Patents Assigned to University
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Publication number: 20210355548Abstract: The present invention relates to systems, devices and methods for diagnosing cancer. In various embodiments, the present invention provides a method for performing sequencing of 5?-htRNA in an RNA sample including obtaining a DNA library of 5?-htRNA and sequencing the DNA library of 5?-htRNAs in the RNA sample. The invention also teaches a method for quantifying 5?-htRNA half molecules in an RNA sample including (a) treating an RNA sample containing 5?-htRNAs half molecules having a 3? cyclic phosphate with a T4 polynucleotide kinase to form 3?-dephosphrylated 5?-tRNA halves, (b) 3?-AD ligating the 3?-dephosphrylated 5?-tRNA halves to form ligated RNA products, and (c) quantifying the ligated RNA products by RT-qPCR using a plurality of target primers and probes configured to simultaneously quantify at least two cP-containing 5?-tRNA half species. The treating of step (a) is simultaneously performed as one step in a single tube with the 3?-AD ligating of step (b).Type: ApplicationFiled: May 6, 2021Publication date: November 18, 2021Applicant: Thomas Jefferson UniversityInventors: Yohei Kirino, Shozo Honda, Megumi Shigematsu
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Publication number: 20210355499Abstract: The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant.Type: ApplicationFiled: May 11, 2021Publication date: November 18, 2021Applicant: University of Maryland, College ParkInventor: Anne Elizabeth Simon
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Publication number: 20210356361Abstract: Systems and methods are provided for fault detection in a component of a machine during operation. Vibration data is acquired based on a vibration signal output from a sensor associated with the component. The vibration data is analyzed with at least two machine learning models to predict a condition of the component.Type: ApplicationFiled: April 20, 2021Publication date: November 18, 2021Applicants: Deere & Company, Iowa State University Research FoundationInventors: Shawn A. Kenny, Jeffrey S. Sidon, Sriram Krishnaswamy, Mohammad Kazem Sadoughi, Hao Lu, Chao Hu
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Publication number: 20210355492Abstract: The application relates to extracellular vesicles derived from red blood cells and particularly, although not exclusively, extracellular vesicles derived from red blood cells containing a cargo. The cargo may comprise small molecules, proteins, nucleic acids or components of the CRISPR/Cas9 gene editing system. The extracellular vesicles derived from red blood cells may be used in the treatment of medical disorders such as a genetic disorder, inflammatory disease, cancer, autoimmune disorder, cardiovascular disease or a gastrointestinal disease. Also provided is a method for loading the cargo into the extracellular vesicles derived from red blood cells by electroporation.Type: ApplicationFiled: December 6, 2018Publication date: November 18, 2021Applicant: City University of Hong KongInventors: Jiahai Shi, Thi Nguyet Minh Le, Waqas Muhammad Usman
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Publication number: 20210353564Abstract: The present disclosure is directed to methods of treating Zika virus infections using selective estrogen receptor modulators (SERMs), such as Tamoxifen, or a compound selected from CALP-1, A7, PMA, Chelerythrine, PHTPP, Tariquidar or S-Equol.Type: ApplicationFiled: October 28, 2019Publication date: November 18, 2021Applicant: Saint Louis UniversityInventors: Christopher ARNATT, James BRIEN, Amelia PINTO
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Publication number: 20210355443Abstract: Provided herein are methods for the production of tissue resident memory-like T cells by the combination of hypoxia and TGF?. Further provided herein are methods of using the tissue resident memory T cells as adoptive cell therapy.Type: ApplicationFiled: October 18, 2019Publication date: November 18, 2021Applicant: Board of Regents, The University of Texas SystemInventors: Cassian YEE, Farah HASAN
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Publication number: 20210353769Abstract: The invention relates to surface modified extracellular vesicles, wherein the extracellular vesicles comprise an exogenous polypeptide tag that is covalently linked to a membrane protein of the extracellular vesicles. In a particular embodiment, the tag is covalently linked to the membrane protein of microvesicles by sortase-mediated ligation. Methods of preparing said extracellular vesicles and methods of using said extracellular vesicles loaded with therapeutic molecules for treating a disease are also disclosed herein.Type: ApplicationFiled: September 20, 2019Publication date: November 18, 2021Applicant: City University of Hong KongInventors: Jiahai Shi, Thi Nguyet Minh Le, Likun Wei, Chanh Tin Pham, Waqas Muhammad Usman, Migara Kavishka Jayasinghe
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Publication number: 20210353686Abstract: The purpose of the present invention is to provide a novel method for making it possible to efficiently induce/produce endocrine cells from pluripotent stem cells. Insulin-producing cells including cells that are insulin-positive and NKX6.1-positive cells in a ratio of at least 30% and cells that are insulin-positive and NKX6.1-negative in a ratio of more than 15%.Type: ApplicationFiled: September 18, 2019Publication date: November 18, 2021Applicants: Takeda Pharmaceutical Company Limited, Kyoto UniversityInventors: Ryo ITO, Noriko YAMAZOE, Hideyuki HIYOSHI, Taisuke MOCHIDA, Hikaru UENO, Kensuke SAKUMA, Junji YAMAURA, Hirokazu MATSUMOTO, Taro TOYODA, Shuhei KONAGAYA
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Publication number: 20210359668Abstract: A narrow pulse generation circuit used in a sequential equivalent sampling system. The circuit comprises a crystal oscillator, an edge sharpening circuit, an avalanche transistor single-tube amplifying circuit and a shaping network connected in sequence, wherein the edge sharpening circuit is used for carrying out edge sharpening on a square wave signal generated by the crystal oscillator; the avalanche transistor single-tube amplifying circuit is used for carrying out avalanche amplification on the sharpened square wave signal to generate a Gaussian pulse signal to adjust the amplitude of a pulse; and the RC shaping network is used for shaping the Gaussian pulse signal to adjust the pulse width at the bottom of the pulse to form a narrow pulse signal. The narrow pulse circuit has a simple structure and narrow pulse width at the bottom and facilitates increasing a signal-to-noise ratio of a whole sequential sampling system.Type: ApplicationFiled: January 14, 2019Publication date: November 18, 2021Applicant: Nantong Institute of Nanjing University of Posts and Telecommunications Co.,Ltd.Inventors: Zhikuang CAI, Xuanchen QI, Wenhua LIN, Guowei SHI, Jian XIAO, Yufeng GUO
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Publication number: 20210358647Abstract: A machine-learning tool learns from sensors' data of a nuclear reactor at steady state and maps them to controls of the nuclear reactor. The tool learns all given ranges of normal operation and responses for corrective measures. The tool may train another learning tool (or the same tool) that forecasts the behavior of the reactor based on real-time changes (e.g., every 10 seconds). The tool implements an optimization technique for differing half-life materials to be placed in the reactor. The tool maximizes isotope production based on optimal controls of the reactor.Type: ApplicationFiled: April 21, 2021Publication date: November 18, 2021Applicant: Oregon State UniversityInventors: Steven R. Reese, Ophir Frieder, Mario Enrique Gomez Fernandez
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Publication number: 20210352944Abstract: The invention relates to a non-bitter low-sodium salt containing diet fiber carrageenan, a method for preparing the same and an application thereof. The non-bitter low-sodium salt containing diet fiber carrageenan is a solid salt and is prepared from 40-60 portion by weight of sodium chloride, 40-60 portion by weight of potassium chloride and 4-18 portion by weight of kappa-carrageenan by performing dissolving, mixing, drying, grinding and sieving. According to the invention, based on the mechanism that sulfate groups on kappa-carrageenan molecules can specifically bind to potassium ions, kappa-carrageenan is added to chelate potassium ions, thereby effectively masking the bitter taste of potassium chloride and significantly enhancing the salty taste of low-sodium salt as compared with the prior art. Carrageenan used in the invention is a common food additive which is easily available and cost-effective, so that the invention has good prospect in industrial popularization.Type: ApplicationFiled: July 29, 2021Publication date: November 18, 2021Applicant: Shanghai Jiao Tong UniversityInventors: Yapeng FANG, Wei LU, Cuixia SUN, Yiguo ZHAO, Xuelian ZHOU
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Publication number: 20210357630Abstract: Disclosed are a system and method for quantifying changes in animal posture from video recordings of multiple interacting animals. Also disclosed are a system and method for training a posture identification algorithm efficiently with minimal human effort and evaluating the posture of millions of animal images. The disclosed process employs video recordings of behaving animals to produce a full set of geometrical coordinates for each body part over time. Inter alia, the disclosed system should be useful for organizations interested in doing large small-molecule screens to find drugs that affect the behavior of animals, and for those investigating new behavioral diagnostics for human patients. The disclosed system allows one to record video of animals and then automatically calculate the position of each body part over time. The output of this calculation can be used for simple analysis of the amount of movement for specific body parts, or part of a more complex scheme for measuring behaviors.Type: ApplicationFiled: October 4, 2019Publication date: November 18, 2021Applicant: The Trustees of Princeton UniversityInventors: Joshua W. Shaevitz, Mala Murthy, Talmo D. Pereira, Diego E. Aldarondo
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Publication number: 20210355007Abstract: A system for predicting an effluent parameter associated with a wastewater treatment process including a predictor module configured to receive a first input dataset comprising a plurality of wastewater inflow parameters to predict a biodegradable type of effluent wastewater; a mechanistic simulator configured to receive the biodegradable type of effluent wastewater and the plurality of wastewater inflow parameters as a second input dataset to predict the effluent parameter.Type: ApplicationFiled: December 13, 2018Publication date: November 18, 2021Applicants: SEMBCORP INDUSTRIES LTD., National University of SingaporeInventors: Ching Kwek POOI, How Yong NG, Xueqing SHI, Adrian Piah Song YEO, Wangdong NI
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Publication number: 20210357476Abstract: The present invention relates to computing-implemented method and system that improves matrix multiplication efficiency, especially to method and system optimizing matrix multiplication using sparse basis approach. Matrices to be multiplied are organized into specially ordered vectors with zero values, facilitates speed up during linear combination computation or synthesis process.Type: ApplicationFiled: May 12, 2020Publication date: November 18, 2021Applicant: National Cheng Kung UniversityInventors: Gwo Giun Lee, Shih-Yu Chen
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Publication number: 20210357434Abstract: Embodiments may provide a cache for query results that can adapt the cache-space utilization to the popularity of the various topics represented in the query stream. For example, a method for query processing may perform receiving a plurality of queries for data and requesting data responsive to at least one query from a data cache comprising a temporal cache, wherein the temporal cache is configured to store data based on a topic associated with the data and is configured to retrieve data based on a topic, and wherein the data cache is configured to retrieve data responsive to at least one query from the computer system.Type: ApplicationFiled: July 21, 2021Publication date: November 18, 2021Applicant: Georgetown UniversityInventors: Ophir Frieder, Ida Mele, Raffaele Perego, Nicola Tonellotto
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Publication number: 20210359420Abstract: A low-sidelobe plate array antenna includes a radiation layer and a feed layer. The radiation layer is superimposed on the feed layer and includes a first plate and a radiation array disposed on the first plate. The radiation array is formed by n2 radiation units which are distributed in 2(k-1) rows and 2(k-1) columns. Each radiation unit in the radiation layer is constituted by two first radiation assemblies and two second radiation assemblies. Each first radiation assembly comprises a first rectangular bar, a first rectangular cavity, a second rectangular cavity and a third rectangular cavity. The first rectangular cavity, the second rectangular cavity and the third rectangular cavity in the first radiation assembly are stacked in presence of an azimuth deviation to form a three-layer coupled structure, and the first rectangular bar located in the first rectangular cavity can better restrain cross polarization and reduce the sidelobe.Type: ApplicationFiled: December 7, 2020Publication date: November 18, 2021Applicant: Ningbo UniversityInventors: Yang YOU, Jifu HUANG, Ling Zhang, Qingchun YOU, Yunlong Lu
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Patent number: 11175641Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to obtain a system of nonlinear equations characterizing a physical system, to construct a flexible embedded system from the system of nonlinear equations, wherein the flexible embedded system is configurable with any of a plurality of arbitrary reference states as respective starting points, to utilize the flexible embedded system to generate at least one output providing a solution to the system of nonlinear equations, and to establish one or more operating parameters of the physical system based at least in part on the output generated utilizing the flexible embedded system. The physical system is configured in accordance with the one or more established operating parameters. The physical system in some embodiments illustratively comprises an electric power system, an integrated circuit, or another type of electrical or electronic system or circuit.Type: GrantFiled: July 26, 2019Date of Patent: November 16, 2021Assignee: Cornell UniversityInventors: Hsiao-Dong Chiang, Tao Wang
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Patent number: 11177398Abstract: A silicon solar cell with high photoelectric conversion efficiency is disclosed. A solar cell for converting light incident from an outside into electricity according to the present invention includes a substrate, a lower electrode, a ferroelectric layer, an auxiliary electrode, a first conductivity-type semiconductor layer, a second conductivity-type semiconductor layer, and an upper electrode. The lower electrode is formed on the substrate. The ferroelectric layer is formed on the substrate and outside the lower electrode. The auxiliary electrode is formed on the ferroelectric layer. The first conductivity-type semiconductor layer is formed on the lower electrode and the auxiliary electrode. The second conductivity-type semiconductor layer is formed on the first conductivity-type semiconductor layer, and is composed of a semiconductor of a second conductivity type opposite to a first conductivity type.Type: GrantFiled: February 12, 2016Date of Patent: November 16, 2021Assignee: University of Seoul Industry Cooperation FoundationInventor: Byung-Eun Park
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Patent number: 11176960Abstract: A system for distinguishing between a human voice generated command and an electronic speaker generated command is provided. An exemplary system comprises a microphone array for receiving an audio signal collection, preprocessing circuitry configured for converting the audio signal collection into processed recorded audio signals, energy balance metric determination circuitry configured for calculating a final energy balance metric based on the processed recorded audio signals, and energy balance metric evaluation circuitry for outputting a command originator signal based at least in part on the final energy balance metric.Type: GrantFiled: June 18, 2019Date of Patent: November 16, 2021Assignee: University of Florida Research Foundation, IncorporatedInventors: Patrick G. Traynor, Logan E. Blue, Luis Vargas
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Patent number: 11174201Abstract: Carbon dioxide and ash are two major waste by-products from coal fire production. Presented herein is are methods, material, and devices for storing carbon using high ash-content building material. The idea is to generate materials with commercial values to offset the cost for carbon capture. Ash with alkali activator (geopolymer) concrete has been studied extensively for its superior performance (higher strength) than ordinary Portland cement (OPC) concrete. However, most geopolymer concrete needs energy input in the forms of pressure and heat, which in turn are usually based on electricity produced through power plants.Type: GrantFiled: October 23, 2019Date of Patent: November 16, 2021Assignee: The University of North Carolina at CharlotteInventor: Shen-En Chen