Abstract: An object of the present invention is to provide a therapeutic agent for hereditary spastic paraplegia (HSP) SPG4. Specifically, the present invention relates to a composition for preventing or treating a neurodegenerative disease such as hereditary spastic paraplegia SPG4, the composition comprising, as an active ingredient, a substance that inhibits a function of miR-33a.

Abstract: The present invention discloses a method for evaluating fracture connectivity and optimizing fracture parameters based on complex network theory, comprising the following steps: obtaining natural fracture distribution laws and characteristic parameters of the formation based on previous knowledge of natural fractures in the formation and statistical analysis of fractures in the core, and establishing a discrete fracture network model of natural fractures based on the previous step; setting up hydraulic fractures, determining intersection relations in the fracture network and coordinates of intersection points of fractures: converting the actual fracture network into a complex network dual topology diagram based on complex network theory, and calculating evaluative indexes of the complex network to realize the evaluation of fracture network connectivity; changing the hydraulic fracture parameters to get the evaluation indexes of different hydraulic fracture schemes.

Abstract: The present invention discloses a method for modeling sequence impedance of a modular multilevel converter (MMC) under phase locked loop (PLL) coupling. The method includes the following steps: S1, establishing a circuit topology model; S2, establishing a PLL output characteristic model; S3, establishing a PI controller output control small signal model under a dq axis; S4, deducing a modulation small signal; and S5, calculating MMC port impedance. According to the method, a precise MMC port impedance model is established by analyzing a double mirror frequency coupling effect in the output of a modulation signal in a control link caused by a phase angle disturbance and comprehensively considering the combination of the multi-harmonic coupling effect of an MMC.

Abstract: Embodiments of the invention employ frequency selective surfaces that resonate at defined frequencies depending on geometry. Tag-based embodiments allow the ability to have passive, battery-free, systems that can be used for applications including but not limited to inventory tracking, locating, and indoor radar (e.g. determining whether something labeled with a tag is in range of a particular wireless network signal). The shape of the resonator, among other available factors, influences the interference frequency. Embodiments may include metal based tags on a non-conductive material that will be used to disturb, for example, frequencies from 3 KHz to 300 GHz. These disturbances at specific resonant frequencies are useable to, for example, locate the tags/labels using WiFi Mapping, sending a WiFi signal and getting unique feedback on a router.

Abstract: Systems and methods for multimodal classification include a plurality of expert modules, each expert module configured to receive data corresponding to one of a plurality of input modalities and extract associated features, a plurality of class prediction modules, each class prediction module configured to receive extracted features from a corresponding one of the expert modules and predict an associated class, a gate expert configured to receive the extracted features from the plurality of expert modules and output a set of weights for the input modalities, and a fusion module configured to generate a weighted prediction based on the class predictions and the set of weights. Various embodiments include one or more of an image expert, a video expert, an audio expert, class prediction modules, a gate expert, and a co-learning framework.

Abstract: A process for the preparation of a granulated or pelletized weak anion exchange medium from a phenol-containing organic material like peat, followed by low-temperature torrefaction of the granules to produce a high degree of physical stability of the granules at high-pH conditions, followed by chemical pretreatment of the stable granule via a hydrolysis reaction, and optionally surface treatment with acids, followed by the main chemical treatment of the hydrolyzed granule via separate aldehyde and amine reagents, or alternatively via an adduct reagent like hexamethylenetetramine is provided by this invention. The weak anion exchange medium of this invention can be used in a variety of aqueous solution treatment processes, such as wastewater treatment for removing mineral acids like H2SO4, HNO3, HCl, HBr, HF, H3PO4, HI, or formic acid from the wastewater. The resulting anion exchanger medium is particularly useful for treating wastewaters in a low-pH environment.

Abstract: A hearing training device, is provided, including: a wearable device configured for being worn on the head of a user; a playing device arranged on the wearable device; an acupoint stimulation device, served as a physiotherapy device, comprising a plurality of acupoint stimulation mediums arranged on the wearable device, respectively configured for stimulating a plurality of acupoints on the head of the user and related to hearing, and arranged at the positions of the wearable device corresponding to the acupoints respectively; and a control device being in signal connection with the playing device and storing at least one music file, wherein the control device controls the playing device to play the music file, a beat is formed in an audio track of the music file, and the beat decreases with time, and is fixed until the beat is between 10 Hz and 15 Hz.

Abstract: A method for targeted delivery of cargo to a target locus in a subject and components of the system. Generally, the method includes administering to the subject a cell that has an artificial saccharide-derived target presented on the surface of the cell, allowing the cell to localize to a target locus in the subject, then administering to the subject an agent that specifically binds to the artificial target. In some embodiments, the agent can include a therapeutic compound. In some embodiments, the agent can include a detectable label. In some of these embodiments, that method can further include detecting the detectable label.

Abstract: Apparatus and method for photo-chemical oxidation are disclosed herein. In one embodiment, a system for treating a dialysis fluid includes: a nanostructured photo-electrochemical anode; a source of light configured to illuminate the photo-electrochemical anode; and a cathode that is permeable to oxygen provided to the dialysis fluid and non-permeable to a liquid of the dialysis fluid. The photo-electrochemical anode is configured to remove urea from the dialysis fluid by converting the urea in the dialysis fluid into oxidation products through a photo electrochemical reaction.

Abstract: Disclosed are a plane coding target and an image splicing system and method applying the same. The plane coding target comprises a plurality of coding units distributed in an array, the coding unit comprises one central coding point, a plurality of normal coding points and at least one positioning point, and a positioning point distribution style of the positioning point is used for determining coordinates of the central coding point and the normal coding points in a coding unit coordinate system; and coding numerical value sequences of the coding units are different from each other and unique. The plane coding target can realize large-area coding and positioning functions, and the image splicing system applying the plane coding target can solve the problems of splicing error and error accumulation caused by an identification error of a splicing location, thus realizing large-range, high-precision and short-time two-dimensional image splicing.

Abstract: Disclosed herein are flexible plasma applicators based on fibrous layers that are capable of rapidly sanitizing a surface via either direct or indirect contact with said surface.

Abstract: The invention provides UV-sensitive monomers, comprising a cyclopropenone-containing group, which acts as a masked dibenzocyclooctyne (DBCO)/dibenzoazocyclooctyne (DIBAC) group. The monomers of the invention can be polymerized for example via reversible addition fragmentation chain transfer (RAFT) polymerization techniques to yield a polymer comprising the masked DBCO/DIBAC group. In certain embodiments, the DBCO/DIBAC group can be unmasked under controlled conditions, allowing conjugation of small molecules and/or macromolecules to the polymer through highly selective and efficient strain-promoted azide alkyne click chemistry (SPAAC).

Abstract: Implantable sensors for determining bone health that can be utilized in conjunction with orthopedic implants are described. The sensors can include passive strain gauges or passive chemical sensors that can be read by radiographic imaging techniques. Sensors can be affixed to implantable support devices so as to non-invasively monitor the effect of load on the implant; for instance, to provide a quantitative assessment of when a fracture is sufficiently healed to allow safe weight-bearing upon the limb. Alternatively, sensors can monitor the health of a local implant area; for instance, to monitor the implant area of early stage infection or healing of a fusion procedure.

Abstract: A fall prevention device configured to be coupled to a person and comprising a mechanical torso configured to be coupled to the person's torso and a mechanical structure configurable to be coupled to the mechanical torso from its first end. The mechanical structure and mechanical torso resist forces at least along one direction to maintain their posture relative to each other. In operation the second end of the mechanical structure is positioned behind the person and substantially close to the ground. When the second end of the mechanical structure contacts the ground, contact points of legs of the person on the ground and contact points of the second end of the mechanical structure outline a multi-sided polygon on the ground. If the vertical projection of the center of gravity of the person to the ground intersects the ground within the multi-sided polygon, the person and fall prevention device remain stable.

Abstract: Wireless power transmission (WPT) systems are provided. For example, the WPT system can use one or more power transmitting coils and a receiver for electromagnetically coupled wireless power transfer. The electrodynamic receiver can be in the form of an electrodynamic transducer where a magnet is allowed to oscillate near a receiving coil to induce a voltage in the receiving coil, a piezoelectric transducer where the magnet causes a vibrating structure with a piezoelectric layer to move, an electrostatic transducer where movement of the magnet causes a capacitor plate to move, or a combination thereof. An alternating magnetic field from the transmitting coil(s) excites the magnet in the receiver into mechanical resonance. The vibrating magnet then functions similar to an energy harvester to induce voltage/current on an internal coil, piezoelectric material, or variable capacitor.

Abstract: Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.

Abstract: A camera orientation control system for changing one or more camera orientations of one or more cameras towards a potential incident that is not currently in a field of view of the one or more cameras. The camera control system processes image frames for head orientation extraction, determines an amount of synchronous alignment in a proportion of head objects of the head objects to computationally assess that they are towards a new direction, and controls at least one camera to move the field of view of at least one camera of the one or more cameras towards the new direction. The system is useful for incident detection and extending or augmenting the capabilities of CCTV infrastructure.

Abstract: A system and method is presented for cuff-less blood pressure measurement in a mobile device. A key aspect of this disclosure is the discovery of a new location for blood pressure measurement at the fingertip of a subject and that reflectance-mode photoplethysmography can be used to help make this measurement. Through experiments in human subjects, it was discovered that it is indeed possible to measure systemic blood pressure by having a subject press the fingertip against a reflectance-mode photo-plethysmography-force sensor unit under visual guidance and then compute blood pressure from the resulting variable-amplitude blood volume oscillations and applied pressure via an oscillometric algorithm.

Abstract: Disclosed herein is a method for controlling nematode populations, particularly soil nematode populations. Certain embodiments comprise applying 4-hydroxybenzylalcohol, Sinapis alba plant extract, Sinapis alba seed meal, or a combination thereof, to soil, optionally in the presence of a trap crop. A hatching factor and/or a nematicide may also be applied to the soil, either substantially simultaneously with the 4-hydroxybenzyl alcohol, Sinapis alba plant extract, Sinapis alba seed meal, or combination thereof, or sequentially in any order. Certain embodiments concern applying 4-hydroxybenzyl alcohol to soil that contains potato cyst nematode eggs. The 4-hydroxybenzyl alcohol may be obtained by an aqueous extraction of Sinapis alba plant material.