Abstract: This invention provides a strengthening and tumor eliminating traditional Chinese medicine composition, its preparation method and application, which specifically relate to the technical field of the treatment of intermediate and advanced stage and postoperative malignant tumor, wherein the strengthening and tumor eliminating traditional Chinese medicine composition comprises: 8-30 parts of Radix codonopsis, 5-30 parts of Rhizoma atractylodis Macrocephalae, 5-30 parts of Poria cocos, 5-30 parts of Pseudobulb of Appendiculate cremastra, 5-30 parts of Scutellaria barbata, 5-30 parts of Sarcandra glabra, 3-30 parts of peach kernel, 2-30 parts of Ligustrum lucidum, 5-30 parts of Eclipta and 1-20 parts of licorice. This invention also provides a preparation method of the described strengthening and tumor eliminating traditional Chinese medicine composition.

Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.

Abstract: A vehicle interior material made of a rose-gold-colored copper alloy may include 0.07 to 0.21 wt % of aluminum (Al), 0.06 to 0.19 wt % of magnesium (Mg), 0.17 to 0.52 wt % of zinc (Zn), and a balance of copper (Cu) and unavoidable impurities, wherein the sum of the aluminum (Al), the magnesium (Mg), and the zinc (Zn) is 0.5 to 1.5 at %.

Abstract: Provided herein are isolated antibodies or antibody fragments thereof that immunospecifically bind to platelet factor 4 (PF4). In some embodiments the isolated antibodies or antigen-binding fragments thereof comprise a light chain CDR and framework region comprising SEQ ID NO: 4 and a heavy chain CDR and framework region comprising SEQ ID NO: 10. Also provided herein are methods for treating heparin-induced thrombocytopenia (HIT) and methods for reducing the likelihood that subject will become afflicted with HIT. Further disclosed are uses of the isolated antibodies or antibody fragments in the treatment of HIT or the manufacture of compositions for the treatment of HIT.

Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.

Abstract: A method for detecting and/or preventing an adversarial attack against a target machine learning model may be provided. The method may include training, based at least on training data, a defender machine learning model to enable the defender machine learning model to identify malicious input samples. The trained defender machine learning model may be deployed at the target machine learning model. The trained defender machine learning model may be coupled with the target machine learning model to at least determine whether an input sample received at the target machine learning model is a malicious input sample and/or a legitimate input sample. Related systems and articles of manufacture, including computer program products, are also provided.

Abstract: The present disclosure discloses a method for preparing 2,5-dimethylphenol by selective catalytic conversion of lignin, relates to the technical field of chemistry, and includes the following steps: mixing lignin, a catalyst, and ethanol, and then carrying out a catalytic conversion reaction of lignin under the gaseous supercritical conditions of ethanol; and cooling the reaction product by quenching after the completion of reaction, and then subjecting it to separation and extraction to obtain 2,5-dimethylphenol. The catalyst comprises a modified sepiolite carrier, an active metal Mo, and auxiliary agents Zr and Fe. The process of the present disclosure is simple, and the prepared catalyst is a solid catalyst, which avoids problems of difficult recovery, serious environmental pollution and equipment corrosion caused by the use of homogeneous organic acid-base catalysts.

Abstract: This disclosure relates to inhibitors of Mcl-1 stimulated homologous recombination (HR) DNA repair and uses for treating cancer. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an inhibitor of Mcl-1 in combination with other anti-cancer agents, e.g., that induce DNA replication stress. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering compounds disclosed herein in combination with hydroxyurea, olaparib, or combinations thereof.

Abstract: Provided are methods and compositions for treatment of angiogenic disorders using anti-VEGF agents. The anti-VEGF agents comprise VEGF binding domains and have the ability to bind vitreous. Provided are exemplary embodiments of Fc-IgG fusion proteins with VEGF binding domains with strong heparin-binding characteristics, strong inhibition of VEGF mitogenic activity, and improved pharmacokinetics, namely longer half-lives of the anti-VEGF agents and consequently less frequent dosing.

Abstract: Pharmaceutical or nutraceutical formulations are provided for treating inflammation in a subject in need thereof, as well as methods of treating inflammation in a subject in need thereof by administering one of the formulations. In some aspects, the pharmaceutical or nutraceutical formulation includes an effective amount of (i) palmitoylethanolamide or a derivative thereof, and (ii) one, two, three or more different small-molecule polyphenols or derivatives thereof to alleviate one or more causes or symptoms of the inflammation in the subject. In some aspects, the formulations include all three, e.g. the formulations includes (i) palmitoylethanolamide or a derivative thereof, (ii) quercetin or a derivative thereof, and (iii) curcumin or a derivative thereof. In some instances, the components (i)-(iii) discussed above are present at a mass ratio of about (i) 4 mg to 6 mg of palmitoylethanolamide or a derivative thereof to (ii) about 0.5 to 2.5 mg curcumin or a derivative thereof, and (iii) about 0.5 mg to 1.

Abstract: The present invention relates to pharmaceutical compositions for preventing or treating pulmonary metastasis of cancer. More specifically, the present invention relates to compositions that enhance anti-cancer immunity of the lung rather than induce death of advanced cancer, thus being effective in inhibiting, preventing or treating pulmonary metastasis of cancer.

Abstract: A hydrogen gas sensor with a substrate and a zinc oxide nanostructured thin film deposited on the substrate, wherein the zinc oxide nanostructured thin film has a lattice structure with a weight ratio of low binding energy O2? ions to medium binding energy oxygen vacancies in a range of 0.1 to 1.0, and a method of fabricating a gas sensor by thermally oxidizing a metal thin film under low oxygen partial pressure. Various combinations of embodiments of the hydrogen gas sensor and the method of fabricating the gas sensor are provided.

Abstract: A electronic blackbody cavity is provided. The electronic blackbody cavity comprises an inner surface; a chamber surrounded by the inner surface; an opening configured to make an electron beam enter the chamber; and a porous carbon material layer located on the inner surface. The porous carbon material layer consists of a plurality of carbon material particles and a plurality of micro gaps. The plurality of micro gaps are defined by the plurality of carbon material particles. A secondary electron detection device using the electronic blackbody cavity is also provided.

Abstract: A MXene support for a noble metal that forms a catalyst having active sites comprising single metal-layer nanostructures. The catalyst is stable under conditions for methane conversion to higher hydrocarbons and provides reduced coke formation. The results show a supported metal catalyst using the MXene where Pt atoms form one or more layers of atoms on the surface of the Mo2TiC2Tx support after it is reduced at 750° C. The catalyst shows high selectivity for C2-hydrocarbons with reduced coke formation, which can cost effectively convert methane into other valuable products.

Abstract: The invention relates to methods for the preparation of a pharmaceutical-vesicle formulation comprising steps of: preparing and processing vesicle components and a pharmaceutical agent to entrap the pharmaceutical agent in the vesicle and form a pharmaceutical-vesicle formulation, wherein the pharmaceutical-vesicle formulation is reconstituted in a known quantity of the pharmaceutical agent dissolved in a pharmaceutically-acceptable carrier to provide a biphasic pharmaceutical-vesicle formulation. The invention also relates to the associated pharmaceutical-vesicle formulations, pharmaceutical kits and uses as a medicament, in particular for the prevention or treatment of infection by bacteria such as Burkholderia pseudomallei and Francisella tularensis, and viruses such as Venezuelan Equine Encephalitis Virus (VEEV).

Abstract: A high temperature resistant wire is provided. The high temperature resistant wire comprises a carbon nanotube wire and a boron nitride layer coated on a surface of the carbon nanotube wire. The boron nitride layer is coaxially arranged with the carbon nanotube wire. A working temperature of the high temperature resistant wire in the air ranges from 0K to 1600K. A working temperature of the high temperature resistant wire in vacuum ranges from 0K to 2500K. A detector using the high temperature resistant wire is also provided.

Abstract: A quantitative phase microscopy (QPM) system and methods are provided for sample imaging and metrology in both transmissive and reflective modes. The QPM system includes a first illuminating beam propagating along a transmission-mode path and a second illuminating beam propagating along a reflection-mode path, a microscope objective lens disposed in the reflection-mode path, and a common-path interferometer comprising a diffraction grating, a Fourier lens, a pinhole, and a 2f system lens to collimate the reference beam and the imaging beam such that the collimated reference beam and imaging beam interfere with each other to form an interferogram at a final image plane.

Abstract: A geopolymer thermal energy storage (TES) concrete product comprising at least one binder; at least one alkali activator; at least one fine aggregate with high thermal conductivity and heat capacity; and at least one coarse aggregate with high thermal conductivity and heat capacity.

Abstract: A casing-protective horizontal directional drilling coaxial coring device for geological investigation includes a casing pipe, a coring tube and a conversion adapter. Both the casing pipe and the coring tube are tubular, and the coring tube is coaxially set within the casing pipe. The conversion adapter, having a cylindrical structure fitted with the casing pipe, is coaxially set at a back end portion of the casing pipe and is slidably connected with an inner wall of the casing pipe. A screw motor is located between the conversion adapter and the coring tube, two ends of the screw motor are fixedly connected with the conversion adapter and the coring tube, respectively. Under an action of an external force, the screw motor drives the coring tube to move along an axial direction of the casing pipe till the coring tube extends out of or retracts into the casing pipe.

Abstract: A switching device including a GaN substrate; an unintentionally doped GaN layer on a first surface of the GaN substrate; a regrown unintentionally doped GaN layer on the unintentionally doped GaN layer; a regrowth interface between the unintentionally doped GaN layer and the regrown unintentionally doped GaN layer; a p-GaN layer on the regrown unintentionally doped GaN layer; a first electrode on the p-GaN layer; and a second electrode on a second surface of the GaN substrate.