Abstract: Virtual humans exhibit behaviors associated with inputs and outputs of an autonomous control system for medical monitoring of patients. To foster the awareness and trust, the virtual humans exhibit situational awareness via apparent (e.g., rendered) behaviors based on inputs such as physiological vital signs. The virtual humans also exhibit situational control via apparent behaviors associated with outputs such as direct control of devices, functions of control, actions based on high-level goals, and the optional use of virtual versions of conventional physical controls. A dynamic virtual human who continually exhibits awareness of the system state and relevant contextual circumstances, along with the ability to directly control the system, is used to reduce negative feelings associated with the system such as uncertainty, concern, stress, or anxiety on the part of real human patients.

Abstract: AAV vectors expressing anti-influenza antibodies are provided. Also described are pharmaceutical compositions useful in delivery same for prophylactic or anti-viral purposes. Methods of delivering such vectors are provided.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a cancer associated antigen as described herein. The CAR may comprise a mutant CD28 costimulatory domain.

Abstract: The present invention relates to the modification of gene expression in plants in order to manipulate stomatal number, in particular to the modification of expression in plants of epidermal patterning factor (EPF). The invention also relates to genetically modified plants or plant parts with altered stomatal patterning compared to corresponding wild type plants or plant parts, where the plant stomatal development is altered by modification of the expression of EPF.

Abstract: Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded DNA, for which knock-ins are notoriously inefficient for relying on random integration of homologous DNA sequences into the break site by repair proteins. To address these issues, described herein are novel recombinant fusion proteins that actively recruit linear DNA inserts in closer proximity to the genomic cleavage site, increasing integration efficiency of large DNA fragments into the genome. Such improvements to genomic editing technology allow one to use lower linear DNA concentrations without sacrificing efficiency and can be further combined with other features, such as fluorescent protein reporting systems.

Abstract: Disclosed herein are safety devices that are positioned on the end of a fiberoptic cable, such as those used in surgical procedures, to prevent patients and other objects from the risk of burn from light or heat emitted from the end of the cable when not connected to an optical instrument. The disclosed safety devices can be added to the ends of existing cables and/or can be included at the end of cables during manufacture. In some embodiments, the safety device replaces an existing connector at the end of a cable, and in some embodiments the safety device is added in addition to a connector at the end of the cable. In some embodiments, a slit end cover is included over an open end of an adaptor that is mounted on a distal connector of a fiberoptic cable.

Abstract: Provided are a macromolecular material that exhibits high toughness and self-healing properties, and that can be produced by a simple process, as well as a method for producing the material. The macromolecular material contains a crosslinked polymer crosslinked by the interaction between a host group and a guest group. The crosslinked polymer contains a repeating structural unit represented by the following formula (1a) and a repeating structural unit represented by the following formula (2a).

Abstract: A culture system for co-culturing a first cell group consisting of one or more kinds of cells and a cell layer or tissue formed of a second cell group consisting of one or more kinds of cells different from the former cells comprising: a first culture tank for co-culturing under anaerobic conditions the first cell group consisting of one or more kinds of cells and the cell layer or tissue formed of the second cell group consisting of one or more kinds of cells; a second culture tank for pooling a liquid culture medium of aerobic conditions; one or more substance-exchange structures that are disposed so as to connect the first culture tank to the second culture tank; and the aforesaid cell layer or tissue that is disposed so as to cover the surface on the first culture tank side of the substance-exchange structure(s).

Abstract: A nuclear microbattery is disclosed comprising: a radioactive material that emits photons or particles; and at least one diode comprising a semiconductor material arranged to receive and absorb photons or particles and generate electrical charge-carriers in response thereto, wherein said semiconductor material is a crystalline lattice structure comprising Aluminium, Indium and Phosphorus.

Abstract: The present disclosure provides a lignite char supported nano-cobalt composite catalyst and a preparation method thereof. In the method, lignite is used as a raw material, and a lignite char supported high dispersion nano-cobalt composite catalyst is obtained by a modified impregnation method followed by a high temperature pyrolysis process. The composite catalyst prepared by the present disclosure has a hierarchical pore structure, a high specific surface area, and uniformly dispersing nano-sized cobalts on the lignite char with controllable particle size, so that the obtained catalyst has an excellent catalytic activity for low-temperature CO2 methanation; moreover, the preparation process is simple and feasible, the raw materials used are cheap and easily available. Therefore, the composite catalyst is very suitable for industrial production and application.

Abstract: Gene sequences are tailored for protein expression by measuring ribosome dynamics, training a statistical model of the relationship between DNA sequence and translation speed; and using this model to design an optimal DNA sequence encoding a given protein.

Abstract: Provided are organometallic compounds including a ligand LA of the following Formula I Also provided are formulations including these organometallic compounds. Further provided are OLEDs and related consumer products that utilize these organometallic compounds.

Abstract: A reactor system for decomposing at least one of a per- or polyfluoroalkyl substance (PFAS) is provided. The system includes a material having an interior surface that defines a compartment; a subaqueous liquid in the compartment; and an electron donor in the subaqueous liquid, the electron donor configured to release a hydrated electron upon ultraviolet (UV) irradiation. The reactor system is configured so that when the electron donor releases a hydrated electron into the subaqueous liquid, the hydrated electron has a longer lifespan relative to an electron released in normal bulk phase water, and when a PFAS is present within the subaqueous liquid, the hydrated electron is capable of reductively defluorinating the PFAS and to generate fluoride ions (F). A method of operating the system to decompose PFAS is also provided.

Abstract: An implantable or injectable scaffold comprising immunostimulatory compounds and a suppressor of regulatory T cell induction is provided for use in immunotherapy treatments, including the treatment of cancers and other tumors, in particular solid tumors including inoperable tumors, as well as for other applications of immune enhancement and/or suppression.

Abstract: The inventive biorefinery system and method accepts municipal solid waste, sewage sludges, and/or ag-wastes and processes it through three primary conversion unit operations to produce a variety of value-added products. In a preferred embodiment, the three primary conversion units are gasification, thermal depolymerization or torrefaction/pyrolysis, and biotreatment.

Abstract: A frequency domain feedforward compensation method based on a power exponential method for a seismic simulation shaking table is provided. According to the method, a frequency domain amplitude transfer function of a system is identified, the frequency domain amplitude transfer function is modified by adjusting the power and limiting an amplitude, then an inverse frequency domain amplitude transfer function is obtained, an amplitude and a phase of a driving acceleration signal are computed, finally a time domain driving acceleration signal is obtained by using the Euler's formula for computation in a complex domain and conducting inverse Fourier transform, the shaking table is driven again to collect an acceleration signal output by a table top, whether the acceleration signal meets a shaking table test waveform use requirement is determined, a test is finished under the condition that the acceleration signal meets the shaking table test waveform use requirement.

Abstract: A method and system for multi-object tracking is set forth. Object data for boundaries of a plurality of objects are received. Poisson multi-Bernoulli mixture filtering is performed on the object data to form a filtered set of object data. Ultimately, the filtered set of object data is used to control the operation of the vehicle. Identifiers and probabilities are associated with the objects to reduce the set of object data.

Abstract: Methods of treating and preventing kidney injury through inhibiting interleukin 11 (IL-11)-mediated signalling are disclosed, as well as agents for use in such methods.

Abstract: An AUV/UUV docking station is provided that is tethered to a wave energy converter that is in turn tethered to a flotation buoy. The AUV/UUV docking station has a cone for directing an AUV/UUV into a charging dock that is rotatable between a horizontal docking position and a vertical charging position such that in the vertical position the docking station and docked AUV/UUV have a reduced profile so as not to interfere with the operation of the wave energy converter. Energy from the wave energy converter is directed to the dock to charge the AUV/UUV.

Abstract: A method and system of operating a vehicle includes a first sensor generating first sensor data for an object comprising a first bounding box from a first sensor. The first sensor data comprising a first confidence score. A second sensor generates second sensor data for the object comprising a second bounding box from a second sensor different than the second sensor. The second sensor data comprises a second confidence score. A bounding box circuit is programmed to generate a third confidence score for the object based on the first sensor data and the second sensor data and utilize the first sensor data, the second sensor data and the third confidence score to control operation of a vehicle system.