Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure.

Abstract: A method for generating encoded data includes: generating at least one local LDPC matrix and a global LDPC matrix, the global LDPC matrix relating to each of the at least one local LDPC matrix; repeatedly selecting one of the at least one local LDPC matrix as a target local LDPC matrix until a number t of the target local LDPC matrices are selected, where t is a user-defined number that is greater than one; generating a block matrix that includes the target local LDPC matrices; generating a primary LDPC matrix that includes a first primary matrix part relating to the block matrix, and a second primary matrix part relating to the global LDPC matrix; and encoding data based on the primary LDPC matrix.

Abstract: Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit toxicity towards normal host tissues and the complications associated with graft-versus-host-disease, is also described.

Abstract: The present disclosure relates to compounds having the Formula (Formula (I)) which are inhibitors of STAT5.

Abstract: A fluid sensing device includes an outer shell, a three-axis force and moment balance, a strut, and a centerbody. The outer shell has an inlet at a first end of the outer shell, an aft vent at an opposing second end of the outer shell, and an interior space connecting the inlet and the aft vent. The three-axis force and moment balance is positioned in the interior space of the outer shell. The strut is connected to the outer shell and the three-axis force and moment balance such that the strut supports the three-axis force and moment balance in the interior space. At least a portion of the centerbody is positioned in the interior space of the outer shell. The centerbody is connected to the three-axis force and moment balance such that the three-axis force and moment balance is configured to measure force, moment, and/or movement of the centerbody.

Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.

Abstract: The measuring cup includes numerous embodiments configured for a user to precisely determine the cup contents without need to lift the cup to one's eye level or to lower the eye level to the level of the cup contents. The various embodiments include folding cups; cups having transparent passages in the wall; cups having adjustably positionable bottoms; cups having level indicator rods in the cup interior extending upward from the cup bottom; cups having one or more filaments extending across the cup interior; cups having rigid level indicators spanning the cup interior; cups having adjustably positionable level indicator tabs therein; cups having buoyant level indicator tabs adjustably positionable in the cup interior; and cups having removable clip-on scales extending down along the interior of the cup wall, the scales having a plurality of attachment points for the removable attachment of a level indicator tab at a desired attachment point.

Abstract: An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms in Parkinson's disease (PD) and other movement disorders. During the stimulation, the patient is engaged in a behavioral task using a system consisting of two force transducers and a controller. The patient holds the transducers, one in each hand, and is engaged in a task that requires the brain to assign forces to each arm so that the sum of the forces matches an instructed amount. In an electrode placement specifically for PD, bilateral primary motor cortices are simultaneously stimulated according to a specific algorithm that depends on the forces that the PD affected individual produces in the behavioral task.

Abstract: Described herein is the synthesis of adhesive complex coacervates and their use thereof. The adhesive complex coacervates are composed of a mixture of one or more polycations and one or more polyanions. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices.

Abstract: The present invention includes a system, apparatus and method for generating a three-dimensional image, the system comprising: a medium comprising a optical molecular switch molecule, wherein the optical molecular switch molecule has a non-fluorescent state and a fluorescent state, wherein at one wavelength of optical excitation the molecule has a first state, and at a second state the molecule fluoresces a second wavelength of excitation; and at least a first light source and a second light source into the medium, wherein light emitted by the at least first and second light sources are directed to contact the optical molecular switch molecule, e.g., scanning, weaving, diagonally or other pattern; wherein the optical molecular switch molecule is converted into a fluorescent “on state” by irradiation from the first light source, and the second light causes the optical molecular switch to emit light.

Abstract: Methods, systems, and devices are disclosed for the identification of chemical agents and determination of their level of exposure using electrochemical detection and advanced signal processing. In one aspect, a method includes collecting a sample from a surface containing a chemical agent to an electrode on a sensor such that the chemical agent transfers on the electrode, detecting an electrochemical signal of the chemical agent on the electrode to transduce chemical information associated with the chemical agent to an electrical signal, processing the electrical signal to obtain electrochemical spectral signature data to identify the chemical agent and generating a series of coefficients of the electrochemical spectral signature data to reduce the data, and classifying the chemical information based on the series of coefficients among preselected data sets to determine a level of exposure to the chemical agent.

Abstract: A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to generate filtered ECG signals. The method further includes identifying a heart vector from the filtered ECG signals, and measuring a velocity of the heart vector movement. A change in curvature of the identified heart vector movement is quantified and a risk of ventricular tachycardia is determined based at least on the measured velocity and the quantified change in curvature of the identified heart vector movement.

Abstract: The present invention generally concerns isolated nanoparticles via the decomposition of a ternary metal hydride. More specifically, the present invention harnesses increased energy densities from two distinct nanoparticles isolated by a precise decomposition of LiAlH4. The singular material is air stable and is a nanocomposite of Li3AlH6 nanoparticles, elemental Al nanoparticles, an amount of Ti metal, and a nanoscale organic layer, which we call nMx. The nanocomposite protects and preserves the high energy densities of the core metals isolated from the controlled reaction and makes the nanoparticles safe to handle in air. The final composite is devoid of byproducts or phase transitions that will decrease the energy output of the nanocomposite. The method of the present invention creates a narrow distribution of nanoparticles that have unique burning characteristics useful for many applications.

Abstract: A video analytics algorithm, system, and method for use in real time allowing accurate, reliable, and timely warnings that facilitate traffic safety and efficiency. The system and method are readily implemented with minimal computational resources, providing broad applicability. In an embodiment, a video analytics method may include (a) obtaining a sequence of real-time images as input from a traffic monitoring system; (b) identifying a plurality of vehicles within a pre-defined region of interest; (c) tracking vehicles within the predefined region of interest; and (d) detecting a conflict event when the vehicles are located within a pre-determined maximum separation threshold based on each vehicles coordinates in a spatial-temporal domain.

Abstract: A system and method for performing initial synchronization during wireless sector searches. The system includes a first subsystem for coarse timing alignment including a decimator to reduce computational complexity and a long-lag differential correlator, a second subsystem for jointly estimating RTE and FFO utilizing a short-lag differential correlator, and a third subsystem for jointly detecting IFO and SID utilizing segmental FD MFs. The system and method of the present disclosure accounts for intercell interference, ICI, and multipath fading with assistance from inherent diversity.

Abstract: Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a DE loop sequence of RANKL protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.

Abstract: Methods and systems for producing a biofuel using genetically modified sulfur-oxidizing and iron-reducing bacteria (SOIRB) are disclosed. In some embodiments, the methods include the following: providing a SOIRB that have been genetically modified to include a particular metabolic pathway to enable them to generate a biofuel; feeding a first source of ferric iron to the SOIRB; feeding sulfur, water, and carbon dioxide to the SOIRB; producing at least the first particular biofuel, a first source of ferrous iron, sulfate, excess ferric iron, and an SOIRB biomass; electrochemically reducing the excess ferric iron to a second source of ferrous iron; providing an iron-oxidizing bacteria that have been genetically modified to include a particular metabolic pathway to enable them to generate a second biofuel; producing at least the second biofuel, a second source of ferric iron, and an IOB biomass; and feeding the second source of ferric iron to the SOIRB.

Abstract: A bending mold device for bidirectional pipe bending includes a mounting base which is horizontally arranged on a rack in a sliding manner. The mounting base includes a translation lead screw driving the mounting base to slide. The rack includes a lead screw nut. A pipe bending spindle is rotatably disposed on the mounting base and a power mechanism is disposed on the mounting base. The upper end of the pipe bending spindle is movably connected to a lower rotating base. The lower rotating base includes a first pipe bending shaft and a second pipe bending shaft, which respectively include a first bending mold lower mold and a second bending mold lower mold. The rack includes a cylinder above the lower rotating base. The end part of a piston rod of the cylinder fixedly includes an upper limiting plate and a lower limiting plate in a sleeving manner.

Abstract: A method for detecting T-cell lymphoma characterized in that gene mutations of at least one base selected from a group comprising base numbers 50, 331, 334, and 482 or gene mutations of base numbers 49 to 51 in the base sequence of an RHOA gene collected from a subject are analyzed, and the analysis results and T-cell lymphoma are associated with each other.

Abstract: By forming a monolayer of metal core-shell nanoparticles, transferring the monolayer to various substrates and removing the shells surrounding the particles by way of selective etching, it is possible to form large-area uniform nanogap structures very easily. In addition, a nanogap is formed by an ultrasmall void having no limitation in diffusion between metal cores through Van der Waals interaction between the metal core particles, as the etching proceeds. It is possible to enhance a near-field significantly around the nanogap structure.