Abstract: The invention provides a droplet encapsulate comprising: a drop of a hydrophobic medium; a peripheral layer of non-polymeric amphipathic molecules around the surface of the drop; and an aqueous droplet within the peripheral layer, the aqueous droplet comprising: (a) an aqueous medium and (b) an outer layer of non-polymeric amphipathic molecules around the surface of the aqueous medium. The invention also provides processes for preparing the droplet encapsulates. Various uses of the droplet encapsulates are also described, including their use as drug delivery vehicles, in synthetic biology, and in the study of membrane proteins.
Type:
Grant
Filed:
November 2, 2012
Date of Patent:
February 4, 2020
Assignee:
Oxford University Innovation Limited
Inventors:
John Hagan Pryce Bayley, Andrew Heron, Gabriel Villar
Abstract: A bypass feature and an emergency shutdown valve that includes such a bypass feature, which is selectively operable to permit a flow of material to pass through the emergency shutdown valve when a shutoff element thereof is closed so as to otherwise prohibit flow through the valve, as well as an associated method of testing an emergency shutdown valve.
Abstract: The present disclosure relates to an organic light emitting device including: a first electrode; a second electrode provided to face the first electrode; and an electron transport layer, an emitting layer and a hole transport layer provided between the first electrode and the second electrode, and the emitting layer contains doped protein quantum dots.
Type:
Grant
Filed:
September 4, 2018
Date of Patent:
February 4, 2020
Assignee:
Research & Business Foundation Sungkyunkwan University
Inventors:
June Kyun Park, Yong Han Roh, Sang Hyun Lee, Byung Chan Seo, Jae Won Jeong
Abstract: The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.
Type:
Grant
Filed:
November 29, 2018
Date of Patent:
February 4, 2020
Assignee:
Southern Methodist University
Inventors:
John G. Wise, Pia D. Vogel, Frances K. Brewer, Courtney A. Follit
Abstract: The present invention relates to a use of 3,6-anhydro-L-galactose for preventing dental caries. More specifically, 3,6-anhydro-L-galactose inhibits the growth of oral microorganisms and exhibits anti-caries activity to inhibit the production of acids caused by the consumption of a carbon source by the oral microorganisms. Thus, 3,6-anhydro-L-galactose can be used in pharmaceuticals, food products, oral hygiene preparations, etc. for preventing, ameliorating or treating oral diseases caused by oral microorganisms, such as dental caries, gingivitis, periodontitis, oral mucosal ulcer, halitosis or xerostomia.
Type:
Grant
Filed:
October 14, 2016
Date of Patent:
February 4, 2020
Assignee:
Korea University Research and Business Foundation
Inventors:
Kyoung Heon Kim, In-Geol Choi, Eun-Ju Yun, Ah-Reum Lee
Abstract: A pressure sensing catheter system includes a urethral catheter and a sensor array formed on the urethral catheter. The sensor array includes a plurality of pressure sensors distributed along a length of the urethral catheter. The sensor array is configured to produce a dynamic pressure distribution profile along a urethra.
Abstract: The present disclosure relates to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates Beyond 4th-Generation (4G) communication system such as Long Term Evolution (LTE). An operation method for a receiving end in a wireless communication system includes receiving signals from a plurality of transmitting ends; determining filters for each of the plurality of transmitting ends; and filtering the signals using each of the filters.
Type:
Grant
Filed:
December 9, 2016
Date of Patent:
February 4, 2020
Assignees:
Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
Inventors:
Chanhong Kim, Daesik Hong, Sung Woo Weon, Insik Jung
Abstract: Embodiments of the present invention provide a task scheduling method and apparatus on a heterogeneous multi-core reconfigurable computing platform. The method includes: when determining that a to-be-executed hardware task is in a ready state, adding the to-be-executed hardware task into a target hardware task queue corresponding to a function of the to-be-executed hardware task; reconfiguring, according to a priority of the to-be-executed hardware task and a usage status of multiple reconfigurable resource packages, at least one reconfigurable resource package in the multiple reconfigurable resource packages into a target intellectual property IP core that can execute the to-be-executed hardware task.
Type:
Grant
Filed:
July 14, 2017
Date of Patent:
February 4, 2020
Assignees:
Huawei Technologies Co., Ltd., University of Science and Technology of China
Abstract: A method for performing magnetic resonance imaging with variable flip angle (VFA) readouts includes preparing longitudinal magnetization of a spin system associated with a subject to a target state, yielding a prepared longitudinal magnetization. The prepared longitudinal magnetization is converted to an image using a VFA readout sequence, wherein the VFA readout sequence comprises a plurality of radio-frequency pulses with corresponding flip-angles varying according to a modulation function.
Type:
Grant
Filed:
December 11, 2014
Date of Patent:
February 4, 2020
Assignees:
Siemens Healthcare GmbH, The Governors of the University of Alberta
Inventors:
Kelvin Chow, Richard Thompson, Bruce S. Spottiswoode
Abstract: Provided are a data discard method for a file system and a memory management apparatus thereof. Specifically, the data discard method for a file system includes: unlinking an inode and a data block corresponding to a file stored in a storage from among inodes and data blocks in a file system when a kernel event of deleting the file occurs; updating state values for the unlinked inode and data block, respectively, to a bitmap block of the file system; checking bit values of all of inodes in an inode block including the updated inode from among inode blocks of the file system; and transmitting discard commands with respect to the inode block including the updated inode and the data block, respectively, to the storage if all of the inodes of the inode block are clean bits as a result of the check.
Type:
Grant
Filed:
May 26, 2017
Date of Patent:
February 4, 2020
Assignee:
Research & Business Foundation Sungkyunkwan University
Abstract: The present disclosure provides a wearable computing device. The wearable computing device includes one or more sensors that output sensor data. The wearable computing device includes a machine-learned smoking gesture detection model trained to detect a smoking gesture based on the sensor data. The wearable computing device includes one or more processors and one or more non-transitory computer-readable media that store instructions that, when executed by the one or more processors, cause the one or more processors to perform operations. The operations include inputting the sensor data into the machine-learned smoking gesture detection model. The operations include receiving, as an output of the machine-learned smoking gesture detection model, a gesture classification that indicates whether the sensor data is indicative of the smoking gesture.
Type:
Grant
Filed:
April 9, 2018
Date of Patent:
February 4, 2020
Assignee:
University of South Carolina
Inventors:
Homayoun Valafar, Casey A. Cole, James F. Thrasher, Scott M. Strayer
Abstract: The present disclosure is related to the microwave measuring field, and in particularly to a coaxial resonant cavity and system and method for measuring the dielectric constant of material. The coaxial resonant cavity includes a coupling mechanism and a cavity body. The coupling mechanism is accommodated in the cavity body for exciting or coupling microwaves inside the cavity body. The coaxial resonant cavity further includes a probe extending out of the cavity body and being coaxial with the cavity body. The cavity body is shaped as an annular column, and a ratio of an outer radius of the annular column to an inner radius of the annular column is (3-5):1. The present disclosure still provides a system and method for measuring the dielectric constant of material using the coaxial resonant cavity.
Type:
Grant
Filed:
July 19, 2017
Date of Patent:
February 4, 2020
Assignee:
University of Electronic Science and Technology of China
Inventors:
Yong Xiang, Cong Wang, Xuesong Feng, Fenfen Liu
Abstract: The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients.
Type:
Grant
Filed:
August 7, 2015
Date of Patent:
February 4, 2020
Assignee:
The Curators of the University of Missouri
Abstract: A device and methods for performing a simulated CT biopsy on a region of interest on a patient. The device comprises a gantry (22) configured to mount an x-ray emitter (24) and CT detector (26) on opposing sides of the gantry, a motor (28) rotatably coupled to the gantry such that the gantry rotates horizontally about the region of interest, and a high resolution x-ray detector (172) positioned adjacent the CT detector in between the CT detector and the x-ray emitter.
Type:
Grant
Filed:
August 4, 2017
Date of Patent:
February 4, 2020
Assignee:
The Regents of the University of California
Abstract: A composite material comprising graphene or reduced graphene oxide and a polymer-derived ceramic material, such as SiOC, is provided. The composite materials can be used to construct anodes (16), which can be used in batteries (10), particularly lithium ion batteries. The anodes exhibit relatively high charge capacities at various current densities. Moreover, the charge capacity of the anodes appears exceptionally stable even after numerous charging cycles, even at high current densities.
Type:
Grant
Filed:
March 20, 2014
Date of Patent:
February 4, 2020
Assignee:
Kansas State University Research Foundation
Abstract: A method for treatment of a hexachlorodisilane and its hydrolyzed product is disclosed. It comprises adding a hexachlorodisilane or its hydrolyzed product into a sulfuric acid solution for reaction.
Type:
Grant
Filed:
May 23, 2018
Date of Patent:
February 4, 2020
Assignee:
National Kaohsiung University of Science and Technology
Abstract: A structured composite surface includes a backing layer and a plurality of composite posts in contact with the backing layer, each composite post having a core made of a first material and an outer shell made of a second material, the outer shell is in contact with and surrounding the core, the core has a Young's modulus of at least 50 times greater than the outer shell. A method of transfer printing includes pressing a stamp including at least one composite post to a substrate, the at least one composite post having a core made of a first material and an outer shell made of a second material, the outer shell is in contact with and surrounding the core, the core has a Young's modulus at least 50 times greater than the outer shell, and retracting the stamp from the substrate by applying a shear load to the stamp.
Type:
Grant
Filed:
May 28, 2015
Date of Patent:
February 4, 2020
Assignee:
The Trustees of the University of Pennsylvania
Abstract: The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
Type:
Grant
Filed:
June 10, 2016
Date of Patent:
February 4, 2020
Assignees:
The Broad Institute, Inc., Massachusetts Institute of Technology, University of Tokyo, President and Fellows of Harvard College
Inventors:
Silvana Konermann, Alexandro Trevino, Mark Brigham, Fei Ran, Patrick Hsu, Chie-yu Lin, Osamu Nureki, Hiroshi Nishimasu, Ryuichiro Ishitani, Feng Zhang
Abstract: Compositions and methods for treatment of glioma are disclosed. In particular, the invention relates to methods of treating glioma by inhibiting pleiotrophin signaling to limit high-grade glioma invasion.
Type:
Grant
Filed:
August 15, 2018
Date of Patent:
February 4, 2020
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Michelle Monje-Deisseroth, Elizabeth Qin