Abstract: Systems and methods are described herein for modeling neural architecture. Regions of interest of a brain of a subject can be identified based on image data characterizing the brain of the subject. the identified regions of interest can be mapped to a connectivity matrix. The connectivity matrix can be a weighted and undirected network. A multivariate transformation can be applied to the connectivity matrix to transform the connectivity matrix into a partial correlation matrix. The multivariate transformation can maintain a positive definite constraint for the connectivity matrix. The partial correlation matrix can be transformed into a neural model indicative of the connectivity matrix.

Abstract: A computer-based method for quantitative evaluation of computed tomography (CT) images of the head, particularly in circumstances of neurological emergency such as acute intracranial hemorrhage, evidence of intracranial mass effect, and acute stroke. The method comprises: calculation of volumes of abnormal areas such as locations of hemorrhage; quantification of severity of midline shift and basilar cistern effacement; and rapid identification of anatomical locations of abnormal findings. The methods comprise use of heuristics, convolutional neural networks, deep learning, edge detection, and Hough transform.

Abstract: A method for acoustic beamforming filter generation may be provided. Applying eigen decomposition to generate a matrix of eigenvectors and a matrix of eigenvalues to solve a pseudoinverse of a matrix of transfer functions. Substituting any eigenvalues in the matrix of eigenvalues that are less than a value of a gain control parameter with the value of the gain control parameter to form a revised matrix of eigenvalues. A matrix of spatial filter coefficients to apply to a sound signal received at least at the first speaker and at the second speaker may be calculated based on the matrix of eigenvectors, the revised matrix of eigenvalues, and a matrix of desired frequency responses.

Abstract: An in vitro microfluidic device includes a device configured to model a blood-brain barrier. The device includes a center well in fluidic communication with each of an inlet and an outlet. Each of the center well, inlet, and outlet includes a porous membrane that separates a “blood” portion (a fluid flow portion) from a “brain” portion (a fluid containing portion). The porous membrane is seeded with endothelial cells such as the human venule endothelial cells (HUVECs) on the blood side, and with astrocytes on the brain side, to accurately model the blood-brain barrier. Fluid flows between the inlet, the center well, and the outlet to test the permeability of the porous membrane, thereby providing an accurate in vitro model of a blood-brain barrier.

Abstract: A method, apparatus, and system of optimizing transmission of data in a power domain non-orthogonal multiple access system is described. The method includes generating a first encoded data stream associated with a first user device, and generating a second encoded data stream associated with a second user device. The method also includes generating a superimposed signal using the first encoded data stream and the second encoded data stream. In addition, the method includes determining a first minimum beam power associated with a first beam vector, and determining a second minimum beam power associated with a second beam vector. The method also includes transmitting the superimposed signal to the first user device at the first minimum beam power, and transmitting the superimposed signal to the second user device at the second minimum beam power.

Abstract: A recombinant adeno-associated virus (rAAV) having an AAV8 capsid which is suitable for intra-retinal injection is provided herein. The rAAV comprises a vector genome packaged within the capsid which contains, operably linked to regulatory elements which direct expression of anti-human vascular endothelial growth factor (VEGF) antigen binding antibody fragment (aVEGF), a coding sequence for aVEGF, wherein the coding sequence is operably linked to regulatory elements which direct expression of the anti-VEGF Fab in the eye. Also provided herein are liquid suspensions containing these rAAV8.aVEGF and methods of using same for treatment of wet AMD and other ocular conditions.

Abstract: Pharmaceutical compositions comprising two or more therapeutically active agents, such as two or more anticancer agents, conjugated to one or more biocompatible polymers, wherein the molar ratio of the agents and/or schedules of delivery provide a synergistic therapeutic effect, are described. Methods of making and using the pharmaceutical compositions are further described. In one embodiment, the pharmaceutical compositions contain topoisomerase I and topoisomerase II inhibitors conjugated to the same or different biocompatible polymers. The two or more anticancer agents are covalently coupled to the polymer(s), and thereby can be delivered to a tumor at a molar ratio which provides a synergistic effect. Optionally, the agents are coupled indirectly to the polymer(s) via a linker.

Abstract: A nerve activity blocking system (100) includes a blocking electrode (102) configured to generate a blocking electrical signal that blocks, at least in part, an action potential propagating through a nerve system of a body. using a low frequency alternating current. The blocking electrical signal prevents propagation of the action potential by overriding another electrical signal controlling an organ of the body.

Abstract: Disclosed herein are UBAP2L targeting agents and use of such agents for the treatment of a neurodegenerative disorder. Further disclosed herein are methods of monitoring the progression of a neurodegenerative disorder and methods of determining the efficacy of a neurodegenerative disorder therapy.

Abstract: A hand-held device, such as a remote control, is provided for operation of a consumer appliance and is equipped with one or more biometric sensors to capture and report on the health condition of a user of the hand-held device. The data captured by such a hand-held device may be evaluated locally in the hand-held device itself or may be conveyed to a target consumer appliance either for local evaluation by that consumer appliance or for onward transmission to a central off-site monitoring service.

Abstract: A photothermal absorbance detection apparatus comprises a flow cell comprising a first temperature responsive device on an input side, a second temperature responsive device on an output side, and a detection region between the first temperature responsive device and the second temperature responsive device; and a light-emitting device positioned proximate to the detection region and configured to transmit electromagnetic radiation towards the detection region; wherein the first temperature responsive device and the second temperature responsive device together measure a change in temperature of a fluid passing through the detection region.

Abstract: An edge mount magnetic component includes a bobbin and two E-core halves. The bobbin is configured to receive the two E-core halves when body portions of the two E-core halves are positioned vertically. The bobbin includes a first outer flange, a second outer flange, and a passageway spanning therebetween. The bobbin further includes first, second, third, and fourth pin supports. The first and second pin supports are connected to an outer surface of the first end flange and are spaced apart by at least a width of the passageway. The third and fourth pin supports are connected to an outer surface of the second end flange and are spaced apart by at least the width of the passageway. The bobbin further includes slots for routing a winding to a pin and includes walls to ensure the winding is electrically separated from the E-core halves.

Abstract: A resampling method based on window function for flexible sampling rate conversion in broadband frequency measurement devices is described. The resampling algorithm can satisfy the requirements of different sampling rates. The frequency responses of the filter in the resampling model based on the Farrow structure are analyzed, and the design criterion of the filter in resampling model is considered. A fractional delay filter design model based on window function method is described. A fractional delay filter matrix, which is expressed by polynomial form, is constructed. Then the expression related to subfilter coefficients is obtained and subfilter coefficients are solved for by the least square method.

Abstract: Network wavefield imaging methods are able to image significantly complex discontinuities or shapes in plate-like structures for superior ultrasonic structural health monitoring (SHM)/nondestructive evaluation (NDE). The imaging provides high-resolution location, shape and/or size images of a structure, and for discontinuities with more complicated profiles. Guided wave (GW) network wavefield imaging methods combine tomography and wavefield/wavenumber imaging algorithms. Metallic plate damage detection uses guided ultrasonic waves and non-contact laser vibrometry. Guided waves are generated by piezoelectric transducers (PZT). A non-contact scanning laser Doppler vibrometer (SLDV) measures the full velocity plate guided wave wavefields. Developed network wavefield imaging algorithms account for multiple-actuator excitations from different angles enclosing the discontinuity, with algorithms using intrinsic wave characteristics such as wavefield, wavenumber, or reconstructed wave energy.

Abstract: Described herein are materials and methods useful for the treatment of neurodegenerative disorders and bone disorders, as well as healing wounds, in a subject. Materials described herein include polysaccharide digestive products resulting from the enzymatic hydrolysis of low acyl gellan gum. Also described herein are pharmaceutical compositions comprising one or more of such materials, and methods for their preparation and use.

Abstract: A method of modifying a retina fundus image for a deep learning model is disclosed. In a described embodiment, the method includes converting a retina fundus image to a binary image by converting pixels of the retina fundus image to low intensity modified pixels and high intensity modified pixels of the binary image, and determining a first boundary between the low intensity modified pixels and high intensity modified pixels of the binary image. The method further includes removing outlier boundary values from the first boundary, constructing a second boundary from remaining boundary values, identifying the pixels of the retina fundus image that are within the second boundary, and constructing a modified retina fundus image containing the identified pixels for a deep learning model.

Abstract: Disclosed herein are antisense oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA at the 5?-end of UBE3A-AS, which is downstream of SNORD115-45 snoRNA. Also disclosed are pharmaceutical compositions and methods for treatment of Angelman syndrome.

Abstract: Embodiments of the present disclosure provide for biaryl ligands (also referred to herein as “biaryl compound”), biaryl complexes, methods of making biaryl compounds, methods of making single enantiomers of these biaryl compounds, methods of use (e.g., catalysis), and the like.

Abstract: A system and method for controlling a device, such as a virtual reality (VR) and/or a prosthetic limb are provided. A biomimetic controller of the system comprises a signal processor and a musculoskeletal model. The signal processor processes M biological signals received from a residual limb to transform the M biological signals into N activation signals, where M and N are integers and M is less than N. The musculoskeletal model transforms the N activation signals into intended motion signals. A prosthesis controller transforms the intended motion signals into three or more control signals that are outputted from an output port of the prosthesis controller. A controlled device receives the control signals and performs one or more tasks in accordance with the control signals.

Abstract: The present invention discloses a hard rock roadway and tunnel boring machine with actively rotating hobs, including a rack provided with a crawler track unit. The rack is provided with a hydraulic power unit and a high-pressure abrasive jet generation system connected therewith. A transmission box is fixedly arranged at one of ends of the rack. The transmission box is provided with two input shafts and one output shaft. The input shafts are connected with planetary reduction mechanisms. Input ends of the planetary reduction mechanisms are connected with cantilever disc driving motors. A cantilever disc is fixed to the output shaft. Four cantilevers are hinged to the cantilever disc. Cantilever driving motors are further arranged on the cantilever disc. Actively rotating hob devices are arranged at ends of the cantilevers away from the cantilever disc. The transmission box is further provided with rotary sealing devices.