Abstract: In certain embodiments a lentiviral vector for the treatment of Wiskott-Aldrich Syndrome (WAS) is provided. In certain embodiments the vector comprises an expression cassette comprising a nucleic acid construct comprising an effective fragment of the endogenous promoter of the WAS gene where said promoter has maximum length of 600 bp and contains the sequence of HS1pro, and a nucleic acid that encodes the Wiskott-Aldrich Syndrome protein (WASp) operably linked to the effective fragment of the endogenous promoter of the WAS gene.

Abstract: A method of preparing iron oxide nanoparticles using an herbal mixture comprising Capparis spinosa, Cichorium intybus, Solanum nigrum, Cassia occidentalis, Terminalia arjuna, Achillea millefolium, and Tamarix gallica. The method produces crystalline ?-Fe2O3 nanoparticles which are superparamagnetic. The iron oxide nanoparticles are used in a method of killing or inhibiting the growth of a bacteria and/or fungus, particularly in the form of a biofilm. The nanoparticles are also used in a method of treating colon cancer.

Abstract: User-specific neurostimulation settings are efficiently determined and optimized based on an optimized set of population-based neurostimulation settings. The population data are clustered and a set of test settings for a new user are selected as settings that efficiently discriminate between the clusters. User preference of the test settings are used to map the user to a particular cluster of settings, which can be used to determine user-specific neurostimulation settings. The user-based settings can be iteratively updated and/or optimized using information from the population data, such as by using average preference score surfaces in the population data to identify and/or filter new test settings for the user.

Abstract: A read-out circuit includes an operational amplifier configured to receive an input voltage through a positive input terminal; a feedback capacitor connected between an output terminal of the operational amplifier and a negative input terminal of the operational amplifier; a sensor charging and discharging circuit configured to charge or discharge a sensor during a first time; a switching circuit connecting the sensor and the operational amplifier during a second time after the sensor is charged or discharged; and a duty control circuit configured to determine a duty ratio of the first time and the second time according to a capacitance of the sensor.

Abstract: A method for recommending a drilling target of a new well based on cognitive computing is provided, including: establishing a reservoir geological model; acquiring a dynamic parameter and a static parameter; establishing multiple fuzzy rules bases; inputting the dynamic and static parameters into the fuzzy rules base to obtain aggregated output fuzzy sets of membership values; defuzzifying the fuzzy set of the membership values to obtain crisp values of the fuzzy variables; inputting the crisp values into the fuzzy rules base to obtain a aggregated output fuzzy set of DA membership values of drilling attractiveness DA as a fuzzy variable; defuzzifying the DA to obtain a score of the DA; establishing a drilling attractiveness region with a radius R by taking each grid as a center; calculating region drilling attractiveness RDA score of the region; and determining a region with a highest score as the location of the new well.

Abstract: Provided herein are methods for predicting whether a cancer patient will respond to treatment with bevacizumab based on determining a level of small extracellular vesicle (sEV)-associated VEGF in the patient. Also provided are methods of treating patients with either bevacizumab or a VEGFR tyrosine kinase inhibitor, a VEGFR neutralizing antibody, or a VEGF ligand trap based on the level of small extracellular vesicle (sEV)-associated VEGF in the patient.

Abstract: The present disclosure features a luminescent molecule, including a luminophore (e.g., a fluorescent dye); and a moiety including a heteroaryl core covalently and directly bonded to the luminophore. The luminescent molecule has an increased photoluminescence quantum yield relative to an analogous luminophore without a covalently bonded moiety including the heteroaryl core.

Abstract: An aqueous solvent composition is provided, comprising a nucleophilic component having one or more sterically unhindered primary or secondary amine moieties, a Brønsted base component having one or more basic nitrogen moieties, a water-soluble organic solvent, and water. A biphasic composition is provided, comprising one or more carbamate compounds, one or more conjugate acids of Brønsted base, a water-soluble organic solvent, and water. A biphasic CO2 absorption process is also provided, utilizing the biphasic solvent composition.

Abstract: Methods to detect contaminants in a solution and applications thereof are described. Generally, solutions are printed onto a substrate and then imaged via Raman spectroscopy, which can be utilized to detect signals derived from contaminants.

Abstract: A hip assist actuation system is configured to allow a user to experience free movement of hip extension and hip flexion over a predetermined range and receive a torque assist in response to performing a lifting or pushing activity. The hip assist actuation system may be configured to determine whether the lifting or pushing activity is occurring and provide the torque assist in response to the determination.

Abstract: There is provided a multi-layered membrane for separating components in an aqueous sample. There is also provided a method of preparing said multi-layered membrane, a method of separating blood plasma from a whole blood sample and a diagnostic device for separation of blood plasma from a whole blood sample.

Abstract: A cotton harvester estimates the mass of cotton as it is harvested using sensor devices and compares the mass of each module against the estimated mass of the module as determined by the sensors so that a calibration factor may be determined and actively updated for more accurate crop yield determination. The mass flow for a specific module is accumulated and processed during harvesting using a base calibration factor and the module is weighed and compared against the expected mass using the base calibration factor to develop a candidate updated calibration factor. The base calibration factor is selectively replaced by the candidate updated calibration factor for processing a subsequent module based on machine feedback information relating to the operation of the harvester. Harvested crop data determined using the calibration factor is used to generate highly accurate yield maps.

Abstract: An optically pumped magnetometer includes cells configured to form a first cell region and a second cell region on a measurement target, a pump laser, a probe laser, a first optical system configured to cause pump light to be incident on the first cell region, a second optical system configured to cause the pump light having passed through the first cell region to be incident on the second cell region, a third optical system configured to cause first probe light to be incident on the first cell region, a fourth optical system configured to cause second probe light to be incident on the second cell region, detection portions configured to detect the first probe light having passed through the first cell region and the second probe light having passed through the second cell region, and a deriving portion configured to derive an intensity of a magnetic field.

Abstract: An apparatus for correcting a posture of an ultrasound scanner for artificial intelligence-type ultrasound self-diagnosis, includes an ultrasound scanner including an ultrasound probe configured to acquire and transmit an ultrasound image of a patient; a mapper configured to acquire a body map of the patient in which a plurality of virtual interested organs is arranged on a body image; a scanner navigator configured to calculate current position coordinates of the ultrasound scanner on the body map and the ultrasound image; augmented reality glasses configured to display the ultrasound image and a virtual object image; and a processor configured to determine whether the patient has a disease and a risk degree of the disease based on an artificial neural network result of an implemented deep learning neural network trained on ultrasound training images provided with the ultrasound image.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: The present invention relates to biodegradable polymers, particularly to a method for converting biodegradable polymers into humus with a low release amount of CO2 and use thereof. A composite material system is formed from the biodegradable polymers and the materials that can slowly release nutrient nitrogen or nutrients nitrogen and phosphorus, in which the mass ratio of carbon to nitrogen in the composite material system is (1-35):1. The materials of the present invention can promote the biodegradable polymers to be converted into soil humus or compost humus, rather than to be converted into greenhouse gas CO2, which is to be emitted into the atmosphere. Therefore, the method is of great significance for energy conservation and emission reduction, green and efficient utilization of biodegradable polymers and efficient and green utilization of biodegradable polymers wastes.

Abstract: A method for constructing a body-in-white (BiW) spot welding deformation prediction model based on a graph convolutional network (GCN) includes: 1) acquiring a welding feature and 3D coordinates of a spot weld to form an eigenvector and extracting designed 3D coordinates at each 3D coordinate measurement point; 2) encoding, by an encoder, eigenvectors and designed 3D coordinate vectors into hidden space vectors of spot welds and hidden space vectors of the coordinate measurement points, respectively, and constructing a graph topology G through a k-nearest neighbors algorithm; 3) decomposing a Laplacian eigenvector of the constructed graph topology G to acquire frequency domain components, and linearly transforming eigenvalues corresponding to the frequency domain components to construct a multi-layer GCN; 4) inputting the thermodynamic and kinetic information of each coordinate measurement point into a deep neural network and decoding a final deformation at each coordinate measurement point; and 5) optimizing

Abstract: Two approaches for on-chip ESD detection include variable dielectric width capacitor, and vertical metal-oxide-semiconductor (MOS) capacitor MOSCAP array. The variable dielectric width capacitor approach employs metal plates terminated with sharp corners to enhance local electric field and facilitate ready breakdown of a thin dielectric between the metal plates. The vertical MOSCAP array is composed of a capacitor array connected in series. Both approaches are incorporated in an example 22 nm fully depleted silicon-on-insulator. Vertical MOSCAP arrays detect ESD events starting from about 6 V with about 6 V granularity, while the variable dielectric width capacitor is suitable for detection of high ESD voltage from about 40 V and above.

Abstract: This system and method of for providing a tunable orbital angular momentum system for providing higher order Bessel beams comprising: an acousto-optical deflector configured to receive an input beam, deflect a first portion of the input beam a first deflection angle relative to an axis of propagation and along an optical axis and deflect a second portion of the input beam a second deflection angle relative to the optical axis; a line generator disposed along the optical angle for receiving the first portion and the second portion of the input beam and provide an elliptical Gaussian mean; a log-polar optics assembly disposed along the optical angle for receiving the elliptical Gaussian beam and wrapping the elliptical Gaussian beam with an asymmetric ring; and, a Fourier lens configured to receive the wrapped elliptical Gaussian beam.

Abstract: Provided are a heat dissipation structure and a heat dissipation system. The heat dissipation structure includes a heat dissipation channel and a plurality of heat dissipation fins. The plurality of heat dissipation fins are arranged on at least one side of the heat dissipation channel. Heat dissipation fins arranged on the same side of the heat dissipation channel are arranged along an extension direction of the heat dissipation channel. The heat dissipation channel and the plurality of heat dissipation fins are each formed as a cavity structure. Each heat dissipation fin includes a first end and a second end arranged opposite to each other. The first end is a closed end, and the second end is an open end. The second end communicates with the heat dissipation channel.