Abstract: A system for assessing performance of a procedure comprises a tissue model or a tool comprising assessment indicators applied thereto, one or more image-capturing devices for capturing one or more assessment images of the assessment indicators while or after a user performs the medical procedure, and a processor configured to analyze the assessment indicators in the one or more assessment images and provide feedback to the user. A system can also comprise a tissue model, one or more image-capturing devices each configured to capture one or more images of the tissue model, and a processor configured to analyze the one or more images from the one or more image-capturing devices to determine a deformation of the tissue model and determine a force exerted on the tissue model based on the determined deformation of the tissue model.

Abstract: An energy efficient rapid single flux quantum (ERSFQ) logic register wheel includes a circular shift register having a plurality of destructive read out (DRO) cells. Each entry of the circular shift register includes a data block, a tag, and a valid bit. A compare and control logic is coupled to the circular shift register to compare a source specifier or a destination register specifier against a register tag stored in the wheel following each cycle of the register wheel. At least one or more read ports and at least one or more write ports are coupled to the circular shift register to write to or to read from a different entry each in the register wheel following each cycle of the register wheel. A RSFQ clearable FIFO with flushing and a crosspoint memory topology for integrating MRAM devices with ERSFQ circuits are also described.

Abstract: A method for treatment of a hexachlorodisilane and its hydrolyzed product is disclosed. It comprises adding a hexachlorodisilane or its hydrolyzed product into a sulfuric acid solution for reaction.

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

Abstract: The present invention provides a method of generating organic compounds and an organic-compound-generating system capable of efficiently generating organic-compounds even under a low-temperature environment by controlling a pH of an aqueous solution within a range from 5 to 10 during electrolysis in a case generating organic compounds by electrolyzing the aqueous solution containing carbon dioxide.

Abstract: This invention relates to a method of controlling a Solid State Transformer (SST).

Abstract: A composite material comprising graphene or reduced graphene oxide and a polymer-derived ceramic material, such as SiOC, is provided. The composite materials can be used to construct anodes (16), which can be used in batteries (10), particularly lithium ion batteries. The anodes exhibit relatively high charge capacities at various current densities. Moreover, the charge capacity of the anodes appears exceptionally stable even after numerous charging cycles, even at high current densities.

Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.

Abstract: Edge-emitting laser diodes having high confinement factors and lattice-matched, porous cladding layers are described. The laser diodes may be formed from layers of III-nitride material. A cladding layer may be electrochemically etched to form a porous cladding layer having a high refractive index contrast with an active junction of the device. A transparent conductive oxide layer may be deposited to form a top-side cladding layer with high refractive index contrast and low resistivity.

Abstract: The present invention relates to compositions and methods of generating modified hematopoietic stem or progenitor cells. One aspect of the invention includes a modified hematopoietic stem or progenitor cell comprising a nucleic acid capable of decreasing expression of an endogenous gene or a portion thereof, wherein the endogenous gene encodes a polypeptide comprising an antigen domain targeted by a chimeric antigen receptor (CAR). Another aspect of the invention includes a method for generating a modified hematopoietic stem or progenitor cell. Also included are methods and pharmaceutical compositions comprising the modified cell for adoptive therapy and treating a condition, such as an autoimmune disease or cancer. In certain embodiments, the invention includes a modified hematopoietic stem or progenitor cell comprising a nucleic acid capable of decreasing expression of CD33.

Abstract: The disclosure relates to the field of fusion proteins. In some aspects, the invention to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosures relates to compounds produced by artificial cytochrome P450 enzymes.

Abstract: Mycolic acid antigen containing liposomes, and an electrode immobilised antigens of tuberculous mycobacterial origin are produced. A diagnostic sample from a human suspected of having tuberculosis is diluted and divided into first and second samples. A control sample comprising the first sample and a redox probe is exposed to the liposomes. A test sample comprising the second sample and a redox probe is exposed to liposomes not containing mycolic acid antigens. The control sample is contacted with the immobilised antigens to allow antibodies therein to bind to the antigens. The test sample is contacted with the immobilised antigens to allow any antibodies therein to bind to the antigens. The degree of binding in the samples is compared by electrochemical impedance spectroscopy. Any observed lesser binding by the control sample is an indicator of antibodies to the antigens in the diagnostic sample, indicating tuberculosis in the human.

Abstract: The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.

Abstract: Methods of controlling the maturation of plants and/or plant products (e.g. fruit, vegetable, ornamentals, etc.) by manipulating Alternative Oxidase (AOX) activity. An increase in activity hastens the maturation process while a decrease in activity slows or stops maturation.

Abstract: In various embodiments, methods and devices are provided for generating a radiotherapy treatment plan for a subject to be implemented on a radiotherapy device. In certain embodiments the methods involve determining all feasible radiotherapy beam orientations free of collision for said radiotherapy device and said subject to provide a set of radiotherapy beam orientations; selecting from the set of all feasible radiotherapy beam orientations a subset of beams that meet treatment goals to be used in treatment of the subject to provide a selected beam set; calculating a navigation trajectory for the radiotherapy device to delivery said subset of beams to the subject where the trajectory is free of collision; and generating and writing instruction files to a tangible medium that can be executed by said radiotherapy device.

Abstract: The present disclosure provides a wearable computing device. The wearable computing device includes one or more sensors that output sensor data. The wearable computing device includes a machine-learned smoking gesture detection model trained to detect a smoking gesture based on the sensor data. The wearable computing device includes one or more processors and one or more non-transitory computer-readable media that store instructions that, when executed by the one or more processors, cause the one or more processors to perform operations. The operations include inputting the sensor data into the machine-learned smoking gesture detection model. The operations include receiving, as an output of the machine-learned smoking gesture detection model, a gesture classification that indicates whether the sensor data is indicative of the smoking gesture.

Abstract: A carbon material-polymer strain sensitive film and its preparation method are disclosed. The carbon material-polymer strain sensitive film includes multiple layers of carbon sensitive films and multiple layers of polymer films, wherein the multiple layers of carbon sensitive films and the multiple layers of polymer films form a multi-layer composite film in sequence through a layer-by-layer assembly process. The preparation method includes steps of: cleaning, processing a hydrophilic treatment and processing a hydrophobic treatment on a rigid substrate in sequence; preparing a carbon material in dispersion solution and a polymer dispersion solution; through a layer-by-layer self-assembly process, growing the polymer and the carbon material in a form of layer-by-layer on the rigid substrate; transferring the composite film from the rigid substrate to a flexible substrate; and pasting two electrodes at two ends of the composite film and encapsulating with a flexible film.

Abstract: Provided is a point cloud attribute compression method based on a KD tree and optimized graph transformation, wherein same, with regard to point cloud data, reduces the influence of a sub-graph issue on the graph transformation efficiency by means of a new transformation block division method, optimizes a graph transformation kernel parameter, and improves the compression performance of the graph transformation, and comprises: point cloud pre-processing, point cloud KD tree division, graph construction in the transformation block, graph transformation kernel parameter training, and a point cloud attribute compression process.

Abstract: Methods of identifying target binding molecules by target guided synthesis are provided. The methods include providing two or more fragments capable of reacting to form the target binding molecule and mixing the fragments with the target. The methods can be used to identify target binding molecules that bind targets such as proteins or nucleic acids, including those that bind shallow binding pockets on the surface of such targets. The methods are applied to the Bcl-XL and Mcl-1 proteins from the Bcl-2 family of proteins. Using thio acid and sulfonyl azide fragments capable of reacting through sulfo-click chemistry, new acyl sulfonamides are identified that bind one or both of the Bcl-XL and Mcl-1 proteins. Pharmaceutical formulations of these target binding molecules are also provided.

Abstract: Some embodiments of the invention include a method of preparing a sample for sequencing that includes receiving a sample and amplifying at least one marker within the sample. In some embodiments, amplification of the first marker may include mixing the sample with a first oligonucleotide that comprises a first universal tail sequence and a second oligonucleotide that comprises a second universal tail sequence. In some aspects of the invention, the first universal tail sequence and the second universal tail sequence are different sequences.