Abstract: The present disclosure provides pharmaceutical agents, including those of the formula: (I) wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents are also provided. The compounds may be used for the inhibition or antagonism of integrins ???1 and/or ?5?1. In some embodiments, the compounds provided herein exhibit reduced inhibitory or antagonistic activity of integrins ???3, ???5, ???6, ???8, and/or ?IIb?3.

Abstract: Described herein, inter alia, are peptide containing polymers, and methods of making and using the same.

Abstract: The present invention provides production of hydroxylated fatty acid by a hydration reaction using a novel enzyme derived from Lactobacillus and using fatty acid as a substrate, and further, a production method of oxo fatty acid by an enzyme reaction or chemical oxidation reaction using the hydroxylated fatty acid as a substrate. In addition, a valuable novel rare fatty acid obtained by such production method is also provided.

Abstract: An electro-hydraulic actuator includes a deformable shell defining an enclosed internal cavity and containing a liquid dielectric, first and second electrodes on first and second sides, respectively, of the enclosed internal cavity. An electrostatic force between the first and second electrodes upon application of a voltage to one of the electrodes draws the electrodes towards each other to displace the liquid dielectric within the enclosed internal cavity. The shell includes active and inactive areas such that the electrostatic forces between the first and second electrodes displaces the liquid dielectric within the enclosed internal cavity from the active area of the shell to the inactive area of the shell. The first and second electrodes, the deformable shell, and the liquid dielectric cooperate to form a self-healing capacitor, and the liquid dielectric is configured for automatically filling breaches in the liquid dielectric resulting from dielectric breakdown.

Abstract: A solar energy powered Stirling duplex cooler is presented which includes a Stirling engine and a Stirling cooler. The Stirling engine drives the Stirling cooler to produce cold temperatures for refrigeration or air conditioning. The Stirling duplex cooler includes a solar concentrator to focus high temperature solar radiation upon the Stirling engine expansion space. The Stirling duplex cooler further includes a thermal storage tank to receive and store heat rejected from the cooler expansion space. This stored heat is used to operate the cooler at night. A flywheel connected operatively to engine and cooler expansion space pistons and a crankshaft connected operatively to engine and cooler compression space pistons actuate the pistons to move a working fluid between the expansion and compression spaces.

Abstract: Disclosed are a system for predicting optical properties of molecules based on machine learning and a method thereof. More particularly, the system for predicting optical properties according to an embodiment includes a preprocessor that receives molecular information of a target molecule and surrounding molecules, and vectorizes the molecular information of a target molecule and surrounding molecules; a feature extractor that receives the vectorized information of the target molecule and surrounding molecules and extracts the features of the target molecule and surrounding molecules; an integrated feature extractor that receives both features of the target molecule and surrounding molecules and extract the integrated features of the target molecule and surrounding molecules by using an algorithm; and an optical property predictor that receives the integrated features of the target molecule and surrounding molecules and predicts optical properties of the target molecule affected by surrounding molecules.

Abstract: An information processing system includes a storage device that stores therein a trained model, and a processor. The trained model is trained to output a position and shape of an object in a training image based on training data. The training data is data in which the training image is provided with an annotation indicating the position and shape of the object. The training image is an image captured with an angle of view including the object whose position and shape are not clearly displayed in an image. The processor executes detection processing on a detection image to output detected information indicating the position and shape of the object. The processor then causes a display device to display the detected information superimposed on the detection image.

Abstract: The present disclosure discloses a wind-solar reactor system and a working method thereof. The wind-solar reactor system comprises a nuclear reactor system, a wind power generation system, a solar power storage system and a balance energy system, wherein the nuclear reactor system uses an integrated small modular reactor design, the solar power storage system uses a tower-type solar power storage system design, and a hydrogen production system uses a copper-chlorine cycle hydrogen production technology. A reactor keeps rated full-power operation, generated electricity is adjusted and distributed through a power controller, most of the electricity is used for smoothing the fluctuation of wind power generation, and the excess electricity is used for hydrogen storage of the hydrogen system. Solar power is used for heating saturated steam generated by the reactor into superheated steam through a heater, and then the superheated steam enters a high-pressure cylinder to do work by expansion.

Abstract: Processes and systems for electrochemical exfoliation that use a compression reactor and, more particularly, to processes and systems for electrochemical exfoliation of planar parent materials, such as graphite. A reactor for electrochemical exfoliation may include a container configured to hold an electrolyte solution. The reactor may further include a porous chamber, wherein the porous chamber is configured to hold a parent material in fluid communication with the electrolyte solution. The reactor may further include a pressure source positioned to apply a pressure along a length of the porous chamber to thereby compress the parent material in the porous chamber. The reactor may further include a first counter electrode. The reactor may further include a working electrode. The reactor may further include an electrical power source in electrical communication with the first counter electrode and the working electrode.

Abstract: A composition of matter useful in an electrolyte, comprising a polymer including: a repeat unit, the repeat unit including a backbone section; and a side chain attached to the backbone section, wherein the side chain includes a ligand moiety configured to ionically bond to a lithium ion. The polymer has a glass transition temperature (e.g., less than room temperature) wherein the polymer is in a solid state during operation of a lithium ion battery comprising an electrolyte including the polymer.

Abstract: The present invention provides a gradient material layer and a method for manufacturing the same. The gradient material layer has a base-material region, a diffusion region, and a compound region, wherein the diffusion region is located between the base-material region and the compound region. The base-material region includes a metal material. The diffusion region doped with nitrogen includes the metal material. The compound region includes metal nitride. The nitrogen content of the compound region is greater than that of the diffusion region.

Abstract: The present disclosure provides compositions and methods for promoting stem cell and/or progenitor cell proliferation and/or differentiation. The provided compositions may be useful in treating a disease or condition that is related to mucosal barrier function, e.g., wound healing, treating skin conditions (e.g., atopic dermatitis, psoriasis, bed sores, or condition related to the aging of skin), treating a lung disorders (e.g., asthma), a condition related to improving mucosal barrier function, and/or treating injury to GI mucosa in a subject in need thereof. The present disclosure also provides methods for promoting the proliferation and/or differentiation of stem cells and/or the progenitor cells in a subject in need of such treatment by administering a composition. The ability to stimulate the proliferation and/or differentiation of stem cells and/or the progenitor cells in vivo, ex vivo and/or in vitro provides tremendous benefit.

Abstract: Maillard reaction products produced by heating carbohydrates with one or more amino acids (e.g., lysine), at basic pH and for a selected reaction time at a particular concentration in solution, can exhibit inhibitory activity against Aggregatibacter actinomycetemcomitans.

Abstract: A family of platinum(II) complex with mixed ligands as anticancer agents. The platinum(II) ion is coordinated to dicyclopentadiene and dithiocarbamate ligands. Also described are a pharmaceutical composition incorporating the platinum(II) complex, a methods of synthesizing the platinum(II) complex, and a method of treating cancer. The platinum(II) complexes exhibit potent cytotoxicity against lung and cervical cancer cell lines as well as low nephrotoxicity.

Abstract: Systems and methods in accordance with embodiments of the invention implement all-microwave stabilized microresonator-based optical frequency comb. In one embodiment, an all-microwave stabilized microresonator-based optical frequency comb includes: an optical pump configured to generate pulses of light; a microresonator including an input configured to receive pulses generated by an optical pump and an output configured to generate an optical frequency comb signal characterized by frep and ?; where frep describes spacing of frequency components in the optical frequency comb; where the optical frequency comb includes a primary comb and a plurality of subcombs and ? is a frequency offset between subcombs; and two phase locked loops that phase lock frep and ? to low noise microwave oscillators by modulating output power and pump frequency of the optical pump.

Abstract: Disclosed herein are methods for treating or limiting development of cardiovascular disease-related neurological disorders by administering a compound of general formula (I), as defined herein.

Abstract: A method of diagnosing Alzheimer's disease and related dementias (ADRD) in a patient comprising obtaining a plasma sample from the patient; determining a level of a biochemical sulfide in the plasma sample from the subject by trapping volatilized H2S in the plasma sample using alkaline buffer with monobromobiamine, and detecting the level of biochemical sulfide in the plasma sample, the biochemical sulfide being one of acid-labile sulfide, bound sulfide, and total sulfide; and diagnosing the patient with ADRD when the level of the biochemical sulfide is at least an elevated threshold level for the biochemical sulfide.

Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's meta-bolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Abstract: The present invention relates to an antioxidant, skin-whitening and wrinkle-reducing multifunctional cosmetic composition containing a fermented rice by-product extract or a fraction thereof as an active ingredient. By using a fermented rice by-product extract or a fraction thereof according to the present invention, the total phenolic content of a rice by-product can be increased by means of fermentation, extraction and fractionation, and a cosmetic composition showing high antioxidant capability and excellent skin-whitening and wrinkle-reducing effects can be provided.

Abstract: Provided are 2-coordinate metal complexes compounds as sensitizers of fluorophores. Also provided are formulations comprising these 2-coordinate metal complexes compounds. Further provided are OLEDs and related consumer products that utilize these 2-coordinate metal complexes compounds. The OLED includes an emissive region that contains a first compound that is a sensitizer having a structure of Formula I: and an acceptor.