Abstract: Embodiments of the present invention are directed to small molecule inhibitors of PHGDH. Other embodiments of the present invention relate to methods of treating cancers using the small molecule inhibitors of PHGDH disclosed herein. Still other embodiments of the present invention relate to methods for using the small molecule inhibitors of PHGDH to study serine metabolism.

Abstract: Provided herein is a capacitive torque sensor, which can completely offset forces/torques in all axial directions, except for force/torque in a direction of a central axis, by measuring variations in capacitances of four sensing cells arrayed at angular intervals of 90 degrees on the basis of a center of the sensor and can offer a sensing value for the torque in a central axis direction.

Abstract: A method for designing an off-axis three-mirror imaging system with freeform surfaces is provided. A primary mirror initial structure, a secondary mirror initial structure, and a tertiary mirror initial structure are established. A number of first feature rays are selected, while the primary mirror initial structure and the secondary mirror initial structure unchanged. The first feature rays are forward ray tracked from an object space to an image detector. A number of first feature data points are calculated to obtain a tertiary mirror. A number of fields and a number of second feature rays are selected, while the secondary mirror initial structure and the tertiary mirror unchanged. The second feature rays are reverse ray tracked from the image detector to the object space. A number of second feature data points are calculated to obtain the primary mirror.

Abstract: The method includes collecting a schedule job list from a database, generating a plurality of schedules for a schedule job to be processed with respect to the schedule job list, calculating an evaluation index for the plurality of generated schedules, determining whether the calculated evaluation index for the plurality of schedules has reached a target evaluation index, selecting a schedule corresponding to two evaluation indices when the calculated evaluation index does not reach the target evaluation index and generating two new schedules using a genetic algorithm, and setting a selection probability so that a schedule having the highest evaluation index is selected and returning the selection probability to a user when the calculated evaluation index reaches the target evaluation index.

Abstract: Peptides of 5 to 14 amino acids in length that stimulate subcutaneous adipogenesis in mammals and uses thereof are provided.

Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.

Abstract: A method of preventing or treating an oral disease by reducing adhesion of microorganisms, e.g. Candida albicans, to dental appliances fabricated and/or repaired by an autopolymerizing acrylic reinforcement resin comprising zirconium dioxide nanoparticles.

Abstract: In one embodiment, a robotic end effector configured to mount to a robotic manipulator includes gripping elements configured to grasp objects, a drive mechanism configured to open and close the gripping elements, and a central controller configured to control operation of the drive mechanism and the gripper elements, the central controller hosting a control program that enables control of the end effector independent of the robotic manipulator.

Abstract: Systems and methods in accordance with embodiments of the invention utilize technology to facilitate student question creation. Interactive platforms such as mobile phones or tablets can allow questions to be written, saved, and communicated electronically. In one embodiment, a method for collaboratively generating a question includes generating question data in response to input of a question and answer choices on a first device, sending the question data to a repository, sending the question data from the repository to a second device, displaying the question and answer choices on the second device, generating revised question data in response to input that changes the question, sending the revised question data to the repository, sending the revised question data to a third device, displaying the question and answer choices on the third device, receiving input of the selection of answer choices on the third device, and providing feedback whether the selection is correct.

Abstract: A composite material comprising a polymer and a carbonized hemp filler, wherein the carbonized hemp filler is produced by carbonizing hemp at a temperature of at least 1100 C to produce a char; and milling the char to produce a particle size, wherein the filler comprises 95% of particles of less than 10 microns in size; and wherein the hemp filler comprises between 1 and 50% of the total mass of the composite.

Abstract: The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the volume in the subject to form MRF data. The MRF data is then compared to simulated MRF signal to determine parameters associated with phosphate metabolites and the chemical exchange rates between these metabolites. These parameters and exchange rates can be used in diagnosing a metabolic disorder in a subject.

Abstract: The present invention provides an ecological method for denitrification and phosphorus removal in wastewater treatment process, which relates to the field of sewage treatment technology, The present invention provides a nitrogen and phosphorus removal system, comprising a nitrogen and phosphorus removal unit and a sulfate adsorption unit. The nitrogen and phosphorus removal unit is packed with coarse sand layer, deoxidizing layer and sulfur/iron mixture layer, while the sulfate adsorption unit is filled with modified hydrotalcite. Both of the units are filled with solid material, which effectively avoid the contamination that causes by liquid carbon source feeding. The application of the present invention can realize a completely denitrification, which achieve a maximum removal rate of 100%, a phosphorus removal efficiency of about 80%. The TP concentration is below 0.5 mg/L in the treated effluent, while the average sulfate removal rate is about 50%.

Abstract: The present invention relates to an ink formulation comprising two-dimensional inorganic layered particles. The ink formulations of the present invention are for inkjet printing. The present invention also relates to a process for the preparation of these ink formulations, to the use of these ink formulations for the production of printed films and tracks comprising the inorganic material, to the films or tracks produced by the inkjet printing of these ink formulations, to devices that comprise these films or tracks, and to systems comprising an array of these devices.

Abstract: An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring micro/nanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring micro/nanoparticle and at least another group that results in hydrophobicity. The hierarchical structuring micro/nanoparticles are dispersed in the liquid silane. Another effective amount of synthetic adhesive, selected from thermosetting binders, moisture curing adhesives or polymers that form a strong interaction with a surface, is in solution with a solvent. Upon curing, the layer has a contact angle greater than 90° and a sliding angle of less than 10° and, less than 5% of an area of the layer is removed in a Tape test.

Abstract: Disclosed a method of fabricating a gallium nitride substrate using hydride vapor phase epitaxy (HVPE), including a step of injecting ammonia (NH3) gas to perform first surface treatment on a sapphire substrate; a step of injecting ammonia gas and hydrogen chloride (HCl) gas to form a buffer layer on the sapphire substrate; a step of injecting ammonia gas to perform second surface treatment on the sapphire substrate; and a step of allowing gallium nitride (GaN) to grow on the sapphire substrate while lowering the flow rate ratio of ammonia gas to hydrogen chloride gas stepwise.

Abstract: In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Abstract: Gold(I) complexes and gold(I) dithiocarbamate polymers as anticancer therapeutics. The Au(I) ion within the gold(I) complexes is coordinated to two phosphine ligands. The repeating unit formed by Au(I) ion coordinating to dithiocarbamte ligands are connected by Au(I)-Au(I) interactions within the gold(I) dithiocarbamate polymers. Also disclosed are methods of synthesis, pharmaceutical compositions incorporating the gold(I) complexes, pharmaceutical compositions incorporating the gold(I) dithiocarbamate polymers, and methods of treating cancer.

Abstract: A light emitting diode and a method of fabricating the same are described. The light emitting diode has: a hole transport layer, an active layer and an electron transport layer. The active layer is disposed on the hole transport layer, and the active layer has a mesophase structure of an organic amine compound and a perovskite structure compound. The electron transport layer is disposed on the active layer.

Abstract: The present invention relates to a method for detecting renal disease and for assessing the efficacy of dialysis treatment using imaging agents having desirable in vivo properties.

Abstract: Electrodes comprising conducting graphite, paraffin oil pasting liquid, and a rare earth metal impregnated zeolite, such as lanthanum or cerium impregnated mordenite electrodes. Methods and voltammetric applications, such as square wave anodic stripping voltammetry, of these rare earth metal impregnated zeolite modified electrodes for the detection and quantification of heavy metal ions such as Pb(II) and Cd(II) in aqueous solutions.