Abstract: Described herein, inter alia, are compositions of HER3 ligands and methods for treating diseases using the same.

Abstract: Materials and methods for treating major depressive disorder by modulating the aryl hydrocarbon receptor system are provided herein.

Abstract: Embodiments of a Flow Conditioning System (“FCS”) of this disclosure may be used for homogenizing a fluid containing a gas phase and a liquid phase. In some embodiments the FCS may be applied to a fluid containing hydrocarbons. The FCS may be located where appropriate, including but not limited to subsea. The FCS may be used for homogenizing slug flow. In embodiments, the FCS may be composed of an outer shroud pipe section, into which a concentric perforated smaller pipe is inserted at the top. The inlet slug flow regime is changed at the shroud section whereby the slugs are broken, transitioning to well-mixed flow regimes, such as bubbly flow or continuous churn flow. The bubbly or continuous churn flow that occur in the shroud section are forced to pass through the perforations of the perforated smaller diameter pipe, which promote a more thorough mixing of the phases upstream of devices such as multiphase pumps.

Abstract: This invention is directed to systems and methods that track a specified stored energy level profile for a BESS in a microgrid. The systems and methods including using a control algorithm that tracks the stored energy level profile for the BESS. The controller algorithm includes a Kalman Filter design for a model-based state reconstruction to overcome sensor/communication errors during real-time operation. The latter is important to guarantee the ability of the microgrid to continue its seamless operation during periods of erroneous sensor measurements or flawed communication.

Abstract: A system for a social media data provider to provide verification of a social media data query-result. The system receives a social media dataset from a social media network operator, receives a query about the social media dataset from a social media data consumer, queries the social media dataset based on the query and generate the query-result based thereon, generates verification information by which the social media data consumer is to verify a trustworthiness of the query-result, and provides the query-result and the verification information to the social media data consumer.

Abstract: Methods of preparing and using a metal-organic framework (MOF) are provided herein, including methods of using an MOF comprising a repeat unit of the formula [ML]n, wherein M is a divalent metal ion and L is a ligand of the formula: The MOFs provided herein may be used in the separation of two or more molecules from each other. In some embodiments, the molecules are ethylene and ethane. In some embodiments, UTSA-280 may be synthesized from calcium oxide (CaO) or calcium hydroxide (Ca(OH)2) and squaric acid (SA) through mechanochemical synthesis.

Abstract: A method for predicting formation permeability by measuring diffusional tortuosity in several directions by pulse gradient NMR. The method comprises evaluating an anisotropic diffusion coefficient by pulsed gradient NMR, determining diffusional tortuosity from the restricted diffusion data, supplementing the NMR results with resistivity and sonic logging data, measuring anisotropic tortuosity and porosity by resistivity and sonic data and combining all components in a single fitting model. The 11-coefficient model is trained to recognize the true values of permeability by comparing the real oil permeabilities measured in a library of oil-carrying rock cores with the NMR, resistivity and sonic correlates. The fitting coefficients are extracted by minimizing the discrepancy between the laboratory measured permeabilities and the predicted values combining all rapid logging information components with the agreement-maximizing weights.

Abstract: Compositions comprising multivariate metal-organic frameworks and other single-linker metal-organic frameworks are used for containing and storing a gas or fluid or for water harvesting or water purification applications.

Abstract: Embodiments disclose a system for determining a sensitivity of a networked system. The system identifies a vertex (V) that represents a constituent and a state of the constituent, and an interaction (E) between at least two Vs. An interaction-dependent function provides a probability that, when a perturbation occurs, a V will be in a certain state given that it is currently in a determined state and its neighbors are currently in determined states. A network reliability is used to determine a probability that a V's state holds when a perturbation occurs. The system evaluates only a certain amount of terms in a Taylor series from a sample, and identifies interpolating polynomials between the Taylor series. A cost function optimizes a property of the networked system for a fixed cost. The system perturbs the networked system until reliability is zero to estimate a sensitivity of the networked system.

Abstract: A method of preserving the one or more chemical and/or biological species in a polymer matrix comprising pullulan and trehalose is described. The method includes combining the one or more chemical and/or biological species, an aqueous pullulan and a trehalose solution and drying the resultant mixture to provide a solid polymeric matrix. A polymeric matrix comprising one or more chemical and/or biological species and its use, for example, on surfaces for food preparation, for food preservation and in biological preparations is also described.

Abstract: A method of performing a ritual of chucking during Hajj includes an authentication process, a connectivity process which connects a remote user to a chucking system located at the religious site, and a notification process. The authentication process allows a remote user, who is preferably a pilgrim unable to attend Hajj due to physical disability, age or sickness, to connect to the chucking system. The connectivity allows the pilgrim to perform the ritual of chucking remotely. To do so, the chucking system includes a primary pebble reservoir providing pebbles to a set of secondary pebble reservoirs, and a set of pebble projecting units. The remote user remotely connects to the set of pebble projecting units to chuck pebbles at the stoning sites, wherein the required pebbles are stored in the set of secondary pebble reservoirs. When chucking is complete, the remote user is notified regarding completion.

Abstract: The disclosure provides fusion proteins useful for detecting and quantifying cyclic dinucleotides. The fusion proteins can comprise a functional cyclic dinucleotide binding domain linked to a first fluorescent domain and a second fluorescent domain. The first fluorescent domain and a second fluorescent domain can produce a detectable signal when brought into sufficiently close proximity, such as a FRET pair or split luciferase. The fusion protein can be used to assay the presence and/or concentration of cyclic dinucleotides in vitro or in a cell. The method of use include monitoring the cyclic dinucleotide activity, or activity of cyclic dinucleotide synthases. Furthermore, the methods can include screening compounds that may modulate cyclic dinucleotide activity, production, importation, and the like.

Abstract: To provide a transplant-use tendon harvesting device that can harvest a tendon more easily. The transplant-use tendon harvesting device 1 includes a mantle portion 5 and a tendon separation element 8. The mantle portion 5 is configured to be inserted into a body from an incision portion 4 and moved along a tendon 3 to be harvested. The tendon separation element 8 is formed of an elastic member and attached to the mantle portion 5 to move along the tendon 3 together with the mantle portion 5 so as to separate an end portion of the tendon 3 on the moving direction side from another tissue. The tendon separation element 8 includes a separation functional portion 6 to cause the tendon 3 to pass inside at a time of moving along the tendon 3 to separate the tendon 3 and linear portions 11 and 12 inserted into the mantle portion 5 to be fixed.

Abstract: Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

Abstract: Control systems, apparatus, and methods for use with thrusters are disclosed. A disclosed propulsion system includes a PPT including circuitry configured to generate plasma from a propellant and a magnetic field that propels the plasma away from the PPT in an expulsion direction. The propulsion system also includes a sensor including a laser receiver and a laser transmitter that are positioned on the PPT. The laser receiver is configured to receive a signal from the laser transmitter. The propulsion system also includes a controller connected to the circuitry and the sensor. In response to the plasma interrupting the signal, the controller is configured to detect an observed parameter of the plasma via the sensor, calculate an observed thrust efficiency of the PPT based on the observed parameter, and modulate, via the circuitry, the magnetic field to maintain the observed thrust efficiency at a target thrust efficiency of the PPT.

Abstract: Continuous positive airway pressure (CPAP) devices and systems including patient-specific mandibular and nasal component, configured to deliver pressurized air to nasal and oral passageways of a subject. Mask-less and strap-less CPAP devices designed to provide dual delivery of continuous pressurized air to a mouth and nose of a subject. Methods of treating and ameliorating sleep apnea, hypopnea syndrome, and obstructive sleep apnea.

Abstract: Disclosed is a protective layer to protect a lithium metal negative electrode for a lithium secondary battery, in which the protective layer may inhibit formation of lithium dendrite and improve thermal/chemical stability, and conductivity of lithium ions. Further, disclosed are a production method of the protective layer, and a lithium secondary battery including the protectively layer. The protective layer contains a poly(arylene ether sulfone)-poly(ethylene glycol) graft copolymer represented by a following Chemical Formula 1: where, in the Chemical Formula 1, n is an integer of 60 to 80, and m is an integer of 40 to 45.

Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.

Abstract: The present disclosure relates to methods, apparatuses, and computer programs for processing computed tomography images. Precise segmentation of the left atrium (LA) in computed tomography (CT) images constitutes a crucial preparatory step for catheter ablation in atrial fibrillation (AF). We aim to apply deep convolutional neural networks (DCNNs) to automate the LA detection/segmentation procedure and create a three-dimensional (3D) geometries. The deep learning provides an efficient and accurate way for automatic contouring and LA volume calculation based on the construction of the 3D LA geometry. Non-pulmonary vein (NPV) trigger has been reported as an important predictor of recurrence post atrial fibrillation (AF) ablation. Elimination of NPV triggers can reduce the post-ablation AF recurrence. The deep learning was applied in pre-ablation pulmonary vein computed tomography (PVCT) geometric slices to create a prediction model for NPV triggers in patients with paroxysmal atrial fibrillation (PAF).

Abstract: Mixed ligand phosphinogold(I) complexes as anticancer agents. The gold(I) ion of the complexes is coordinated to a phosphine and a dithiocarbamate or halogen ligand. Also described are a pharmaceutical composition incorporating the phosphinogold(I) complex, a method of synthesizing the phosphinogold(I) complex, and a method of treating cancer. The phosphinogold(I) complexes exhibit potent cytotoxicity against lung, cervical, and liver cancer cells.