Abstract: The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.

Abstract: The invention provides universally acceptable “off-the-shelf” hypoimmune pluripotent (HIP) cells and hypoimmune chimeric antigen receptor T (CAR-T) cells derived from the HIP cells. The engineered therapeutic cells can be administered to subjects as an adoptive cell-based immunotherapy to treat cancer.

Abstract: An oral and oropharyngeal cancer screening system and associated methods are disclosed. In at least one embodiment, the screening system provides an at least one oral and oropharyngeal cancer screening device configured for selectively capturing images of an oropharyngeal area of an at least one patient. The screening device provides an elongate, relatively compact housing, a distal end of the housing being selectively bendable. An imaging module is positioned within the housing, the imaging module providing a lens, an at least one light source, and an imaging sensor positioned in the distal end of the housing. A user application resides in memory on an at least one user device in selective communication with the at least one screening device. The user application is configured for receiving images captured by the at least one screening device and recording risk factors, automatically analyzing the captured images and potential health-risk factors to screen for OPML and oral and oropharyngeal risk.

Abstract: A positive electrode for a solid-state lithium battery, the positive electrode including: a positive active material; and a first solid electrolyte, wherein a ratio ? of an average particle diameter of the positive active material to an average particle diameter of the first solid electrolyte is 3???40, wherein the positive active material has an average particle diameter of 1 ?m to 30 ?m, and wherein the first solid electrolyte has an average particle diameter of 0.1 ?m to 4 ?m.

Abstract: The disclosed embodiments relate to the design of a new type of transistor called a “field-effect bipolar transistor” (FEBT). This FEBT includes a substrate, which comprises a body of the FEBT. It also includes a source comprising an N+ doped region of the substrate, and a drain comprising a P+ doped region of the substrate. The FEBT also includes one or more gates composed of a dielectric material, and a low-doped or undoped semiconductor channel sandwiched between the one or more gates and the substrate, wherein the low-doped or undoped semiconductor channel is bounded by the source and the drain.

Abstract: Disclosed is a composition and method for a therapeutic treatment that is able to combat triple negative breast cancers (TNBCs). The class of urea compounds acts by blocking at inhibiting the mTOR signaling pathway, which, as a central regulator of mammalian metabolism and physiology that when inhibited leads to the induction of autophagocytosis. The disclosed compounds are further capable of reinitiating the p53 cycle as well as inhibition of the BNIP3/BNIP3L pathway. The disclosed compounds also shows the ability to cross the blood-brain-barrier where metastases can form. This new drug has the potential to be a powerful new treatment to combat invasive TNBCs.

Abstract: Systems and methods are provided for simultaneously assaying cell adhesion or cell rolling for multiple cell specimens. One embodiment provides a system for assaying adhesion or cell rolling of multiple cell specimens that includes a confocal imaging system containing a parallel plate flow chamber, a pump in fluid communication with the parallel plate flow chamber via a flow chamber inlet line and a cell suspension in fluid communication with the parallel plate flow chamber via a flow chamber outlet line. The system also includes a laser scanning system in electronic communication with the confocal imaging system, and a computer in communication with the confocal imaging system and laser scanning system. In certain embodiments, the laser scanning system emits multiple electromagnetic wavelengths simultaneously it cause multiple fluorescent labels having different excitation wavelength maximums to fluoresce.

Abstract: A heat exchanger for thermal management of an electronic device includes a liquid delivery layer thermally coupled to the electronic device and configured to receive a liquid from a source. The heat exchanger also includes an evaporation layer comprising hollow pillars configured to receive a continuous flow of the liquid from the liquid delivery layer and evaporate the continuous flow of the liquid from droplets maintained on the hollow pillars. Each hollow pillar has an evaporation surface and a pore configured to channel the continuous flow of the liquid through the hollow pillar to the evaporation surface. The evaporation surface being configured to maintain a droplet on the respective hollow pillar within a contact line. The evaporation surface has a wetting efficiency of at least about 95% and the contact line has a length of less than about 0.0314 mm.

Abstract: Disclosed herein are a method and a system for forming an air layer over a portion of an engineered surface, wherein the air layer is formed with a reduced flux and preferentially steering gas away from, or toward, a specific location by way of a hydrophobic surface, a hydrophilic surface, and/or a structured surface. Moreover, disclosed are a method and a system for recovering or separating a portion of the gas or other fluid layer.

Abstract: Time multiplexing an electromagnetic trap beam may be used to generate trap shapes/geometries to trap one or more particles with one electromagnetic beam by directing the electromagnetic beam at a pattern of different locations with sufficient rapidity to form an effective shape/geometry. Additionally, multiplexing an electromagnetic trap beam may be used to shutter trapping electromagnetic radiation to protect a viewer, use the same beam for multiple functions, move and organize particles, and generate illumination effects.

Abstract: Disclosed is a method for obtaining information on a risk of a decrease in a respiratory function of a patient with interstitial pneumonia, the method comprising measuring at least one biomarker in a biological sample of the patient with interstitial pneumonia, wherein the biomarker comprises CCL17 and CXCL9, and a measurement result of the biomarker is an index of the risk of a decrease in the respiratory function of the patient.

Abstract: The application provides methods of prognosing and classifying uterine serous carcinoma (USC) patients into poor survival groups or good survival groups and for predicting response to therapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application.

Abstract: The present method predicts and separates dispersive surface waves from seismic data using dispersion estimation and is completely data-driven and computer automated and no human intervention is needed. The method is capable of predicting and suppressing surface waves from recorded seismic data without damaging the reflections. Nonlinear signal comparison (NLSC) is used to obtain a high resolution and accurate dispersion. Based on the dispersion, surface waves are predicted from the field recorded seismic data. The predicted surface waves are then subtracted from the original data.

Abstract: A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.

Abstract: The present disclosure provides a compressed ultrafast imaging velocity interferometer system for any reflector, comprising a light source and target system, an etalon interference system, a compressed ultrafast imaging system, a timing control system and a data processing system. An imaging device in the traditional imaging velocity interferometer system for any reflector is replaced by a compressed ultrafast imaging system, a compressed ultrafast Photography (CUP) is introduced in an imaging process, multi-frame images, i.e.

Abstract: A double variable sliding isolator including a bottom sliding plate, a top sliding plate, and a friction piece is provided. The bottom sliding plate has a bottom sliding surface that has at least two curvatures. The top sliding plate is disposed over the bottom sliding plate and has a top sliding surface that has at least two curvatures. The friction piece is disposed between the top sliding plate and the bottom sliding plate and the friction piece is in contact with the bottom sliding surface and the top sliding surface. When an external force is applied to the bottom sliding plate and the top sliding plate, the bottom sliding plate and the top sliding plate will generate a relative displacement, so that the friction piece slides along the bottom sliding plate and the top sliding plate.

Abstract: Disclosed is an integrated washing and spinning tub and an energy-saving and healthy household washing machine with a tub replacing function. The integrated washing and spinning tub comprises a water holding tub, a spinning tub is arranged in the water holding tub, and the water holding tub and the spinning tub are connected in a sliding groove mode. The energy-saving and healthy household washing machine with a tub replacing function comprises a washing machine shell, the integrated washing and spinning tub is arranged in the washing machine shell, a spring telescopic support corresponding to the integrated washing and spinning tub is arranged on the inner wall of the upper portion of the washing machine shell, a support frame is arranged at the bottom of the integrated washing and spinning tub, and a reduction gear and a motor which are connected are arranged on the support frame.

Abstract: Among the various aspects of the present disclosure is the provision of a method of reducing interference (e.g., the Hook effect) in an immunoassay (e.g., a single-step homogeneous turbidometric or nephelometric immune assay).

Abstract: a) A Gabor domain optical coherence microscopy (GD-OCM) system providing high resolution of structural and motion imaging of objects such as tissues is combined with the use of reverberant shear wave fields (RevSW) or longitudinal shear waves (LSW) and two novel mechanical excitation sources: a coaxial coverslip excitation (CCE) and a multiple pronged excitation (MPE) sources providing structured and controlled mechanical excitation in tissues and leading to accurate derivation of elastographic properties. Alternatively, general optical computed tomography (OCT) is combined with RevSW or LWC in the object to derive elastographic properties. The embodiments include (a) GD-OCM with RevSW; (b) GD-OCM with LSW; (c) General OCT with RevSW; and General OCT with LSW.

Abstract: An interferometric optical fibre sensor comprises optical fibre defining an optical circuit configured to propagate a first optical wave via an environment in which the optical fibre can be exposed to a stimulus that modifies the first optical wave, and a second optical wave, and to combine the first optical wave and the second optical wave to create an interference signal containing information about the stimulus, wherein optical fibre propagating either or both of the first optical wave and the second optical wave comprises hollow core optical fibre configured to propagate the optical wave or waves by an antiresonant optical guidance effect.