Abstract: Cyclopentene monomers and methods of polymerization, including the polymerization of the cyclopentene monomers. The cyclopentene monomers include allylic substituted cyclopentene monomers that may be racemic or enantiopure. The methods of polymerization may permit the resulting polymers to have one or more desirable structural features.

Abstract: Functionalized pyrano[2,3-d]pyrimidin-7-one derivatives, methods for making the derivatives, and methods of using the derivatives as protein kinase inhibitors.

Abstract: An all-fabric iontronic supercapacitive pressure sensing device utilizing a novel iontronic nanofabric as the sensing element is disclosed. The sensing device can be applied in several various wearable health and biomedical applications on complex body topologies. As an alternative to conventional flexible sensors, the all-fabric iontronic pressure sensor provides an ultrahigh device sensitivity with a single Pascale resolution. The device also allows rapid mechanical responses (in the milliseconds range) for high-frequency biomechanical signals, e.g., blood pressure pulses and body movements. The fabrication process for the device is low-cost highly compatible with existing industrial manufacturing processes.

Abstract: A gait training system has a motor connected to a first linkage system by an actuator. The first linkage system has multiple linkage members connected to multiple joints and an endpoint that is configured to produce a cyclic gait motion when the motor is activated. First and second linkage members have an adjustable length. A method of customizing a gait pattern on a gait training system is also described.

Abstract: Two-dimensional material based filters, their method of manufacture, and their use are disclosed. The filters may include at least one active layer disposed on a porous substrate. The at least one active layer may include intrinsic and/or intentional formed pores. In some embodiments, the flow resistance of the porous substrate may be selected to limit flow through defects and intrinsic pores in the at least one active layer.

Abstract: A continuous process for preparing a solid lipid nanoparticle of ibuprofen utilizing hot melt extrusion which avoids additional steps such as high-pressure homogenization, ultrasonication, or solvent evaporation. The continuous process includes preparing a pre-emulsion comprising a lipid, and continuously processing the pre-emulsion through a hot melt extruder device.

Abstract: The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.

Abstract: Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.

Abstract: A nanoscale conductor/semiconductor/insulator device includes a substrate with a lattice and a plurality of nanotubes in crystallographic alignment with the lattice at an interface between the plurality of nanotubes and the substrate. Another such device includes a substrate, meandering tracks in the substrate and a plurality of nanotubes adhering to cut-atomic-step edges of the meandering tracks. Methods of making the nanoscale conductor/semiconductor/insulator devices are also disclosed.

Abstract: The invention provides methods and compositions for treatment of spinal muscular atrophy (SMA). In one aspect of the invention, a series of compositions comprising an antisense oligonucleotide targeting the Element 1 site on the SMN2 pre-mRNA and a Morpholino backbone is disclosed. In another aspect of the invention, a method of treating SMA patients by modulating the splicing of SMN2 pre-mRNA to increase the amount of full-length SMN is disclosed. Certain embodiments of the inventive method comprise administering an E1-targeting antisense oligonucleotide, such as Morpholino based antisense oligonucleotide, to a SMA subject.

Abstract: The present invention provides compositions and methods for inhibiting Dkk-1 for treating or preventing an inflammatory or inflammatory-related disease or disorder.

Abstract: Described herein are compositions that may include a triblock self-assembling polypeptide and a molecule attached to the polypeptide. Also described herein are methods of making the compositions and methods of using the compositions.

Abstract: Although Fiber Reinforced Polymers (FRPs), as alternatives for the corrosive steel reinforcement in concrete structures, have shown promising performance under gravity loads, their performance under reversal cyclic loading is still one of the main concerns. The linear behavior of FRP reinforcement has a two-sided effect on the seismic performance of FRP-reinforced concrete (RC) moment-resisting frames. Although the linear nature of FRP reinforcement could be advantageous in terms of limiting the residual damage after an earthquake event, it lowers the energy dissipation of the structure which can compromise its seismic performance. Disclosed herein is the addition of steel plates at selected locations in moment-resisting frames to improve seismic performance of FRP-RC structures while still being able to take advantage of its linear behaviour (minimal residual damage after earthquake). The effectiveness of the proposed solution was tested both experimentally and analytically.

Abstract: Embodiments of the disclosed subject matter provide a device having a substrate, at least one organic light-emitting layer disposed over the substrate, and at least one down-conversion layer. The at least one down-conversion layer may generate the NIR emission by absorbing at least a portion of the light emitted by the at least one organic light emitting layer, and re-emitting light at a longer NIR wavelength or range of wavelengths having a peak NIR emission that may be greater than 700 nm, greater than 750 nm, or greater than 800 nm. An out-of-plane optical density of the at least one down-conversion layer may be less than 0.1 for all wavelengths of light in a range from 400 nm to 600 nm.

Abstract: A fingerprint scanner for capturing fingerprints of infant children is described. The fingerprint scanner includes a transparent tube configured for an infant child hand and an array of camera sensors spaced apart on the transparent tube so that each camera sensor captures an overlapping part of an image captured by its neighboring camera sensor. The array of camera sensors is arranged below a surface, along a periphery of a circumference and substantially along a length of the transparent tube up to a processor compartment. The fingerprint scanner also includes a processing circuitry configured to: simultaneously receive multiple images from the array of camera sensors, and process the multiple images including merging the multiple images to remove overlapping portions and recover a single image of the infant child's fingertips and palm.

Abstract: A frequency conversion device, including a source of a pump beam of electromagnetic radiation of a first wavelength, and an array of mutually spaced semiconductor islands including at least one III-V semiconductor compound and configured so that the pump beam of electromagnetic radiation of the first wavelength incident upon the semiconductor islands and electromagnetic radiation of a second wavelength incident upon the semiconductor islands cause the semiconductor islands to emit electromagnetic radiation of a third wavelength different to the first and second wavelengths by at least one of a sum frequency generation process and a difference frequency generation process, wherein the semiconductor islands are supported by a transparent support such that the support is substantially transparent to radiation of the third wavelength, wherein at least the radiation of the third wavelength passes through the transparent support.

Abstract: Disclosed herein, inter alia, are compositions and methods for modulating Ras and treating cancer.

Abstract: Aspects of the subject disclosure may include, for example, receiving, by a receiver through a medium from a transmitter, signals over an acoustic channel, where the receiving over the acoustic channel utilizes a high center frequency and provides for a high data rate, and where the medium is a fluid or a semi-solid medium. The device can receive power from the transmitter over the acoustic channel. Other embodiments are disclosed.

Abstract: Disclosed herein, inter alia, are agents having antiviral activity and methods of use thereof.

Abstract: An augmented reality system includes a first scene and a second scene. Further, the augmented reality system includes a partially reflective surface positioned relative to the first scene, the second scene, and an audience to facilitate viewing of one of the first scene or the second scene through the partially reflective surface and to facilitate reflection of the other of the first scene or the second scene toward the audience as augmented reality imagery. A sensor of the augmented reality system is designed to detect and generate data indicative of a characteristic of the first scene, and a correlative effect system is operable to receive the data and adjust the second scene based thereon.