Abstract: A method of performing time series prediction by improper learning comprising calculating a plurality of filters based on a symmetric matrix and generating a mapping term based on a time series input and a function. The method may include comprising iteratively: transforming the function using the calculated plurality of filters; predicting an interim output using the transformed function and the mapping term; computing an error of the interim output based on a known output; and updating the mapping term based on the computed error. The method may include generating the mapping term through iterations over a predetermined interval and performing a time series prediction using the mapping term generated over the iterations.
Abstract: A method for preparing an organic manganese fertilizer for engineering wound soil remediation includes a step of: effectively compounding chitin oligosaccharide or/and wormcast or/and silkworm excrement, water or/and hydrogen peroxide, an organic manganese element solution, polysorbate and sodium carboxymethyl cellulose under certain conditions. The present invention has significant effects on improving physical and chemical properties of engineering wound soil, enhancing availability of manganese element in the soil, preventing plants from physiological diseases caused by lack of manganese, and promoting growth and development of the plants.
Abstract: The present invention relates to a method of labelling biological molecules with 18F, via attachment to fluorine to a macrocyclic metal complex of a non-radioactive metal, where the metal complex is conjugated to the biological molecule. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
Type:
Grant
Filed:
January 22, 2013
Date of Patent:
October 5, 2021
Assignees:
GE Healthcare Limited, University of Southampton
Inventors:
Rajiv Bhalla, Sajinder Kaur Luthra, Gill Reid, I, William Levason
Abstract: The present disclosure provides infectious recombinant adeno-associated virus (rAAV) virions that comprise a variant capsid protein and a heterologous nucleic acid. The present disclosure further provides the variant adeno-associated virus (AAV) capsid proteins (and/or a nucleic acid encoding the variant AAV capsid proteins), which confer to an infectious rAAV virion an increased resistance to human AAV neutralizing antibodies. The present disclosure further provides host cells comprising an infectious rAAV virion and/or a nucleic acid encoding a subject variant AAV capsid protein. The present disclosure further provides methods of delivering a heterologous nucleic acid to a target cell where the target cell is contacted with a subject infectious rAAV virion. The present disclosure further provides methods of delivering a gene product to an individual, the methods generally involving administering an effective amount of a subject rAAV virion to an individual in need thereof.
Type:
Grant
Filed:
May 29, 2014
Date of Patent:
October 5, 2021
Assignee:
The Regents of the University of California
Inventors:
David V. Schaffer, Melissa A. Kotterman, Bum-Yeol Hwang, James T. Koerber
Abstract: Embodiments of the disclosed subject matter provide an emissive layer, a first electrode layer, a plurality of nanoparticles and a material disposed between the first electrode layer and the plurality of nanoparticles. In some embodiments, the device may include a second electrode layer and a substrate, where the second electrode layer is disposed on the substrate, and the emissive layer is disposed on the second electrode layer. In some embodiments, a second electrode layer may be disposed on the substrate, the emissive layer may be disposed on the second electrode layer, the first electrode layer may be disposed on the emissive layer, a first dielectric layer of the material may be disposed on the first electrode layer, the plurality of nanoparticles may be disposed on the first dielectric layer, and a second dielectric layer may be disposed on the plurality of nanoparticles and the first dielectric layer.
Abstract: Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
October 5, 2021
Assignee:
Duke University
Inventors:
Edward F. Patz, Jr., Michael J. Campa, Elizabeth Gottlin, Barton F. Haynes, Hua-Xin Liao, M. Anthony Moody
Abstract: IgA-based Fc-folate conjugates as a treatment for cancer are provided. The conjugates utilize only the Fc portion of IgA to target its receptor on neutrophils (Fc?R1) to elicit antibody-dependent cellular-cytotoxicity (ADCC).
Abstract: A method for encoding image signal, according to the present invention, can: encode a partial block coefficient flag indicating whether a coefficient of a current partial block is a non-zero coefficient; encode a first flag indicating whether an absolute value of the coefficient is greater than 1, encode a second flag indicating whether the absolute value of the coefficient is greater than 2; encode the residual coefficients, which have not been encoded, on the basis of the first flag or the second flag in the current partial block; and encode a code for the coefficient of the current partial block.
Type:
Grant
Filed:
April 28, 2020
Date of Patent:
October 5, 2021
Assignee:
Industry Academy Cooperation Foundation of Sejong University
Inventors:
Joo Hee Moon, Dong Jae Won, Sung Won Lim
Abstract: Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and identified under a set of defined conditions, such as in the presences of antibiotics, in order to obtain an engineered ribosome that is resistant to the antibiotic.
Type:
Grant
Filed:
October 7, 2019
Date of Patent:
October 5, 2021
Assignee:
Northwestern University
Inventors:
Michael Christopher Jewett, Brian R. Fritz
Abstract: An equalizer circuit provides both passive and active cell voltage equalization in a battery pack to improve charge and discharge capacity at a low cost. The equalizer circuit is a bilevel circuit that uses both passive equalizers and active equalizers to balance cell voltage. The cells may be grouped into size limited sections which are balanced by passive equalizers. The sections are balanced by active equalizers to promote increased pack charge and discharge capacity. The equalizer circuit can use a current detector or a voltage controlled oscillator to assist in closed loop current control to reduce switching losses and permit use of smaller transistors. The equalizer circuit can use open line protection with capacitors to store excess charge and prevent voltage overload of the switching devices.
Abstract: Disclosed is a design and implementation of a Wi-Fi based network (e.g., roadside hotspot network designed to operate at vehicular speeds and picocell, meter-sized, cells). The disclosed access points (APs) make delivery decisions to the vehicular clients they serve at millisecond-level granularities, exploiting path diversity in roadside networks. In order to accomplish this, buffer management algorithms are employed that allow participating APs to manage each other's queues, rapidly quenching each other's transmissions and flushing each other's queues. An example embodiment of the disclosed approach employs an eight-AP network alongside a nearby road, and was evaluated with mobile clients moving at up to 25 mph. Depending on mobility speed, the disclosed approach achieves a 2.4-4.7 times TCP throughput improvement over a baseline fast handover protocol that captures the state of the art in Wi-Fi roaming, the IEEE 802.11k and 802.11r standards.
Abstract: An embodiment involves receiving a request to write data to a memory unit. The memory unit is divided into one or more logical blocks, each subdivided into groups of sub-blocks encrypted in accordance with a stream cipher. The memory unit maintains a transaction journal that marks each sub-block as dirty or clean. The memory unit stores keycount values for each of the logical blocks. The embodiment also involves: determining that the request seeks to write a portion of the data to a particular sub-block marked as dirty in the transaction journal, decrypting the particular logical block in accordance with the stream cipher, writing the portion of the data to the particular sub-block, incrementing the keycount value of the particular logical block, encrypting the particular logical block using the stream cipher, a key, and the keycount value, and writing the particular logical block to the memory unit.
Type:
Grant
Filed:
February 1, 2019
Date of Patent:
October 5, 2021
Assignee:
The University of Chicago
Inventors:
Bernard Dickens, III, Haryadi Gunawi, Ariel Feldman, Henry Hoffmann
Abstract: A method, a system, and a computer program product for determining a location of a communication device. Data corresponding to a detected transmission of a data packet between a tag device and one or more communication devices is received on one or more communication channels. At least one of a channel state information and a signal strength associated with the detected transmission for each frequency band in a plurality of frequency bands are determined. Based on the determined channel state information, one or more lengths of signal paths corresponding to the detected transmission of the data packet are determined. A shortest length in across one or more communication devices is selected to determine a location of the tag device.
Type:
Grant
Filed:
December 31, 2019
Date of Patent:
October 5, 2021
Assignee:
The Regents of the University of California
Inventors:
Sai Roshan Ayyalasomayajula, Dinesh Bharadia, Deepak Vasisht, Dina Katabi
Abstract: The invention relates to alpha conotoxin (?-conotoxin) peptides and methods for their preparation. Also described are pharmaceutical compositions comprising alpha conotoxin (?-conotoxin) peptides and their use in the treatment or prevention of indications 5 associated with nicotinic acetylcholine receptors and/or voltage gated calcium channels.
Type:
Grant
Filed:
February 16, 2017
Date of Patent:
October 5, 2021
Assignee:
The University of Queensland
Inventors:
Richard James Clark, James Travis Daniel
Abstract: The present invention relates to methods and compositions for the high throughput screening of protein-protein interactions in yeast liquid culture. Protein fusions non-native to yeast may be expressed to replace endogenous sexual agglutination proteins and mediate library-by-library interrogation of protein interactions. The methods and compositions of the invention can be utilized for the characterization of protein interaction networks in high throughput for both binding affinity and specificity, which is crucial for understanding cellular functions, screening therapeutic candidates, and evaluating engineered protein networks.
Type:
Grant
Filed:
November 6, 2020
Date of Patent:
October 5, 2021
Assignee:
University of Washington
Inventors:
David Baker, David Younger, Eric Klavins
Abstract: In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient; and comparing the coagulation characteristic value of the patient to a coagulation characteristic value of a healthy individual, the coagulation characteristic value of the healthy individual obtained by subjecting a blood sample from a healthy individual to the viscoelastic analysis in the presence of the known amount of the thrombolytic agent, wherein a difference in the coagulation characteristic value of the patient as compared to the coagulation characteristic value of the healthy individual identifies the patent as having aberrant fibrinolysis.
Type:
Grant
Filed:
November 5, 2015
Date of Patent:
October 5, 2021
Assignee:
The Regents of the University of Colorado, a body corporate
Inventors:
Michael P. Chapman, Hunter B. Moore, Eduardo Gonzalez Barreda, Ernest E. Moore
Abstract: This invention provides gene expression profiles useful for diagnosing lacunar stroke and for distinguishing lacunar stroke from non-lacunar stroke.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
October 5, 2021
Assignee:
The Regents of the University of California
Abstract: A method for encoding image signal, according to the present invention, can: encode a partial block coefficient flag indicating whether a coefficient of a current partial block is a non-zero coefficient; encode a first flag indicating whether an absolute value of the coefficient is greater than 1, encode a second flag indicating whether the absolute value of the coefficient is greater than 2; encode the residual coefficients, which have not been encoded, on the basis of the first flag or the second flag in the current partial block; and encode a code for the coefficient of the current partial block.
Type:
Grant
Filed:
September 11, 2020
Date of Patent:
October 5, 2021
Assignee:
Industry Academy Cooperation Foundation of Sejong University
Inventors:
Joo Hee Moon, Dong Jae Won, Sung Won Lim
Abstract: ‘BL 5-552’ is a new and distinct variety of Persea americana tree. The variety exhibits an open, upright habit. The fruit is rhomboidal, or occasionally, obovate or high spheroid shaped, lacks shoulders, is generally green skinned, is distributed throughout the canopy and commonly is larger size than that of the ‘Hass’ variety. The leaves are displayed in a similar quantity to ‘Hass’ and are similar in shape to those of the ‘Lamb/Hass’ variety. ‘BL 5-552’ has moderate resistance to Persea mites. The variety is suitable for the production of quality avocado crop under commercial growing conditions.
Type:
Grant
Filed:
February 6, 2018
Date of Patent:
October 5, 2021
Assignee:
The Regents of the University of California
Inventors:
Mary Lu Arpaia, Eric Focht, Gray E. Martin, Berthold O. Bergh