh phase angle and a size of the assisting force to be imparted to a lower leg-side brace, to obtain the size of the assisting force to be imparted to the lower leg-side brace at that sampling point, and executes operational control for an actuator unit such that the assisting force having the size is output.

Abstract: The present invention discloses a method for enhancing the recovery factor of heavy oil by in-situ oil-water emulsion with high phase inversion point, and the method is aimed at the development of heavy oil reservoir by water injection under the condition that the performance parameters of crude oil emulsion meet the following three specific requirements: (A) The viscosity of the crude oil is less than 6,000 mPa·s; (B) At the reservoir temperature, the phase inversion point of the crude oil emulsion is greater than or equal to 70%, and the emulsion viscosity corresponding to the phase inversion point is 2-6 times of the crude oil viscosity; (C) At the reservoir temperature, when the water cut is less than or equal to the phase inversion point, the flow rate ratio of crude oil emulsion to crude oil is 0.2 to 0.9.

Abstract: Methods for increasing or decreasing Nitrogen (N) uptake/assimilation and/or usage in plants comprising over-expressing or repressing one or more transcription factors that have been identified by evaluating temoporal transcription of the TFs in response to N signaling and validated based on TF perturbation studies in plant cells and plants. Combinations of TFs may be used, where each TF may be independently induced or repressed to achieve a desired increase or decrease in N uptake/assimilation.

Abstract: A selective laser sintering system includes a leveling roller having a first orientation. The leveling roller is configured to roll over a first feed bin. The build chamber is configured to receive, from the first feed bin and by the leveling roller, a transfer of a portion of matrix material. The selective laser sintering system is configured to transfer the portion to the build chamber in a number of orientations.