Abstract: Systems and methods for a multi-primary color system for display. A multi-primary color system increases the number of primary colors available in a color system and color system equipment. Increasing the number of primary colors reduces metameric errors from viewer to viewer. One embodiment of the multi-primary color system includes Red, Green, Blue, Cyan, Yellow, and Magenta primaries. The systems of the present invention maintain compatibility with existing color systems and equipment and provide systems for backwards compatibility with older color systems.

Abstract: A method of treating an RNA virus infection in a subject in need that includes administering a therapeutically effective amount of a heparanase inhibitor. The RNA virus includes SARS-CoV-1, SARS-CoV-2, HTLV-1, HIV-1, and any combination thereof. The heparanase inhibitor includes heparin, a heparin mimetic, or any combination thereof. In some aspects, the heparanase inhibitor is Roneparstat. In some aspects, the administration of the therapeutically effective amount of the heparanase inhibitor results in the inhibition of infection by the RNA virus and associated inflammatory cytokine production.

Abstract: A genetically engineered bacterium includes a genome of the Eschericia coli and a mutant encoding gene hisG* of a Corynebacterium glutamicum ATP phosphoribosyl transferase HisG on the genome, and the gene hisG* is strongly expressed to enhance activity of a key enzyme HisG for histidine synthesis. The gene hisG* has a nucleotide sequence as shown in SEQ ID NO: 1; a copy number of histidine operon genes hisDBCHAFI of the Eschericia coli is further increased on the genome to enhance a terminal synthetic route of histidine; an encoding gene lysE from an arginine/lysine transportprotein of the Corynebacterium glutamicum is further integrated to the genome and strongly expressed to promote the intracellular histidine secrete to the extracellular space; and an encoding gene rocG of glutamate dehydrogenase of Bacillus subtilis is further integrated to the genome and strongly expressed to promote generation of histidine.

Abstract: Artificial meniscal scaffolds characterized by a composite of circumferential polymer fiber network and orthogonal polymer fiber network embedded in an arcuate bioresorbable matrix comprised of collagen and hyaluronic acid. The orthogonal polymer fiber network prevents separation of the circumferential polymer fiber networks. The polymer fiber networks convert axial compressive forces on the scaffolds to tensile loads on the circumferential polymer fibers. The composite scaffold can be anchored to bone by novel anchoring components that protect the polymer fibers and ensure immediate securement of the artificial meniscal scaffold to bone.

Abstract: An electromagnetic pulse additive device for a connection ring of a heavy-lift carrier rocket is provided. The device includes brackets, a gear disk rotatably matched with the annular ground rail through a plurality of rolls arranged in a circumferential direction of the gear disk, a first drive motor, an annular ground rail, and a guide rail in a semicircular shape arranged at top ends of the brackets. An output shaft of a first drive motor is fixedly provided with a first drive gear engaged with the gear disk. The guide rail is slidably provided with three lifting modules which respectively drive a bending module, an electromagnetic head arranged electromagnetic coil electrically connected with a capacitor and a discharge circuit, and a rotational friction and extrusion module including a second drive motor and a friction bar fixedly connected to an output shaft of the second drive motor to rise and fall.

Abstract: The present disclosure belongs to the technical field of biomedicine, and provides an engineered circular RNA circmiR-29b and use thereof in preparation of a medicine for treating muscle atrophy. The present disclosure provides a circular RNA circmiR-29b including an effective sequence and a random sequence, wherein 6-13 repetitions of the effective sequence are connected in series, the random sequence is inserted between the effective sequences, and the nucleotide sequence of the effective sequence is shown in SEQ ID NO: 1. The present disclosure delivers circmiR-29b to skeletal muscle by AAV8, enabling stable expression of circmiR-29b in the skeletal muscle, thereby effectively inhibiting various types of muscle atrophy. Therefore, the present disclosure also provides a gene therapy based on the AAV8 virus vector delivering the engineered circular RNA circmiR-29b to achieve the objective of treating muscle atrophy.

Abstract: A system for generating a dynamic tree trimming schedule, comprising a network vegetation model system operating on a first processor and configured to receive a network vegetation model and weather forecast data and to generate a real-time tree trimming schedule as a function of the network vegetation model and weather forecast data and a remote user interface operating on a second processor and configured to receive the real-time tree trimming schedule and to generate one or more user interface controls as a function of the real-time tree trimming schedule.

Abstract: Disclosed are uses of NAD+ and/or NAD+ agonists and/or NAD+ inhibitors for preparing a preparation or a kit, and a combination preparation including T cells and NAD+ and/or NAD+ agonists and/or NAD+ inhibitors. The preparation or kit is used for regulating T cell activity, regulating the expression level of CD69 on the surface of T cells, and/or regulating the phosphorylation level in T cells, and/or treating diseases related to T cell activity.

Abstract: The inventors have found that compounds of formula (I) have an effect to protect cartilage. Accordingly the disclosure provides a pharmaceutical composition for protecting cartilage comprising a compound of formula (I) or an ester, oxide, pharmaceutically acceptable salt, or solvate thereof. The pharmaceutical composition can be used for treating and/or preventing a disease associated with cartilage degeneration such as osteoarthritis.

Abstract: A system for assessing extubation includes a respiratory assistance device, an artificial intelligence platform, and a hospital information system. The respiratory assistance device is adapted to communicate with a trachea of a patient. The artificial intelligence platform includes a prediction module. A method for assessing extubation includes the following steps. Measured values of respiratory parameters of the patient are recorded by the respiratory assistance device. The recorded times and the measured values of the respiratory parameters corresponding to each of the recording times are transmitted to the artificial intelligence platform. The prediction module analyzes the measured values of respiratory parameters within a predetermined time period according to a prediction model to generate a prediction result. The prediction result is transmitted to the hospital information system and is recorded into a medical record of the patient.

Abstract: Devices for and related methods of treating a subject having a neurological injury to prevent or mitigate secondary injury are described. In an example, the devices include a base and a plurality of microneedles protruding from the base, the microneedles including a biocompatible and biodegradable matrix, and a neurologically active ingredient disposed within the matrix. In an example, a portion of the plurality of microneedles is shaped to penetrate the dura when the device is placed in contact with the dura.

Abstract: The present invention provides a hydrogen storage and release material including a two-dimensional hydrogen boride-containing sheet including a two-dimensional network containing n(HxBy) (n?4, 0.001?x/y?0.999) having a molar ratio of boron to hydrogen from 1:0.999 to 1:0.001, the molar ratio being determined by thermal desorption spectroscopy, and mass measurement before and after a temperature rise, wherein the hydrogen storage and release material has: peaks derived from B1s of boron at 187.5±1.0 eV and 191.2±1.0 eV to 193±1.0 eV in X-ray photoelectron spectroscopy, and a peak derived from a B—H stretching vibration at from 2400 cm?1 to 2600 cm?1 and also a peak derived from a B—H—B stretching vibration at from 1200 cm?1 to 1800 cm?1 in infrared spectroscopy.

Abstract: Disclosed is a snow shoveling and snow discharging assembly of a snow sweeping robot. The snow shoveling and snow discharging assembly comprises a snow stirring structure, a snow feeding structure and a snow raising structure. Stirring cutters in the snow stirring mechanism are driven by a stirring cutter shaft to stir bottom area snow into a snow feeding pipe of the snow feeding structure, an air blower in the snow feeding structure blows accumulated snow into a snow raising pipe of the snow raising structure through a connecting pipe, the snow raising pipe can be driven by a steering motor to rotate by a certain angle to control the snow raising direction, and a second electric push rod acts to control pitching of the guide part, so that the height of snow during snow raising is controlled.

Abstract: A positron emission tomography (PET) technique that can enhance the image resolution and system sensitivity of a clinical PET/CT scanner for imaging a whole body or a target region of a subject is provided. The system includes a detector array and a detector panel. The detector array includes an array of gamma ray detectors defining a field of view of a scanner and configured to detect at least one coincidence event. The detector panel includes an array of gamma ray detectors having a higher intrinsic spatial resolution than the detector array and positioned in closer proximity to a patient table than the detector array. The detector panel is positioned outside the field of view defined by the detector array during at least a portion of scanning by the PET system. The detector panel is configured to detect at least one coincidence event in cooperation with the detector array.

Abstract: Enzyme-immobilizing MOFs and methods for their use in enzymatically catalyzed reactions are provided. The MOFs are channel-type MOFs that present a hierarchical pore structure comprising a first set of large channels sized for enzyme immobilization and a second set of smaller channels running alongside of the large channels that remain enzyme-free and allow for reactant delivery to the enzymes and product expulsion from the larger channels.

Abstract: An exemplary transaction sharding method comprises splitting a distributed ledger into a plurality of shards; and storing a shard across the subgroup of computer nodes associated with the shard. Such a method further comprises assigning a new transaction to one of the plurality of shards, wherein assigning the new transaction comprises iteratively choosing one of the plurality of shards; in each iteration, determining a transaction-to-shard score measuring a probability that a subgroup of computing nodes associated with the chosen shard for the current iteration would be involved in a same-shard transaction for the new transaction; in each iteration, determining a latency-to-shard score by estimating a confirmation latency of the new transaction under the chosen shard for the current iteration; and selecting the new transaction to be assigned to the shard based on a combination of the transaction-to-shard score and the latency-to-shard score.

Abstract: A method for measuring a seam on aircraft skin based on a large-scale point cloud is disclosed. A point cloud density of each point in an aircraft skin point cloud is calculated. Seam and non-seam point clouds are divided according to a discrepancy of the calculated point cloud density. A point is selected from the point cloud of the seam area, and a section at the point is extracted. A certain range of the seam and non-seam point clouds is projected to the section and a projected point cloud is acquired. A calculation model of flush and gap is constructed, and the flush and the gap of the aircraft skin seam at the measuring point is calculated according to the projected point cloud and the calculation model.

Abstract: A system can include: a superconducting or permanent magnet; a high field portion corresponding to the superconducting or permanent magnet, wherein the high field has a range of 0.1-20 T; a low field portion positioned outside of the superconducting or permanent magnet, wherein the low field has a range of 0.01 nT-100 mT; a shuttling mechanism configured to deliver a sample between the low field portion and the high field portion; and a polarization sub-assembly configured to hyperpolarize the sample while the sample is within the low field portion. A device can be configured to cause nuclear spin hyperpolarization in diamond particles such that the hyperpolarization is transferable to at least one of an external liquid or an external solid.

Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: A lithographic method for making an out-of-plane optical coupler includes forming a photoresist layer of positive photoresist material over a substrate. The positive photoresist layer undergoes a flood exposure to light through a binary mask to pattern a latent image of a mirror blank in the photoresist layer. A laser beam is scanned over the latent image of the mirror blank to apply controlled dosages of light at specified locations to form a latent image of a planar mirror surface that is oriented at a prescribed non-zero angle to a plane in which the substrate extends. The positive photoresist material is developed so that a remaining portion of the developed positive photoresist material forms an out-of-plane optical coupler having a planar mirror surface that is oriented at the prescribed angle.