Abstract: The present invention provides new compounds and compositions thereof that release carbon monoxide for the treatment of medical disorders that are responsive to carbon monoxide, for example, inflammatory, pain, and dermatological disorders.
Type:
Application
Filed:
April 16, 2021
Publication date:
August 5, 2021
Applicant:
Georgia State University Research Foundation, Inc.
Inventors:
Binghe Wang, Xingyue Ji, Ladie Kim De La Cruz, Xiaoxiao Yang
Abstract: A flexible dry electrode comprises a multi-walled carbon nanotube (MWCNT)/polydimethylsiloxane (PDMS) composite. The flexible dry electrode may be utilized for monitoring electrocardiogram (ECG) signals. The dry ECG electrode may be fabricated by screenprinting silver (Ag) ink on flexible polyethylene terephtha late (PET) substrate, followed by bar coating of a MWCNT/PDMS composite.
Type:
Application
Filed:
February 8, 2021
Publication date:
August 5, 2021
Applicant:
The Board of Trustees of Western Michigan University
Abstract: The present disclosure relates to a device and a method for swinging power generation and vibration suppression by using arc-shaped wing plates with rough surfaces. The device consists of two parts, namely, a rotary swinging system and a collector system. The rotary swinging system includes a collector riser, steering bearings, nanometer material arc-shaped power generation wing plates, and flexible tail plates. The collector system includes telescopic power generation cylinders, a waterproof electric slip ring, and a waterproof power transmission line. The suppression of energy-consumption-free vortex-induced vibration is realized under the combined action that the nanometer material arc-shaped power generation wing plates divide a flowing space and adjust a flow direction, the nanometer material arc-shaped power generation wing plates drive the flexible tail plates to swing to destroy a tail vortex street, and hemispherical bulges and trumpet-shaped deflector holes disturb a boundary layer around flow.
Abstract: Providing an auxin derivative that can exert its intended effect more efficiently, while reducing any unintended effects. A compound represented by the General Formula (1) having a specific substituent at the 5- and/or 6-position of the auxin indole ring.
Type:
Application
Filed:
March 8, 2018
Publication date:
August 5, 2021
Applicants:
University of Washington, National University Corporation Nagoya University
Abstract: An automatic nut tapping equipment is provided. The automatic nut tapping equipment includes a tap rotating mechanism, a nut clamping mechanism, an axial transmission mechanism, and a nut placing slot. The tap rotating mechanism includes a tap rotary motor and a tap, wherein the tap is driven by the tap rotary motor. The nut clamping mechanism includes a clamping assembly and a sliding rail, wherein the clamping assembly is disposed on the sliding rail and is configured for clamping a to-be-tapped nut to restrict the to-be-tapped nut from rotating. The axial transmission mechanism controls the clamping assembly to axially translate one pitch in response to the tap rotating one revolution, such that a forward nut-tapping motion and a backward nut-retracting motion are performed by the nut clamping mechanism. The nut placing slot is configured to arrange and control the dropping of another to-be-tapped nut.
Abstract: Methods and systems for digitally reconstructing a patient tissue sample are described herein. In one embodiment, the method may include projecting a first structured light pattern onto the patient tissue sample, receiving a first reflection of the first structured light pattern from the patient tissue sample, and reconstructing the patient tissue sample based on the first reflection and the projected first structured light pattern. In another embodiment, the system may include a projector adapted or configured to project the first structured light onto the patient tissue sample, a charge-coupled device (CCD) adapted or configured to receive the first reflection from the patient tissue sample, and a reconstruction device adapted or configured to reconstruct the patient tissue sample based on the first reflection and the projected first structured light pattern.
Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.
Abstract: A method for separating iron from an aluminium alloy comprises providing a first zone of an aluminium alloy at a first temperature at which the aluminium alloy is partially melted and any iron-containing particles therein are fully molten, and providing a second zone of the alloy at a second temperature at which the aluminium alloy is fully molten, such that a temperature gradient is created between the first zone and the second zone. By applying a static homogeneous magnetic field to the alloy, and maintaining the temperature gradient and the magnetic field for a period of time, the iron content of the first and/or second zone can be reduced.
Abstract: Disclosed is a method for manufacturing a functionalized separator having a zwitterionic coating thereon. The method includes preparing a porous separator; coating a linker on a surface of the porous separator; and chemically reacting zwitterions with the linker such the zwitterions are grafted to the linker on the surface of the separator. The zwitterions grafted to the linker acts as a monolayer to functionalize the surface of the separator. The functionalized separator may disallow elution of polysulfide compound in a lithium-sulfur battery. Further, the functionalized separator may increase ion conductivity of electrolyte of the lithium-sulfur battery and thus ensure high output characteristics.
Type:
Application
Filed:
August 11, 2020
Publication date:
August 5, 2021
Applicant:
Research & Business Foundation Sungkyunkwan University
Inventors:
Pil Jin YOO, Ho Seok PARK, Duk Joon KIM, Jun Hyuk LEE, Jeong Seok YEON, Sung Mo KANG
Abstract: Tubular prostheses are provided for use in airways, upper digestive, and urinary tracts. Each of these uses has its own specific sets of biological specifications, based on what it must contain and exclude and the physical and chemical pressures and stresses to which it is subjected. The prostheses may be made from allogeneic cells. Thus they can be manufactured and stored prior to an individual's personal need arising.
Type:
Application
Filed:
April 21, 2021
Publication date:
August 5, 2021
Applicants:
Humacyte, Inc., Yale University
Inventors:
Laura Niklason, Angela Huang, Liping Zhao, Shannon Dahl
Abstract: The present invention includes methods for detecting and reducing or inhibiting ischemic stroke in a mammal, the method comprising: (a) selecting microRNAs to downregulate selected from the group consisting of hsa-miR-96-5p, hsa-miR-99a-5p, hsa-miR-122-5p, hsa-miR-186-5p, hsa-miR-211-5p, hsa-mir-760, PC-3p-57664, orPC-5p-12969, (b) selecting microR-NAs to upregulate selected from the group consisting of ggo-miR-139, hsa-miR-30d-5p, hsa-miR-22-3p, hsa-miR-23a-3p, mmu-miR-5124a, mmu-mir-6240-5p, PC-3p-32463, or PC-5p-211, and combinations thereof, and (c) administering an agent that: downregulates that targets in (a), upregulates the targets in (b), or both, to the subject in an amount sufficient to reduce or inhibit ischemic stroke in the mammal. The present invention also includes the detection of the markers for use with stroke patients.
Abstract: Disclosed are methods and pharmaceutical compositions for treating and inhibiting conical vascularization including conical vascularization associated with viral infection, chemical injury, autoimmune conditions, and post-corneal transplantation or in subjects having a PAX6 mutation associated with conical vascularization. The methods and pharmaceutical compositions are utilized in administering treatment that results in increased concentration of FOXC1 in a subject's cornea in order to treat or inhibit corneal vascularization.
Type:
Application
Filed:
April 13, 2021
Publication date:
August 5, 2021
Applicants:
Northwestern University, The Governors of the University of Alberta
Abstract: An aminated siliceous adsorbent, which is the reaction product of dried acidified rice husk ash having disordered mesopores and an amino silane, wherein amine functional groups are present on an external surface and within the mesopores of the dried acidified rice husk ash, and wherein the aminated siliceous adsorbent has a carbon content of 24 to 30 wt. %, based on a total weight of the aminated siliceous adsorbent. A method of making the aminated siliceous adsorbent and a method of capturing CO2 from a gas mixture with the aminated siliceous adsorbent.
Type:
Application
Filed:
February 5, 2020
Publication date:
August 5, 2021
Applicant:
King Fahd University of Petroleum and Minerals
Inventors:
Chanbasha BASHEER, Isam H. ALJUNDI, Rashed Saed BAKDASH
Abstract: The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of African American males or non-Hispanic white males.
Type:
Application
Filed:
April 9, 2021
Publication date:
August 5, 2021
Applicants:
Duke University, George Washington University
Inventors:
Jennifer Freedman, Yanru Wang, Hongliang Liu, Qingyi Wei, Daniel George, Steven Patierno, Bi-Dar Wang, Norman Lee
Abstract: Provided is a method for producing regulatory T cells, comprising the step of culturing mammalian-derived peripheral T cells in a medium comprising TGF? and IL-2 in the presence of CD3 stimulation and in the absence of CD28 stimulation. The medium may further comprise ascorbic acid. The method may further comprise the step of culturing the obtained cell culture in a medium comprising IL-2.
Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.
Type:
Application
Filed:
June 14, 2019
Publication date:
August 5, 2021
Applicant:
University of Utah Research Foundation
Inventors:
Stefan M. Pulst, Daniel R. Scoles, Sharan Paul
Abstract: Methods of treating cancer in a subject and compositions are provided. The methods include administering a therapeutically effective amount of a poly (ADP ribose) polymerase (PARP) inhibitor to the subject in need thereof and administering a therapeutically effective amount of a folic acid supplement to the subject. Also described herein are methods for identifying a subject having cancer and having an elevated folate receptor expression level relative to a folate receptor expression level in a subject free of cancer and administering a therapeutically effective amount of a PARP inhibitor to the subject having the elevated folate receptor level. Also described herein are compositions including a PARP inhibitor and a folic acid supplement.
Abstract: Provided herein are compositions comprising: a scaffold polymer having one or more acryloyl groups or one or more methacryloyl groups; optionally a porogen and a crosslinking agent, compositions that upon crosslinking form a hydrogel for use in cell encapsulation and methods for immunocytochemistry of encapsulated cells. Scaffold polymers used are selected from: Poly(ethylene glycol) diacrylate (PEGDA); Poly(ethylene glycol) dimethylacrylate (PEGDMA); Poly(ethylene glycol) methyl ether acrylate (PEGMEA); Poly(ethylene glycol) methacrylate (PEGMA); and Poly(ethylene glycol) methyl ether methacrylate (PEGMEMA), and porogens selected from: Poly(ethylene glycol) (PEG); Chitosan; Agarose; Dextran; Hyaluronic acid; Poly(methyl methacrylate) (PMMA); Cellulose and derivatives thereof; Gelatin and derivatives thereof; and Acrylamide and derivatives thereof. The invention also provides, at least in part, compositions for forming a porous hydrogel around a cell suitable for immunostaining of cells within the hydrogel.
Abstract: The present disclosure provides methods for detecting a high-risk phenotype of a mast cell tumor (MCT) in a biological sample from a mammal, preferably a dog. Kits, PCR probes and primers to detect high-risk MCT are also provided.