Abstract: Cyclic peptide pro-gelator compositions, and methods of therapeutic use, which assemble into macromolecular hydrogel when administered through cleavage by endogenous enzymes upregulated at a site of tissue injury, such as a myocardial infarction.

Abstract: The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrimidine-5-carboxamide compounds which may be useful in the treatment or prevention of a disease or medical condition mediated through signaling of CaMK1 isoforms. For example, such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers, metabolic diseases including type-2 diabetes, and/or immune-mediated disorders.

Abstract: The instant invention describes compounds having IL-6 modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by IL-6.

Abstract: Disclosed herein are compositions and methods for detecting RNA binding sites and RNA interacting partners involving the use of a modified capture oligonucleotide having a dual toehold design.

Abstract: A method for anti-counterfeit inspection of a QR code of an agricultural product based on a watermark library. The method includes establishing a watermark-containing QR code library; tracing a QR code watermark image; and verifying the QR code watermark image. Watermark-containing QR codes are generated by a QR code generation module and a watermark library, and the watermark-containing QR codes are constructed as the watermark-containing QR code library. The watermark-containing QR code library is used to verify the QR code watermark image, and the QR code watermark image is obtained by tracing the watermark-containing QR codes. In the method for anti-counterfeit inspection of a QR code of an agricultural product based on a watermark library, an image watermark library is designed, so that the embedding of a watermark is no longer single.

Abstract: The present disclosure relates to techniques for developing artificial intelligence algorithms by distributing analytics to multiple sources of privacy protected, harmonized data. Particularly, aspects are directed to a computer implemented method that includes receiving an algorithm and input data requirements associated with the algorithm, identifying data assets as being available from a data host based on the input data requirements, curating the data assets within a data storage structure that is within infrastructure of the data host, and integrating the algorithm into a secure capsule computing framework. The secure capsule computing framework serves the algorithm to the data assets within the data storage structure in a secure manner that preserves privacy of the data assets and the algorithm. The computer implemented method further includes running the data assets through the algorithm to obtain an inference.

Abstract: A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.

Abstract: Disclosed is a method for degrading antibiotics by aqueous phase transfer catalysis using an anionic liquid and hydrogen peroxide, including: adding hydrogen peroxide to a wastewater containing the antibiotics to obtain a first mixture, and adjusting a pH of the first mixture to 3-4 to form an aqueous phase, and adding a catalyst to a water-insoluble ionic liquid to obtain a second mixture, and stirring the second mixture to form an ionic liquid phase, wherein the catalyst is selected from the group consisting of ferrocene, iron dodecyl sulfonate, ferrous dodecyl sulfonate, and copper dodecyl sulfonate; and mixing the aqueous phase and the ionic liquid phase in a volume ratio of (8-11):1 to obtain a mixed phase, and stirring the mixed phase to degrade the antibiotics.

Abstract: A system and method for chat-based studies utilizing a plurality of users may be provided, utilizing at least one chat room processor and a plurality of remote processors. The chat room processors may be configured to receive a chat room template, create a plurality of chat rooms based on the chat room template, assign participants to one chat rooms, provide instructions associated with the chat room when all participants are present, provide questions or prompts at times defined by the chat room template or when conditions defined by the chat room template are met, collect all messages received from each participant, and storing information that includes the message, a time stamp the message was sent and/or received, and at least one unique identification code associated with the participant sending the message.

Abstract: A substrate comprising a III-N base layer comprising a first portion and a second portion, the first portion of the III-N base layer having a first natural lattice constant and a first dislocation density; and a first III-N layer having a second natural lattice constant and a second dislocation density on the III-N base layer, the first III-N layer having a thickness greater than 10 nm. An indium fractional composition of the first III-N layer is greater than 0.1; the second natural lattice constant is at least 1% greater than the first natural lattice constant; a strain-induced lattice constant of the first III-N layer is greater than 1.0055 times the first natural lattice constant; and the second dislocation density is less than 1.5 times the first dislocation density.

Abstract: A radio therapy system includes a first x-ray source. The first x-ray source is configured to produce first x-ray photons in a first energy range suitable for imaging and project the first x-ray photons onto an area designated for imaging. The system includes a second x-ray source configured to produce second x-ray photons in a second energy range higher energy than the first energy range, produce third x-ray photons in a third energy range higher energy than the first energy range, project the second x-ray photons onto the area designated for imaging, and project the third x-ray photons onto an area designated for treatment. The system includes an analytical portion configured to collect and combine data to create a composite output including at least one image, the combining based in part on a spectral analysis.

Abstract: Systems and methods for transmitting power to wirelessly powered sensors using a pipeline as a circular waveguide are disclosed. In an embodiment, a transmitter transmits electromagnetic waves to at least one wirelessly powered sensor positioned along the pipeline, wherein the pipeline is used as a waveguide to transmit the electromagnetic waves using a particular waveguide mode form of electromagnetic radiation, where the at least one wirelessly powered sensor is configured to be operated without a battery and to be powered by the electromagnetic waves emitted by the electromagnetic transmitter and senses at least one characteristic of the pipeline.

Abstract: Fluidic devices, systems, and methods for analyzing an analyte are described. In an embodiment, the fluidic devices include a housing defining a lysis chamber shaped to receive a biological sample; a lysis buffer storage chamber disposed within the housing and carrying a lysis buffer configured to lyse cells of the biological sample; a cap configured to cooperatively couple to the housing; a compressor configured to compress the lysis buffer storage chamber and expel the lysis buffer from the lysis buffer storage chamber and into the lysis chamber when the cap is uncoupled from the housing; and a porous membrane in selective fluidic communication with the lysis chamber.

Abstract: A continuously variable transmission including a main planetary gear set. A sun gear of the main planetary gear set coupled to an input shaft and a ring gear of the main planetary gear set may be coupled to an output shaft. A continuous range of transmission ratios between the input shaft and the output shaft provided by gradually changing an rpm of a carrier of the main planetary gear set. To this end a vane coupling mechanism may be coupled with the main planetary gear set. The vane coupling mechanism including an inner rotor coupled with the main carrier, where the inner rotor may be rotatably disposed within an outer rotating chamber. The outer rotating chamber coupled with the main sun gear.

Abstract: Described herein are novel methods for fractionating and isolating platelets, platelet- and extracellular vesicle-derived growth factors, exosomes, globulins, fibrinogen and albumin, and methods of using the isolated platelets, platelet and extracellular vesicle-derived growth factors, exosomes, globulins, fibrinogen and albumin for regenerating tissue in a subject, treating fibrinogenemia or a clotting deficiency in a subject, treating ischemia and hypoxia, treating dry-eye syndrome, an orthopedic disorder, or a dental disorder in a subject. Also described herein are growth media for culturing mammalian (e g , human) cells.

Abstract: A new family of mononuclear organometallic complexes of a divalent metal bound to sequential tetradentate monoanionic {ONNN}-type ligands, and polymerization of cyclic esters such as lactides utilizing same are provided. Novel tetradentate monoanionic {ONNN}-type ligands usable for forming these complexes are also provided.

Abstract: The present disclosure provides for an organic electroluminescent device (OLED) including an anode; a cathode; and an emissive layer, disposed between the anode and the cathode. The emissive layer includes a phosphorescent dopant, a first host, and a second host, wherein the first host transports holes, the second host transports electrons, and the first host is fully or partially deuterated. Consumer products that include the OLED are also provided.

Abstract: N-methyl-d-aspartate receptors (NMDAR) and/or potentiating y-aminobutyric acid receptors (GABAAR) agents and uses thereof are described. Uses of these agents include methods of treating or preventing various psychiatric diseases, disorders, or conditions and methods of treating or preventing alcohol use disorder in a subject in need thereof.

Abstract: Methods and systems for reverse design of micro-nano structure based on a deep neural network. The method includes step 101 of acquiring initial data of a micro-nano structure according to the micro-nano structure to be reversely designed. The method also includes step 102 of inputting the initial data of the micro-nano structure into a trained optical parameter prediction model to obtain optical prediction parameters. The method further includes step 103 of evaluating the optical prediction parameters. The method also includes optimizing the initial data of the micro-nano structure, inputting the optimized data of the micro-nano structure into the trained optical parameter prediction model, and performing steps 102 and 103 again until the evaluation result of the optical prediction parameters obtained in a current iteration satisfies the preset condition. Through the method of the present application, the electromagnetic response calculation time of the reverse design is greatly shortened.

Abstract: A method of manufacturing a CNT paste emitter in accordance with an exemplary embodiment of the present disclosure includes a process of mixing first CNT powder, graphite nanoparticles, SiC nanoparticles, Ni nanoparticles, a dispersant and distilled water and then performing a dispersion process by means of ultrasonication, a process of acquiring second CNT powder by filtering a solution dispersed during the dispersion process, a process of mixing the second CNT powder with a graphite binder and then preparing a CNT paste by means of ball milling, and a process of forming an interface layer on a metal or graphite substrate and then bonding the CNT paste.