Abstract: The present invention provides benzo-thiazolo-imidazole compounds and pharmaceutical compositions comprising such benzo-thiazolo-imidazole compounds and at least one pharmaceutically acceptable carrier, diluent and/or excipient. Further provided are methods of treatment of cancer comprising the administration of said compounds and compositions and methods of using said compounds and compositions for the manipulation of cultured cells.

Abstract: This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor in the GI tract.

Abstract: Residual, refractory or relapsed cancer is treated by immunostimulation in the presence of allogeneic immune effector cells, optimally in combination with radiation therapy. The methods of the disclosure induce a systemic allogeneic anti-tumor immune response that results in tumor regression in untreated sites of disease, i.e. non-injected, non-irradiated, etc.

Abstract: A computer-implemented method includes: collecting, by a processor of a computer, analysis information from a source code of a computer program; tracing, by the processor of the computer, program behavior starting with a main entry point to produce trace data; and visualizing, by the processor of the computer, the trace data as a sequence diagram, wherein the trace data comprises a representation corresponding to a sequence diagram.

Abstract: The invention includes light-activated compositions and methods that are useful for promoting cell death or growth. In certain embodiments, the compositions comprise quantum dots (QD).

Abstract: A vertical stack transistor includes: a first transistor and a second transistor, located in a vertical direction, wherein the first transistor includes a first gate electrode, a first insulating layer, a first electrode, a first channel, and a second electrode, which are sequentially stacked in the vertical direction, and the second transistor includes a second gate electrode, a second insulating layer, a third electrode, a second channel, and a fourth electrode, which are sequentially stacked in the vertical direction, wherein the second gate electrode and the second electrode are the same electrode.

Abstract: An article comprises a carbon fibre reinforced plastic (CFRP) substrate, a buffer layer disposed adjacent the substrate, the buffer layer comprising a poly(para-xylylene) polymer; and a moisture barrier coating disposed adjacent the buffer layer.

Abstract: The present invention provides a polyploid adeno-associated virus (AAV) capsid, wherein the capsid comprises capsid protein VP1, wherein said capsid protein VP1 is from one or more than one first AAV serotype, wherein said capsid protein VP2 is from one or more than one first AAV serotype and capsid protein VP3, wherein said capsid protein VP3 is from one or more than one second AAV serotype and wherein at least one of said first AAV serotype is different from at least one of said second AAV serotype and is different from at least one of said third AAV serotype, in any combination.

Abstract: Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator configured to generate a pulse sequence for on-resonance magnetization transfer preparation. The pulse sequence includes an adiabatic tip-down pulse and a matched adiabatic flip-back pulse for separating spins in a mobile spin pool from spins in a bound spin pool of an anatomical region of interest for imaging. The system includes radio frequency (RF) coils configured to transmit RF pulses in response to the pulse sequence and to acquire RF data in response to transmission of the RF pulses. Further, the system includes a processing system configured to process the RF data to provide a display image indicating different tissue types with discrimination.

Abstract: Described is a novel method for feature extraction for automatic gait recognition. This method uses Multi-kernel Fuzzy-based Local Gabor Binary Pattern. From a captured gait video sequence, the gait period is determined then a gait energy image is constructed to represent the spatial-temporal variations during one motion cycle of the gait sequence. Then, each gait sequence is represented with a feature vector. The computation of this vector is conducted by first applying the 2D Gabor filter bank then encoding the variations in the Gabor magnitude using a multi-kernel fuzzy local binary pattern operator. Finally, gait classification is performed using a support vector machine.

Abstract: A voltage feedback circuit for a power factor correction circuit couples an output voltage to a voltage feedback input terminal of the power factor correction circuit. The voltage feedback circuit includes a first voltage sensing resistor, a second voltage sensing resistor and a third voltage sensing resistor. A stabilization capacitor is connected across the third voltage sensing resistor. During a normal mode of operation, a feedback voltage has a magnitude determined by the first, second and third voltage sensing resistors. When the output voltage increases rapidly, the stabilization capacitor bypasses the increased voltage around the third voltage sensing resistor to cause the magnitude of the feedback voltage to be determined by only the first and second voltage sensing resistors. The power factor correction circuit detects a transient overvoltage condition at a lower output voltage than if the third voltage sensing resistor were not bypassed.

Abstract: A semiconductor device may comprise a plurality of chips coupled in a ring structure, and the plurality of chips includes a first chip. Each of the plurality of chips may include a key port receiving or outputting a key to circulate the key through the ring structure. The first chip is configured to be in a standby state until an amount of available token becomes equal to or greater than an amount of required token to perform a specific operation in the first chip, when the first chip has the key.

Abstract: A further exemplary embodiment of the present disclosure can be, for example, a coil arrangement, which can include a loops including a plurality of first conductors extending in a first direction; a plurality of second conductors extending in a second direction, where the first direction is different from the second direction, and a plurality of linking points linking the first conductors to the second conductors, where the loop(s) can be configured to stretch in a third direction, and a perimeter of the loop is constant. The third direction can be different from the first and second directions, or it can be the same as the first direction or the second direction. The linking points can mechanically and pivotally connect the first conductors to the second conductors. The linking points can include flexible conductors, or the linking points can link the first conductors and the second conductors to a substrate. The substrate can be a trellis substrate.

Abstract: Composite ion-exchange materials for use in an ion-exchange column are provided. Also provided are ion-exchange columns packed with the materials and methods for using the materials to remove metal ions from samples, such as waste water samples. The composite ion-exchange materials comprise a composite material comprising a metal chalcogenide and an alginate, wherein the composite material is mixed with a granular material.

Abstract: Methods are provided for identifying and selecting antibodies that are internalized into cells via the macropinocytosis pathway. Additionally antibodies that are internalized via this pathway are provided as well as immunoconjugates comprising such antibodies.

Abstract: A computer data security system, useful in protecting audit logs, includes symmetric key based techniques, requires only a small-constant number of cryptographic hash operations at the signer side sending a prospective audit log or other computer record data to a primary repository to achieve forward-secure and append-only authentication. The verification is performed by independent parties sharing parts of the symmetric key, wherein the presence of single honest party among all verifier parties ensures a conditional non-repudiation. It also ensures that an active adversary cannot generate authentication tags on behalf of the signer, unless it compromises all verification parties.

Abstract: A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a relatively low voltage electric field in such a way as to effectively unpin the anatomical reentry. Preferably, the relatively low voltage electric field is defined by at least one unpinning shock(s) that are lower than an expected lower limit of vulnerability as established, for example, by a defibrillation threshold test. By understanding the physics of the electric field distribution between cardiac cells, the method permits the delivery of an electric field sufficient to unpin the core of the anatomical reentry, whether the precise or estimated location of the reentry is known or unknown and without the risk of inducting ventricular fibrillation. A number of embodiments for performing the method are disclosed.

Abstract: Systems and methods of use and fabrication are described for a non-volatile resistive random access memory (RRAM) multi-terminal device including a first electrode, a second electrode, a metal oxide disposed between the first electrode and the second electrode, and an at least first gate configured to apply a voltage bias to change a resistive state in the metal oxide.

Abstract: A combination of a common-mode choke and two integrated RF inductors includes first and second E-core. At least one E-core includes first and second protrusions extending from a body portion. Each protrusion is configured to accommodate a respective winding. In a first embodiment, each protrusion extends from the body portion at an angle perpendicular to legs extending from the body portion. In a second embodiment, each protrusion extends from the body portion in an opposite direction from the legs extending from the body portion, and each protrusion includes a respective channel to receive a respective winding. In a third embodiment, each protrusion extends from the body portion in an opposite direction from the legs extending from the body portion, and each protrusion is sized and shaped to extend into a respective opening in a printed circuit board. Each opening is surrounded by a respective printed circuit winding.

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.