Abstract: Microbial consortia exert great influence over the physiology of humans, animals, plants, and ecosystems. However, difficulty in controlling their composition and population dynamics have limited their application in medicine, agriculture, biotechnology, and the environment. The approach disclosed herein provides an effective method to dynamically control population compositions in microbial consortia, which we demonstrate in the context of co-culture fermentations for chemical production. Co-culture fermentations can improve chemical production from complex biosynthetic pathways over monocultures by distributing enzymes across multiple strains, thereby reducing metabolic burden, overcoming endogenous regulatory mechanisms, or exploiting natural traits of different microbial species. However, stabilizing and optimizing microbial sub-populations for maximal chemical production remains a major obstacle in the field.

Abstract: A sequencing method, system and kit of low molecular weight heparin (LMWH) oligosaccharides are provided.

Abstract: An implantable or injectable scaffold comprising immunostimulatory compounds and a suppressor of regulatory T cell induction is provided for use in immunotherapy treatments, including the treatment of cancers and other tumors, in particular solid tumors including inoperable tumors, as well as for other applications of immune enhancement and/or suppression.

Abstract: Embodiments of a system for controlling an object using brainwaves are disclosed. The system includes a set of EEG electrodes configured to be positioned on a head of a user and to collect EEG signals. The system further includes one or more computer readable storage mediums storing a framework configured to execute an extensible architecture through which EEG signals are interpreted for control of the object. The framework includes an EEG device plugin associated with the set of EEG electrodes and configured to extract the EEG signals from the set of EEG electrodes. The framework also includes an interpreter plugin configured to convert the EEG signals extracted by the EEG device plugin into a command. Further, the framework includes an object control plugin configured to access the command through an extension point of the interpreter plugin and to execute the command to control the object.

Abstract: A nanomedicinal composition comprising a nanocarrier and a pharmaceutical agent mixture comprising an anti-cancer therapeutic and an antioxidant. The nanocarrier comprises a porous silicate matrix and particles of a magnetic ferrite disposed in the pores of the porous silicate matrix. The pharmaceutical agent mixture is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating breast cancer.

Abstract: Novel cyclic silicon precursors and oxidants are described. Methods for depositing silicon-containing films on a substrate are described. The substrate is exposed to a silicon precursor and a reactant to form the silicon-containing film (e.g., elemental silicon, silicon oxide, silicon nitride). The exposures can be sequential or simultaneous.

Abstract: One embodiment of the user authentication method using brainwave signal according to imagined speech includes extracting and storing characteristic information of a first brainwave signal generated by an imagined speech of a first user based on preset imagined speech induction information provided to the first user by the user authentication apparatus, and determining whether a second user matches the first user by extracting characteristic information of a second brainwave signal generated by an imagined speech of the second user, based on preset imagined speech induction information provided to the second user, comparing the characteristic information of the first brainwave signal with the characteristic information of the second brainwave signal stored according to the extracting and storing, and analyzing a result of the comparing by the user authentication apparatus.

Abstract: A logic circuit for biometric authentication based on learning parity with noise. The logic circuit includes a sensor. The sensor is configured to acquire a biometric signal. The logic circuit is configured to generate a response signal from the biometric signal by implementing a finite state machine (FSM).

Abstract: Provided are nucleotide sequences encoding polypeptides with ribonuclease III activity, wherein the nucleotide sequences have been modified to reduce their regulation by miRNAs. In some embodiments, the nucleotide sequences are at least 50% and as much as 100% identical to SEQ ID NO: 20 or SEQ ID NO: 22, and/or encode polypeptides that are at least 90% percent identical to SEQ ID NO: 23. Also provided are vectors and host cells that include the nucleotide sequences, methods for expressing the nucleotide sequences in cells, tissues, and organs, which in some embodiments can be in the eye of a subject in need thereof, methods for preventing and/or treating development of diseases or disorders and/or for restoring undesirably low DICER1 expression using the nucleotide sequences, and pharmaceutical compositions that have the presently disclosed nucleotide sequences.

Abstract: The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing cancer. CMV determination methods, compositions, and kits also are provided.

Abstract: An AUV/UUV docking station is provided that is tethered to a wave energy converter that is in turn tethered to a flotation buoy. The AUV/UUV docking station has a cone for directing an AUV/UUV into a charging dock that is rotatable between a horizontal docking position and a vertical charging position such that in the vertical position the docking station and docked AUV/UUV have a reduced profile so as not to interfere with the operation of the wave energy converter. Energy from the wave energy converter is directed to the dock to charge the AUV/UUV.

Abstract: A method and system of operating a vehicle includes a first sensor generating first sensor data for an object comprising a first bounding box from a first sensor. The first sensor data comprising a first confidence score. A second sensor generates second sensor data for the object comprising a second bounding box from a second sensor different than the second sensor. The second sensor data comprises a second confidence score. A bounding box circuit is programmed to generate a third confidence score for the object based on the first sensor data and the second sensor data and utilize the first sensor data, the second sensor data and the third confidence score to control operation of a vehicle system.

Abstract: Provided is a vaccine composition including a recombinant DNA vaccine against a pathogen. The recombinant DNA vaccine includes an expression cassette operably linked to a promoter, and the expression cassette encodes a non-structural protein of a Sindbis virus and an antigenic protein of the pathogen. Also provided is a method of producing a protective immune response against a pathogen in a subject in need thereof by administering the vaccine composition to the subject.

Abstract: Systems and methods for artificial intelligence enable control of hemodyamics in an individual are provided. A number of embodiments use a phenotypic response surface (PRS) that describes a physiological response to a vasopressor and/or a vasodilator to guide administration of the vasopressor and/or vasodilator. Various embodiments continually update the PRS based on changes in physiological response to the vasopressor and/or vasodilator.

Abstract: A UV-curable and recyclable thermoset shape memory polymer is provided. The polymer includes a vitrimer-based monomer and a photoinitiator. The vitrimer-based monomer includes a first unit rendering a high chain stiffness upon polymerization of the monomer, and a second photopolymerizable unit for photopolymerization of the monomer under a UV irradiation. The polymer has high strength, high stiffness, high recovery stress, high energy storage, reasonable recycling efficiency, and is printable using SLA with high resolution.

Abstract: A wireless charging apparatus according to an embodiment of the present disclosure includes a pad determinor configured to determine a receiving pad mounted on an electric vehicle entering a wireless charging station, and a power transmitter configured to select a transmitting pad to correspond to the receiving pad determined by the pad determinor, and transmit charging power to the receiving pad through the transmitting pad.

Abstract: Aspects of the invention include a method of treating hair of a subject with an artificial melanin material comprises contacting in a solution artificial melanin precursors with an oxidizing agent at a temperature greater than or equal to 30° C. in the presence of the hair of the subject to form the artificial melanin material; wherein the artificial melanin material associates with the hair of the subject, thereby treating the hair of the subject. Optionally, the contacting step results in deposition of the artificial melanin material on the hair of the subject and/or uptake of the artificial melanin material into the hair of the subject.

Abstract: A therapeutic treatment for preventing or reducing the formation of fibrosis comprising administering to a patient a UTX or JMJD3 inhibitor that are effective in preventing or reducing fibrosis in situations wherein access to an injury or dysmorphogenetic tissues before the fibrotic process becomes established in the tissues.

Abstract: Computer vision systems and methods for time-aware needle tip localization in two-dimensional (2D) ultrasound images are provided. A consecutive fused image sequence, derived from fusion of the enhanced frames and the corresponding B-mode frames, is processed by a time-aware neural network which includes a unified convolutional neural network (CNN) and a long short-term memory (LSTM) recurrent neural network. The CNN acts as a feature extractor, with stacked convolutional layers which progressively create a hierarchy of more abstract features. The LSTM models temporal dependencies in time-series data. The system learns spatiotemporal features associated with needle tip movement, for example, needle tip appearance and trajectory information, and successfully localizes the needle tip in the presence of abrupt intensity changes and motion artifacts.

Abstract: A new on chip system, named Acoustic Gym, to apply a surface acoustic wave (SAW) has been developed to control the swimming exercise of a large number of small animals such as C. elegans and Zebra fish, at desired intensities and durations. The SAW device consists of a circular chamber filled with fluid, which is placed in the center between a pair of offset interdigital transducers (IDTs) that are deposited on a piezoelectric substrate. Upon actuation from a radio frequency (RF) source, the SAW is generated and propagates along the substrate towards the microchamber. Once the SAW reaches the chamber, it induces an acoustic streaming in the fluid inside the chamber to stimulate swimming exercise of small animals. The streaming velocity can be precisely controlled via the RF signal input power, thus regulating the duration and intensity of exercise of the animals.