Patents Assigned to University
  • METHODS AND COMPOSITIONS FOR TREATING AND DIAGNOSING PANCREATIC CANCERS
    Publication number: 20210260092
    Abstract: The application relates to methods based on modulating pancreatic and/or gastrointestinal microbiota and related antifungal compositions. Specifically, the application relates to the use of microbiome for prevention, treatment and diagnosis of pancreatic cancers or tumors, such as pancreatic ductal adenocarcinoma.
    Type: Application
    Filed: September 30, 2020
    Publication date: August 26, 2021
    Applicant: New York University
    Inventors: George MILLER, Berk AYKUT, Deepak SAXENA, Smruti PUSHALKAR
  • CHITIN/GRAPHENE COMPOSITE SPONGE AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20210260241
    Abstract: Disclosed are a chitin/graphene composite sponge and a preparation method and a use thereof. The method comprises mixing and ball-milling a certain amount of flake graphite and chitin, dissolving a mixture of the flake graphite and the chitin in a NaOH/urea solvent, performing centrifugal separation, dispersing evenly, cross-linking with an epichlorohydrin cross-linking agent, standing, dialyzing, and freeze-drying, thus obtaining the chitin/graphene composite sponge.
    Type: Application
    Filed: October 31, 2019
    Publication date: August 26, 2021
    Applicant: South China University of Technology
    Inventors: Xiaoying WANG, Xiaoyun LI, Shanshan LI
  • MATRIX BOUND NANOVESICLES AND THEIR USE
    Publication number: 20210260246
    Abstract: A composition is disclosed herein that includes isolated ECM-derived nanovesicles and a pharmaceutically acceptable carrier. Methods are producing the ECM-derived nanovesicles are also disclosed. These ECM-derived nanovesicles can be included in pharmaceutical compositions, bioscaffolds, and devices. Methods for using these ECM-derived nanovesicles are provided.
    Type: Application
    Filed: October 16, 2020
    Publication date: August 26, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Stephen Francis Badylak, Luai Huleihel, George S. Hussey, Juan Diego Naranjo Gutierrez
  • RESTRUCTURED HYDROGEL AND PREPARING METHOD OF THE SAME
    Publication number: 20210260556
    Abstract: The present disclosure relates to a method for preparing a restructured hydrogel, including forming a hydrogel containing a first polymer, unidirectionally shrinking and dehydrating the hydrogel, and additionally cross-linking and rehydrating the dehydrated hydrogel.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Applicant: Research & Business Foundation Sungkyunkwan University
    Inventors: Jae Yun KIM, Donghwan JI
  • Alpha-Synuclein Detection Assay and Method for Diagnosing Alpha-Synucleinopathies
    Publication number: 20210263049
    Abstract: A method of detecting the presence of alpha-synuclein aggregation in a biological sample is provided whereby a biological sample is mixed with a reaction sample comprising a population of beads, a fluorophore adapted to hind to protein aggregates and to increase fluorescence when bound to protein aggregates, and alpha-synuclein or a fragment or variant thereof to forum a reaction mixture, the reaction mixture is illuminated and at the same time incubated with intermittent agitation cycles, wherein a significant increase in the fluorescence of the reaction mixture during incubation is indicative of the presence of aggregates of alpha-synuclein in the biological sample. Method of diagnosing alpha-synucleinopathies such as Parkinson's disease or Dementia with Lewy Bodies.
    Type: Application
    Filed: May 17, 2021
    Publication date: August 26, 2021
    Applicant: The University Court of the University of Edinburgh
    Inventors: Alison Green, Graham Fairfoul
  • TRIBLOCK COPOLYMER STABILIZERS FOR THE FORMATION OF NANOPARTICLES ENCAPSULATING SOLUBLE BIOLOGICS, THERAPEUTICS, AND IMAGING AGENTS
    Publication number: 20210259984
    Abstract: Hydrophilic molecules such as biologics, which can include peptides, proteins, and other biologically-derived materials, can be used as therapeutic agents in medical applications. They can face administration challenges because of poor membrane permeability and rapid clearance from the blood stream. Methods for the formation of a core-shell-brush nanoparticle from an A-B-C triblock copolymer are set forth. A hydrophilic core can contain the biologic and the C Block of the copolymer. The shell can be comprised of the precipitated B Block, and the A Block can form a stabilizing brush layer. The particles can be assembled by sequential precipitations under defined mixing conditions. Presented herein are methods to tune release based on process parameters during particle assembly and triblock characteristics.
    Type: Application
    Filed: July 19, 2019
    Publication date: August 26, 2021
    Applicant: The Trustees of Princeton University
    Inventors: Robert K. PRUD'HOMME, Chester E. MARKWALTER, Robert F. PAGELS
  • LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT
    Publication number: 20210261612
    Abstract: The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.
    Type: Application
    Filed: August 19, 2020
    Publication date: August 26, 2021
    Applicant: The Regents of the University of California
    Inventors: Kit S. Lam, Ruiwu Liu, Wei Yao, Nancy Lane
  • COMPOSITION FOR PREVENTING AND TREATING BREAST CANCER INCLUDING SELENOPSAMMAPLIN A AS ACTIVE INGREDIENTS
    Publication number: 20210259997
    Abstract: Provided is a composition for the prevention and treatment of one or more cancers selected from the group consisting of breast cancer, liver cancer, and gastric cancer, the composition comprising selenopsammaplin A as active ingredients. The selenopsammaplin A and derivatives thereof of the present invention have been confirmed to exhibit excellent anticancer activity against breast cancer, liver cancer, and gastric cancer cells, and exhibit not only a strong effect of suppressing breast cancer growth compared to existing psammaplin A but also an excellent effect of suppressing the metastasis of breast cancer cells, and thus the selenopsammaplin A and derivatives thereof are expected to be effectively usable as a pharmaceutical composition for the prevention and treatment of breast cancer, liver cancer, and/or gastric cancer, and for the suppression of breast cancer metastasis.
    Type: Application
    Filed: October 15, 2019
    Publication date: August 26, 2021
    Applicant: Seoul National University R & DB Foundation
    Inventors: Sang Kook LEE, Hyeung Geun PARK, Woong Sub BYUN, Hae Ju HAN
  • MEDICAL MEMBRANE MATERIAL
    Publication number: 20210260248
    Abstract: The present invention provides a medical film material which comprises a flat-plate-like or film-like demineralized dentin matrix (DDM) that is derived from a removed bovine tooth and completely demineralized, and which has an area falling within the range front 2 to 50 cm2. The present invention also provides a method for surgerizing a non-human animal using the medical film material. The present invention also provides a method for producing the medical film material, which comprises thinning and demineralizing a removed bovine tooth to produce a demineralized dentin matrix (DDM) film that is completely demineralized, wherein either one of the thinning procedure and the demineralization procedure may be carried out first.
    Type: Application
    Filed: July 22, 2019
    Publication date: August 26, 2021
    Applicant: National University Corporation Hokkaido University
    Inventor: Naoto Okubo
  • HETEROBIMETALLIC CATALYSTS AND SITE-DIFFERENTIATED LIGANDS FOR PREPARATION THEREOF
    Publication number: 20210260567
    Abstract: Phosphine phosphonate and phenoxyphosphine ligands bearing polyethylene glycol (PEG) chains are used as described herein to produce heterobimetallic catalysts. The ligands can be metallated selectively with palladium or nickel and secondary metal ions to provide well-defined heterobimetallic compounds. These heterobimetallic complexes exhibit accelerated reaction rates and greater thermal stability in olefin polymerization compared to other catalysts.
    Type: Application
    Filed: June 26, 2019
    Publication date: August 26, 2021
    Applicant: University of Houston System
    Inventors: Loi Hung Do, Zhongzheng Cai, Thi Tran, Dawei Xiao
  • MICROGRID POWER SUPPLY SYSTEM DC-DC CONVERTER AND CONTROLLING METHOD
    Publication number: 20210265919
    Abstract: A DC-DC voltage converter includes an input circuit, a parallel linked leg (PLL), an output circuit and a controller. The PLL includes an active leg switch, a leg inductor, a leg capacitor and a leg diode. The controller is configured to i) turn on the active input switch and the active leg switches while maintaining the active output switch at a turn off state for the first duty cycle period ii) turn off the active input switch and the active leg switches, and turn on the active output switch for a second duty cycle period following the first duty cycle period, and iii) turn off the active output switch while maintaining also turn off states of the active input switch and the active leg switches for a remaining period following the second duty cycle period. A method of controlling the DC-DC converter includes steps of i) to iii).
    Type: Application
    Filed: February 24, 2020
    Publication date: August 26, 2021
    Applicant: Prince Sultan University
    Inventors: Mahajan Sagar BHASKAR, Dhafer J. ALMAKHLES, Umashankar SUBRAMANIAM, Sanjeevikumar PADMANABAN, Sakthivel RATHINASAMY
  • Synthetic Cytotoxic Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment
    Publication number: 20210261583
    Abstract: Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.
    Type: Application
    Filed: June 14, 2019
    Publication date: August 26, 2021
    Applicants: The Regents of the University of California, Universite de Montreal
    Inventors: Aimee Edinger, Stephen Hanessian
  • Compounds with Antimicrobial Properties
    Publication number: 20210261616
    Abstract: Embodiments of the present invention relate to a novel compound of Formula (I) or stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, for use in treatment of infection caused by Gram-negative bacteria.
    Type: Application
    Filed: May 17, 2019
    Publication date: August 26, 2021
    Applicant: Northeastern University
    Inventors: Kim Lewis, Yu Imai, Quentin Favre-Godal, Akira Iinishi, Kirsten Meyer
  • AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
    Publication number: 20210261613
    Abstract: The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, and inhibition of apoptosis and necrosis to treat, prevent or ameliorate the symptoms of autoimmune diseases or condition.
    Type: Application
    Filed: October 7, 2020
    Publication date: August 26, 2021
    Applicant: Cornell University
    Inventor: Hazel H. Szeto
  • USE OF EOMESODERMIN TO DETERMINE RISK OF ALLOGRAFT REJECTION
    Publication number: 20210263013
    Abstract: Pre-existing alloreactive memory T cells are a major barrier to the induction of allograft tolerance in organ transplant recipients. The use of Eomesodermin (Eomes) expression in memory T cells to determine the risk of allograft rejection in a subject is described. Also described is the use of Eomes expression in memory T cells of transplant recipients to modify immunosuppressive therapy.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 26, 2021
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Mohamed B. Ezzelarab, Angus W. Thomson
  • Pre-Loadable Dried Biological Heart Valve and Preparation Method Thereof
    Publication number: 20210260247
    Abstract: A pre-loadable dried biological heart valve and a preparation method thereof. The preparation method includes: Step A: soaking a fresh animal pericardium in an aqueous solution of soluble elastin or glycosaminoglycan, and then subjecting the pericardium to a first cross-linking reaction in a mixed solution of carbodiimide or N-hydroxysuccinimide to allow the soluble elastin or glycosaminoglycan to bind to the pericardium via a chemical bond; and Step B: subjecting the pericardium after the first cross-linking to a second cross-linking reaction in an aqueous glutaraldehyde solution, and then drying the pericardium after the second cross-linking, to obtain the pre-loadable dried biological heart valve. The dried biological heart valve obtained by the above preparation method has good toughness, and is rapidly flattened out in a simulated folding and pressing test.
    Type: Application
    Filed: May 6, 2021
    Publication date: August 26, 2021
    Applicants: VENUS MEDTECH (HANGZHOU), INC., Sichuan University
    Inventors: Yunbing Wang, Yang Lei, Gaocan Li, Li Yang, Hou-Sen Lim, Dajun Kuang, Jincheng Yu
  • DIELECTRIC BARRIER DISCHARGE PLASMA REACTOR COMPRISING MACROPOROUS SILICA AS DIELECTRIC MATERIAL
    Publication number: 20210260558
    Abstract: The present invention relates to a dielectric barrier discharge (DBD) plasma reactor for the preparation of C2+ hydrocarbons from methane, wherein the DBD plasma reactor comprises macroporous silica, as a dielectric material, and optionally a photocatalyst that is impregnated into the pores of the macroporous silica.
    Type: Application
    Filed: October 20, 2020
    Publication date: August 26, 2021
    Applicants: Sogang University Research & Business Development Foundation, Korea Advanced Institute of Science and Technology
    Inventors: Kyoung-Su Ha, Jinwoo Lee, Juchan Kim, Namheon Lee, Seongseop Kim, Yeongkwang Bae
  • CHANNEL ESTIMATION METHOD OF STEEL PENETRATION SYSTEM
    Publication number: 20210266196
    Abstract: A channel estimation method of a steel penetration system is configured to reduce computational complexity and required memory. The method includes: reconstructing, at a receiving end, a channel estimation with a compressed-sensing sparse reconstruction algorithm according to a received pilot signal to obtain estimation values of a channel state response of the steel penetration system; and equalizing a received signal of the receiving end according to the estimation values of the channel state response to obtain an equalized signal.
    Type: Application
    Filed: July 9, 2020
    Publication date: August 26, 2021
    Applicant: University of Science and Technology Beijing
    Inventors: Tao LIU, Hongwei ZHANG, Jiajia LIU
  • QUININE AND ITS USE TO GENERATE INNATE IMMUNE RESPONSE
    Publication number: 20210260144
    Abstract: The invention provides methods and compositions for assaying infectivity of viruses and potential treatments of such viruses in the upper respiratory tract using an air-liquid interface model with nasal epithelium cells; and treatment of viral infections of the upper respiratory tract by treating with bitter taste receptor agonists that stimulate NO production and/or antimicrobial protein production.
    Type: Application
    Filed: April 21, 2021
    Publication date: August 26, 2021
    Applicants: The Trustees of the University of Pennsylvania, Monell Chemical Senses Center, GeneOne Life Science, Inc.
    Inventors: Noam A. Cohen, Robert J. Lee, Susan R. Weiss, Joel N. Maslow, Christine C. Roberts, Sara Cherry, Michael Kohanski, Nithin D. Adappa, James N. Palmer, Li Hui Tan
  • TRAINING DATA PROCESSING METHOD AND ELECTRONIC DEVICE
    Publication number: 20210265058
    Abstract: A training data processing method and an electronic device are provided. The method includes: obtaining medical history data including at least one first disease suffered by a user; setting a plurality of disease types according to a target disease; setting a time interval; obtaining at least one second disease in the time interval from the medical history data; performing a pre-processing operation on the second disease according to the disease types to obtain processed data; and inputting the processed data to a neural network to train the neural network.
    Type: Application
    Filed: April 9, 2020
    Publication date: August 26, 2021
    Applicants: Acer Incorporated, National Yang-Ming University
    Inventors: Pei-Jung Chen, Tsung-Hsien Tsai, Liang-Kung Chen, Li-Ning Peng, Fei-Yuan Hsiao, Shih-Tsung Huang