Patents Assigned to University
  • Publication number: 20210355548
    Abstract: The present invention relates to systems, devices and methods for diagnosing cancer. In various embodiments, the present invention provides a method for performing sequencing of 5?-htRNA in an RNA sample including obtaining a DNA library of 5?-htRNA and sequencing the DNA library of 5?-htRNAs in the RNA sample. The invention also teaches a method for quantifying 5?-htRNA half molecules in an RNA sample including (a) treating an RNA sample containing 5?-htRNAs half molecules having a 3? cyclic phosphate with a T4 polynucleotide kinase to form 3?-dephosphrylated 5?-tRNA halves, (b) 3?-AD ligating the 3?-dephosphrylated 5?-tRNA halves to form ligated RNA products, and (c) quantifying the ligated RNA products by RT-qPCR using a plurality of target primers and probes configured to simultaneously quantify at least two cP-containing 5?-tRNA half species. The treating of step (a) is simultaneously performed as one step in a single tube with the 3?-AD ligating of step (b).
    Type: Application
    Filed: May 6, 2021
    Publication date: November 18, 2021
    Applicant: Thomas Jefferson University
    Inventors: Yohei Kirino, Shozo Honda, Megumi Shigematsu
  • Publication number: 20210355499
    Abstract: The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 18, 2021
    Applicant: University of Maryland, College Park
    Inventor: Anne Elizabeth Simon
  • Publication number: 20210356361
    Abstract: Systems and methods are provided for fault detection in a component of a machine during operation. Vibration data is acquired based on a vibration signal output from a sensor associated with the component. The vibration data is analyzed with at least two machine learning models to predict a condition of the component.
    Type: Application
    Filed: April 20, 2021
    Publication date: November 18, 2021
    Applicants: Deere & Company, Iowa State University Research Foundation
    Inventors: Shawn A. Kenny, Jeffrey S. Sidon, Sriram Krishnaswamy, Mohammad Kazem Sadoughi, Hao Lu, Chao Hu
  • Publication number: 20210355492
    Abstract: The application relates to extracellular vesicles derived from red blood cells and particularly, although not exclusively, extracellular vesicles derived from red blood cells containing a cargo. The cargo may comprise small molecules, proteins, nucleic acids or components of the CRISPR/Cas9 gene editing system. The extracellular vesicles derived from red blood cells may be used in the treatment of medical disorders such as a genetic disorder, inflammatory disease, cancer, autoimmune disorder, cardiovascular disease or a gastrointestinal disease. Also provided is a method for loading the cargo into the extracellular vesicles derived from red blood cells by electroporation.
    Type: Application
    Filed: December 6, 2018
    Publication date: November 18, 2021
    Applicant: City University of Hong Kong
    Inventors: Jiahai Shi, Thi Nguyet Minh Le, Waqas Muhammad Usman
  • Publication number: 20210353564
    Abstract: The present disclosure is directed to methods of treating Zika virus infections using selective estrogen receptor modulators (SERMs), such as Tamoxifen, or a compound selected from CALP-1, A7, PMA, Chelerythrine, PHTPP, Tariquidar or S-Equol.
    Type: Application
    Filed: October 28, 2019
    Publication date: November 18, 2021
    Applicant: Saint Louis University
    Inventors: Christopher ARNATT, James BRIEN, Amelia PINTO
  • Publication number: 20210355443
    Abstract: Provided herein are methods for the production of tissue resident memory-like T cells by the combination of hypoxia and TGF?. Further provided herein are methods of using the tissue resident memory T cells as adoptive cell therapy.
    Type: Application
    Filed: October 18, 2019
    Publication date: November 18, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Cassian YEE, Farah HASAN
  • Publication number: 20210353769
    Abstract: The invention relates to surface modified extracellular vesicles, wherein the extracellular vesicles comprise an exogenous polypeptide tag that is covalently linked to a membrane protein of the extracellular vesicles. In a particular embodiment, the tag is covalently linked to the membrane protein of microvesicles by sortase-mediated ligation. Methods of preparing said extracellular vesicles and methods of using said extracellular vesicles loaded with therapeutic molecules for treating a disease are also disclosed herein.
    Type: Application
    Filed: September 20, 2019
    Publication date: November 18, 2021
    Applicant: City University of Hong Kong
    Inventors: Jiahai Shi, Thi Nguyet Minh Le, Likun Wei, Chanh Tin Pham, Waqas Muhammad Usman, Migara Kavishka Jayasinghe
  • Publication number: 20210353686
    Abstract: The purpose of the present invention is to provide a novel method for making it possible to efficiently induce/produce endocrine cells from pluripotent stem cells. Insulin-producing cells including cells that are insulin-positive and NKX6.1-positive cells in a ratio of at least 30% and cells that are insulin-positive and NKX6.1-negative in a ratio of more than 15%.
    Type: Application
    Filed: September 18, 2019
    Publication date: November 18, 2021
    Applicants: Takeda Pharmaceutical Company Limited, Kyoto University
    Inventors: Ryo ITO, Noriko YAMAZOE, Hideyuki HIYOSHI, Taisuke MOCHIDA, Hikaru UENO, Kensuke SAKUMA, Junji YAMAURA, Hirokazu MATSUMOTO, Taro TOYODA, Shuhei KONAGAYA
  • Publication number: 20210359668
    Abstract: A narrow pulse generation circuit used in a sequential equivalent sampling system. The circuit comprises a crystal oscillator, an edge sharpening circuit, an avalanche transistor single-tube amplifying circuit and a shaping network connected in sequence, wherein the edge sharpening circuit is used for carrying out edge sharpening on a square wave signal generated by the crystal oscillator; the avalanche transistor single-tube amplifying circuit is used for carrying out avalanche amplification on the sharpened square wave signal to generate a Gaussian pulse signal to adjust the amplitude of a pulse; and the RC shaping network is used for shaping the Gaussian pulse signal to adjust the pulse width at the bottom of the pulse to form a narrow pulse signal. The narrow pulse circuit has a simple structure and narrow pulse width at the bottom and facilitates increasing a signal-to-noise ratio of a whole sequential sampling system.
    Type: Application
    Filed: January 14, 2019
    Publication date: November 18, 2021
    Applicant: Nantong Institute of Nanjing University of Posts and Telecommunications Co.,Ltd.
    Inventors: Zhikuang CAI, Xuanchen QI, Wenhua LIN, Guowei SHI, Jian XIAO, Yufeng GUO
  • Publication number: 20210358647
    Abstract: A machine-learning tool learns from sensors' data of a nuclear reactor at steady state and maps them to controls of the nuclear reactor. The tool learns all given ranges of normal operation and responses for corrective measures. The tool may train another learning tool (or the same tool) that forecasts the behavior of the reactor based on real-time changes (e.g., every 10 seconds). The tool implements an optimization technique for differing half-life materials to be placed in the reactor. The tool maximizes isotope production based on optimal controls of the reactor.
    Type: Application
    Filed: April 21, 2021
    Publication date: November 18, 2021
    Applicant: Oregon State University
    Inventors: Steven R. Reese, Ophir Frieder, Mario Enrique Gomez Fernandez
  • Publication number: 20210352944
    Abstract: The invention relates to a non-bitter low-sodium salt containing diet fiber carrageenan, a method for preparing the same and an application thereof. The non-bitter low-sodium salt containing diet fiber carrageenan is a solid salt and is prepared from 40-60 portion by weight of sodium chloride, 40-60 portion by weight of potassium chloride and 4-18 portion by weight of kappa-carrageenan by performing dissolving, mixing, drying, grinding and sieving. According to the invention, based on the mechanism that sulfate groups on kappa-carrageenan molecules can specifically bind to potassium ions, kappa-carrageenan is added to chelate potassium ions, thereby effectively masking the bitter taste of potassium chloride and significantly enhancing the salty taste of low-sodium salt as compared with the prior art. Carrageenan used in the invention is a common food additive which is easily available and cost-effective, so that the invention has good prospect in industrial popularization.
    Type: Application
    Filed: July 29, 2021
    Publication date: November 18, 2021
    Applicant: Shanghai Jiao Tong University
    Inventors: Yapeng FANG, Wei LU, Cuixia SUN, Yiguo ZHAO, Xuelian ZHOU
  • Publication number: 20210357630
    Abstract: Disclosed are a system and method for quantifying changes in animal posture from video recordings of multiple interacting animals. Also disclosed are a system and method for training a posture identification algorithm efficiently with minimal human effort and evaluating the posture of millions of animal images. The disclosed process employs video recordings of behaving animals to produce a full set of geometrical coordinates for each body part over time. Inter alia, the disclosed system should be useful for organizations interested in doing large small-molecule screens to find drugs that affect the behavior of animals, and for those investigating new behavioral diagnostics for human patients. The disclosed system allows one to record video of animals and then automatically calculate the position of each body part over time. The output of this calculation can be used for simple analysis of the amount of movement for specific body parts, or part of a more complex scheme for measuring behaviors.
    Type: Application
    Filed: October 4, 2019
    Publication date: November 18, 2021
    Applicant: The Trustees of Princeton University
    Inventors: Joshua W. Shaevitz, Mala Murthy, Talmo D. Pereira, Diego E. Aldarondo
  • Publication number: 20210355007
    Abstract: A system for predicting an effluent parameter associated with a wastewater treatment process including a predictor module configured to receive a first input dataset comprising a plurality of wastewater inflow parameters to predict a biodegradable type of effluent wastewater; a mechanistic simulator configured to receive the biodegradable type of effluent wastewater and the plurality of wastewater inflow parameters as a second input dataset to predict the effluent parameter.
    Type: Application
    Filed: December 13, 2018
    Publication date: November 18, 2021
    Applicants: SEMBCORP INDUSTRIES LTD., National University of Singapore
    Inventors: Ching Kwek POOI, How Yong NG, Xueqing SHI, Adrian Piah Song YEO, Wangdong NI
  • Publication number: 20210357476
    Abstract: The present invention relates to computing-implemented method and system that improves matrix multiplication efficiency, especially to method and system optimizing matrix multiplication using sparse basis approach. Matrices to be multiplied are organized into specially ordered vectors with zero values, facilitates speed up during linear combination computation or synthesis process.
    Type: Application
    Filed: May 12, 2020
    Publication date: November 18, 2021
    Applicant: National Cheng Kung University
    Inventors: Gwo Giun Lee, Shih-Yu Chen
  • Publication number: 20210357434
    Abstract: Embodiments may provide a cache for query results that can adapt the cache-space utilization to the popularity of the various topics represented in the query stream. For example, a method for query processing may perform receiving a plurality of queries for data and requesting data responsive to at least one query from a data cache comprising a temporal cache, wherein the temporal cache is configured to store data based on a topic associated with the data and is configured to retrieve data based on a topic, and wherein the data cache is configured to retrieve data responsive to at least one query from the computer system.
    Type: Application
    Filed: July 21, 2021
    Publication date: November 18, 2021
    Applicant: Georgetown University
    Inventors: Ophir Frieder, Ida Mele, Raffaele Perego, Nicola Tonellotto
  • Publication number: 20210359420
    Abstract: A low-sidelobe plate array antenna includes a radiation layer and a feed layer. The radiation layer is superimposed on the feed layer and includes a first plate and a radiation array disposed on the first plate. The radiation array is formed by n2 radiation units which are distributed in 2(k-1) rows and 2(k-1) columns. Each radiation unit in the radiation layer is constituted by two first radiation assemblies and two second radiation assemblies. Each first radiation assembly comprises a first rectangular bar, a first rectangular cavity, a second rectangular cavity and a third rectangular cavity. The first rectangular cavity, the second rectangular cavity and the third rectangular cavity in the first radiation assembly are stacked in presence of an azimuth deviation to form a three-layer coupled structure, and the first rectangular bar located in the first rectangular cavity can better restrain cross polarization and reduce the sidelobe.
    Type: Application
    Filed: December 7, 2020
    Publication date: November 18, 2021
    Applicant: Ningbo University
    Inventors: Yang YOU, Jifu HUANG, Ling Zhang, Qingchun YOU, Yunlong Lu
  • Patent number: 11175641
    Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to obtain a system of nonlinear equations characterizing a physical system, to construct a flexible embedded system from the system of nonlinear equations, wherein the flexible embedded system is configurable with any of a plurality of arbitrary reference states as respective starting points, to utilize the flexible embedded system to generate at least one output providing a solution to the system of nonlinear equations, and to establish one or more operating parameters of the physical system based at least in part on the output generated utilizing the flexible embedded system. The physical system is configured in accordance with the one or more established operating parameters. The physical system in some embodiments illustratively comprises an electric power system, an integrated circuit, or another type of electrical or electronic system or circuit.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: November 16, 2021
    Assignee: Cornell University
    Inventors: Hsiao-Dong Chiang, Tao Wang
  • Patent number: 11177398
    Abstract: A silicon solar cell with high photoelectric conversion efficiency is disclosed. A solar cell for converting light incident from an outside into electricity according to the present invention includes a substrate, a lower electrode, a ferroelectric layer, an auxiliary electrode, a first conductivity-type semiconductor layer, a second conductivity-type semiconductor layer, and an upper electrode. The lower electrode is formed on the substrate. The ferroelectric layer is formed on the substrate and outside the lower electrode. The auxiliary electrode is formed on the ferroelectric layer. The first conductivity-type semiconductor layer is formed on the lower electrode and the auxiliary electrode. The second conductivity-type semiconductor layer is formed on the first conductivity-type semiconductor layer, and is composed of a semiconductor of a second conductivity type opposite to a first conductivity type.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: November 16, 2021
    Assignee: University of Seoul Industry Cooperation Foundation
    Inventor: Byung-Eun Park
  • Patent number: 11176960
    Abstract: A system for distinguishing between a human voice generated command and an electronic speaker generated command is provided. An exemplary system comprises a microphone array for receiving an audio signal collection, preprocessing circuitry configured for converting the audio signal collection into processed recorded audio signals, energy balance metric determination circuitry configured for calculating a final energy balance metric based on the processed recorded audio signals, and energy balance metric evaluation circuitry for outputting a command originator signal based at least in part on the final energy balance metric.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: November 16, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Patrick G. Traynor, Logan E. Blue, Luis Vargas
  • Patent number: 11174201
    Abstract: Carbon dioxide and ash are two major waste by-products from coal fire production. Presented herein is are methods, material, and devices for storing carbon using high ash-content building material. The idea is to generate materials with commercial values to offset the cost for carbon capture. Ash with alkali activator (geopolymer) concrete has been studied extensively for its superior performance (higher strength) than ordinary Portland cement (OPC) concrete. However, most geopolymer concrete needs energy input in the forms of pressure and heat, which in turn are usually based on electricity produced through power plants.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: November 16, 2021
    Assignee: The University of North Carolina at Charlotte
    Inventor: Shen-En Chen