Abstract: In one embodiment, an electromagnetic soft actuator includes a first soft outer member comprising a soft internal electrically conductive coil, a second soft outer member comprising a soft internal electrically conductive coil, and a soft inner shaft on which the first and second soft outer members are mounted, the first and second soft outer members being linearly displaceable along a length of the soft inner shaft, the soft inner shaft comprising a permanent magnet, wherein the first and second outer members linearly move under an electromagnetic force relative to the soft inner shaft and each other when an electric current is applied to the soft internal electrically conductive coils.

Abstract: A Ras protein degradation inducing molecule that can induce degradation of Ras proteins, and a pharmaceutical composition that contains this Ras protein degradation inducing molecule are provided. The Ras protein degradation inducing molecule is a conjugate of a Ras protein affinity molecule which has affinity to Ras proteins, and a proteolysis-inducing tag which has affinity to protease and does not inhibit proteolysis of proteins by the protease.

Abstract: A method for optically detecting mutations in a sequence of DNA is disclosed. The method includes generating an optically coded input sequence by optically coding an input sequence, generating an optically coded reference sequence by optically coding a reference sequence, generating an aligned sequence by overlapping the optically coded input sequence with the optically coded reference sequence, and determining a mutation in the input sequence with respect to the reference sequence. The input sequence includes an input arrangement of a plurality of elements. Each of the plurality of elements includes an element value of a plurality of element values. The reference sequence includes a reference arrangement of the plurality of elements. Each element of the aligned sequence includes one of a low-value element or a high-value element. The mutation is determined responsive to detecting the low-value element in the aligned sequence.

Abstract: The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.

Abstract: An apparatus for creating movement in a virtual reality for a user includes a computer includes a virtual reality headset in communication with the computer that is worn on the head of the user so the user sees the virtual reality shown by the headset and produced by the computer in the headset. The apparatus includes a foot controller in communication with the computer against which the user moves at least one of his feet to create control signals with the foot to cause movement in the virtual reality. A method for creating movement in a virtual reality for a user having the steps of the user seeing the virtual reality shown by a virtual headset and produced by a computer in the headset, a virtual reality headset in communication with the computer that is worn on the head of the user.

Abstract: Methods, systems, and devices are disclosed for systemic delivery and selective and localized activation of nanoparticles containing an agent in an inactive form or a prodrug in a subject.

Abstract: A planar Hall effect (PHE) sensor for measuring at an external magnetic field includes a plurality of elongated magnetic regions. Each magnetic region includes a ferromagnetic material that is magnetized along a longitudinal axis. The magnetic regions cross one another at an overlap region that is characterized by a plurality of easy magnetic axes. At least two pairs of electrical leads are each aligned along one of the easy magnetic axes. A current source may be connected to a first pair of the electrical leads to cause a current to flow through the overlap region along a first easy magnetic axis. A voltage measurement device may be connected to another pair of the electrical leads to measure a PHE voltage that is generated by a component of the external magnetic field that is perpendicular to the easy magnetic axis along which the overlap region is magnetized.

Abstract: Provided are methods for characterizing nucleotide accessibility and nucleic acid structure at single nucleotide resolution, using a combination of low-yield bisulfite conversion and next-generation sequencing (NGS). Cytosine (C) nucleotides that are in base-paired states or bound to proteins, etc. are less accessible to chemical reactions and thus exhibit lower bisulfite conversion yields. Analysis of NGS results of a low-yield bisulfite conversion product can thus inform nucleotide accessibility and nucleic acid structure. Compared to other methods for chemical probing of nucleic acid structure, the present methods provide higher information throughput, because each NGS read simultaneously reports on the base pair status of multiple nucleotides.

Abstract: This invention provides a multinary solid solution fine particle represented by PdxRuyMz (M is at least one member selected from the group consisting of Rh, Pt, Cu, Ag, Au and Ir. x+y+z=1, x+y=0.01 to 0.99, z=0.99 to 0.01, x:y=0.1:0.9 to 0.9:0.1), a method for producing the same, and a supported catalyst.

Abstract: A magnetic resonance spectrometer and a control apparatus for the magnetic resonance spectrometer based on an FPGA. The control apparatus includes a control unit and a conversion receiving unit. The control unit includes a clock source. A waveform generation unit and a signal receiving unit inside the control apparatus are synchronized by means of the same clock source. The control apparatus includes two working modes: a continuous wave mode and an impulse wave mode. The control apparatus can output a microwave signal which is modulated by any wave and has higher synchronism and time resolution.

Abstract: A metal detector for buried and abandoned chemical weapons is provided, comprising: a transmitting circuit to transmit a detection signal; a frequency selection unit electrically connected to the transmitting circuit and configured to regulate a frequency of the detection signal; a receiving circuit to receive a reflected signal returned from the substance detected; an analog-digital conversion unit electrically connected to the receiving circuit and configured to convert the reflected signal into a digital signal; and a control unit electrically connected to the analog-digital conversion unit. In the present disclosure, the frequency of the detection signal can be regulated by changing a current frequency of the transmitting circuit, so that several forms of iron compound can be detected, thereby increasing the detection accuracy of the ACWs.

Abstract: A method for determining a physical similarity simulation material of a solid backfill body is provided. A compaction test is run on a gangue backfill body in a lab, to obtain a ?-? curve regarding the gangue backfill body in the compaction process. Backfill blocks are made by using a thin wood board, sponge, and a paper sheet in different proportions, and then an unconfined compression test is separately run on the backfill blocks used for physical similarity simulation, to obtain ?i-?i curves regarding the backfill blocks in the compression process. A sum of squared errors ?(?i??0)2 is introduced to separately calculate a sum of squared errors of the backfill block and that of the gangue backfill body, and accordingly an error between ?-? curves regarding the test block and the gangue backfill body is determined. Finally, a backfill block for which the sum of squared errors is less than 0.5 is determined as a physical similarity simulation material of the gangue backfill body.

Abstract: Lightweight masonry hollow bricks of a substantially rectangular cuboid shape having central cavities and side indentations. A concrete composition of the masonry hollow bricks includes cement, water, sand, a coarse aggregate, and an insulating material, e.g. perlite, polyethylene, crumb rubber. The developed masonry hollow bricks met the ASTM requirements for non-load bearing masonry bricks in addition to satisfying the ASTM standard as being lightweight masonry bricks.

Abstract: Organic light emitting materials and devices comprising phosphorescent metal complexes comprising ligands comprising aryl or heteroaryl groups substituted at both ortho positions are described. An organic light emitting device, comprising: an anode, a hole transport layer; an organic emissive layer comprising an emissive layer host and an emissive dopant; an electron impeding layer; and electron transport layer; and a cathode disposed, in that order, over a substrate.

Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.

Abstract: A dental treatment method is provided. In this method, a tooth of a patient is extracted and prepared to provide a root part. A root canal in the extracted tooth is prepared and treated. A post of an abutment is fitted into the root canal to attach the root part to the abutment. The abutment having the root part is attached to a dental implant. With the root part attached to the abutment, periodontal connective tissue maintains the jaw bone associated with the extracted tooth, without significant hard tissue loss.

Abstract: Provided is an antiangiogenic agent in the form of a vehicle, e.g., a nanoparticle associated (directly or indirectly) with at least one ocular angiogenesis growth factor aptamer, wherein said association labile to interaction between the aptamer and an ocular angiogenesis growth factor.

Abstract: A layered metal oxide field effect electrode includes multiple metal strips and layered metal oxide films. The band gap width of the first thin metal oxide film material is less than 3 eV; the band gap width of the second thin metal oxide film material is greater than 3 eV; the band gap width of the third thin metal oxide film material is less than 3 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the first thin metal oxide film material is greater than 1 eV; the difference between the band gap width of the second thin metal oxide film material and the band gap width of the third thin metal oxide film material is greater than 1 eV; and the thicknesses of the first thin metal oxide film, the second thin metal oxide film, and the third thin metal oxide film are each smaller than or equal to 10 nm. The layered metal oxide field effect electrode has the advantages of high light transmittance and a good field conduction performance.

Abstract: A laboratory device for simulating the cement sheath consolidation in the frozen soil strata includes the main body, the pressure system and the measuring system. The main body includes the fixing plate, the detachable plate and the base plate. The circular hole is provided in the center of the base. The central column or the heat insulating casing is mounted on the base through the circular hole. The fixing plate, the detachable plate, the base plate and the central column or the heat insulating casing form a cavity for preparing the core and the cement sheath. During use, the device is placed in a low temperature context, and then the frozen soil core with a hollow cylinder can be artificially fabricated. Further, the heat insulating casing holder is placed, and the cement is added to simulate the state of the cement sheath consolidation under the actual strata conditions.

Abstract: The present disclosure provides proteins comprising antibody antigen binding domains that bind to Fn14 and uses thereof. The present disclosure also provides methods for treating wasting disorders, such as cachexia.