Abstract: Aspects of the present disclosure include methods of making barcoded solid supports. In some embodiments, the methods include producing a concatemer by rolling circle amplification (RCA) of a circular nucleic acid template, where the circular nucleic acid template includes a barcode and a stem-loop forming region, and where the concatemer includes a plurality of linked units, each unit including the barcode and a stem-loop structure formed from the stem-loop forming region. Such methods further include disposing the concatemer on a solid support to produce a barcoded solid support including a plurality of the stem-loop structures extending from the surface of the solid support. The methods may further include treating the stem-loop structures with an agent that produces stem structures having ends compatible with target nucleic acids, and attaching the target nucleic acids to the stem structures. Barcoded solid supports and methods of using the barcoded solid supports are also provided.

Abstract: An information processing apparatus according to an aspect of the present invention includes an information processing circuit configured to generate a finite state machine based on a predetermined matching condition with respect to sequence data of an event that is input to the information processing apparatus; to process the sequence data so as to substantially remove data that does not match the matching condition from the sequence data; and to output the processed sequence data.

Abstract: Embodiments of the claimed invention are directed to a device, comprising: an anode that includes a lithiated silicon-based or lithiated carbon-based material or pure lithium metal or metal oxides and a sandwich-type sulfur-based cathode, wherein the anode and the cathode are designed to have porous structures. An additional embodiment of the invention is directed to a scalable method of manufacturing sandwich-type Li—S batteries at a significantly reduced cost compared to traditional methods. An additional embodiment is directed to the use of exfoliated CNT sponges for enlarging the percentage of sulfur in the cathode to have large energy density.

Abstract: The present invention relates to Candida strains comprising a mutation or deletion in the first and/or second XYL2 allele which can be used for producing one or more sugar alcohols from a lignocellulosic feedstock. The preferred sugar alcohol is xylitol.

Abstract: A manually-operated quantification soft tissue mobilization (QSTM) device includes a pressure applicator and a sensor member. The pressure applicator is configured to enable a user to dynamically apply a stroking mechanical force as the pressure applicator is moved over an area treatment areas of a patient's soft tissue. The sensor member including an accelerometer and a gyrometer is configured to determine various parameters of the dynamically applied stroking mechanical force in three dimensions as the pressure applicator is moved over the treatment areas of the patient's soft tissue. These parameters include a force magnitude in three dimensions, an angle in multiple axes, a stroke position, a stroke frequency, a sensed vibration magnitude at dominant spectral frequencies, and/or a rate of the stroking mechanical force dynamically applied to the soft tissue.

Abstract: There is provided herein a method for expanding human CD4-CD8- regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), preferably the DN Tregs are ??-TCR-CD56- or alternatively ?8-TCR+.

Abstract: The present invention relates to covalent adaptable networks (CANs) having exchangeable crosslinks that are able to undergo repeated covalent bond reshuffling through photo-activation at ambient temperatures. The invention provides covalent adaptable network forming compositions as well as methods of forming, remolding and recycling the CANs of the invention.

Abstract: A tactile display device including a nodule having variable stiffness under a surface to provide a near-real feeling of palpation for a physician. The device utilizes granular jamming technology using pneumatic actuation to control a nodule that maintains its shape while allowing the modulation in stiffness. The nodule includes two hemispheres, a contact portion and an actuation portion, forming a sphere. The contact portion and the actuation portion include different thicknesses and/or materials, while the dimensions of the dimensions of the nodule are maintained. As such, a physician can utilize the device to identify the difference between a normal lump and an affected lump even if the shape of each lump appears to be the same. With the tactile display device, due to the different levels of stiffness, a physician can detect the severity of the lump.

Abstract: This document describes a data processing system for processing a speech signal for voice-based profiling. The data processing system segments the speech signal into a plurality of segments, with each segment representing a portion of the speech signal. For each segment, the data processing system generates a feature vector comprising data indicative of one or more features of the portion of the speech signal represented by that segment and determines whether the feature vector comprises data indicative of one or more features with a threshold amount of confidence. For each of a subset of the generated feature vectors, the system processes data in that feature vector to generate a prediction of a value of a profile parameter and transmits an output responsive to machine executable code that generates a visual representation of the prediction of the value of the profile parameter.

Abstract: A laser-assisted microfluidics manufacturing process has been developed for the fabrication of additively manufactured structures. Roll-to-roll manufacturing is enhanced by the use of a laser-assisted electrospray printhead positioned above the flexible substrate. The laser electrospray printhead sprays microdroplets containing nanoparticles onto the substrate to form both thin-film and structural layers. As the substrate moves, the nanoparticles are sintered using a laser beam directed by the laser electrospray printhead onto the substrate.

Abstract: Embodiments provide a stationary X-ray source for a multisource X-ray imaging system for tomographic imaging. The stationary X-ray source includes an array of thermionic cathodes and, in most embodiments a rotating anode. The anode rotates about a rotation axis, however the anode is stationary in the horizontal or vertical dimensions (e.g. about axes perpendicular to the rotation axis). The elimination of mechanical motion improves the image quality by elimination of mechanical vibration and source motion; simplifies system design that reduces system size and cost; increases angular coverage with no increase in scan time; and results in short scan times to, in medical some medical imaging applications, reduce patient-motion-induced blurring.

Abstract: In a general aspect, an apparatus can include a first carbon nanotube array that is patterned to define a first electrode having a first plurality of electrode segments. The apparatus can also include a second carbon nanotube array that is patterned to define a second electrode having a second plurality of electrode segments. The second plurality of electrode segments can be interdigitated with the first plurality of electrode segments. The apparatus can further include a biorecognition agent disposed on a surface of the first electrode and disposed on a surface of the second electrode. The first plurality of electrode segments can each have a height-to-width aspect ratio of at least 1 to 1.

Abstract: Provided herein are metal organic frameworks comprising metal nodes and N-donor organic ligands which have high selectivity and stability in the present of gases and vapors including H2S, H2O, and CO2. Methods include capturing one or more of H2S, H2O, and CO2 from fluid compositions, such as natural gas.

Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.

Abstract: An imaging system including a transmitter configured to transmit a signal in a direction of a scene of interest. The transmitted signal is spatially and temporally incoherent at a point where the transmitted signal reaches the scene of interest. The system includes a receiver set including at least a first receiver and a second receiver. The first receiver and the second receiver are configured to receive a reflected signal. The reflected signal is a reflection of the transmitted signal from the scene of interest. The system further includes an active incoherent millimeter-wave image processor configured to obtain the reflected signal and reconstruct a scene based on the reflected signal. The system also includes a display device configured to display the scene.

Abstract: The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging:

Abstract: Microparticulate drug compositions comprising nanocrystals of poorly soluble drugs combined with a carrier are disclosed. Also disclosed are pharmaceutical compositions that include the microparticulate drug compositions. Further disclosed are methods of preparing and using the microparticulate drug compositions/pharmaceutical compositions.

Abstract: In one embodiment, the orthotic device can include a powered hand portion, a switching element, and a controller. The wearer can interact with the switching element to generate input signals for adjusting an operation of the powered hand portion. The controller can receive the input signals and generate control signals to accordingly adjust the operation of the powered hand portion. In some embodiments, a powered hand portion can be comprised of a plurality of linkages and at least one powered actuator to assist with an opening and closing of the hand portion. The plurality of linkages can be operated by at least one electric motor with quick-connect elements to link onto fingers of a user. In some embodiments, an electrically-actuated clutch mechanism can be affixed to an upper arm section and a lower arm section of an orthotic device. The clutch mechanism can be configured into different positions.

Abstract: An anomaly flow detection device and an anomaly flow detection method thereof are provided.