Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.

Abstract: Disclosed herein is a multi-layered composite thin film material formed from graphene quantum dots (GQDs) and metal nanocrystals in a layer-by-layer design, wherein the metal nanocrystals can be selected from the group consisting of Ru, Rh, Os, Ir, Pd, Au, Ag and Pt. In a preferred embodiment, the multi-layered composite thin film material is prepared via a facile, green, and easily accessible layer-by-layer (LbL) self-assembly strategy. In this strategy, positively charged GOQDs and negatively charged metal nanocrystals are alternately and uniformly integrated with each other in a “face-to-face” stacked fashion under substantial electrostatic attractive interaction, and then the obtained GOQDs/metal composite thin film is calcined into GQDs/metal composite thin film. The composite thin film material disclosed herein may be used to catalyse a wide range or reactions, including selective reduction of aromatic nitro compounds in water and electrocatalytic oxidation of methanol at ambient conditions.

Abstract: Described herein is a new antidote for the rapid elimination of carbon monoxide from hemoglobin, including brain, heart, and red cell hemoglobin. The disclosed therapy involves the use of modified human globins, particularly neuroglobins modified at residue 64 and cytoglobins modified at residue 81, which bind carbon monoxide with extremely high affinity. The monomeric mutant globins are infused into blood, where they rapidly and irreversibly sequester carbon monoxide, and thus limit toxic effects of carbon monoxide on cellular respiration and oxygen transport and utilization.

Abstract: A method named as Magnet Shifting to reduce torque ripple of permanent magnet synchronous motor is disclosed. A way of reasonably choosing the repeating unit of magnetic pole, the shifting ways and the shifting angle calculation of the first and second magnet shifting is described, which are carried on the repeating unit of magnetic poles individually or repeatedly to improve the performance of the motor. The method can be applied to surface, surface-inset and inner-embedded permanent magnet motors, which can reduce torque ripple caused by different torque components, including cogging torque, reluctance torque or permanent magnet torque. It also can quickly calculate the shifting angle of the magnetic pole by choosing repeating unit reasonably. Magnet shifting can effectively enhance the sinusoidal degree of back electrodynamic force (back-EMF) waveform, where the repeating units can offset the torque ripple between the maximum and the minimum value to reduce the different torque harmonics.

Abstract: Provided herein are methods of treating and/or preventing endometriosis or symptom thereof, assays for diagnosing/prognosing endometriosis, compositions and formulations for treating and/or preventing endometriosis or symptom thereof, and populations of endometiotic cells, including life-extended populations of cells.

Abstract: The present invention relates to a method for producing pancreatic progenitor cells from pluripotent stem cells. More specifically, the present invention relates to a method for producing pancreatic progenitor cells, comprising causing the action of a factor having the inhibitory activity for cyclin-dependent kinase 8 and/or cyclin-dependent kinase 19 (hereinafter, also abbreviated to CDK8/19).

Abstract: The present invention provides a method for 3D waveform mapping of full-parallel structure, first, a 3D waveform mapping database is created according to the size of a 3D waveform image, the number of bits of probability value and the ADC's resolution of data acquisition module, then the 3D waveform mapping database is divided into Mt×Ma independent mapping storage areas along the time axis and the amplitude axis, and each independent mapping storage area is assigned a RAM, then RAMs are selected and addresses are calculated based on the sampling values and the structure of created 3D waveform mapping database, finally, parallel mappings are performed simultaneously on the time axis and the amplitude axis according to the selected RAMs and calculated addresses. Thus, the mapping time are shorten, especially in vector mapping mode, several RAMs are used for mapping, so the WCR of DSO is improved.

Abstract: Biodegradable antimicrobial films are provided that are solid at room temperature and substantially liquefy in situ after implantation into a mammal, such as a human patient. Methods of using the films to cover a medical device, such as a breast implant, prior to insertion into a subject are also provided.

Abstract: Provided is a novel photoinitiator in the form of a hybrid nanoparticle constructed of a semiconductor and metallic regions, and uses thereof.

Abstract: The disclosure provides a system and a method for recognizing a gait. The method includes: bearing a first foot of a user by a bearing surface of a sensing device; sensing a gait applied by the first foot to the bearing surface by a sensor of the sensing device; and recognizing the user based on the gait by a processing device.

Abstract: This is a system and method for homomorphic encryption comprising: a key generation module configured to generate a secret key, a public key and a bootstrapping key; a private-key encryption module configured to generate a first ciphertext using the secret key; a public-key encryption module configured to generate a second cyphertext using the public key; a private-key decoding module configured to decode a first ciphertext, a second ciphertext and an encrypted analytic result; a homomorphic computational module configured to perform an analytical operation, according to an analytical operation request on the first ciphertext and the second ciphertext without decrypting the first ciphertext and the second ciphertext using the bootstrapping key; and, wherein the encrypted analytical result is provided by the homomorphic computational module and are encrypted with the secret key.

Abstract: A method of analyzing performance of a brain stimulation tool is disclosed. The method comprises: obtaining encephalography data collected from a brain of a subject electrically stimulated by at least one of the electrode contacts of the brain stimulation tool; segmenting the data into a plurality of epochs, each corresponding to a single stimulation event generated by the brain stimulation tool; and applying a spatiotemporal analysis to the epochs so as to determine at least one of (i) location of the at least one electrode contact in the brain, and (ii) therapeutic effect of the at least one electrode contact.

Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

Abstract: The present disclosure relates to recombinant proteins that induce epigenetic gene silencing and to methods of using such proteins for reducing the expression of genes in plants.

Abstract: Compositions and uses involving L. monocytogenes PssZ, as well as homologs, variants, and fragments thereof, are described.

Abstract: A compound that has the structure according to Formula M(LA)x(LB)y(LC)z: wherein ligand LA is ligand LB is and ligand LC is and devices and formulations containing these compounds are disclosed. In Formula M(LA)x(LB)y(LC)z: M is a metal having an atomic number greater than 40; x is 1 or 2; x+y+z is the oxidation state of the metal M; X1-X4 and A1-A8 are C or N; at least one of A1-A8 is N; X is O, S, or Se; two adjacent RB form a six-member aromatic ring E fused to ring B; wherein ring E can be substituted by RE; each RA-RE and R1-R4 is independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.

Abstract: A method of differentiating benign melanocytic nevi from malignant melanomas is disclosed. The method generally includes treating and subjecting a skin lesion sample from a patient to mass spectrometry to obtain a mass spectrometry proteomic profile. This profile is compared to mass spectrometry proteomic profiles of reference samples, which include benign melanocytic nevi and/or malignant melanomas. Classification of the skin lesion sample as a benign melanocytic nevus or a malignant melanoma is based on similarities and/or difference between the mass spectrometry proteomic profiles.

Abstract: A hybrid radiation imaging sensor includes a low x-ray attenuating substrate, a photoconductor disposed over the substrate, and a scintillator disposed over the photoconductor. By combining direct x-ray conversion to electron-hole pairs in the photo-conductor with indirect conversion of x-rays downstream of the photoconductor within the scintillator, improved x-ray imaging can be attained through an electronic readout located upstream of both the photoconductor and the scintillator without the need for excessive x-ray dosing.

Abstract: A method for controlling radiation scattering, comprises: directing radiation to a metamaterial having an array of individually tunable and near field coupled resonators, varying an individual resonance frequency of at least one of the resonators to provide a collective resonance scattering of the radiation by the metamaterial, measuring a scattering signal of the collective resonance scattering of the radiation, and identifying the metamaterial based on the scattering signal.

Abstract: This invention relates generally to a method and system for hybrid classical-quantum communication. The method comprises transmitting a single photon having a particular quantum state over a communication medium using a quantum mode set; and transmitting a classical light beam over the same communication medium using a classical mode set, wherein the classical and quantum mode sets comprise non-separable modes in common. The non-separable modes in common may be two degrees of freedom of a single photon or classical light and may thus be spatial modes in one or more indexes, and polarisation. The invention relates also to a system to implement the method accordingly.