Abstract: The present invention discloses an automatic loading system and method for service functions of a hydraulic machine. The loading system includes an acquiring portion for acquiring i service function component chains of a hydraulic machine, a determining portion for determining a demand sequence of the service function component chains used by a user within each preset time period in a measuring cycle based on the acquired service function component chains and a deciding portion for automatically loading a service function of the hydraulic machine in a next moment according to the demand sequence based on a current input operation command of the user. By adopting the automatic loading system or method provided by the present invention, response speed of intelligent services of the hydraulic machine can be improved.

Abstract: The invention provides compositions including epinephrine nanoparticles and methods for therapeutic use of the compositions in the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine nanoparticles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required. Additionally, the invention provides methods for fabrication of stabilized epinephrine nanoparticles for use in the described compositions.

Abstract: Provided herein are kits for performing for nucleic acid sequences.

Abstract: Herein provided are peptide inhibitors and methods for treating polyglutamine (polyQ) diseases. Also disclosed are related compositions and kits for therapeutic use in the treatment of polyQ diseases.

Abstract: The present disclosure provides CasX proteins, nucleic acids encoding the CasX proteins, and modified host cells comprising the CasX proteins and/or nucleic acids encoding same. CasX proteins are useful in a variety of applications, which are provided. The present disclosure provides CasX guide RNAs that bind to and provide sequence specificity to the CasX proteins, nucleic acids encoding the CasX guide RNAs, and modified host cells comprising the CasX guide RNAs and/or nucleic acids encoding same. CasX guide RNAs are useful in a variety of applications, which are provided. The present disclosure provides archaeal Cas9 polypeptides and nucleic acids encoding same, as well as their associated archaeal Cas9 guide RNAs and nucleic acids encoding same.

Abstract: A solar simulator filter that includes a flexible substrate and one or more layers of oxide materials, e.g. fluorine-doped tin oxide and indium-doped tin oxide, wherein a thickness of said layers is no more than 500 nm, and wherein the solar simulator filter generates a spectral output that closely matches a solar irradiance spectrum. Various embodiments of the solar simulator filter and a method of fabricating thereof is described.

Abstract: Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.

Abstract: The present invention relates to isolated immunogenic polypeptides and their use. In one aspect, the isolated immunogenic polypeptide includes a scaffold polypeptide having a hairpin loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond. The scaffold polypeptide directs self-assembly with two other of the scaffold polypeptides to form a trimeric structure, which constrains the one or more epitopes to a conformation that is (i) substantially similar to one or more native pathogen epitopes in trimeric conformation and (ii) capable of binding an antibody reactive to the one or more native pathogen epitopes in trimeric conformation. Another aspect relates to an isolated immunogenic polypeptide that includes a scaffold polypeptide having a native loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond.

Abstract: A fiber comprising a carbon chain backbone and amidoxime, carboxylate, and nitrile pendant groups. The fiber may be used for removing uranium from seawater and toxic metals from drinking water.

Abstract: A four-biomarker panel for diagnosis of chronic graft-versus-host disease (cGVHD) and methods of prognosing and/or diagnosing cGVHD using the biomarker panel are disclosed.

Abstract: In some embodiments, the present invention provides methods including the steps of providing cellulosic material, associating the cellulosic material with an organic acid (e.g., lactic acid) to form a mixture, and heating the mixture to a temperature between 100° C. and 120° C. for at least ten minutes to form a treated cellulosic material, wherein the water retention value of the treated cellulosic material is decreased by at least 10% as compared to untreated cellulosic material.

Abstract: A technique for separating components of a microfluid, comprises a self-intersecting micro or nano-fluidic channel defining a cyclic path for circulating the fluid over a receiving surface of a fluid component separating member; and equipment for applying coordinated pressure to the channel at a plurality of pressure control areas along the cyclic path to circulate the fluid over the receiving surface, applying a pressure to encourage a desired transmission through the separating member, and a circulating pressure to remove surface obstructions on the separating member. The equipment preferably defines a peristaltic pump. Turbulent microfluidic flow appears to be produced.

Abstract: In an embodiment, a unit delay circuit comprises a first path configured to delay a first input signal to output a first output signal when a selection signal is inactivated, a second path configured delay a second input signal to output a second output signal when the selection signal is inactivated, and a third path configured to delay the first input signal to output the second output signal when the selection signal is activated.

Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.

Abstract: A method for regulating arterial vascular tone in a subject, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A and B are each individually selected from O or S; a is 1 to 4; and Ar is optionally substituted aryl or optionally substituted heteroaryl.

Abstract: Novel and advantageous insulator discs with embedded resonator coils are provided. By linking the insulator discs in a series using an appropriate mechanical mechanism, the insulator discs form an insulator or insulator string for a high power transmission line system. The resonator coils embedded inside the insulator discs therefore form a series of relay resonators that can be used for wireless power transfer through the principle of near-field magnetic coupling and resonance. The insulator string can provide the simultaneous functions of voltage insulation and wireless power transfer over the length of the string. Applications include, but not limited to, wireless power transfer in a high-voltage environment such as that encountered in high-voltage power transmission line systems.

Abstract: A wearable apparatus comprises a passive artificial knee that comprises first and second links coupled at a knee joint, a passive compressive force generator coupled to the second link, and a release mechanism coupled to the first link. When an angle of the first and second links is less than a toggle angle, the release mechanism locks in a first operational mode, and the force generator compresses, resisting flexing of the second link. When the angle is larger than the toggle angle, the force generator decompresses and encourages flexion of said second link. When the force generator is extended and said compressive force is small, the release mechanism moves into a second operational mode, wherein the force generator neither resists nor encourages extension and flexion of said second link from said first link. The wearable apparatus comprises an exoskeleton trunk configured to couple to an upper body of a user.

Abstract: An edible composition of matter having an apparent viscosity of from about 150 cP to about 2000 cP at about 30 s?1; a yield stress of from 0 Pa to about 20 Pa at 1 s?1; and a flow index of from about 0.2 to about 0.6. The composition may include an imaging agent. The compositions are useful for providing sustenance to dysphagic subjects and for evalualuating dysphagia.

Abstract: Systems and techniques for a low power wrist-worn RFID reader capable of reading RFID tags within the area of a localized personal body network. The wrist-worn reader provides a means for tracking how a user interacts with their environment. The wrist-worn reader may distinguish between tagged objects within the range of the reader and objects held by the user. The reader may also distinguish when a tagged object has been picked up and when it has been released.

Abstract: A metamaterial comprising, a plurality of acoustic vector field sensors, each configured to sense an acoustic vector field of a fluid within a fluid-filled space in response to fluid waves, and producing an electrical signal corresponding to the sensed acoustic vector field; a processor configured to perform a time and space transform on the electrical signal; and at least one phased array transducer, configured to emit fluid waves according to a produced acoustic vector field pattern dependent on a result of the time and space transform, a within a portion of the fluid.